1.Effect of Testosterone on the Relaxation of Rabbit Corpus Cavernosum.
Jong Ki KIM ; Young Deuk CHOI ; Woo Sik CHUNG ; Jae Yup HONG ; Yong Yo PARK ; Hyung Ki CHOI
Korean Journal of Urology 1997;38(10):1033-1038
Androgen was thought to be linked to sexual activity in man but it did not identify the peripheral action and its mechanism of androgen. The present study was designed to determine the role of testosterone in the relaxation of the corpus cavernosum. Effect of testosterone on the relaxation of rabbit corpus cavernosum was investigated from three groups of rabbit; two groups were castrated and the third underwent a sham operation (control). After castration, one group, received subcutaneous injection of testosterone (testosterone propionate 10 mg/day). Strips of rabbit corpus cavernosum were isolated and mounted in 10 ml organ chambers. Isometric tension measurement of acetylcholine (Ach: 10(-5)M) and papaverine (10(-5)M) in the precontracted cavernosal muscle strips with phenylephrine (5 x 10(-6)M) were performed in all groups; control, castration group (four sub-groups: 1, 2, 4 and 8 weeks after castration) and testosterone replacement group (four sub-groups: testosterone was given from 1, 2, 4 and 8 weeks after castration for 14 days respectively). The relaxation response of corpus cavernosal muscle to acetylcholine and papaverine was significantly decreased in castrated group and restored up to the level of control after testosterone replacement. The maximum inhibitory effect of castration on the relaxation of corpus cavernosal muscle began to be shown at 4 weeks after castration. Based on these results, we conclude that testosterone regulates the tone of cavernosal smooth muscle through the pathway including cholinergic endothelium mediated relaxation.
Acetylcholine
;
Castration
;
Diethylpropion
;
Endothelium
;
Injections, Subcutaneous
;
Muscle, Smooth
;
Papaverine
;
Phenylephrine
;
Relaxation*
;
Sexual Behavior
;
Testosterone*
2.Doctor's Perspectives for Epilepsy in Kwangju, Chollanam-do Area.
Ki Choon SHIN ; Byung Chae KIM ; Yo Sik KIM ; Myung Kyu KIM ; Ki Hyun CHO ; Sei Hong KIM
Journal of the Korean Neurological Association 1995;13(2):214-223
The attitude and awareness of medical practitioner for epilepsy have influence on that of the public and the patient. We intended to evaluate medical practitioner's perspectives for epilepsy. The questionnaire which used in this study was designed specifically to evaluate the medical practitioner's perspectives for epilepsy. It is studied in 160 medical practitioners at Kwangju city and Chollanam-do province, who had answered over 50% of the.questionnaire and certified themselves. The results are as follows; 1) The 'prejudice' toward epilepsy is common finding even in medical practitioners regardless of their experience and training. It is more common in older doctors over 40 years old. 2) The number of lately treated patients with epilepsy is about 3.7 per one medical practitioner in this area. It falls short of expected number which is calculated with already reported prevalence of epilepsy by others. 3) The treatment of epilepsy is being performed by medical practitioners individually without any interdepartmental relationship in our society. 4) Most of the medical practitioners lack basic knowledge about epilpsy such as International Classification, first line antiepileptic drugs for different seizure type regardless Of their age, training and experience for treatment of patient with epilepsy. These results suggested that effective education is necessary for medical practitioner about epilepsy.
Adult
;
Anticonvulsants
;
Classification
;
Education
;
Epilepsy*
;
Gwangju*
;
Humans
;
Jeollanam-do*
;
Prevalence
;
Surveys and Questionnaires
;
Seizures
3.Removal of a Strangulating Polyethylene Ring from the Penis with a Heated Blade.
Ha Na YOON ; Ki Poong SUNG ; Woo Sik CHUNG ; Jae Yup HONG ; Young Yo PARK
Korean Journal of Andrology 1998;16(1):111-113
Methods of removing strangulating objects from the penis have been described in many cases. We report a unique method, namely, melting a polyethylene tereftalate ring with a heated blade, which was very effective and safe for removal.
Foreign Bodies
;
Freezing
;
Hot Temperature*
;
Male
;
Penis*
;
Polyethylene*
4.Left Ventricular Pacing after Mitral, Tricuspid Valve Replacement without Interruption of Anticoagulation.
