Atrial myxomas are uncommon, but surgical treatment offers a potential cure. Early diagnosis is essential so that tumors can be promptly removed in order to reduce morbidity or mortality from atrioventricular valve dysfunction and embolic complications. They are intracavitary tumors occurring within any of the cardiac chambers, but they have a predilection for the atria, particulary the left atrium. The development of noninvasive, echocardiogaphic technique has made it possible to screen large numbers of patients with atrial myxoma with ease and safty. Recently the development of diagnostic procedure and cardiac surgery increased the accuracy of diagnosis and the opportunity of successful ereatment. We report the two cases of left artial myxomas which were removed successfully by surgery.
Diagnosis ; Early Diagnosis ; Echocardiography ; Heart Atria ; Humans ; Mortality ; Myxoma* ; Thoracic Surgery

Epdemiological studies were done on 721 patients detected and confirmed as leprosy patients at the Department of Dermatology at Chonnam University Hospitai in the ten years period from l969 to 1978. Statistically, 491 cases were male and 230 cases were female, comprising 2. 1% of the total number of outpatients (34, 631) and showing a decreasing yearly tendency, The percentage of each group, or type; tuberculoid, borderline, lepromatous and indeterminate, was 53.8%, 9.6%, 31.2%, and 5.4%, respectively. The most common age at discovery for males was 30 39 and for female 20~29 with the largest group being adults aged 20~49, 482 cases (66.9%). The sex ratio was 2.1: l, male to female. However, for the tuberculoid types the ratio was 2.5: 1 which was higher than that of the lepromatous type, I. 7: 1, By disease type the most common age group was 20 29 for tubercekid type, 30 39 for lepromatous and borderline group and 10~19 for the indeterminated group. Geographically, 652 cases(90. 4%) were from Chonnam Province and 61 cases (8.5%) from Chonbuk Province. We also observed some significant sequential changes of the type of disease descovered even though 10 years is a relatively short period. There was a tendency towards decreased detection of the tuberculoid type and increased detection of the borderline an.d indeterminate group.
Adult ; Dermatology ; Female ; Humans ; Jeollabuk-do ; Jeollanam-do ; Leprosy* ; Leprosy, Paucibacillary ; Male ; Outpatients ; Sex Ratio

Livedo reticularis with summer ulceration was first reported by Feldaker et al in 1955, that is characterized by livedo reticularis and ulcerations of the legs or feet beginning primarily the summer or warmer months of the year, and healing the winter months. A 32-year old rnan has suffered from periodic painful ulcerations, which were occurred during the summer, on the both ankles and brown to bluish colored reticulated discoloration on the lower legs for about 10 years. Histopathological findings showed endothelial proliferation and partial occlusion of the dermal capillaries, fibrinoid material on the superficial blood vessels, and partial epidermal necrolysis. This patient. was treated with antiplatelet aggregating medications and antihypertensive drug.
Adult ; Ankle ; Blood Vessels ; Capillaries ; Foot ; Humans ; Leg ; Livedo Reticularis* ; Ulcer*

The results of this study which had been investigated for the purpose of analyzing heavy metal concentrations in women's blood and urine, their correlation degree and significance of cadmium as indicator of accumulated heavy metals are as follows. 1) In blood, concentrations of Cd, Pb, Cu and Zn are respectively 0.0110+/-0.14 ug/ml, 0.208+/-138 ug/ml, 0.899+/-0.153 ug/ml and 5.432+/-1.020 ug/ml. 2) In urine, concentrations of Cd, Pb, Cu and Zn are respectively 0.003+/-0.12 ug/ml, 0.025+/-0.18 ug/ml, 0.013+/-0.12 ug/ml and 0.277+/-0.192 ug/ml. 3) Correlation coefficients between blood and urine are only significant in Zn (r=0.363, p<0.01). 4) In blood, correlation coefficients of Cd concentration and Pb, Zn are respectively 0.518 (p<0.01). 5) Correlation coefficients between Cd concentration in blood and Pb, Cu and Zn in urine are respectively r=-0.012, r=0.027, r=0.241 (p<0.05), and only Cd concentration and Zn is significant.
Cadmium ; Metals, Heavy

Cytochrome P-450 (CP-450) is one of the three components of the liver microsomal enzyme system which hydroxylates fatty acids, hydrocarbons and a variety of drugs and other foreign compounds. Female Balb/c mice were immunized with purified polychlorinated biphenyl (PCB) – induced CP-450 LMII. The spleen cells derived from immunized mice were fused with SP2 myeloma cells using polyethylene glycol (PEG 3500). The hybrid cells were selected by hypoxanthine-aminopterin-thymidine (HAT) medium and the culture fluid were screened by enzyme-linked immunosorbent assay to CP450 LMII. The hybrid cells(×107) were inoculated into intraperitoneal cavity of Balb/c mice for the purpose of production of ascetic fluids. Monoclonal antibody (Mab) was purified from ascitic fluid by DEAE cellulose ion exchange chromatography and I¹²⁵ labeled Mab was also confirmed by autoradiography and SDS-polyacrylamide gel electrophoresis (MW:55,000 and 110,000)
Animals ; Ascitic Fluid ; Autoradiography ; Chromatography, Ion Exchange ; Cytochrome P-450 Enzyme System* ; Cytochromes* ; DEAE-Cellulose ; Electrophoresis ; Enzyme-Linked Immunosorbent Assay ; Fatty Acids ; Female ; Humans ; Hybrid Cells ; Hydrocarbons ; Liver* ; Mice ; Polyethylene Glycols ; Rats* ; Spleen

