1.Clinical Review of Recurrent Kawasaki Disease.
Jong Woon CHOI ; Soon Ki KIM ; Byong Kwan SON
Journal of the Korean Pediatric Society 1996;39(8):1139-1145
PURPOSE: The recurrence of Kawasaki disease has not been considered significant and has not been reported on literatures in Korea. Authors reviewed cases with recurrent Kawasaki disease to get informations about recurrent Kawasaki disease and to know whether there is any factor, if present, that can predict recurrence. METHODS: We reviewed and analyzed the hospital records of patients with recurrent Kawasaki disease who had been admitted to Inha University Hospital from January 1986 through December 1994. RESULTS: The total number of cases with Kawasaki disease was 266 during that period in Inha University Hospital. Seven patients were diagnosed as having recurrent Kawasaki disease, but four of them fulfilled five or more items of the diagnostic criteria for Kawasaki disease. So the proportion of recurrent cases was 1.5%(4/259)(or 2.7% (7/259) ?). Sex ratio was M:F=3:1. The ages at the first episodes of illness were from 7 months to 3 years 2 months (median=24 months), and those of the second episodes were from 11 months to 6 years 3 months (median=4 years 3 months). The intervals between two episodes were from 4 months to 4 years 2 months (median=1 year 9 months). No special aspect could be found in the clinical and laboratory findings of primary cases, compared with other cases with kawasaki disease. The clinical manifestations and courses of recurred cases were not significantly different from those of primary cases, except one recurred case who developed coronary aneurysm. CONCLUSIONS: The recurrence rate of Kawasaki disease seems to be higher than 1.5%(or 2.7%) at least. The risk factors for recurrence could not be found, and there was no specific aspect in the clinical manifestations and courses of recurrent Kawasaki disease.
Coronary Aneurysm
;
Hospital Records
;
Humans
;
Korea
;
Mucocutaneous Lymph Node Syndrome*
;
Recurrence
;
Risk Factors
;
Sex Ratio
2.Normal Predicted values of Pulmonary function Test in Korean Primary School-Aged Children.
Dae Hyun LIM ; Jeong Hee KIM ; Jun Hee PARK ; Jong Woon CHOI ; Soon Ki KIM ; Byong Kwan SON
Journal of the Korean Pediatric Society 1994;37(2):240-249
Pulmonary function test is one of the most important tools in the management of patients with respiratory tract diseases and allergic diseases. As with the difficulties in performing the test, it has been seldom used in pediatric field. But with the advent of simple, computerized tools, pediatric pulmonologist and allergist try to manage the patients using PFT. Still the normal predicted values are variable among the reports. So it is important to have normal predicted value in Korean children. From April to July 1992, pulmonary function test was performed in 965(male: 490, female: 475) primary school-aged children except <3 or >97 percentile of Korean-children Physical developemental standards with history of allergic diseases and respiratory tract diseases ay SungNam, KyongKiDo. We evaluated the predicted normal values of the FEV1.0, FVC and PEFR and logarithmic regression equation setting the predicted values by using the microspirometer of Micromedical Ltd. England that could that could be easily applied to children. 1) Predicted values of pulmonary function test items were generally higher in boys than those of girls. 2) Correlation coefficient to the parameters examined was the highest in height 0.78, then age 0.75, weight 0.70 and chest circumference 0.61.
Child*
;
England
;
Female
;
Gyeonggi-do
;
Humans
;
Peak Expiratory Flow Rate
;
Reference Values
;
Respiratory Function Tests*
;
Respiratory Tract Diseases
;
Thorax
3.The Effect of Alfacalcidol in the Treatment of Idiopathic Myelofibrosis in Children.