Yo Han KU ; Hyung Wook PARK ; Seong AHN ; Sang Yoon HA ; Rim LEE ; Ki Hong LEE ; Jeong Gwan CHO
Soonchunhyang Medical Science 2014;20(2):88-90
Pacemaker implantation for patients with mechanical tricuspid valve is quite challengeable because lead insertion through prosthetic tricuspid valve may cause valve dysfunction or lead impingement. Also complications due to interrupt of anticoagulation should be considered. A 65 years old woman received AAI (atrium paced, atrium sensed, inhibited) pacemaker for sick sinus syndrome and mechanical mitral valve replacement for severe mitral steno-insufficiency at the same time 16 years before. She needed to undergo mechanical tricuspid valve replacement (TVR) because of severe tricuspid regurgitation despite of medical therapy. Complete atrioventricular block developed during the TVR operation and it was not recovered even after several days of temporary pacing. We decided left ventricular pacing through coronary sinus because ventricular lead could not pass mechanical tricuspid or mitral valve and also planned to continue oral anticoagulation therapy. We could find a place where high pacing output did not pace phrenic nerve with acceptable sensing, pacing threshold. The patient recovered well without any periprocedural complications. Left ventriclcular pacing lead implantation through coronary sinus without interruption of anticoagulation can be an alternative to epicardial pacing for patients with mechanical tricuspid valve.
Atrioventricular Block
;
Coronary Sinus
;
Female
;
Humans
;
Mitral Valve
;
Phrenic Nerve
;
Sick Sinus Syndrome
;
Tricuspid Valve Insufficiency
;
Tricuspid Valve*
5.Influence of Total Ginseng Saponin on the Blood Pressure of the Rat.
Dong Yoon LIM ; Kyu Baik PARK ; Kyu Hyeong KIM ; Jae Kyu MOON ; Kang Soo LEE ; Yoon Ki KIM ; Yo Han CHUNG ; Soon Pyo HONG
Korean Circulation Journal 1987;17(3):491-499
This study is an attempt to investigate the effect of total Ginseng saponin (GTS) on the blood pressure of the rat and to elucidate its mechanism of action. GTS, when injeced into a femoral vein of the rat, caused dose-related fall in blood pressure with secondarily elevation of the blood pressure. The depressor effect of GTS was blocked by treatment of atropine and prazosin, but not affected by pretreatment with chlorisondamine or cyproheptadine. GTS inhibited significantly the pressor response evoked by norepinephrine. The pressor effect of GTS was not affected by treatment with atropine or cyproheptadine, but was attenuated markedly by pretreatment with chlorisondamine. From the above mentioned results, it is thought that GTS produces the pressor and the depressor actions in the rat, and that its depressor response is exerted partly through the stimulation of cholinergic muscaric receptors with the blockade of adrenergic alpha-receptors, and that its pressor response is revealed by stimulation of nicotinic receptors in autonomic ganglia.
Animals
;
Atropine
;
Blood Pressure*
;
Chlorisondamine
;
Cyproheptadine
;
Femoral Vein
;
Ganglia, Autonomic
;
Norepinephrine
;
Panax*
;
Prazosin
;
Rats*
;
Receptors, Adrenergic, alpha
;
Receptors, Nicotinic
;
Saponins*
6.A Case of Behcet's Disease with Pleural Effusion.
Yo Seb HAN ; Jee Hong YOO ; Jung Hyun NOH ; Ki Deuk NAM ; Hong Mo KANG ; Mu Hyoung LEE
Tuberculosis and Respiratory Diseases 1999;47(6):850-856
Behcet's disease is a complex multisystem disease that features recurrent aphthous stomatitis, recurrent genital ulcerations, and eye lesions(uveitis or chorioretinitis). Among the systemic manifestat ions, pulmonary involvement is known to be rare and only a few cases have been documented. The most important features of pulmonary lesions in Behcet's disease are recurrent hemoptysis, which is often massive, and fatal pleuritic chest pain and recurrent high fever and fleeting nature of the pulmonary infiltrates. We report a case of Behcet's disease manifestated as high fever and pleural effusions which was complicated by pulmonary infarction ans a result of pulmonary arteritis.
