Purpose: The purpose of this study was to analyze the experiences of acute care hospital nurses’ on spiritual care with focus group interviews. Methods: Data were collected from 24 nurses recruited from one acute-care hospital in a southern province of Korea. Six focus groups were assembled considering age and religion. All interviews were recorded and transcribed. Data were analyzed using qualitative content analysis. Results: Five categories with 14 sub-categories emerged: 1) ambiguous concept: confusing terms, an additional job; 2) assessment of spiritual care needs: looking for spiritual care needs, not recognizing spiritual care needs; 3) spiritual care practices: active spiritual care, passive spiritual care ; 4) outcomes of spiritual care: comfort of the recipient, comfort of the provider; and 5) barriers to spiritual care: fear of criticism from others, lack of education, lack of time, space constraints, and absence of a recording system. Conclusion Participants perceived spiritual care as an uncertain concept. Some participants recognized it as a form of nursing care, and others did not. They practiced spiritual care in acute-care settings according to their personal perceptions of spiritual care. Therefore, in order to perform spiritual nursing in acute-care hospitals, it is a priority for nurses to recognize the concept of spiritual nursing accurately. It is also necessary to prepare a hospital environment suitable for the provision of spiritual care.

PURPOSE: The aim of this study is to evaluate the clinical characteristics and outcomes of patients with cardiac arrest without obvious extracardiac cause who underwent emergency angiography to determine the factors related to significant coronary artery disease in patients in whom coronary angiography was performed. We also addressed the issues around the survival benefit of coronary angiography and subsequent coronary intervention. METHODS: In total 91 patients during the period between 2004 and 2012 were included in the study. Clinical characteristics and coronary angiographic data were collected retrospectively. The success measurement of the study was set as survival at the time of hospital discharge. RESULTS: In comparison of the demographic and clinical variables of patients with and without emergency coronary angiography, only the electrocardiogram differed significantly between the two groups. Fifty four patients underwent an emergency coronary angiography, which was performed later for the remaining seven patients. Acute coronary lesions were observed in 38 patients (62%). Findings of electrocardiograms before and after return of spontaneous circulation (ROSC) were not statistically significant in relation to the prevalence of a culprit lesion. Neither an emergency coronary angiography nor successful coronary intervention showed correlation with survival at the time of hospital discharge. A shorter duration to return of spontaneous circulation, an initial shockable rhythm, and the absence of shock were found to be independent factors affecting discharge of patients alive in the overall study population (n=91). CONCLUSION: Considering the angiographic findings, neither the presence of a shockable rhythm nor ST-segment elevation myocardial infarction (STEMI) before and after ROSC were factors favouring acute coronary artery disease. The emergency coronary angiography did not show correlation with survival at hospital discharge in patients with a resuscitated cardiac arrest without non-cardiac cause. Factors positively related to survival should be considered when deciding on coronary angiography in order to identify patients in whom routine angiography is futile (e.g., the delay for return of spontaneous circulation and presence of shock).
Angiography ; Cardiopulmonary Resuscitation ; Coronary Angiography* ; Coronary Artery Disease ; Electrocardiography ; Emergencies* ; Heart Arrest ; Humans ; Myocardial Infarction ; Out-of-Hospital Cardiac Arrest* ; Prevalence ; Retrospective Studies ; Shock

Purpose: This study aimed to explore the adolescent child-rearing experiences of nurses and describe the meaning and structure of child-rearing experiences from their perspectives. Methods: A phenomenological methodology with a qualitative approach was used for the study design. The participants were 7 nurses with adolescent children. In-depth individual interviews were conducted from December 2023 to April 2024 and analyzed using the Giorgi phenomenological method. Results: Five constituents and 16 subconstituents were identified. The 5 constituents were “difficulties in balancing work and family,” “a supportive family,” “pride as a nurse,” “adolescent child who does not seem like my own,” and “changing parenting attitudes.” Conclusion This study revealed the practical significance of nurses’ experiences in raising adolescent children. The results of this study provide basic data for nurses to implement various programs to raise adolescent children. This program enables nurses to better understand adolescent children and provide parenting assistance based on their changes.

Purpose: This study aimed to explore the adolescent child-rearing experiences of nurses and describe the meaning and structure of child-rearing experiences from their perspectives. Methods: A phenomenological methodology with a qualitative approach was used for the study design. The participants were 7 nurses with adolescent children. In-depth individual interviews were conducted from December 2023 to April 2024 and analyzed using the Giorgi phenomenological method. Results: Five constituents and 16 subconstituents were identified. The 5 constituents were “difficulties in balancing work and family,” “a supportive family,” “pride as a nurse,” “adolescent child who does not seem like my own,” and “changing parenting attitudes.” Conclusion This study revealed the practical significance of nurses’ experiences in raising adolescent children. The results of this study provide basic data for nurses to implement various programs to raise adolescent children. This program enables nurses to better understand adolescent children and provide parenting assistance based on their changes.

Purpose: This study aimed to explore the adolescent child-rearing experiences of nurses and describe the meaning and structure of child-rearing experiences from their perspectives. Methods: A phenomenological methodology with a qualitative approach was used for the study design. The participants were 7 nurses with adolescent children. In-depth individual interviews were conducted from December 2023 to April 2024 and analyzed using the Giorgi phenomenological method. Results: Five constituents and 16 subconstituents were identified. The 5 constituents were “difficulties in balancing work and family,” “a supportive family,” “pride as a nurse,” “adolescent child who does not seem like my own,” and “changing parenting attitudes.” Conclusion This study revealed the practical significance of nurses’ experiences in raising adolescent children. The results of this study provide basic data for nurses to implement various programs to raise adolescent children. This program enables nurses to better understand adolescent children and provide parenting assistance based on their changes.

