1.Effect of Testosterone Replacement Therapy on Bone Mineral Density in Patients with Klinefelter Syndrome.
Dae Gi JO ; Hyo Serk LEE ; Young Min JOO ; Ju Tae SEO
Yonsei Medical Journal 2013;54(6):1331-1335
PURPOSE: Klinefelter syndrome (KS) is related to testicular insufficiency, which causes low testosterone levels in serum. Generally, sex hormone levels and bone mineral density (BMD) are lower in patients with KS than normal. We investigated the effects of testosterone replacement on serum testosterone levels and BMD in KS patients. MATERIALS AND METHODS: From December 2005 to March 2008, 18 KS patients with a 47, XXY karyotype were treated with initial intramuscular injections of long-acting testosterone undecanoate (Nebido(R), 1000 mg/4 mL) at baseline and second injections after six weeks. An additional four injections were administered at intervals of 12 weeks after the second injection. BMD was measured at the lumbar spine (L2-4), the left femoral neck and Ward's triangle, using dual energy X-ray absorptiometry. Medical histories, physical examinations and prostate specific antigen, hematology and serum chemistry were conducted for each patient. In addition, total testosterone and sex hormone-binding globulin levels were measured. RESULTS: Following testosterone replacement, mean serum total testosterone increased significantly from baseline (0.90 vs. 4.51 ng/mL, p<0.001), and total testosterone rose to normal levels after replacement in all patients. The mean BMD of the lumbar spine increased significantly (0.91 vs. 0.97 g/cm2, p<0.001). Similar increases of BMD were also observed at the femoral neck, but this increase was not significant. CONCLUSION: These findings suggest that testosterone replacement therapy may be effective in treating BMD deficiency in men with testosterone deficiency, especially those with Klinefelter syndrome.
Adult
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Bone Density/*drug effects
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Female
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Hormone Replacement Therapy/*methods
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Humans
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Klinefelter Syndrome/*drug therapy
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Male
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Testosterone/*therapeutic use
2.Site-specific effect of testosterone on bone mineral density in male hypogonadism.
Hak Ryong CHOI ; Sung Kil LIM ; Moo Sang LEE
Journal of Korean Medical Science 1995;10(6):431-435
To assess the correlation between the remaining serum testosterone and bone mineral density(BMD), and to determine the effect of exogenous testosterone on BMD in subjects with male hypogonadism, we evaluated the serum testosterone levels and BMDs of the femur neck, Ward's triangle and the spine(L1-4) in 20 subjects with Klinefelter's syndrome and 7 with hypogonadotropic hypogonadism before and after testosterone replacement. BMDs of the femur neck, Ward's triangle and the spine were below the age-matched normal mean at 77.8%(21/20), 74.1%(20/27) and 88.9%(24/27), respectively. There were significant differences in serum testosterone levels and the spinal BMD between the two groups and the BMD of the spine closely correlated with the serum testosterone level (R = 0.63, p < 0.001). Following a mean 11.8 +/- 4.9 months of testosterone replacement, the BMD at all sites increased significantly and the pretreatment difference in spinal BMD between the two groups disappeared. We conclude that, although testosterone may increases the bone density, it has a site-specific effect of maintaining and increasing the bone mass especially at the spine in male hypogonadism.
Adult
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Bone Density/*drug effects/physiology
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Human
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Hypogonadism/blood/*metabolism
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Klinefelter Syndrome/blood/drug therapy/*metabolism
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Male
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Middle Age
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Testosterone/blood/metabolism/*pharmacology
3.Testosterone level not significantly correlates to endothelial progenitor cells in Klinefelter's syndrome patients.
Bo-zhan RU ; Xing-cheng GAO ; Wei-wei YUE ; Peng HU
National Journal of Andrology 2012;18(1):67-69
OBJECTIVETo explore the correlation of the testosterone level with circulated endothelial progenitor cells in patients with Klinefelter's syndrome (KS) and its clinical significance.
METHODSThis study included 36 patients affected by non-mosaic 47, XXY KS, each with one or more cardiovascular risk factors. Serum hormone levels and the content of circulated endothelial progenitor cells were determined by radioimmunology and cell culture methods, respectively, and the measurement was repeated after 6 months of testosterone replacement therapy.
RESULTSAfter testosterone replacement therapy, the testosterone level was increased from (8 +/- 3) to (24 +/- 10) nmol/L, while the content of endothelial progenitor cells ([41 +/- 48] cells/ml) showed no significant rise.
