1.Clear cell sarcoma of the kidney: a case report.
Joong Seok SEO ; Yong Wook PARK ; Kye Yong SONG ; Seon Taek CHANG
Journal of Korean Medical Science 1989;4(3):149-153
Clear cell sarcoma of the kidney (CCSK) is a highly malignant childhood tumor, distinguished from classic Wilms' tumor by its propensity to metastasize to the skeletal system. Authors described a case of CCSK from a 3-year-old boy in the right kidney, showing various histologic features, such as classic, epithelioid, trabecular, neurilemmoma-like, cystic and entrapped collecting tubular pattern. Ultrastructurally epithelial differentiation was absent. Immunohistochemically, none of the intrinsic tumor cells showed positive staining with the antibodies against the keratin, S-100 protein, carcinoembryonic antigen, vimentin, desmin and myoglobin, suggesting primitive mesenchymal cell in origin.
Child, Preschool
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Humans
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Immunohistochemistry
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Kidney Neoplasms/metabolism/*pathology
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Male
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Neoplasm Metastasis
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Sarcoma/metabolism/*pathology
2.Pathologic features of recently identified renal cell carcinoma.
Xiang FAN ; Qiu RAO ; Li-hua ZHANG
Chinese Journal of Pathology 2013;42(8):569-573
Adenocarcinoma, Follicular
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genetics
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metabolism
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pathology
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Carcinoma, Papillary
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genetics
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metabolism
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pathology
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Carcinoma, Renal Cell
;
genetics
;
metabolism
;
pathology
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Diagnosis, Differential
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Humans
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Immunohistochemistry
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Kidney Diseases, Cystic
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genetics
;
metabolism
;
pathology
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Kidney Neoplasms
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genetics
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metabolism
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pathology
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Thyroid Neoplasms
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genetics
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metabolism
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pathology
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Translocation, Genetic
3.Renal schwannoma with peripheral lymphocytic cuffing: report of a case.
Chinese Journal of Pathology 2013;42(10):698-699
Aged
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Angiomyolipoma
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metabolism
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pathology
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Diagnosis, Differential
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Humans
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Kidney Neoplasms
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metabolism
;
pathology
;
surgery
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Leiomyoma
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metabolism
;
pathology
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Lymphocytes
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pathology
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Male
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Nephrectomy
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Neurilemmoma
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metabolism
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pathology
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surgery
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S100 Proteins
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metabolism
4.Lymphoepithelial carcinoma of renal pelvis: report of a case.
Chinese Journal of Pathology 2010;39(11):772-773
Carcinoma, Squamous Cell
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metabolism
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pathology
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surgery
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Female
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Follow-Up Studies
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Humans
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Keratin-7
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metabolism
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Keratins
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metabolism
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Kidney Neoplasms
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metabolism
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pathology
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surgery
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Kidney Pelvis
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Middle Aged
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Mucin-1
;
metabolism
5.Metanephric stromal tumor: report of a case.
Fang-fang GUO ; Kai-yan WU ; Ying REN ; Li-fu WANG ; Ling-fei KONG
Chinese Journal of Pathology 2010;39(9):632-633
Adenofibroma
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metabolism
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pathology
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Antigens, CD34
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metabolism
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Child, Preschool
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Diagnosis, Differential
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Female
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Humans
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Kidney Neoplasms
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metabolism
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pathology
;
surgery
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Neoplasms, Germ Cell and Embryonal
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metabolism
;
pathology
;
surgery
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Nephroma, Mesoblastic
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metabolism
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pathology
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Sarcoma, Clear Cell
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metabolism
;
pathology
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Stromal Cells
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metabolism
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pathology
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Vimentin
;
metabolism
6.Concept of perivascular epithelioid cells and neoplasms with perivascular epithelioid cell differentiation.
Jun-na CAI ; Min SHI ; Jian WANG
Chinese Journal of Pathology 2011;40(1):59-64
Actins
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metabolism
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Angiomyolipoma
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pathology
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Carcinoma, Renal Cell
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pathology
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Diagnosis, Differential
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Epithelioid Cells
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metabolism
;
pathology
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Female
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Gastrointestinal Neoplasms
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pathology
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Gastrointestinal Stromal Tumors
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pathology
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Humans
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Kidney Neoplasms
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metabolism
;
pathology
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Lung Neoplasms
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pathology
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Lymphangioleiomyomatosis
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pathology
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Male
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Melanoma
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pathology
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Melanoma-Specific Antigens
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metabolism
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Pancreatic Neoplasms
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pathology
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Perivascular Epithelioid Cell Neoplasms
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metabolism
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pathology
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Sarcoma, Clear Cell
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pathology
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Skin Neoplasms
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pathology
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Uterine Neoplasms
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pathology
7.Nephroblastomatosis and nephroblastoma: report of a case.