Band 3, the predominant 95,000 dalton anion transport protein, is the major intrinsic glycoprotein of the human erythrocyte membrane. This anion carrier exists as a dimer and binds the cytoskeletons such as spectrin, ankyrin and actin. And the liposomes are vesicular structures which form spontaneously upon hydration of phospholipids. These artificial lipid vesicles have been investigated as model of the biological membranes and as a mean of improving the delivery of nucleic acids, drugs, proteins and biological substances to specific target tissues and cells. In this study, we were purified Band 3 from the human erythrocyte membrane (ghost) was prepared by hemolysis of intact human erythrocyte with weak alkali-hypotonic solution. Band 6 was removed from ghost by extracting with solution of an ionic strength of 0.15. Band 3 and Band 4 were solubilized selectively by extracting Band 6-depleted ghosts with Triton X-100 under nondenaturing conditions. Band 3 was then purified from Triton X-100 extract treated with p-chloromercuribenzoate by sucrose density gradient ultracentrifugation. This purified Band 3 was incorporated into liposomes prepared by reverse-phase evaporation. Phosphatidyl L-serine and cholesterol (1:1 molar ratio) were dissolved in chloroform and the chloroform was removed by rotator evaporation under reduced pressure. Band 3 solution without Triton X-100 was introduced into a mixture of lipids and diethylether. Diethylether was subsequently removed by evaporation. This purified Band 3 and its incorporation into liposomes were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Actins ; Ankyrins ; Chloroform ; Cholesterol ; Cytoskeleton ; Electrophoresis ; Erythrocyte Membrane* ; Erythrocytes* ; Glycoproteins ; Hemolysis ; Humans* ; Liposomes* ; Membranes ; Molar ; Nucleic Acids ; Octoxynol ; Osmolar Concentration ; Phospholipids ; Serine ; Sodium ; Spectrin ; Sucrose ; Ultracentrifugation

BACKGROUND: Ota's nevus is not an uncommon pigmenta y disorder in Asian people including Koreans. OBJECTIVE: The purpose of this study was to examine the clinical features of the patients and to determine the existince of any relevance between them. METHODS: We arrid out a retrospective study with cialreviews and phone interviews or direct examinatior. for clinical features of the lesions in acesible patients. RESULTS: The peak age of onset was at birth, pubertyed adolescence in decreasing order. The most frequen1,ly involved site was the eyelid, and the type I was the most common. Bluish black color was pie edorninant. The lesions which did not inili the eyelid or the lesions which developed after birtten were more likely to be light brown in cilc(p<0.05). CONCLUSION: The clrical features of Otas nevus were revwed and analyzed statistically.
Adolescent ; Age of Onset ; Asian Continental Ancestry Group ; Eyelids ; Humans ; Nevus of Ota* ; Parturition ; Retrospective Studies*

Gastrofiberscopic findings under direct vision were analysed in 248 patients who were diagnosed as gastric cancer from Feb. 1980 to March 1983 in Department of internal Medicine, Kang Nam Sacred Heart Hospital, Hallym Medical College, Seoul, Korea. (continue...)
Endoscopy* ; Heart ; Humans ; Internal Medicine ; Korea ; Seoul ; Stomach Neoplasms* ; Stomach*

No abstract available.
Child* ; Humans ; Infant* ; Peptic Ulcer*

Etretinate is a synthetic retinoic acid which has been reported effective in hyperkeratotic disorders. Recently, it has also been tried, on a limited number, for the treatment of viral wart. A 33-year-old male patient presented with multiple, tender, confluent, verrucous lesions on the scalp, both hands and feet of 4 years duration. Before coming to us, he had been treated with intralesional injection of bleomycin and electrodesiccation with little effect. We started etretinate therapy in a daily dose of 70mg(1mg /kg). After 3 weeks treatment, most of his skin lesions were flattened and softened: but an abrupt elevation of serum aminotransferases was noticed, which was normalized soon after cessation of medication. Unfortunately, the drug stop page aggravated most of skin lesions. After two weeks of withdrawal we started again the drug in a daily dose of 30mg and observed a good response without hepatic dysfunction.
Acitretin* ; Adult ; Bleomycin ; Etretinate* ; Foot ; Hand ; Humans ; Injections, Intralesional ; Male ; Scalp ; Skin ; Transaminases ; Tretinoin ; Warts*