No abstract available.
Neurofibromatoses* ; Pseudarthrosis* ; Ulna*

Familial lichen planus is an uncommon disease, and there are 104 cases reported in the English literature. Several theories regarding the etiopathogenesis of lichen planus have been proposed. However, immunological mechanisms and genetic susceptibility have been emphasized the most. Several reports showed HLA analysis in lichen planus patients, and recently 2 cases have revealed an increased frequency of DR1 antigen in patients with lichen planus compared to a control group. We observed two brothers with typical skin lesions of lichen planus of almost simultaneous onset. We confirmed lichen planus by skin biopsies in both brothers and analyzed HLA typing. We also observed the occurrence of DR1 antigen in both of them.
Biopsy ; Genetic Predisposition to Disease ; Histocompatibility Testing ; Humans ; Lichen Planus* ; Lichens* ; Siblings ; Skin

No abstract available.
Glutathione Transferase* ; Glutathione* ; Schistosoma japonicum* ; Schistosoma*

PURPOSE: This study is designed to evaluate the usefulness of (99m)Tc-MAG3 renal scan in the diagnosis of early surgical complication of renal transplantation comparing with that of ultrasonography. METHODS: 203 renal transplantations, from January 2000 to December 2004, were studied retrospectively. (99m)Tc-MAG3 renal scan and ultrasonography were performed routinely for evaluation of allograft kidney at postoperative day 3, 7, 14 and 21 or 28 respectively. RESULTS: Thirteen early surgical complications (6.4%) from 203 recipients were developed during the first one month after transplantation. Six cases of urological complications were noticed. And six cases of hematoma and one case of lymphocele were also developed. (99m)Tc-MAG3 renal scan showed abnormality in ten cases (76.9%) of thirteen early surgical complications. (99m)Tc-MAG3 renal scan revealed all of six urologic complications (100%), and four of six hematomas (66.7%). But one lymphocele was not detected by (99m)Tc-MAG3 renal scan. Ultrasonography showed abnormal findings in eight cases of 13 early surgical complications (61.5%): one of four urine leakage (25%), two of two urinomas (100%), four of six hematomas (66.7%), and one lymphocele (100%). CONCLUSION: (99m)Tc-MAG3 renal scan is more sensitive than ultrasonography in detection of earlysurgical complications of renal transplantation. Then (99m)Tc-MAG3 renal scan is useful test for screening and follow-up of early surgical complications after renal transplantation.
Allografts ; Diagnosis ; Hematoma ; Kidney ; Kidney Transplantation ; Lymphocele ; Mass Screening ; Retrospective Studies ; Ultrasonography* ; Urinoma

PURPOSE: To evaluate the treatment results and prognostic factors after radiotherapy in stage IIB uterine cervix cancer. MATERIALS AND METHODS: We retrospectively analyzed the records of 90 patients with stage IIB uterine cervix cancer who received radiotherapy between 9/94 and 12/99. Age was ranged from 28 to 79 years (median 57). Tumor size was > or = 4 cm in 64 patients. Preteatment SCC level was measured in 76 patients. Twenty nine patients received conventional radiotherapy (QD) and the others received modified hyperfractionated radiotherapy (BID). Only 7 patients in BID had tumor size <4 cm. All patients received high dose rate brachytherapy (4 Gy x 7 or 5 Gy x 6). No patient received concurrent chemotherapy during radiotherapy. Follow up period was ranging from 9 to 76 months (median 38). RESULTS: The 5-year overall and disease free survival rates were 73.4% and 71.6%, respectively. Local recurrences occurred in 10% of patients, and distant metastasis in 18.9%. There was a significant correlation between OS/DFS and tumor size (<4 cm; OS 95.2%, DFS 91.4%, > or = 4 cm; OS 63.4%, DFS 63.4%). Pretreatment SCC level was one of prognostic factors only in univariate analysis. CONCLUSION: With modified hyperfractionated radiotherapy, there was very low local recurrence rate (6.6%) and high 5-year overall and disease free survival rate (75.4% and 70.5%), which is comparable to results after concurrent chemoradiotherapy in bulky, locally advanced stage IIB uterine cervix cancer.
Brachytherapy ; Cervix Uteri* ; Chemoradiotherapy ; Disease-Free Survival ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Neoplasm Metastasis ; Radiotherapy* ; Recurrence ; Retrospective Studies

