Neopterin is a pyrazino-pyrimidine compound, and is known to be a marker associated with cell-mediated immunity in various diseases. We hypothesized that the levels of serum and urine neopterin would be elevated in renal disease, and would correlate with certain clinical parameters. We evaluated serum and urinary neopterin levels in patients with several renal diseases, including nephrotic syndrome (NS, n=19), chronic renal failure (CRF, n=8), end stage renal disease (ESRD, n=64) and controls (n=22). Serum neopterin was elevated in patients with CRF and ESRD, as compared to controls. Urinary neopterin levels were also found to be elevated in patients with CRF and ESRD, as compared to controls. Serum neopterin levels showed significant positive correlation with age, serum BUN and creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, serum albumin and total iron binding capacity. Urine neopterin levels exhibited positive correlation with age and serum creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, BUN and serum albumin. In conclusion, increased serum and urinary neopterin levels were found in some patients with renal disease and were correlated with certain clinical parameters.
Triglycerides/blood ; Radioimmunoassay/methods ; Nephrotic Syndrome/blood/pathology/urine ; Neopterin/*blood/*urine ; Middle Aged ; Male ; Kidney Failure, Chronic/blood/pathology/urine ; Kidney Diseases/blood/*pathology/urine ; Humans ; Hemoglobins/metabolism ; Hematocrit ; Female ; Creatinine/blood ; Blood Urea Nitrogen ; Aged ; Age Factors ; Adult

OBJECTIVETo evaluate the effect of Xinshen capsule upon the chronic kidney disease progress by the study of 7/8 kidney removal rat model.

METHODThe urea nitrogen and the blood creatinine level were estimated by automatic biochemistry analyzer. Hemorheological index level was measured by rheometer. Urine protein was measured by Coomassie brilliant blue. PAS and PASM staining was applied to observe kidney histology change, and semi-quantitative analysis was used to observe the kidney histology change.

RESULTIn model control group, the urine protein excretory rate and the urea nitrogen, the blood creatinine level were up-regulated obviously, erythrocyte aggregation index and whole blood viscosity value were down-regulated significantly, kidney organizations show up pathological change evidently, and leave surgical group compared the difference. After the treatment of Xinshen capsule, the above indicators are improving obviously.

CONCLUSIONXinshen capsule can degrade urine protein, the urea nitrogen and the blood creatinine level, and lower red blood cell accumulation and the whole blood viscosity, alleviate kidney various pathological change, the medicine can effectively delay the progress of chronic kidney disease.

Animals ; Blood Urea Nitrogen ; Blood Viscosity ; drug effects ; Capsules ; Creatinine ; blood ; Erythrocyte Aggregation ; drug effects ; Female ; Kidney ; drug effects ; pathology ; Kidney Failure, Chronic ; blood ; drug therapy ; pathology ; Medicine, Chinese Traditional ; Proteinuria ; urine ; Rats ; Rats, Sprague-Dawley