No abstract available.
Fallopian Tubes* ; Female

Decompression ; Follow-Up Studies ; Head ; Headache ; Humans ; Incidence ; Inflammation ; Jaw ; Joints ; Mandibular Condyle ; Recurrence ; Synovial Fluid ; Temporomandibular Joint

Malocclusion

A 26-year-old male has experienced repeated pruritic and burning erythema and edema over the exposed areas of the skin, especially on the face and hands, after sunlight exposure. He stated that his father, three aunts, and three sisters had similar sunlight sensitivity. The face showed tiny whitish scars. And also there were hypopigmented scars on the dorsum of the hands. Characteristic laboratory findings were as followa: RBC, plasma and stool fluoresced coral red color under the Woods light. 100ml of the RBC contained 245 pg of protoporphyrin. On photosensitive test using sunlight for 60 rninutes, there developed painful sensation at 4 minutes and 40 seconds after exposure, erythema at 12 minutes after, and edema at 20 minutes after. Pathological findings of the specimen obtained from erythematous lesion of the forehead revealed hypergranulosis and acanthosis in the epidermis and perivascular thickening and hyalin deposit around the capillaries in the upper dermis. For treatment, avoidance of exposure to sunlight was recomrnended and symptomatic therapy was tried.
Adult ; Anthozoa ; Burns ; Capillaries ; Cicatrix ; Dermis ; Edema ; Epidermis ; Erythema ; Fathers ; Forehead ; Hand ; Humans ; Hyalin ; Male ; Plasma ; Protoporphyria, Erythropoietic* ; Sensation ; Siblings ; Skin ; Sunlight ; Wood

Autogenous bone graft used for the contouring and reconstruction of craniofacial bone defect has many advantages over the alloplastic material implantations. However, there are several problems associated to the autogenous bone grafting: obtaining the donor site is the most problematic; transplanted bone may be absorbed at the recipient site; and the molding to fit to the recipient site is difficult. Therefore, research in alloplastic materials is inevitable. The current research is focused on two types of hydroxyapatite, calcium phosphate and calcium carbonate. The calcium phosphate is known to show a limited osteogenesis. However, Coral(Biocoral, Inoteb B.P., Saint Gonnery, France) composed of calcium carbonate is known to be more effective in osteogenesis. Fibrin sealant(Duplojet system, Immuno AG. Vienna, Austria), a tissue glue, is known to increase tissue affinity, proliferation of fibroblast and vessel ingrowth. It is also known to have osteoinductive effect. We believe that fibrin sealant improves the effect of coral by increasing bone graft substitution, enhancement of plasticity and stability of the granular material. Therefore, we have undertaken an experimental investigation as following; Using high speed burr, three 10 mm in diameter skull defects were made on 24 New Zealand white rabbits. The defects were treated with implantations, which are divided into three samples: A) Control in which on coral or fibrin sealant, B) Coral 50 mg with fibrin sealant 0.3 cc, C) Coral 50 mg with saline 0.3 cc. The specimens of its skull were collected at 3, 7, 14, 28, 42 and 56 days postoperatively. The operative sites were carefully examined grossly, microscopially and radiologically. The experimental results are as followings: At 56 days post operation date, control group showed a thin layer of only fibrous connective tissue and minimal immature bone filling the defect. Coral with saline given group showed a thick layer of connective tissue and granule of coral, accompanied by partial new bone formation, mostly composed of woven bone, in the middle of the defect. In the group that were given coral with fibrin sealant, a thick layer of fibrous connective tissue and granules of coral, accompanied by more increased new bone formation in the middle of the defect were observed. Another difference from the Group B is a formed new bone replaced by lamellar bone.We concluded that by using coral and fibrin sealant together, contouring and reconstruction of bone defected areas were enhanced. It was difficult to prove directly that fibrin has osteoinductive effect. However, the plasticity and stability, the fibrin sealant gives to coral enhances the osteogenesis. Our study provides evidence that coral used with fibrin sealant will significantly improve the result of the craniofacial bone surgery.
Adhesives ; Anthozoa* ; Bone Transplantation ; Calcium ; Calcium Carbonate ; Connective Tissue ; Durapatite ; Fibrin Tissue Adhesive* ; Fibrin* ; Fibroblasts ; Fungi ; Humans ; Osteogenesis* ; Plastics ; Rabbits ; Saints ; Skull ; Tissue Donors ; Transplants

The statistics of 40,611 new cases of skin diseases seen in Dermatologic department of Chonnam University Hospital from 1971 to 1980 are analysed and significant changes in incidence of the 25 most common dermatoses are discussed in detail and the results are comared with other surveys. The results of this study are summed up in 4 tables. Table 1. Shows the annual frequency of the 25 most common dermatoses. Table 2. Shows the frequency of the 25 most common dermatoses by age group. Table 3. Shows the frequency of the 25 most common derrnatoses by season, sex and region. Table 4. Shows the comparison of frequency of the 20 most common dermatoses with other reports.
Incidence

Female ; Follow-Up Studies ; Headache ; Humans ; Incidence ; Neck ; Neck Pain ; Shoulder Pain ; Temporomandibular Joint