The effects of intravenous Verapamil administration on ventricular function were evaluated using grated radionuclide ventriculography in 15 patients with essential hypertension. Verapamil(0.1mg/kg) was injected as a bolus for 2 minutes followed by an infusion of 0.007mg/kg/min. Heart rate, blood pressure, ejection fraction, peak ejection rate, total filling time, and prak filling rate were assessed before and after Verapamil administration. The results were was as follows ; 1) Verapamil administration increased heart rate from 63+/-5 to 75+/-9 beats/min(p<0.01) and reduced systolic and diastolic blood pressure from 156+/-17/99+/-6mmHg to 139+/-16/88+/-6mmHg(p<0.01). 2) Ejection fraction, peak ejection rate, and total filling time were not changed significantly after Verapamil injection. 3) Right and left ventricular peak filling rate increased significantly only in patients in whom it was subnormal in the basal study) from 1.6+/-0.4 to 2.3+/-1.1 end-diastolic volumes/s, p<0.05 and from 2.5+/-0.6 to 3.1+/-0.8 end-diastolic volumes/s, p<0.05, respectively). In conclusion, it was found that intravenous Verapamil administration enhances ventricular diatolic function in patients with essential hypertension.
Blood Pressure ; Heart Rate ; Humans ; Hypertension* ; Radionuclide Ventriculography ; Ventricular Function ; Ventricular Function, Right* ; Verapamil*

No abstract available.

Turcot's syndrome is a rare hereditary disease marked by the association of central nervous system neuroepithelial tumor with colonic polyposis. Authors report herein a case of a 15-year-old girl diagnosed as having Turcot's syndrome, otherwise known as brain tumor-polyposis syndrome, combined with sigmoid colon cancer. The patient was carried out craniostomy and brain tumor removal. The tumor was confirmed histologically to be oligodendroglioma. The patient visited the department of internal medicine for bloody diarrhea during 6 months. Colonoscopy and biopsy was done. The patient was diagnosed as having Turcot's syndrome combined with sigmoid colon cancer, and was then transferred to the department of surgery for treatment of sigmoid colon cancer. Total proctocolectomy and IPAA (ileal pouch-anal anastomosis) was carried out. Multiple polyps were found in the colon, two large masses were confirmed histologically to be adenocarcinoma. The remaining polyps were adenomas. This case report describes the characteristic features of Turcot's syndrome presented by this patient.
Adenocarcinoma ; Adenoma ; Adolescent* ; Biopsy ; Brain ; Brain Neoplasms ; Central Nervous System ; Colon* ; Colonic Neoplasms* ; Colonoscopy ; Diarrhea ; Female* ; Genetic Diseases, Inborn ; Humans ; Internal Medicine ; Neoplasms, Neuroepithelial ; Oligodendroglioma ; Polyps ; Sigmoid Neoplasms

