No abstract available.
Female ; Humans ; Middle Aged* ; Myofibroblasts

No abstract available.
Anal Canal* ; Paget Disease, Extramammary* ; Radiotherapy* ; Vulva*

BACKGROUND: Several differences in basal cell carcinomas (BCCs) were found, according to the ethnic group; for example, pigmented BCCs was more common in Asian or Hispanic patients. However, there are few reports on the subclinical extension of the BCC in Asian patients. OBJECTIVE: The aim of this study was to evaluate the subclinical infiltration of the basal cell carcinoma in Asian patients. METHODS: All patients with BCC who visited the department of dermatology at Korea University Ansan Hospital were treated with Mohs micrographic surgery. In 81 patients, 83 tumors of BCC were completely eradicated by Mohs micrographic surgery (MMS) from April 2001 to August 2008, and were reviewed in this study. Information recorded included the total margin and the number of stages of Mohs micrographic surgery, anatomic location, tumor size, presence of pigmentation, clinical type, and pathological subtype. We divided the clinical types into nodular, ulcerated, and pigmented, and the pathological types into nodular, micronodular, morpheaform, and adenoid. The BCC was of pigmented type if pigmentation covered more than 25% of the tumor, regardless of whether pigmentation was distinct, or if there was apparent pigmentation that covered more than 10% of the tumor. RESULTS: The nose and cheek were the most common sites requiring more than one stage of surgery. In tumors smaller than 1 cm, 91.7% required only one stage of excision, compared with 60.6% in tumors larger than 1 cm. More than two Mohs stages were required in 25% of non-ulcerated BCCs and in 46.2% of ulcerated BCCs. Sixty eight percent of pigmented BCCs required only one stage of Mohs micrographic surgery. In cases of non-pigmented BCCs, only 45% required one Mohs stage. More than one Mohs stage was required in 19.2% of non-aggressive BCCs and in 42.9% of aggressive BCCs. CONCLUSION: Subclinical infiltration differed between the two groups according to the size of the BCC (1 cm threshold) and most of the BCCs were located in the head and neck area. Considering this result, indication for MMS can be extended for BCCs larger than 1 cm in Asian patients. Ulcerated BCCs required more Mohs stages than non-ulcerated BCCs. Pigmented BCCs might show lesser subclinical infiltration than non-pigmented BCCs. Aggressive pathological subtypes showed more subclinical infiltration than the non-aggressive types; however, after evaluation of the border that was excised with MMS, mixed histologic types were found to be more frequent than generally accepted. Therefore, we consider that, when planning surgery, dermatologists should not place too much confidence in the pathologic subtypes identified by biopsy.
Adenoids ; Asian Continental Ancestry Group ; Biopsy ; Carcinoma, Basal Cell ; Cheek ; Dermatology ; Head ; Hispanic Americans ; Humans ; Hypogonadism ; Korea ; Mitochondrial Diseases ; Mohs Surgery ; Neck ; Nose ; Ophthalmoplegia ; Pigmentation ; Ulcer

Trichorhinophalangeal syndrome (TRPS) is a rare genetic disorder characterized by a number of clinical features including slowly growing sparse scalp hair, a pear-shaped nose, and cone-shaped epiphyses of the phalanges. The syndrome has three subgroups: type I, II, and III. TRPS III is the rarest and most recently recognized form and inherited in an autosomal dominant manner. We describe a 19-year-old male with TRPS III, who presented with characteristic clinical and radiological features. To our knowledge, this is the first report of TRPS III in Korea.
Epiphyses ; Hair ; Humans ; Korea ; Male ; Nose ; Scalp ; Young Adult

A 59-year old man presented with a 0.5 x 0.3 cm-sized area of, pink-colored, dome-shaped papules on the paranasal area. There was no previous history of trauma to the area. Histopathologic diagnosis was consistent with eccrine poroma. We reported a case of eccrine poroma arising on the paranasal area, an unusual location for this condition.
Diagnosis ; Humans ; Middle Aged ; Poroma*

BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is a malignant proliferation of keratinocytes of the epidermis. It may have the potential to metastasize distally in contrast to the cutaneous basal cell carcinoma. OBJECTIVE: We investigated the recent trend of cSCC development from a clinical, histopathological, and prognostic perspective. METHODS: One hundred and sixty cases of cSCC in patients who had visited the Samsung Changwon Hospital over the past 10 years (between 2006 and 2016) were retrospectively studied. We analyzed their age, sex, location, etiologic factor, histopathologic finding, and treatment. RESULTS: The average age of cSCC was 77 years old and the sex ratio was 1:2.27. The most commonly involved location was the head and neck (73.13%). The etiologic factors were unknown (61.88%), actinic keratosis (23.13%), Bowen's disease (10.63%), burn scar (2.5%), chronic eczema (0.63%) and chronic inflammatory disease (0.63%). The average tumor diameter and thickness were 18.1 mm and 3.58 mm, respectively. The degrees of differentiation were well-differentiated (68.75%), moderately differentiated (28.75%) and poorly differentiated (2.5%). The occurrence rate of cSCC metastasis was 6.25% (10 cases/160 cases). The most common primary locations of cSCC metastasis were the lower extremities (5 cases/10 cases) and head and neck (2 cases/10 cases). All 10 cases were metastasis to adjacent lymph nodes. Five cases showed metastasis to distant lymph nodes, the lungs, liver or bone. The average tumor diameter and thickness of cSCC metastasis were 45.3 mm and 9.46 mm, respectively. Histopathologically, the degrees of differentiation were well-differentiated, moderately differentiated and poorly differentiated type (4 cases, 5 cases, and 1 case, respectively). CONCLUSION: The location of the lower extremities (p=0.000) and a size larger than 20 mm (p=0.000) were related to cSCC metastasis. cSCC metastasis was found at an average of 7.5 months after diagnosis. High-risk cSCC patients should be followed closely, particularly during the first 2 years after diagnosis.
Bowen's Disease ; Burns ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell* ; Cicatrix ; Diagnosis ; Eczema ; Epidermis ; Epithelial Cells* ; Gyeongsangnam-do ; Head ; Humans ; Keratinocytes ; Keratosis, Actinic ; Liver ; Lower Extremity ; Lung ; Lymph Nodes ; Neck ; Neoplasm Metastasis* ; Retrospective Studies ; Sex Ratio

