The deadly global outbreak of coronavirus disease-2019(COVID-19)has forged an unrivaled threat to human civilization.Contemplating its profuse impact,initial risk management and therapies are needed,as well as rapid detection strategies alongside treatments with existing drugs or traditional treatments to provide better clinical support for critical patients.Conventional detection techniques have been considered but do not sufficiently meet the current challenges of effective COVID-19 diagnosis.Therefore,several modern techniques including point-of-care diagnosis with a biosensor,clustered regularly interspaced short palindromic repeats(CRISPR)-associated proteins that function as nuclease(Cas)technology,next-generation sequencing,serological,digital,and imaging approaches have delivered improved and noteworthy success compared to that using traditional strategies.Conventional drug treatment,plasma therapy,and vaccine development are also ongoing.However,alternative medicines including Ayurveda,herbal drugs,homeopathy,and Unani have also been enlisted as prominent treat-ment strategies for developing herd immunity and physical defenses against COVID-19.All considered,this review can help develop rapid and simplified diagnostic strategies,as well as advanced evidence-based modern therapeutic approaches that will aid in combating the global pandemic.

Background: The effect of the interplay among inflammation, angiogenesis, extracellular matrix (ECM) degradation, and oxidative stress (OS) on the pathogenesis of endometriosis remains unclear. Previously, we demonstrated the role of OS in endometriosis. Here, we performed a comprehensive investigation of several molecules involved in inflammation, angiogenesis, and ECM degradation in women with endometriosis to study their interplay with OS. Methods: Blood samples were collected from women with endometriosis (N=80), as well as from women with tubal factor infertility as controls (N=80). Interleukin (IL)-1β, tumor necrosis factor-alpha, interferon-gamma, transforming growth factor-beta, IL-4, -10, -2, -6, -8, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2, -9, tissue inhibitor of metalloproteinases (TIMP)-1, -2, and cyclooxygenase (COX)-2 levels in serum samples were measured using an ELISA. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in peripheral blood mononuclear cells was measured using flow cytometry. Results: Cytokines, VEGF, MMPs, and COX-2 were significantly higher and TIMPs were significantly lower in patients with endometriosis. Multivariate statistical analysis indicated that IL-10 was the most significant variable capable of discriminating endometriosis samples from controls. Conclusions Deregulation of NF-κB activation by OS affects the expression of various cytokines in endometriosis. Elevated cytokine levels further up-regulate IL-10, which subsequently activates the MMPs, leading to excessive ECM degradation and angiogenesis. Moreover, IL-10 emerged as the most important molecule involved in the pathogenesis of endometriosis. Measurement of these molecules may help in better management of the patients with endometriosis.