Xiao-li HU ; Lan-yun SONG ; Lin-sheng ZHAO ; Pei-ru NING ; Li ZHAO
Chinese Journal of Pathology 2013;42(12):841-842
Humans
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Infant
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Kidney Neoplasms
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metabolism
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pathology
;
surgery
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Male
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Mucin-1
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metabolism
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Nephrectomy
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Precancerous Conditions
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metabolism
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pathology
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surgery
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Vimentin
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metabolism
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WT1 Proteins
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metabolism
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Wilms Tumor
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metabolism
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pathology
;
surgery
8.Multilocular cystic renal cell carcinoma.
Zhi-qiang LANG ; Wei-dong YAO ; Gui-mei QU ; Lei JIANG
Chinese Journal of Pathology 2006;35(9):574-575
Carcinoma, Renal Cell
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metabolism
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pathology
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surgery
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Cytokines
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metabolism
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Diagnosis, Differential
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Humans
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Immunohistochemistry
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Kidney
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chemistry
;
pathology
;
surgery
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Kidney Diseases, Cystic
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metabolism
;
pathology
;
surgery
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Kidney Neoplasms
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metabolism
;
pathology
;
surgery
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Male
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Middle Aged
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Mucin-1
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metabolism
;
Nephrectomy
9.Renal papillary adenoma in transplant donor kidney: report of a case.
Xue-juan BAI ; Min YANG ; Qi YU ; Ning LI
Chinese Journal of Pathology 2009;38(5):353-354
Adenoma
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metabolism
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pathology
;
surgery
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Humans
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Keratin-7
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metabolism
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Kidney Neoplasms
;
metabolism
;
pathology
;
surgery
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Kidney Transplantation
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Living Donors
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Male
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Mucin-1
;
metabolism
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Young Adult
10.Clinicopathologic features and differential diagnosis of multilocular cystic renal cell carcinoma.
Wei ZHANG ; Yujun LI ; Qing LU ; Jie ZHUANG ; Qiang WANG ; Hui ZHAO ; Wenjuan YU ; Enhao KANG ; Zengwen FENG
Chinese Journal of Pathology 2014;43(11):723-727
OBJECTIVETo investigate the clinicopathological characteristics and the diagnosis of multilocular cystic renal cell carcinoma (MCRCC).
METHODSThe clinicopathological data of 19 MCRCC cases were collected and immunohistochemical staining assays were carried out. Forty-six cases of other cystic kidney lesions within the same period were collected as controls, including extensively cystic clear cell RCC (12 cases), clear cell tubulopapillary renal cell carcinoma (6 cases), tubulocystic carcinoma (2 cases), simple cortical cysts (22 cases), multilocular cystic nephroma (1 cases) and multicystic kidney (3 cases).
RESULTSThe patients included 14 males and 5 females. The ages ranged from 31 to 66 years (median age = 50 years). Most of the MCRCC cases were detected incidentally in physical examination, occasionally accompanied with hematuria, back pain or other symptoms. The follow-up period of 17 patients ranged from 6 to 170 months. All patients were alive without evidence of tumor recurrence or metastasis. Pathological findings showed that macroscopically, tumor size ranges from 1.5 to 7.0 cm in the maximum diameter, generally a entirely of various sized. The cysts contain serous, hemorrhagic or turbid fluid. Solid areas or substantially discernible mural nodules were absent; histologicallly, single layer of cuboidal and flattened epithelial tumor cells were lined in the cysts, described as clear cytoplasm, small nuclear, no nucleoli and low Fuhrman nuclear grade (I or II). Multilayer tumor cells could be observed in a few cysts, with granular cytoplasm and small intracystic papillae formed. The clear tumor cell clusters, similar as cystic lined tumor cells, were seen within pathological fibrous in almost all cases, and significant myofibroblastic proliferation was found in 14 cases. Immunohistochemically, the cysts lined epithelial cells and the clear tumor cell clusters were positive for epithelium markers, including CKpan(19/19), EMA(16/19) and CK7 (15/19); higher percentage of CAIX (17/19) and PAX8(15/19) than control groups, but lower percentage of CD10 (7/19), RCC (6/19) and AMACR(2/19); and all were negative for 34βE12, CD117 and CD68.
CONCLUSIONSMultilocular cysts, clear cells clusters of low Fuhrman grade within fibrous septa and capillary vessel proliferation under epithelium are important features of MCRCC. The united using of CAIX, CK7, CD10 and RCC is helpful for differentiating variable cystic renal tumor. MCRCC usually has an excellent prognosis, nephron sparing surgery is first recommended as a therapeutic strategy.
Adenocarcinoma, Clear Cell ; metabolism ; pathology ; Biomarkers ; Carcinoma, Renal Cell ; metabolism ; pathology ; Cysts ; metabolism ; pathology ; Diagnosis, Differential ; Female ; Humans ; Kidney Diseases, Cystic ; metabolism ; pathology ; Kidney Neoplasms ; metabolism ; pathology ; Male ; Neoplasm Recurrence, Local ; Prognosis ; Racemases and Epimerases ; metabolism