1.Immunoglobulin G4-Related Kidney Disease: A Comprehensive Pictorial Review of the Imaging Spectrum, Mimickers, and Clinicopathological Characteristics.
Nieun SEO ; Jin Hee KIM ; Jae Ho BYUN ; Seung Soo LEE ; Hyoung Jung KIM ; Moon Gyu LEE
Korean Journal of Radiology 2015;16(5):1056-1067
Immunoglobulin G4 (IgG4)-related kidney disease (IgG4-KD) has recently been demonstrated to be an important part of IgG4-related sclerosing disease (IgG4-SD). However, since IgG4-KD is still relatively unfamiliar to radiologists and physicians as compared to IgG4-SD involving other organs, it could, therefore, be easily missed. In this article, we present a comprehensive pictorial review of IgG4-KD with regards to the imaging spectrum, mimickers, and clinicopathologic characteristics, based on our clinical experience with 48 patients during the past 13 years, as well as a literature review. Awareness of the broad imaging spectrum of IgG4-KD and differential diagnosis from its mimickers will thus facilitate its early diagnosis and treatment.
Adult
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Aged
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Aged, 80 and over
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Autoimmune Diseases/pathology/radiography
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Female
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Humans
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Immunoglobulin G/*metabolism
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Kidney Diseases/drug therapy/*pathology/radiography
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Steroids/therapeutic use
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Tomography, X-Ray Computed
2.Interstitial Pneumonitis in a Patient with Chronic Hepatitis C and Chronic Renal Failure on Interferon Therapy.
Eun Jung KANG ; Dong Kyun KIM ; Seong Ran JEON ; Hyun Sook CHOI ; Soung Won JEONG ; Jae Young JANG ; Joon Seong LEE ; Soo Taek UH
The Korean Journal of Gastroenterology 2011;58(1):47-52
After 4-months of alpha interferon (IFN-alpha), a 64-year old woman with chronic hepatitis C developed a cough and dyspnea and showed diffuse infiltrative opacities on her chest X-ray. Her symptoms persisted after stopping the IFN-alpha therapy. Pulmonary function testing revealed a reduced forced vital capacity. High-resolution computed tomography of the lung showed peripheral and peribronchovascular ground glass attenuation and consolidation associated with reticulation. Bronchoalveolar lavage was performed for further evaluation and showed a lymphocyte level of 8.2%, an uncommon finding in IFN-alpha-induced interstitial pneumonitis. We performed a lung biopsy to diagnose her disease and it suggested interstitial pneumonitis. This was considered to be due to the immunomodulatory effects of INF-alpha. Although rare, any sign of significant pulmonary involvement should be evaluated.
Antiviral Agents/*adverse effects/therapeutic use
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Bronchoalveolar Lavage
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Female
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Hepatitis C, Chronic/complications/*drug therapy
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Humans
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Interferon-alpha/*adverse effects/therapeutic use
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Kidney Failure, Chronic/complications
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Lung Diseases, Interstitial/*chemically induced/pathology/radiography
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Middle Aged
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Respiratory Function Tests
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Tomography, X-Ray Computed