Arteritis
;
Chest Pain
;
Fever
;
Hemoptysis
;
Ions
;
Pleural Effusion*
;
Pulmonary Infarction
;
Stomatitis, Aphthous
;
Ulcer
7.Electro-clinico-pathologic Relations of Epileptogenic Foci in Cavernous Angioma.
Dae Won SEO ; Seung Bong HONG ; Seung Chul HONG ; Ki Young JUNG ; Jin Woon PARK ; Yo Sik KIM ; Keyong Won KIM ; Han Bo LEE ; Kwang Ho LEE
Journal of the Korean Neurological Association 1998;16(3):283-292
BACKGROUND AND PURPOSE: Cavernous angiomas are frequently encountered in patients with intractable partial epilepsies. Cavernous angioma can make highly epileptogenic foci and dual pathology. Although it is generally thought that the epileptogenic activity originated in neuronal populations adjacent to the lesion, little is known as to the exact location of the epilepsies on electophysiologic, clinical and pathologic view. We investigated nine intractable epilepsy patients with cavernous angioma regarding relation of EEG, semiology and pathology to verify where are the epileptogenic foci in cavernous angioma. METHODS: We included 9 intractable epilepsy patients with cavernous angioma who had been were undergone video-EEG monitoring. They were aged from 15 to 49 years(average:36.7+15.7)and had cavernous angioma in temporal, frontal lobe, or multiple areas(temporal:7, frontal:1, multiple:1 patients). Four patients had invasive EEG study including subdural and/or depth electrodes. Six patients had undergone epilepsy surgery. We analyzed seizure history, semiology of their seizures, interictal and ictal EEG. To know dual pathology, MRI including hippocampal volumetry, invasive EEG, and pathology were studied. RESULTS: Four patients had multiple auras. Eight patients had complex partial seizures and one had right foot clonic seizure, which were related with the location of cavernous angioma. In scalp EEG, ictal recording showed definite EEG changes, but 3 patients had no definite EEG change in some seizures. In invasive EEG with subdural and/or depth electrodes , interictal spikes were more frequently detected than scalp EEG and ictal EEG revealed not only 3 different ictal onset zones in 3 patients but also EEG seizures without clinical events in 3 patients. Regarding dual pathology, mesial temporal involvement was detected in 2 patients in MRI. Among 6 surgery patients 4 patients including 3 patients with normal hippocampus in MRI had hippocampal or dentate gyral change in pathology. Among 4 patients with invasive ictal EEG, 3 patients including 1 patient with normal hippocampus in MRI and pathology had mesial temporal involvement in ictal onset zones. CONCLUSION: Cavernous angiomas can make multiple epileptogenic foci around themselves and often dual pathology of hippocampus, which can be easily detected by invasive ictal EEG but not by imaging and even by pathology. And the foci can have frequent EEG seizures, which do not make clinical events. Precise localization of epileptogenic foci in cavernous angioma were needed to have good medical and surgical treatments.
Electrodes
;
Electroencephalography
;
Epilepsies, Partial
;
Epilepsy
;
Foot
;
Frontal Lobe
;
Hemangioma, Cavernous*
;
Hippocampus
;
Humans
;
Magnetic Resonance Imaging
;
Neurons
;
Pathology
;
Scalp
;
Seizures
8.Analysis of Carotid Ultrasound Findings on Cardiovascular Events in Patients with Coronary Artery Disease during Seven-Year Follow-Up.