Congenital dermal sinuses are dermal tubes which extended inward from the surface for varying distances and frequently connect the central nervous system or its covering with the surface of the body. The inner end of the sinus may be expanded to form a dermoid or epidermoid cyst. They are the results of incomplete separation of the epithelial ectoderm from the neuroectoderm at the fourth week of fetal development. As cystic expansion of a congenital sinus which is located within the cranium or spinal canal may act as any other mass lesion to interrupt neurologic function by local compression or it may obstruct the normal circulation of spinal fluid. In addition, because of its persistent communication with the skin surface, it serves as a constant potential port of entry for infection into the central nervous system. Since the first report in 1926 by Moise of staphyloccus meningitis secondary to a congenital sacral sinus, numerous reports have appeared of infection secondary to congenital sinuses along the craniospinal axis, particulary in the suboccipital region. Authors report a case of congenital dermal sinus associated with dermoid cyst of posterior fossa which was successfully removed and discuss the pathegenesis of it in embryology, and surgical management of it's complications.
Axis, Cervical Vertebra ; Central Nervous System ; Dermoid Cyst* ; Ectoderm ; Embryology ; Epidermal Cyst ; Fetal Development ; Meningitis ; Neural Plate ; Skin ; Skull ; Spina Bifida Occulta* ; Spinal Canal

Saponin has been known to be a major antioxidant component in panax ginseng. Recent experimental study suggests that some antioxidant materials prevent Parkinson's disease caused by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in an animal model. The present study was performed to demonstrate the effect of ginseng saponins in the Parkinson's disease model induced by MPTP. To verify the effect of ginseng saponin on dopaminergic neurons in the mice brain, the tyrosine hydroxylase-immunoreactive (TH-ir) neurons were observed by immunohistochemical stain and immunoelectron microscopy (preembedding method). Also, in order to estimate the immunoreactivity of dopaminergic neuropils, they were quantified by image analysis. The number of TH-ir neurons of substantia nigra was significantly increased in the high-dose (0.46 mg/kg) ginseng saponin group compared with the MPTP injected group. The immunoreactivity of TH-ir neuropils in striatum was significantly increased in both high and low-dose (0.1 mg/kg) ginseng saponin groups compared with the MPTP injected group. In immunoelectron microscopic observation, TH-ir neurons of the control and both ginseng saponin injected group showed normal nuclei and well preserved cytoplasmic organelles. In the MPTP injected group, dying dopaminergic neurons showed destroyed nuclei and cytoplasmic organelles. These results suggest that ginseng saponin has a protective effect on the Parkinson's disease model induced by MPTP.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Brain ; Cytoplasm ; Dopaminergic Neurons* ; Mice* ; Microscopy, Immunoelectron ; Models, Animal ; Neurons ; Neuropil ; Organelles ; Panax* ; Parkinson Disease* ; Saponins* ; Substantia Nigra ; Tyrosine ; Tyrosine 3-Monooxygenase

BACKGROUND: Mohs micrographic surgery (MMS) achieves higher cure rates for cutaneous squamous cell and basal cell carcinomas than any other therapeutic modality. For a unifocal tumor, a 100% cure rate after MMS should theoretically be possible, however for primary basal cell carcinoma, 98-99% 5-year disease-free rates have been achieved. OBJECTIVE: Our purpose was to investigate the pitfalls in microscopic Interpretation of frozen sections in Mohs micrographic surgery for basal cell carcinoma which decrease the cure rate after surgery. METHODS: From March 1991 to February 1998, fifty-nine patients were diagnosed with basal cell carcinoma at our department. All the tumors were removed with Mohs micrographic surgery and frozen section specimens were stained with hematoxylin-eosin. The microscopic evaluation was done by Mohs surgeon and pathologist. RESULTS: We can summarize the matters that demand special attention during microscopic Interpretation of frozen sections in Mohs surgery as two groups. First, as false negative interpretation, there are 1) small nests of tumor scattered within areas of heavy inflammation 2) tumor present along the hair follicle, 3) tumor present along a cut edge, 4) empty space in a tissue section, 5) hair follicle-like structure of the tumor, 6) gland-like structure of the tumor, and 7) infiltrative BCC-like inflammatory cells. Second, as a false positive interpretation, there are 1) foreign body reactions or scar containing trapped pilosebaceous structures, 2) horizontal and tangential cuts through the pilosebaceous apparatus, 3) some epidermal neoplasms including solar lentigines, seborrheic keratoses, and acantholytic actinic keratoses, and 4) contamination of the tumor tissue. CONCLUSION: With careful attention to the examples which can affect the interpretation as mentioned above, it may be possible to detect complete removal of tumor mass and achieve higher cure rate. We could achieve a 100% of cure rate for primary basal cell carcinoma and 95 % of cure rate for recurrent basal cell carcinoma after Mohs Micrographic surgery in our hospital from March 1991 to February 1998.
Carcinoma, Basal Cell* ; Cicatrix ; Foreign Bodies ; Frozen Sections ; Hair ; Hair Follicle ; Humans ; Inflammation ; Keratosis, Actinic ; Keratosis, Seborrheic ; Lentigo ; Mohs Surgery*