2.Studies on lipoprotein(a) and lipid metabolism abnormalities in patients with chronic renal failure receiving dialysis.
Sung Kyu HA ; Han Sun CHO ; Jong Hoon PARK ; Soo Yeon NAM ; Kui Soon LEE ; Byung Kwon LEE ; Heung Soo KIM ; Ho Yung LEE ; Dae Suk HAN ; Suk Ho JUNG
Korean Journal of Nephrology 1993;12(4):649-657
No abstract available.
Dialysis*
;
Humans
;
Kidney Failure, Chronic*
;
Lipid Metabolism*
;
Lipoprotein(a)*
3.Big Data Research in Chronic Kidney Disease.
Xiao-Xi ZENG ; Jing LIU ; Liang MA ; Ping FU
Chinese Medical Journal 2018;131(22):2647-2650
4.Decreased number of CD14+TLR4+ monocytes and their impaired cytokine responses to lipopolysaccharide in patients with chronic kidney disease.
Zhi LIU ; Yan-hong KAN ; Yu-dan WEI ; Xiu-jiang LI ; Fan YANG ; Yue HOU ; Yu-jun DU
Journal of Huazhong University of Science and Technology (Medical Sciences) 2015;35(2):206-211
This study aimed to examine the number of circulating Toll-like receptor 4 (TLR4) + CD14+ monocytes in patients with different stages of chronic kidney disease (CKD), their responses to lipopolysaccharide (LPS), and to explore the potential association of the number of TLR4+CD14+ monocytes with clinical laboratory measures. The numbers of TLR4+CD14+, LPS-stimulated TNF-α+CD14+ and interleukin (IL)-6+CD14+ monocytes were determined by flow cytometry in 9 patients with stage 3 CKD, 11 with stage 4 CKD, 16 with stage 5 CKD, and 19 healthy controls (HCs). Their laboratory tests were performed by routine methods and the potential association among these measures was analyzed by Pearson's correlation analysis. The numbers of CD14+, CD14+TLR4+, LPSstimulated TNF-α+CD14+ and IL-6+CD14+ monocytes in patients with CKD were significantly less than those of HCs (all P<0.05), and were negatively associated with patient disease severity. The number of CD14+TLR4+ monocytes was positively correlated with estimated glomerular filtration rate (eGFR, P<0.001) and the levels of hematocrit (P<0.01), but negatively correlated with the levels of blood urine nitrogen, serum creatinine, and C-reactive protein (P<0.001 for all), in the CKD patients. Our data indicate that significant reduction in the number of TLR4+ monocytes and their impaired responses to LPS may be associated with the progression of CKD in Chinese patients.
Cytokines
;
metabolism
;
Humans
;
Kidney Failure, Chronic
;
metabolism
;
Lipopolysaccharide Receptors
;
metabolism
;
Lipopolysaccharides
;
pharmacology
;
Monocytes
;
metabolism
;
Toll-Like Receptor 4
;
metabolism
5.A Case of Acquired Ichthyosis Associated with Diabetes Mellitus, Chronic Renal failure and Hypertension.
Korean Journal of Dermatology 2000;38(3):407-409
Acquired ichthyosis is a rare condition and ususually occurs in adult patients with various systemic diseases and drugs that affect cholesterol metabolism. As a rule when the underlying disease goes into remission, the ichtyosis regress. Clinically and histopathologically it is similar to ichthyosis vulgaris. We report a 43-year-old man with acquired ichthyosis, who associated with diabetes mellitus, chronic renal failure and hypertension.
Adult
;
Cholesterol
;
Diabetes Mellitus*
;
Humans
;
Hypertension*
;
Ichthyosis Vulgaris
;
Ichthyosis*
;
Kidney Failure, Chronic*
;
Metabolism
6.An assessment approach to the adequacy of peritoneal dialysis based on modified MART2 network.
Mei ZHANG ; Jing ZHAO ; Yueming HU
Journal of Biomedical Engineering 2009;26(3):475-479
Against the large number of assessment indices to the adequacy peritoneal dialysis and incompatibility of some indices, an intelligent assessment approach to the peritoneal dialysis adequacy based on MART2 (modified from ART2) network is proposed. After non-dimension and weighting preconditioning, the assessment indices were put to MART2 and sorted into many clusters. The center-of-gravity of each cluster was identified as adequacy or inadequacy according to the assessment criteria of dialysis adequacy, and the adequacy of each cluster could be determined by the adequacy of corresponding center-of-gravity when the network threshold was high. Finally, the peritoneal dialysis adequacy of each patient could be judged according to the adequacy of cluster to which the patients' indices belong. Experimental results demounstrate its effectiveness.