Hyung Bin YUK ; Hyun Woong PARK ; Ik Ju JUNG ; Wan Ho KIM ; Ki Hong KIM ; Dong Ju YANG ; Yo Han PARK ; Yong Kyun KIM ; In Geol SONG ; Jang Ho BAE
Korean Circulation Journal 2015;45(1):28-37
BACKGROUND AND OBJECTIVES: Both carotid intima-media thickness (CIMT) and carotid plaque are important factors in the primary prevention of cardiac disease. However, it is unclear which one is more important for prognosis, especially in patients with coronary artery disease (CAD). SUBJECTS AND METHODS: In total, 1426 consecutive CAD patients, proven by angiography, were followed-up for a mean of 85 months. The study population was divided into four groups depending on the CIMT (> or =0.83 mm, >95 percentile in Korea) and the presence or absence of carotid plaque. RESULTS: Patients with carotid plaque and thick CIMT (n=237, 16.6%) had a higher prevalence of hypertension, diabetes mellitus, and dyslipidemia than those had plaque and thin CIMT (n=213, 14.9%), those without plaque and thick CIMT (n=265, 18.6%) and those without plaque and thin CIMT (n=711, 49.9%). The patients with carotid plaque and thick CIMT group had a higher cardiac mortality rate (20.7% vs. 13.1%, 9.4% and 3.9%, respectively, p<0.001) and higher major adverse cardiovascular events (MACE) including death, acute myocardial infarction, and stroke (27.8% vs. 18.8%, 15.5% and 9.3%, respectively, p<0.001) than any other groups. Multivariate Cox regression analysis showed that the presence of carotid plaque with thick CIMT had the highest hazard ratio (HR) compared to other groups (HR 2.23 vs. 1.81, 2.01) for cardiac mortality. Also, carotid plaque had a higher HR than CIMT for mortality (HR 1.56 vs. 1.37) and MACE (HR 1.54 vs. 1.36) in the total study population. CONCLUSION: Carotid plaque is a more important prognostic factor than CIMT in patients with CAD, and adding a thick CIMT to carotid plaque increases the prognostic power for cardiac events.
Angiography
;
Carotid Intima-Media Thickness
;
Carotid Stenosis
;
Coronary Artery Disease*
;
Diabetes Mellitus
;
Dyslipidemias
;
Follow-Up Studies*
;
Heart Diseases
;
Humans
;
Hypertension
;
Mortality
;
Myocardial Infarction
;
Prevalence
;
Primary Prevention
;
Prognosis
;
Stroke
;
Ultrasonography*
9.A Clinical Study of Oral Ketoconazole Therapy in Superficial Fungal Diseases: Multicenter Trials.
Do Sik SONG ; Byung In RO ; Chin Yo CHANG ; Hyung Ok KIM ; Choong Rim HAW ; Jae Bok JUN ; Sook Ja SON ; Jai Il YOUN ; Ki Bum MYUNG ; Jae Hong KIM
Korean Journal of Dermatology 1984;22(3):263-272
Ketoconazole is one of the broad-spectrum oral antimycotic agents recently developed from imidazole derivatives. Authors performed multicenter trials to evaluate the therapeutic effect of ketoconazole in superficial fungal diseases. One hundred and eighty-four patients with superficial fungaI diseases were included in this study during 7 months from April to October, 1983 Patiets were treated with oral administration of 200 mg of ketoconazole(Nizoral) once a day for 4 weeks.-countinue-
Administration, Oral
;
Humans
;
Ketoconazole*
10.Pneumocystis carinii pneumonia in gastric cancer patients without acquired immune deficiency syndrome: 3 cases report and literature review.
So Young YOON ; Hyun Kyun KI ; Sung Yong KIM ; Yo Han CHO ; Hong Ghi LEE ; Moon Won YOO
Journal of the Korean Surgical Society 2012;83(1):50-55
Pneumocystis carinii pneumonia (PCP) has rarely been reported in solid tumor patients. It is a well-known complication in immunosuppressed states including acquired immune deficiency syndrome and hematologic malignancy. PCP has been reported in solid tumor patients who received long-term steroid treatment due to brain or spinal cord metastases. We found 3 gastric cancer patients with PCP, who received only dexamethasone as an antiemetic during chemotherapy. The duration and cumulative dose of dexamethasone used in each patient was 384 mg/48 days, 588 mg/69 days, and 360 mg/42 days, respectively. These cases highlight that the PCP in gastric cancer patients can successfully be managed through clinical suspicion and prompt treatment. The cumulative dose and duration of dexamethasone used in these cases can be basic data for risk of PCP development in gastric cancer patients during chemotherapy.
Acquired Immunodeficiency Syndrome
;
Brain
;
Dexamethasone
;
Hematologic Neoplasms
;
Humans
;
Neoplasm Metastasis
;
Pneumocystis
;
Pneumocystis carinii
;
Pneumonia, Pneumocystis
;
Spinal Cord
;
Stomach Neoplasms