BACKGROUND AND OBJECTIVES: MAGE 3 gene may constitute a potential target for cancer immunotherapy since it is expressed in a variety of cancers but not in normal tissues except the testis. In this study, expression and intracellular location of MAGE 3 gene products were investigated using squamous cell carcinomas of the head and neck. MATERIALS AND METHODS: MAGE 3 protein expression was screened in 40 squamous cell carcinomas, 2 tumor lines, 20 benign diseases, and 20 normal tissues of the head and neck. Immunohistochemical staining with anti-MAGE 3 mAb 57B was conducted from fresh frozen specimens. A correlation between MAGE 3 expression and clinicopathological parameters was also evaluated. RESULTS: MAGE 3 gene product was detected in squamous cell carcinomas (18/40, 45%) and in tumor lines (2/2, 100%), but not in benign diseases and normal tissues. MAGE 3 gene product was identified as a cytoplasmic protein of cancer cells without staining in normal epithelia and stromal tissues coexisting adjacent to cancer cells. No significant correlation between MAGE 3 expression and clinicopathological parameters including tumor cell differentiation, age, gender, primary site, tumor stage, and metastasis was drawn. CONCLUSIONS: MAGE 3 antigen could represent a potential target for immunotherapy in head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell* ; Cell Differentiation ; Cytoplasm ; Head* ; Immunotherapy ; Neck* ; Neoplasm Metastasis ; Testis

BACKGROUND: Acute renal failure (ARF) due to acute pyelonephritis (APN) in patients in the absence of obstructive uropathy, diabetes, or chronic renal failure was reported rarely (12 cases in the last 25 yrs in Clin Inf Dis, 1992; 243-6 by SR Jones)2). Acute renal failure is a rare complication of acute pyelonephritis in patients who do not have urinary obstruction. Although urinary tract infections are common in adults, pyelonephritis is rarely considered in the differential diagnosis of acute renal failure, and when clinicians weigh the possible consequences of bacteriuria, renal failure is not considered to be a reasonable possibility. METHODS: We observed 6 patients of acute pyelonephritis associated with acute renal failure as an initial manifestation on admission in the past 6 months. The analysis of clinical features of these 6 patients (APN+) compared to 7 patients of APN without ARF (APN-) revealed following data. RESULTS: All were female in both groups. The mean age was 331.7 years in APN+ and 48+6 years in APN-, respectively (p, ns). All in both APN- and APN+ were caused by E. coli. But, none in both groups except 1 in APN- had bacteremia. The previous history of UTI was present in 5 in APN-, but none in APN+. Duration of clinical symptoms before admission (8.4+/-0.5 vs. 4.4+/-1.0 days, P<0.05) and admission days (24.2+/-1.8 vs. 11.1+/-1.5 days, p=0.000) were significantly longer in APN+. On admission, HUN and serum creatinine was 45+/-2.7mg/dL and 3.5+/-0.2mg/dL in APN+, respectively. No one in APN+ required dialysis, and subsequently recovered renal function with prompt antibiotic therapy resulting in no significant difference compared to that of APN on discharge (serum creatinine, 1.0+/-0.1 vs. 0.9+/-0.1mg/dL). No differences in leukocytosis and serum electrolyte levels on admission were present. However, significant anemia was noted in APN+ (hemoglobin, 9.0+/-0.7 vs. 11.9+/-0.2gm/dL). The days of fever and leukocytosis before disappearance were not different in both groups, but those of flank pain (12.8+/-1.5 vs. 5.7+/-0.7 days, P=0.001) and pyuria (16+/-1.9 vs. 6.4+/-0.6 days, P=0.000) significantly longer in APN+. Upon ultrasonography, all in APN+ showed enhanced echogenicity, but I in APN . (P=P value, NS=not significant) CONCLUSION: Upon these data, we concluded that ARF associated with APN as an initial manifestation was accompanied by several distinct clinical characteristics, which could be used for the early recognition of its unusual occurrence and subsequent appropriate management including antibiotics leading to a favorable outcome.
Acute Kidney Injury* ; Adult ; Anemia ; Anti-Bacterial Agents ; Bacteremia ; Bacteriuria ; Creatinine ; Diagnosis, Differential ; Dialysis ; Female ; Fever ; Flank Pain ; Humans ; Kidney Failure, Chronic ; Leukocytosis ; Pyelonephritis* ; Pyuria ; Renal Insufficiency ; Ultrasonography ; Urinary Tract Infections