Creatinine
;
metabolism
;
Guideline Adherence
;
Humans
;
Kidney Failure, Chronic
;
metabolism
;
therapy
;
Peritoneal Dialysis
;
instrumentation
;
standards
;
Quality Assurance, Health Care
;
Urea
;
metabolism
7.Changes in Thromboelastographic Findings after Renal Transplantation in Patients with Chronic Renal Failure.
Jaemin LEE ; Eun Sung KIM ; Chul Soo PARK ; Sung Hee KANG
Korean Journal of Anesthesiology 2004;47(1):75-81
BACKGROUND: Recent studies of thromboelastograph (TEG) findings have revealed that the hemostatic process is enhanced in uremic patients, suggesting an increased risk of thrombosis formation. The pathogenesis of hypercoagulability appears to be multifactorial in origin, and to involve associated lipid metabolism abnormalities. The purpose of this study was to investigate changes in TEG findings and lipid metabolism after renal transplantation. METHODS: 23 patients scheduled for renal transplantation were included. PT, PT-INR, and aPTT were used as laboratory blood coagulation tests, and concentrations of triglyceride and total cholesterol as indices of lipid metabolism abnormalities. TEG variables were measured before renal transplantation, and again at one and three weeks after transplantation, and then compared with pre-transplantation values. RESULTS: The pre-transplantation values of alpha-angle, maximal amplitude and A60 were above the normal ranges, showing hypercoagulability. They reduced significantly after successful transplantation suggesting that the hypercoagulable tendency is relieved upon correcting uremia (P < 0.05). The lipid metabolism study showed hypertriglyceridemia before transplantation. Triglyceride concentrations reduced significantly to normal levels after renal transplantation (P < 0.05), and were correlated with changes in alpha-angle, maximal amplitude, A60, TEG index, and LY30 (P < 0.01). CONCLUSIONS: Patients with chronic renal failure, associated with hypertriglyceridemia, as a form of lipid metabolism abnormality, showed hypercoagulability on TEG. With the correction of uremia after renal transplantation, the hypercoagulable findings are relieved and triglyceride levels reduce to normal. The normalization of lipid metabolism after renal transplantation might have a participatory role in relieving hypercoagulability.
Blood Coagulation Tests
;
Cholesterol
;
Humans
;
Hyperlipidemias
;
Hypertriglyceridemia
;
Kidney Failure, Chronic*
;
Kidney Transplantation*
;
Lipid Metabolism
;
Reference Values
;
Thrombophilia
;
Thrombosis
;
Triglycerides
;
Uremia
8.Effcts of Hemodialysis and Contiuous Ambulatory Peritoneal Dialysis on Thyroid Function in Chronic Renal Failure.
Seung Kee KIM ; Eung Suk KIM ; Jeong Ho LEE ; Young Tai SHIN
Korean Journal of Nephrology 1997;16(4):688-694
The changes of thyroid hormones are expected in patients with chronic renal failure(CRF) because the kidney plays an important role in metabolism and excretion of thyroid hormones. In spite of many studies about this issue, there have not been full consensus about the nature and mechanism of thyroid hormone changes. We undertook the present study to reveal the dialysis effects on these hormones. We measured basal levels of serum total T3 (T3), total T4(T4), free T4(FT4), reverse T3(rT3) and TSH, and then calculated the ratio of T3/T4, rT3/T3 and rT3/T4. The following groups were identifed : Group I-10 cases of normal controls, Group II-18 cases of pre-dialysis or treated conservatively, Group III-20 cases treated by maintenance hemodialysis(HD), Group IV-18 cases treated by continuous ambulatory peritoneal dialysis(CAPD). Patients from group II, III and IV revealed significantly decreased levels of T3 and T4, and increased ratio of rT3/T4 in comparison to the control group(P<0.05). Especially, CAPD group revealed significantly increased levels of T4 and FT4 in comparison to HD group(P<0.05). In the long-term dialysis group(>36months), the mean concentrations of free T4 levels revealed signifcantly decreased in comparison to the short-term dialysis group(P<0.05). Thyroid dysfunction are observed in CRF patients with partial recovery after dialysis therapy. Especially, CAPD achieves significantly improved thyroid dysfunction compared to HD, but further study would be necessary.