A 35-year-old woman with advanced lung cancer, treated with intravenous docetaxel and paclitaxel, developed subungual abscesses and secondary onycholysis involving all the finger nails. Bacterial culture demonstrated the growth of Pseudomonas aeruginosa. We report a case of onycholysis and subungual abscesses in a patient treated with docetaxel and paclitaxel.
Abscess* ; Adult ; Female ; Fingers ; Humans ; Lung Neoplasms ; Onycholysis* ; Paclitaxel ; Pseudomonas aeruginosa

Clinical guidelines suggest that suspicious pigmented lesions of the plantar or palmar area require biopsy for early detection of acral melanoma. We present here a case of acral lentiginous melanoma in which various melanocytic atypia was observed at each biopsy site, including focal melanocytic proliferation. We suggest that this atypical melanosis is part of a contiguous phase of invasive tumor growth, which is known as the very early stage of melanoma in situ. In addition, noninvasive dermoscopy has been effective for the early discovery of hidden lesions of acral melanoma.
Biopsy ; Dermoscopy ; Melanoma ; Melanosis

Estrogen and progesterone are widely used in oral contraceptives and hormone replacement therapies and are rarely known to cause a photosensitive reaction. We report a case of photosensitivity induced by the hormonal replacement agents containing estrogen and progesterone. A 36-year-old woman reported a 3-year history of erythematous papules and diffuse erythema on sun-exposed areas. She had taken the hormonal agents for 5 years, following a total abdominal hysterectomy and bilateral salpingo-oophorectomy for cervical cancer. A phototest showed a marked decrease in the minimal erythema dose (MED) of UVA (3J/cm2) and UVB (30mJ/cm2). After the cessation of the hormonal agents, the skin lesions subsided with the disappearance of photosensitivity, and the MED was raised to 5J/cm2(UVA) and 90mJ/cm2 (UVB).
Adult ; Contraceptives, Oral ; Erythema ; Estrogens* ; Female ; Hormone Replacement Therapy ; Humans ; Hysterectomy ; Progesterone* ; Skin ; Uterine Cervical Neoplasms

A study on physically and mentally handicaped children was carried out by health commttee of korean pediatric Association on August, 1977. 654 children in 5 special children's Institutes in Seoul area were observed and the results obtained were as follows ; 1. 393 out of 654 cases were males and male to female ratio was 6 : 4. The most Common age group in institutes were over 10 years (45.6%). As the age goes young, the number of cases were decreased. 2. 43.7% of all cases were orphans. 3. The most common handicap was cerebral palsy(33.3%). Poliomyelitis(24.0%) and mental retardation (20.0%) were the next and these 3 handicaps were ranged 78.1% of all handicaps. The other less common handicaps were Cong. Anomaly(8.1%), mongolism(4.3%) Tb spine or hip joint(2.1%) and microcephaly(2.0%) in order of frequency. 4. Handicaps originated from acquired and congenital were 37.5% and 15.9% respectively. But the remains were obscure in origin. Cong. Anomaly, mongolism and microcephaly were common causes of congenital origin and poliomyelitis, cerebral palsy and Tb hip or spine were frequently acquired. 5. Only 64 cases(18.0%) of cerebral palsy and mental retardation had Known Causes. These were caused by birth injury(24cases), prematurity, Kern icterus or meningigis. 6. 65.4% of all cases had mentally retardation. 87.2% of cerebral palsy nd 83.0% of congenital anomaly were mentally retarded and all cases with mongolism, microcephaly, hydrocephalus and spina bifida mental retardation. 7. The most common site of congenital anomaly was extremities or joints(47.1%) and multiple anomalies were 28.5% of all anomalies. 8. Less than 6 months of institution were common in paid cases(24.9%) in spite of 5~10 year in institule were common in orphans (28.3%). Even in paid cases, economic stase were very low level.
Academies and Institutes ; Cerebral Palsy ; Child* ; Child, Orphaned ; Down Syndrome ; Extremities ; Female ; Hip ; Humans ; Hydrocephalus ; Intellectual Disability ; Jaundice ; Male ; Mentally Disabled Persons ; Microcephaly ; Parturition ; Poliomyelitis ; Seoul ; Spinal Dysraphism ; Spine ; Statistics as Topic*