CONCLUSIONThere is no obvious correlation between the testosterone level and the content of endothelial progenitor cells in KS patients.
Adult ; Cell Count ; Endothelial Cells ; cytology ; Hormone Replacement Therapy ; Humans ; Infertility, Male ; blood ; Klinefelter Syndrome ; blood ; drug therapy ; Male ; Stem Cells ; cytology ; Testosterone ; blood ; therapeutic use
4.Clinical Review of Honeymoon Impotence.
Kweon Sik MIN ; Nam Cheol PARK ; Young Il CHA ; Jong Byung YOON
Korean Journal of Urology 1990;31(6):893-898
Recently, with the influence of mass media and sexual liberation, the patients have been increasing to visit the impotence clinic with male sexual dysfunction during early married period. We studied twenty five patients suffering from honeymoon impotence from Jan. 1985 to Mar. 1990. The results were as follows : 1. Age distributions were 25 to 40 years old with a mean of 30. The interval of impotence prior to visit were 2 days to 3 years after marriage and the 17 patients ( 68.0% ) were within 3 months. 2. There was no significance according to the school career and the occupations of patients. 3. Except 5 patients, 20 were primary impotences that were possible premarital sexual coitus on history. One of these had the history of psychiatric consultation by sexual problems and another had moderate mental retardation. 4. On first visit, 11 of 25 were on doing the separation or divorce suits. 5. Except 1 with Klinefelter's syndrome, all were organically normal erectile function tests including nocturnal penile tumescence test. 6. Of 14 patients who accepted to therapy, 10 were able to gel desirable sexual life with one or the combination of following : supportive psychotherapy, yohimbine administration, intracavernous pharmacotherapy and vacuum tumescence enhancement therapy. The rest 4 were able to get penile erection, but sexual life was also failed with their wives. The honeymoon impotence is mostly pychogenic and also easily curable with its recent increasing frequency. However, because of the associating problems of separation, divorce and alimony, we think that the diagnosis and treatment of honeymoon impotence might be performed with prudent approach.
Adult
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Age Distribution
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Coitus
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Diagnosis
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Divorce
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Drug Therapy
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Erectile Dysfunction*
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Humans
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Intellectual Disability
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Klinefelter Syndrome
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Male
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Marriage
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Mass Media
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Occupations
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Penile Erection
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Psychotherapy
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Spouses
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Vacuum
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Yohimbine
5.A Case of Primary Mediastinal Germ Cell Tumor Associated with Klinefelter's Syndrome.
Yong Jo KIM ; Gyo Seon KWUN ; Young Wo LEE ; Kyung Tae KIM ; Yeon Hee PARK ; Baek Yeol RYOO ; Tae You KIM ; Young Hyuck IM ; Choon Taek LEE ; Yoon Koo KANG ; Kyung Ja CHO ; Jhin Oh LEE ; Tae Woong KANG
Tuberculosis and Respiratory Diseases 1996;43(6):1035-1041
Klinefelter's syndrome is characterized by small testes, azoospermia, gynecomastia, and elevated levels of plasma gonadotropins in men with two or more X chromosomes. Previous investigators reported that patients with Klinefelter's syndrome are predisposed to the development of a non-seminomatous germ cell tumor in the mediastinum. It is suggested that this linkage may be due to the hormonal imbalance in Klinefelter's syndrome and consequently, the formation of dysgenetic germ cell and/or abnomal migration of germ cell. We report here a case of Klinefelter's syndrome in a 24-years-old man who was presented with anterior mediastinal mass. The clinical and laborarotory findings were compatible with Klinefelter's syndrome and he was found to have 47 XXY karyotype. Pathological findings for mediastinal mass revealed mixed germ cell tumor composed of mature cystic teratoma and endodermal sinus tumor. He was treated with cis-platin containing chemotherapy and followed up in partial remission.
Azoospermia
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Drug Therapy
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Endodermal Sinus Tumor
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Germ Cells*
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Gonadotropins
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Gynecomastia
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Humans
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Karyotype
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Klinefelter Syndrome*
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Male
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Mediastinum
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Neoplasms, Germ Cell and Embryonal*
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Plasma
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Research Personnel
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Teratoma
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Testis
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X Chromosome
6.A Case of Recurred Primary Mediastinal Nonseminomatous Germ Cell Tumor Associated with Klinefelters Syndrome.