The clustered regularly interspaced short palindromic repeats (CRISPR) system, a rapidly advancing genome editing technology, allows DNA alterations into the genome of organisms. Gene editing using the CRISPR system enables more precise and diverse editing, such as single nucleotide conversion, precise knock-in of target sequences or genes, chromosomal rearrangement, or gene disruption by simple cutting. Moreover, CRISPR systems comprising transcriptional activators/repressors can be used for epigenetic regulation without DNA damage. Stem cell DNA engineering based on gene editing tools has enormous potential to provide clues regarding the pathogenesis of diseases and to study the mechanisms and treatments of incurable diseases. Here, we review the latest trends in stem cell research using various CRISPR/Cas technologies and discuss their future prospects in treating various diseases.

Optimal experimental design is important for the efficient use of modern highthroughput technologies such as microarrays and proteomics. Multiple factors including the reliability of measurement system, which itself must be estimated from prior experimental work, could influence design decisions. In this study, we describe how the optimal number of replicate measures (technical replicates) for each biological sample (biological replicate) can be determined. Different allocations of biological and technical replicates were evaluated by minimizing the variance of the ratio of technical variance (measurement error) to the total variance (sum of sampling error and measurement error). We demonstrate that if the number of biological replicates and the number of technical replicates per biological sample are variable, while the total number of available measures is fixed, then the optimal allocation of replicates for measurement evaluation experiments requires two technical replicates for each biological replicate. Therefore, it is recommended to use two technical replicates for each biological replicate if the goal is to evaluate the reproducibility of measurements.

Purpose: This study aimed to explore the adolescent child-rearing experiences of nurses and describe the meaning and structure of child-rearing experiences from their perspectives. Methods: A phenomenological methodology with a qualitative approach was used for the study design. The participants were 7 nurses with adolescent children. In-depth individual interviews were conducted from December 2023 to April 2024 and analyzed using the Giorgi phenomenological method. Results: Five constituents and 16 subconstituents were identified. The 5 constituents were “difficulties in balancing work and family,” “a supportive family,” “pride as a nurse,” “adolescent child who does not seem like my own,” and “changing parenting attitudes.” Conclusion This study revealed the practical significance of nurses’ experiences in raising adolescent children. The results of this study provide basic data for nurses to implement various programs to raise adolescent children. This program enables nurses to better understand adolescent children and provide parenting assistance based on their changes.

PURPOSE: Hypotension after emergency endotracheal intubation (ETI) is one of the major complications from emergency airway management. The aim of this study was to determine the possible risk factors that may predict postintubation hypotension (PIH) and its impact on in-hospital mortality. METHODS: We conducted a retrospective, standardized chart review of consecutive emergency department patients that required intubation between January 2011 and December 2014. Patients were divided into 2 groups according to the presence or absence of PIH. PIH was defined as any recorded systolic blood pressure with less than 90 mmHg or mean arterial pressure with less than 65 mmHg within the 60-minute period after intubation. The outcome measures were inhospital mortality, as well as intensive care unit and hospital length of stay. RESULTS: The incidence of PIH was 23% (80 of 352 patients). Patients in the PIH group were slightly older and had more comorbid diseases than those in the non-PIH group. PIH patients had a significantly higher mortality rate (54% vs. 30%, p<0.01). PIH was a strong predictor for in-hospital mortality of intubated patients (hazard ratio, 2.3; 95% confidence interval, 1.3 to 3.4). CONCLUSION: Older age, lack of skill, history of hypertension, low albumin and pH, and elevated were risk factors for the occurrence of hypotension after ETI. Patients with PIH show increased risk of in-hospital mortality.
Airway Management ; Arterial Pressure ; Blood Pressure ; Emergencies ; Emergency Service, Hospital ; Hospital Mortality ; Humans ; Hydrogen-Ion Concentration ; Hypertension ; Hypotension ; Incidence ; Intensive Care Units ; Intubation ; Intubation, Intratracheal* ; Length of Stay ; Mortality ; Outcome Assessment (Health Care) ; Retrospective Studies ; Risk Factors

OBJECTIVE: Hypotension after emergent endotracheal intubation is a serious complication related to in-hospital mortality. We investigated factors including modified shock index to predict the development of hypotension after emergent intubation. METHODS: This retrospective observational study was conducted between January 2011 and December 2016. The study population included intubated patients among all medical patients admitted to the emergency department (ED) except for patients whose systolic blood pressure was below 90 mmHg at any time before intubation. The postintubation hypotension (PIH) groups were compared with the non-PIH group. The secondary outcome was in-hospital mortality. RESULTS: A total of 285 patients were included in this study, of which 92 patients (32.3%) PIH. The age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01–1.06; P=0.001), serum albumin level (OR, 0.62; 95% CI, 0.41–0.92; P=0.019), shock index (OR, 3.25; 95% CI, 1.26–8.38; P=0.015), and modified shock index (MSI) (OR, 2.18; 95% CI, 1.06–4.47; P=0.034) were more closely associated with PIH than any other factors. The average survival of the PIH group was significantly shorter than that of the non-PIH group (13.6±3.5 vs. 35.6±12.0, log-rank test P=0.019). CONCLUSION: Overall, 32.3% of hemodynamically stable medical patients developed PIH in ED. MSI was associated with PIH.
Blood Pressure ; Emergencies* ; Emergency Medical Services ; Emergency Service, Hospital* ; Hospital Mortality ; Humans ; Hypotension* ; Intubation ; Intubation, Intratracheal ; Mortality ; Observational Study ; Retrospective Studies ; Risk Factors ; Serum Albumin ; Shock*