1.Cardiorenal Syndrome.
Korean Journal of Medicine 2016;90(5):378-383
Although combined cardiac and renal dysfunction is common in hospitalized patients and portends a poor prognosis, lack of understanding of the pathogenesis and classification of the condition has hampered the development of therapeutic strategies. Interactions between the heart and kidney involve multiple hemodynamic and nonhemodynamic factors and are usually bidirectional, as acute or chronic dysfunction of the cardiac or renal systems can negatively affect one another. This review introduces a new definition and classification system of cardiorenal syndrome advocated by a consensus conference of the Acute Dialysis Quality Initiative and summarizes the current understanding of cardiorenal syndrome.
Acute Kidney Injury
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Cardio-Renal Syndrome*
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Cardiovascular Diseases
;
Classification
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Consensus
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Dialysis
;
Heart
;
Heart Failure
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Hemodynamics
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Humans
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Kidney
;
Prognosis
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Renal Insufficiency, Chronic
2.Cardiorenal syndrome
Journal of the Korean Medical Association 2020;63(1):20-29
To maintain homeostasis of the cardiovascular system, the heart and kidney act bidirectionally. Therefore, acute or chronic dysfunction of one organ can cause dysfunction in the other. This phenomenon is characterized as cardiorenal syndrome (CRS). Concurrent dysfunction of the heart and kidney adversely affects one another and eventually worsens patient outcomes through a vicious cycle. Although a CRS classification system has been proposed, the underlying pathophysiology is multifactorial and clinical access continues to be difficult. Although several therapies, including agents that target the renin-angiotensin-aldosterone system, have been utilized, there is not enough evidence to demonstrate their effectiveness for CRS. Thus, more effort should be made to optimize the diagnosis and treatment strategies for CRS patients. This review will introduce CRS as it is currently understood, discuss the pathophysiology, and examine management strategies.
Acute Kidney Injury
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Cardio-Renal Syndrome
;
Cardiovascular System
;
Classification
;
Diagnosis
;
Heart
;
Heart Failure
;
Homeostasis
;
Humans
;
Kidney
;
Renal Insufficiency, Chronic
;
Renin-Angiotensin System
3.A Case of Chronic Renal Failure after Exposure to Oral Sodium Phosphate Bowel Purgatives.
Ki Jun CHANG ; Hyo Jeong CHANG ; Byung Gyu KIM ; Bi Ro KIM ; Sang Hyun KIM ; Won Do PARK ; Hyun Jung KIM
Korean Journal of Medicine 2012;83(5):659-663
Renal failure due to nephrocalcinosis after large-bowel cleansing with sodium phosphate preparations before endoscopic procedures is an easily overlooked diagnosis. While it has been reported that acute renal failure can result from the use of oral sodium phosphate preparations, chronic renal failure has not yet been reported. We report a case of chronic renal failure due to oral sodium phosphate, in which a kidney biopsy was performed.
Acute Kidney Injury
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Biopsy
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Cathartics
;
Kidney
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Kidney Failure, Chronic
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Nephrocalcinosis
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Phosphates
;
Renal Insufficiency
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Sodium
4.Clinical Experience of Hemodialysis on Three Cases of Renal Failure using Kill Type Artificial Kidney.
Korean Journal of Urology 1970;11(2):63-70
Hemodialysis using Kiil type artificial kidney was performed on two cases of acute renal failure and a case of chronic renal failure and the following results were obtained: 1. A case of acute renal failure recovered from her deteriorated renal function following four consecutive hemodialyses and another following a single hemodialysis of six hours. 2. A case of chronic renal failure is now stabilized clinically and maintained on ambulatory intermittent long-term hemodialysis.
Acute Kidney Injury
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Kidney Failure, Chronic
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Kidneys, Artificial*
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Renal Dialysis*
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Renal Insufficiency*
5.Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes.
Korean Journal of Medicine 2015;88(4):382-386
Although it was thought that survivors from an acute kidney injury (AKI) recovered kidney function completely, cumulative observational data have shown that AKI can cause end-stage renal disease directly, increase the risk of developing incident chronic kidney disease (CKD), and worsen an underlying CKD. These data have confirmed an association between AKI and an increased risk of permanent kidney damage, with subsequent development of CKD. However, many studies have focused on early injury following ischemic insult; the mechanisms of long-term injury remain poorly understood. Established and new data suggest that endothelial injury, loss of peritubular capillary volume, and chronic hypoxia affect structural changes after an ischemic insult. The repair process after acute kidney injury can be both adaptive and maladaptive. A maladaptive response includes persistent upregulation of proinflammatory and profibrotic signals and maladaptive cellular regeneration; this is thought to be one of the mechanisms leading to progressive renal injury and, ultimately, end-stage renal disease. The purpose of this brief review was to focus on recent advances related to the mechanisms of the progression from AKI to CKD. This review suggests that a new approach is required to manage AKI patients to prevent and/or arrest CKD progression.