Consensus
;
Dialysis
;
Humans
;
Kidney
;
Kidney Failure, Chronic*
;
Metabolism
;
Peritoneal Dialysis*
;
Peritoneal Dialysis, Continuous Ambulatory
;
Renal Dialysis*
;
Thyroid Gland*
;
Thyroid Hormones
9.Association of serum mineral parameters with mortality in hemodialysis patients: Data from the Korean end-stage renal disease registry.
Yunmi KIM ; Kyung Don YOO ; Hyo Jin KIM ; Junga KOH ; Yeonsil YU ; Young Joo KWON ; Gheun Ho KIM ; Tae Hyun YOO ; Joongyub LEE ; Dong Chan JIN ; Bum Soon CHOI ; Yeong Hoon KIM ; Kook Hwan OH
Kidney Research and Clinical Practice 2018;37(3):266-276
BACKGROUND: We investigated the associations between mineral metabolism parameters and mortality to identify optimal targets in Korean hemodialysis patients. METHODS: Among hemodialysis patients registered in the end-stage renal disease registry of the Korean Society of Nephrology between March 2012 and June 2017, those with serum calcium, phosphorus, and intact parathyroid hormone (iPTH) measured at enrollment were included. Association of serum levels of calcium, phosphorus, and iPTH with all-cause mortality was analyzed. RESULTS: Among 21,433 enrolled patients, 3,135 (14.6%) died during 24.8 ± 14.5 months of follow-up. After multivariable adjustment, patients in the first quintile of corrected calcium were associated with lower mortality (hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.71–0.99; P = 0.003), while those in the fifth quintile were associated with higher mortality (HR, 1.39; 95% CI, 1.20–1.61; P < 0.001) compared with those in the third quintile. For phosphorus, only the lowest quintile was significantly associated with increased mortality (HR, 1.24; 95% CI, 1.08–1.43; P = 0.003). The lowest (HR, 1.18; 95% CI, 1.02–1.36; P = 0.026) and highest quintiles of iPTH (HR, 1.24; 95% CI, 1.05–1.46; P = 0.013) were associated with increased mortality. For target counts achieved according to the Kidney Disease Outcomes Quality Initiative guideline, patients who did not achieve any mineral parameter targets hadhigher mortality than those who achieved all three targets (HR, 1.37; 95% CI, 1.12–1.67; P = 0.003). CONCLUSION: In Korean hemodialysis patients, high serum calcium, low phosphorus, and high and low iPTH levels were associated with increased all-cause mortality.
Calcium
;
Follow-Up Studies
;
Humans
;
Kidney Diseases
;
Kidney Failure, Chronic*
;
Metabolism
;
Miners*
;
Mortality*
;
Nephrology
;
Parathyroid Hormone
;
Phosphorus
;
Renal Dialysis*
10.Expression of ghrelin and its receptor GHS-R in the hypothalamus and gastrointestinal tract in rats with chronic renal failure.
Rong-guo FU ; Hao-zheng YUAN ; Li WANG ; Heng GE ; Jun ZHANG ; Qi-lan NING ; Fu-jun ZHANG
Journal of Southern Medical University 2011;31(1):96-99
OBJECTIVETo investigate the expression of ghrelin and its receptor, growth hormone secretagogue receptor (GHS-R), in the hypothalamus and gastrointestinal tract in rats with chronic renal failure (CRF) and explore their relationship with the disorder of gastrointestinal tract motility.
METHODSSD rats were randomly divided into sham-operated group (n=8) and CRF group (n=16), and in the latter group, the rats were subjected to 5/6 nephrectomy to induce CRF. Real-time PCR and immunohistochemical staining were used to detect the distribution of mRNA and protein of ghrelin and GHS-R in the gastric fundus, duodenum, and hypothalamus.
RESULTSThe rats in the CRF group showed a significantly higher expression of ghrelin mRNA and protein in the gastric fundus but a lower expression in the hypothalamus than those in the sham-operated group (P<0.01), but the expression in the duodenum was similar between the two groups (P>0.05). The expression of GHS-R mRNA and protein in the gastric fundus was significantly higher in the CRF group than in the sham-operated group (P<0.01), while in the hypothalamus and duodenum, the expression was significantly lower in the CRF group (P<0.01).
CONCLUSIONThe different distribution patterns of ghrelin and GHS-R in the tissues may be an important pathological basis of gastrointestinal motility disorder in CRF.
Animals ; Gastrointestinal Tract ; metabolism ; Ghrelin ; genetics ; metabolism ; Hypothalamus ; metabolism ; Kidney Failure, Chronic ; metabolism ; Male ; RNA, Messenger ; genetics ; metabolism ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Receptors, Ghrelin ; genetics ; metabolism