1.Scanning laser polarimetry in pulmonary tuberculosis patients on chemotherapy.
Wilson W T TANG ; Jimmy S M LAI ; Clement C Y THAM ; Kam-Keung CHAN ; Kin-Sang CHAN
Annals of the Academy of Medicine, Singapore 2006;35(6):395-399
INTRODUCTIONThe aim of this study was to analyse the thickness of the retinal nerve fibre layer (RNFL) of pulmonary tuberculosis patients on ethambutol and isoniazid.
MATERIALS AND METHODSThis was a prospective cohort study where patients with newly diagnosed pulmonary tuberculosis requiring chemotherapy, including ethambutol and isoniazid, were imaged using scanning laser polarimetry. Their mean baseline RNFL thickness and various scanning laser polarimetry parameters of both eyes were measured 2 weeks after the commencement of chemotherapy. The measurements were repeated at 3 months and 6 months after treatment. The various parameters of the baseline and the follow-up measurements were compared using paired sample t-test with Bonferroni correction.
RESULTSTwenty-four patients (16 males and 8 females; mean age, 51.0 +/- 17.6 years) were recruited. There was no statistically significant difference between the baseline and the follow-up measurements in RNFL thickness and all other scanning laser polarimetry parameters.
CONCLUSIONIn this cohort of subjects, there was no subclinical change in RNFL thickness detected by scanning laser polarimetry in pulmonary tuberculosis patients on chemotherapy, including ethambutol and isoniazid, after 6 months of treatment.
Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents ; adverse effects ; therapeutic use ; Diagnostic Techniques, Ophthalmological ; Ethambutol ; adverse effects ; therapeutic use ; Female ; Humans ; Isoniazid ; adverse effects ; therapeutic use ; Lasers ; Male ; Middle Aged ; Prospective Studies ; Retinal Diseases ; chemically induced ; diagnosis ; Tuberculosis, Pulmonary ; drug therapy
2.The Collaborative Clinical Analysis of 985 Cases of Rheumatic Fever and Rheumatic Carditis in Children for 10 Years(1978~1987) in Korea.
Sung Ho CHA ; Sang Young JEONG ; Du Bong LEE ; Kyong Su LEE ; Sang Bum LEE ; Tae Chan KWON ; Young Chang TOCKGO ; Chang Sung SOHN ; Keun Chan SOHN ; Young Kin HONG ; Chan Young KIM ; Chang Yee HONG ; Yong Soo YUN ; Hong Yun CHOI ; Chang Hwi KIM ; Chul Ho KIM ; Tae Ju HWANG ; Jae Suk MA ; Chan Uhul JOO ; Kyoo Hwan RHEE ; Hahng LEE
Journal of the Korean Pediatric Society 1989;32(12):1621-1631
No abstract available.
Child*
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Humans
;
Korea*
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Myocarditis*
;
Rheumatic Fever*