Acute Kidney Injury*
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Anoxia
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Capillaries
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Humans
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Inflammation
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Kidney
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Kidney Failure, Chronic
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Regeneration
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Renal Insufficiency, Chronic*
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Survivors
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Up-Regulation
7.The effect of hypertension on the progression of renal insufficiency in chronic renal failure patients.
Dae Suk HAN ; Kyu Hun CHOI ; Young Ki KIM ; Dong Hun CHA ; Ho Yung LEE ; Kyo Sun KIM
Korean Journal of Nephrology 1991;10(2):135-144
No abstract available.
Humans
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Hypertension*
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Kidney Failure, Chronic*
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Renal Insufficiency*
8.The effect of hypertension on the progression of renal insufficiency in chronic renal failure patients.
Dae Suk HAN ; Kyu Hun CHOI ; Young Ki KIM ; Dong Hun CHA ; Ho Yung LEE ; Kyo Sun KIM
Korean Journal of Nephrology 1991;10(2):135-144
No abstract available.
Humans
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Hypertension*
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Kidney Failure, Chronic*
;
Renal Insufficiency*
9.Changes of Renal Function and Treatment after CABG in Patients with Elevated Serum Creatinine.
Sam Youn LEE ; Jong Bum CHOI ; Mi Kyuong LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 2005;38(2):146-151
BACKGROUND: Preoperative elevated serum creatinine values are associated with increased risk for both morbidity and mortality in patients undergoing on-pump coronary artery bypass surgery (CABG). We investigated the postoperative changes of renal function and proper management in the patients. MATERIAL AND METHOD: Among 74 consecutive patients who underwent isolated on-pump CABG, 17 patients with increased serum creatinine level (creatinine > or = 1.5 mg/dL) within preoperative one week were included in the study. Seven patients showed preoperative serum creatinine level of 2.0 mg/dL or higher, and 3 of them had been undergoing hemodialysis. Preoperative hemodialysis was performed in the 3 patients due to end-stage renal failure (ESRD) the day before the operation. We started peritoneal dialysis immediately after the cardiopulmonary bypass in patients with ESRD or postoperative acute renal failure if it was necessary to remove intravascular volume and lower serum creatinine level. RESULT: In most of the patients with CABG, postoperative serum creatinine level increased and recovered to the preoperative level at the discharge. In 2 of the 4 patients with serum creatinine level of 2.0 mg/dL or higher and 3 patients with ESRD, intravascular volume, serum creatinine level and serum electrolyte were controlled with peritoneal dialysis. CONCLUSION: Postoperative serum creatinine level increased transiently in most of CABG patients, and intravascular volume and serum creatinine level were controlled by peritoneal dialysis only in the patients with acute renal failure postoperatively and those depending on hemodialysis.
Acute Kidney Injury
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Cardiopulmonary Bypass
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Coronary Artery Bypass
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Creatinine*
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Humans
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Kidney Failure, Chronic
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Mortality
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Peritoneal Dialysis
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Renal Dialysis
;
Renal Insufficiency
10.The Prevention of Contrast Induced Nephropathy by Sarpogrelate: a Prospective Randomized Controlled Clinical Trial
You Jeong KI ; Sun A KWON ; Hack Lyoung KIM ; Jae Bin SEO ; Woo Young CHUNG
Journal of Korean Medical Science 2019;34(40):e261-
BACKGROUND: Although some strategies are used for prophylaxis of contrast induced nephropathy, their efficacy is not fully established. Sarpogrelate can relieve vasospasm and have anti-inflammatory action. This study examined whether sarpogrelate reduces the incidence of contrast induced nephropathy (CIN) or subsequent renal impairment during four weeks after coronary angiography compared with a control group. METHODS: Seventy-four participants with chronic renal failure were randomly assigned to the sarpogrelate or control group. Patients assigned to the sarpogrelate group received oral saporogelate from 24 hours before contrast exposure up to one month after contrast exposure. The primary outcome of this study was the incidence of CIN within 48 hours after exposure to the contrast agent. RESULTS: Thirty-one subjects in the control group and 35 subjects in the sarpogrelate group were used for the analysis. Cumulative CIN occurred numerically more at 48 hours in the sarpogrelate group and less at one month without statistical significance (11.4% vs. 6.5% at 48 hours and 11.4% vs. 16.1% at one month, respectively). Baseline renal function was similar in both groups, but the estimated glomerular filtration rate (eGFR) was lower in the sarpogrelate group at 12 and 48 hours compared with the control group (45.6 vs. 54.7 mL/min/1.73m²; P = 0.023 and 39.9 vs. 50.6 mL/min/1.73m²; P = 0.020, respectively). At one month, the eGFR became comparable between the two groups because the eGFR was aggravated in the control group and maintained in the sarpogrelate group. CONCLUSION: This study failed to demonstrate that sarpogrelate has a renoprotective effect against contrast induced acute kidney injury. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01165567
Acute Kidney Injury
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Coronary Angiography
;
Glomerular Filtration Rate
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Humans
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Incidence
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Kidney Failure, Chronic
;
Prospective Studies
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Renal Insufficiency
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Serotonin