1.Increased Infiltration of CD8⁺ T Cells by Dacarbazine in a Patient with Mucosal Penile Melanoma Refractory to Nivolumab.
Masato FUNAZUMI ; Takeshi NAMIKI ; Yumi ARIMA ; Kohei KATO ; Kohei NOJIMA ; Kentaro TANAKA ; Keiko MIURA ; Hiroo YOKOZEKI
Annals of Dermatology 2016;28(4):486-490
Primary penile melanomas are rare tumors that represent less than 0.1% of all melanomas. We report a case of a 60-year-old Japanese male with a mucosal penile melanoma and describe an increased CD8⁺ T cell infiltration in brain after dacarbazine (DTIC) administration. After partial penectomy and left inguinal lymphadenectomy, he developed multiple lung, bone, spleen, brain and skin metastases. He was treated with interferon-β, DTIC and nivolumab. However, the metastases were not reduced in size. Immunohistochemistry showed an increase of CD8⁺ T cell infiltration and programmed death-ligand 1 (PD-L1) expression after the administration of DTIC, but the expression of programmed cell death protein 1 (PD-1) was negative. We speculate that DTIC exerted immunostimulatory effects, but nivolumab was ineffective due to the negative expression of PD-1 and/or an insufficient infiltration of CD8⁺ T cells. Although this is only one case, this case report could be the first step to discuss the development of effective therapies against melanoma to take advantage of the increased CD8⁺ T cell infiltration elicited by chemotherapeutic agents. It would be beneficial to pay more attention to the relationship between DTIC and immune checkpoint modulators.
Asian Continental Ancestry Group
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Brain
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Cell Death
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Dacarbazine*
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Humans
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Immunohistochemistry
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Lung
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Lymph Node Excision
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Male
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Melanoma*
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Middle Aged
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Neoplasm Metastasis
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Skin
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Spleen
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T-Lymphocytes*
2.A Case of Primary Cutaneous Gamma-Delta T-Cell Lymphoma with Pautrier Microabscess.
Kohei KATO ; Takeshi NAMIKI ; Makiko UENO ; Madoka IIKAWA ; Shown TOKORO ; Aya NISHIZAWA ; Kouhei YAMAMOTO ; Keiko MIURA ; Hiroo YOKOZEKI
Annals of Dermatology 2017;29(2):229-232
No abstract available.
Lymphoma, T-Cell*
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T-Lymphocytes*
3.Multiple Basal Cell Carcinomas with Infundibular Structures and Trichoblastoma
Kohei KATO ; Takeshi NAMIKI ; Rana KAWAI ; Keiko MIURA ; Hiroo YOKOZEKI ; Kazumoto KATAGIRI
Annals of Dermatology 2019;31(2):259-261
No abstract available.
Carcinoma, Basal Cell
4.Small Bowel Obstruction After Ileal Pouch-Anal Anastomosis With a Loop Ileostomy in Patients With Ulcerative Colitis.
Hitoshi KAMEYAMA ; Yoshifumi HASHIMOTO ; Yoshifumi SHIMADA ; Saki YAMADA ; Ryoma YAGI ; Yosuke TAJIMA ; Takuma OKAMURA ; Masato NAKANO ; Kohei MIURA ; Masayuki NAGAHASHI ; Jun SAKATA ; Takashi KOBAYASHI ; Shin ichi KOSUGI ; Toshifumi WAKAI
Annals of Coloproctology 2018;34(2):94-100
PURPOSE: Small bowel obstruction (SBO) remains a common complication after pelvic or abdominal surgery. However, the risk factors for SBO in ulcerative colitis (UC) surgery are not well known. The aim of the present study was to clarify the risk factors associated with SBO after ileal pouch-anal anastomosis (IPAA) with a loop ileostomy for patients with UC. METHODS: The medical records of 96 patients who underwent IPAA for UC between 1999 and 2011 were reviewed. SBO was confirmed based on the presence of clinical symptoms and radiographic findings. The patients were divided into 2 groups: the SBO group and the non-SBO group. We also analyzed the relationship between SBO and computed tomography (CT) scan image parameters. RESULTS: The study included 49 male and 47 female patients. The median age was 35.5 years (range, 14–72 years). We performed a 2- or 3-stage procedure as a total proctocolectomy and IPAA for patients with UC. SBO in the pretakedown of the loop ileostomy after IPAA occurred in 22 patients (22.9%). Moreover, surgical intervention for SBO was required for 11 patients. In brief, closure of the loop ileostomy was performed earlier than expected. A multivariate logistic regression analysis revealed that the 2-stage procedure (odds ratio, 2.850; 95% confidence interval, 1.009–8.044; P = 0.048) was a significant independent risk factor associated with SBO. CT scan image parameters were not significant risk factors of SBO. CONCLUSION: The present study suggests that a 2-stage procedure is a significant risk factor associated with SBO after IPAA in patients with UC.
Colitis, Ulcerative*
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Female
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Humans
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Ileostomy*
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Logistic Models
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Male
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Medical Records
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Risk Factors
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Tomography, X-Ray Computed
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Ulcer*