51 patients with chronic renal failure of stage III (RF III group) were studied concerning clinical, biochemical, hematological with 109 healthy person (control group) and 117 patients with stage IV renal chronic failure (RF IV group). In RF III group, considerable changes were noted including dilation of left auricle and left ventricle, decrease of systolic function an disturbance of diastolic function, increase of pulmonary arterial pressure. In RT IV group, there are many differences in comparing with RT III group (more dilatation of left auricle and ventricle, less functioning of systole and higher level of diastole and of pulmonary arterial pressure. Therefore cardiac complications were more severe in RF IIIb versus RF IVa.
Kidney Failure ; complications ; Heart Diseases

Homocysteine (Hcy) is an intermediate metabolite of methionine metabolism. Hyperhomocysteinemia (HHcy) is defined as a condition characterized by plasma Hcy level above 16 μmol/L which can result from abnormal Hcy metabolism. HHcy has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis and kidney diseases. In this review, we summarize the correlation between HHcy and kidney diseases. Elucidating the role of HHcy in kidney diseases may provide a new strategy to prevent and treat kidney diseases.
Homocysteine ; Humans ; Hyperhomocysteinemia ; complications ; Kidney Diseases ; complications

Humans ; Child ; COVID-19/complications* ; Brain Diseases ; Myositis/complications* ; Kidney ; Liver Failure, Acute/complications* ; Acute Kidney Injury/complications*

Abortion, Habitual ; complications ; Antibodies, Antiphospholipid ; blood ; Antiphospholipid Syndrome ; complications ; pathology ; therapy ; Erythema ; complications ; Heart Valve Diseases ; complications ; Humans ; Kidney Diseases ; complications ; Skin Diseases ; complications ; Thrombosis ; complications

Introduction: Diabetic nephropathy is a microvascular complication and is the leading cause of diabetes related morbidity, mortality and important cause of end-stage kidney disease. Both microalbuminuria and macroalbuminuria are associated with increased risk of cardiovascular disease. Evidence has been accumulating from clinical trials that assessing the levels of apolipoprotein B (ApoB), a constituent of atherogenic lipoproteins: ApoA1, a component of anti-atherogenic high density lipoprotein (HDL) cholesterol; and the ApoB/ApoA1 ratio will provide better prediction of future cardiovascular events than measuring serum low-density lipoprotein (LDL)-cholesterol levels. There is paucity of published data linking ApoB/ApoA1 ratio to diabetic nephropathy especially from developing countries, hence this study was carried out. Materials and Methods: The present study was conducted in the Department of Medicine, CSM Medical University, Lucknow between August 2009 and July 2010. Patients with type 2 Diabetes Mellitus (DM) attending the Diabetic and Medical Out-Patient clinics or who were admitted to the medical wards of Gandhi Memorial and Association Hospital CSM University, Lucknow were included. One hundred patients were enrolled; 64 of those were cases (Micro- and Macroalbuminuria groups) and 36 without nephropathy (Normoalbuminuria) were controls. The cut-off value for higher ApoB/ApoA1 ratio for male was 0.97 and for female was 0.86. Results: Older age, durations and control of DM were significantly correlated with degree of albuminuria. Fifty-six patients (56%) had raised ApoB/ApoA1 ratio, 19.4% in the Normoalbuminuria group (n=7/36), 71.4% in the Microalbuminuria group (n=30/42), and 86.4% in the Macroalbuminuria group (n=19/22). There were no statistical differences in the mean total cholesterol, HDL, LDL, triglycerides among the groups. Conclusion: In our study higher ApoB/ApoA1 ratio was significantly correlated with diabetic nephropathy.
Apolipoprotein A-I ; Apolipoproteins B ; Complications ; Diabetes Mellitus ; Kidney Diseases

Adult ; Female ; Hemangioma ; complications ; Humans ; Kidney Neoplasms ; complications ; Lipoma ; complications ; Lung Diseases ; complications ; diagnosis ; Tuberous Sclerosis ; complications ; diagnosis

We report a case of surgically treated abdominal aortic aneurysm (AAA) in a patient having crossed ectopia with fusion anomaly of the kidney. One artery from the abdominal aorta above the aneurysm supplies the right kidney while three renal arteries (two from the aneurysm itself and one from the left common iliac artery) supply the crossed ectopic kidney. Preoperative imaging to define the arterial and collecting systems along with a detailed planning of the operation is essential to prevent ischemic renal injury as well as ureteral injury during AAA repair.
Aged ; Aortic Aneurysm, Abdominal/*complications/pathology/*surgery ; Choristoma/*complications/pathology ; Human ; *Kidney ; Kidney Diseases/*complications/pathology ; Magnetic Resonance Angiography ; Male

To investigate the effects of mycophenolate mofetil (MMF) on the process of renal interstitial fibrosis, unilateral ureteral obstruction (UUO) model was established in rats. Twenty Sprague-Dawley rats underwent UUO and received vehicle (n = 10) or MMF (20 mg.kg-1.d-1, by daily gastric gavage, n = 10) during a period of 5 days following surgery, and the additional 10 rats were served as sham-operated group. The rats were killed 5 days after surgery. Immunohistochemistry was performed on renal tissue for proliferating cell nuclear antigen (PCNA), alpha-smooth muscle actin (alpha-SMA) and type I and III collagen (col I, col III). Histological studies were also done by MASSON staining. Five days after surgery, proliferating cells in tubules, interstitium as well as interstitial myofibroblast (MyoF) infiltration and interstitial col I, col III deposition were all significantly reduced by MMF treatment. MMF also alleviated the histological changes of UUO rats. These results suggested that the reduction of interstitial MyoF infiltration may be an important event by which MMF prevents renal injury caused by UUO and MMF could be used to limit the progression of renal fibrosis.
Fibrosis ; Kidney/*pathology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Diseases/*prevention & control ; Mycophenolic Acid/*analogs & derivatives ; Mycophenolic Acid/*pharmacology ; Random Allocation ; Rats, Sprague-Dawley ; Ureteral Obstruction/*complications

PURPOSE: We tried to evaluate the safety, feasibility and the clinical usefulness of the retroperitoneoscopic surgery for the treatment of variable renal diseases. MATERIALS AND METHODS: Between June 1998 and March 1999, a total of 18 patients (9 nonfunctioning kidneys, 1 ureter tumor, 3 simple renal cysts, 1 polycystic kidney, 3 ureter stones, 1 UPJ obstruction) underwent retroperitoneoscopic surgery (9 nephrectomies, 1 nephroureterectomy, 4 cyst marsupialization, 3 ureterolithotomy, 1 pyeloplasty) in our hospital. We analyzed the results of each operations. RESULTS: Out of total 18 cases, 15 retroperitoneoscopic surgeries were performed successfully as planed. Mean operative time was 194 minutes(ranged from 100 to 355 minutes) and mean postoperative hospital stay was 4.1 days(2-7 days). There was no significant intraoperative or postoperative complication in successfully completed cases. Open conversion was needed in three patients, all of them were not in an emergent condition, and there was no significant complication. Transfusion was not required in all cases. CONCLUSIONS: Retroperitoneoscopic surgery is a safe and feasible procedure for benign renal diseases, and there seems to be enough rooms for malignant diseases also.
Humans ; Kidney ; Length of Stay ; Nephrectomy ; Operative Time ; Polycystic Kidney Diseases ; Postoperative Complications ; Ureter

Adolescent ; Child ; Child, Preschool ; Cytomegalovirus Infections ; complications ; Female ; Humans ; Kidney Diseases ; etiology ; Kidney Glomerulus ; pathology ; Male