Those involved in end-of-life care need to understand the patient’s view of life and values, and support them so that they can approach the end of their lives in a way that suits them, and this requires sufficient communication. We report a deaf-mute patient who developed advanced lung cancer during treatment of chronic myeloid leukemia. The communication with him was difficult for those who did not use sigh language routinely, but through trial and error, we tried to build a good relationship through nonverbal communication as well as sign language and written communication. It was necessary to recognize and understand that deaf-mute people have different living environments and communities and have their own language and culture. These experiences can be utilized for the treatment of cancer patients in daily clinical practice, and it is considered that the attitude of the medical worker to approach the patient is necessary for mutual understanding.