Won Jong JIN ; Kyu Suck SHIN ; Tae Hyun PARK ; Jung Hwan SUH ; Gwi Lae LEE ; Yong Ho ROH ; Jeong Rye KIM ; Sug Hyung LEE
Tuberculosis and Respiratory Diseases 1997;44(6):1419-1425
Primary mediastinal nonseminomatous germ cell tumor associated with Klinefelter's syndrome is a rare disorder. We experienced a case of recurred primary mediastinal nonseminomatous germ cell tumor developed in a 24-year-old patient with Klinefelter's syndrome. The patient had been treated with surgery and combination chemotherapy under the diagnosis of primary mediastinal nonseminomatous germ cell tumor before. A round mass was found on the right lower lung field in the chest X-ray during follow up. The patient was diagnosed as recurred primary nonseminomatous germ cell tumor and Klinefelter's syndrome through tumor markers, peripheral blood karyotyping, and other tests including hormonal assay and was treated with combination chemotherapy and surgery again. When the patient is diagnosed as primary mediastinal nonseminomatous germ cell tumor, Klinefelter's syndrome and hematologic malignancies should be considered to be associated diseases and vice versa.
Diagnosis
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Drug Therapy, Combination
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Follow-Up Studies
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Germ Cells*
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Hematologic Neoplasms
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Humans
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Karyotyping
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Klinefelter Syndrome*
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Lung
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Neoplasms, Germ Cell and Embryonal*
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Thorax
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Biomarkers, Tumor
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Young Adult
7.Effect of androgen on erythropoietin in patients with hypogonadism.
Yu-Gui CUI ; Jian-Sun TONG ; Qin-Qin PAN ; Fu-Song DI ; Yue JIA ; Ting FENG ; Yu LIU ; Xing-Hai WANG ; Gui-Yuan ZHANG
National Journal of Andrology 2003;9(4):248-251
OBJECTIVESTo observe the change of erythropoietin (EPO) in patients of hypogonadism who received androgen replacement treatment and explore the mechanism of androgen-induced increase of red blood cells and haemoglobin.
METHODSEight patients with Klinefelter's syndrome, divided into two groups, received TU intramuscular injections of 500 mg or 1000 mg dose, respectively. After three months, seven patients received the second injection of crossover dose. Testosterone levels in serum were measured with RIA before and after the injections treatment. RBC count, impacted volume of blood cells and haemoglobin concentration were measured before treatment and 4, 8 weeks after treatment. At the same interval, EPO levels were measured with ELISA method.
RESULTSDevelopment of the secondary sex characters was improved in all patients after the TU injection. Serum testosterone levels raised significantly and reached the peak one week after the injections. Effective level of testosterone lasted for over 6 weeks. RBC count, impacted volume of blood cells and haemoglobin increased at different degrees after TU injections, but these changes were not significant in statistic(P < 0.05). The increased levels remained for 8 weeks. EPO levels were elevated significantly (P < 0.01 or 0.05) after the TU injection(Pbat > 0.05). The second injection could still make the EPO level go up.
CONCLUSIONSAndrogen replacement treatment can increase the EPO levels in patients of hypogonadism, which is one of the mechanism of RBC production increase.
Adolescent ; Adult ; Enzyme-Linked Immunosorbent Assay ; Erythropoietin ; blood ; Humans ; Injections, Intramuscular ; Klinefelter Syndrome ; blood ; drug therapy ; Male ; Radioimmunoassay ; Testosterone ; administration & dosage ; analogs & derivatives ; blood ; therapeutic use
8.Persistent suboptimal molecular response in a patient with chronic myelogenous leukemia and Klinefelter syndrome.
Rajshekhar CHAKRABORTY ; Shiva Kumar Reddy MUKKAMALLA ; Kranthi SINGAM ; Natalia CALDERON
The Korean Journal of Internal Medicine 2014;29(6):827-829
No abstract available.
Adult
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Antineoplastic Agents/therapeutic use
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*Chromosome Deletion
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*Chromosomes, Human, Pair 9
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Cytogenetic Analysis
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DNA Mutational Analysis
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Fusion Proteins, bcr-abl/*antagonists & inhibitors/genetics/metabolism
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Gene Expression Regulation
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Humans
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Incidental Findings
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Klinefelter Syndrome/complications/diagnosis/*genetics
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications/diagnosis/*drug therapy/enzymology/genetics
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Male
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Molecular Targeted Therapy
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Protein Kinase Inhibitors/*therapeutic use
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Remission Induction
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Time Factors
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Treatment Outcome