Soon Ki KIM ; Jeong Hee KIM ; Dae Hyun LIM ; Jong Woon CHOI ; Byong Kwan SON ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1994;37(3):339-346
Idiopathic myelofibrosis (IMF), which is characterized by marrow fibrosis, leukoerythroblastic anemia, teardrop poikilocytosis and splenomegaly due to extrumedullary hematopoiesis, has known to have no form of therapy. On the ground of the possibility of reversing collagen deposion in IMF using 1, 25dihydroxycholecalciferol [1, 25(OH)2D3], we report here our observations of 5 patients (M:F=1:4) with IMF before and after treatment with 0.5 microgram/day of alfacalcidol, precursor of 1, 25(OH)2D3. In 3 fo 5 patients the hemoglobin rose and in 4 of 5 the platelet count increased. Follow-up marrow examination revealed that marrow trephine reticulin fibrosis decreased according as the amelioration of clinical and laboratory findings. But these did not persist except one patient in spite of the sustained use of alfacalcidol. Our results suggest that alfacalcidol may have a therapeutic role in some patients with IMF. More extensive studies will be clarify the action of alfacalcidol in IMF.
Anemia, Myelophthisic
;
Bone Marrow
;
Child*
;
Collagen
;
Fibrosis
;
Follow-Up Studies
;
Hematopoiesis
;
Humans
;
Platelet Count
;
Primary Myelofibrosis*
;
Reticulin
;
Splenomegaly
4.Clinical Experience of Domestic SDS-2 Extracorporeal Shock Wave Lithotriptor (ESWL) for 315 Urinary Calculi.
Ki Woon SON ; Mun Gab SON ; Sang Ik LEE ; Hyeon Soo KIM ; Tae Hee OH ; Hee Young SHIM
Korean Journal of Urology 1996;37(5):553-558
Extracorporeal shock wave lithotripsy monotheraphy was performed in 315 urinary stones from 278 patients with the Domestic SDS-2 lithotriptor using C-arm fluoroscopy between December 1991 and December 1994. Of 315 cases, renal stones were 150 cases(47.6%) and ureteral stones 165 cases(36.1%). No regional or general anesthesia was required but parenteral or oral analgesics were required in some patients. Among 315 cases who completed extracorporeal shock wave lithotripsy, the overall success rate of treatment was 90.5% with 92.4% in 5-9 mm, 94.8% in 10-19 mm, 89.7% in 20-29 mm and 61.5% over 30 mm or staghorn stones. Post lithotripsy complications were transient gross hematuria in 17.1%, renal colic in 11.4%, steinstrasse in 4.8%, petechia in 2.9% and fever in 1.9% and these complications were controlled with conservative treatment or repeated session of extracorporeal shock wave lothotropsy, percutaneous nephrodtomy, Double-J stent insertion or ureterolithotomy. We suggest that extracorporeal shock wave lithotripsy monotheraphy with the Domestic SDS-2 lithotriptor was considered to be effective and safe procedure for the initial treatment of urinary stones.
Analgesics
;
Anesthesia, General
;
Fever
;
Fluoroscopy
;
Hematuria
;
Humans
;
Lithotripsy
;
Renal Colic
;
Shock*
;
Stents
;
Ureter
;
Urinary Calculi*
5.A Case of Renal revascularization using Aortorenal Saphenous Vein Bypass Grafting in Renovascular Hypertension.
Moon Kap SON ; Yun Kil LEE ; Ki Woon SON ; Sang Ik LEE ; Hyun Soo KIM ; Tae Hee OH
Korean Journal of Urology 1997;38(4):449-453
Renovascular hypertension is the leading cause of surgically curable arterial hypertension. With the marked advancement in the technique of vascular surgery, renal revascularization is preferred to nephrectomy. It is used for the recovery of impaired function or the prevention of renal failure and the control of hypertension. We report a case of renovascular hypertension with the nonfunction of the left kidney due to complete renal artery obstruction, treated successfully with an aortorenal bypass graft.
Hypertension
;
Hypertension, Renovascular*
;
Kidney
;
Nephrectomy
;
Renal Artery Obstruction
;
Renal Insufficiency
;
Saphenous Vein*
;
Transplants*
6.The Optimal Dosages of Gammaglobulin and Aspirin in Treating Kawasaki Disease.
Seung Baik HAN ; Jong Woon CHOI ; Soon Ki KIM ; Sei Woo CHUNG ; Jeung Gyu KIM ; Byong Kwan SON
Journal of the Korean Pediatric Society 1996;39(5):703-711
PURPOSE: There are some disagreements about the optimal dosages of intravenous gammaglobulin(IVGG) and oral aspirin(ASA) in the treatment of Kawasaki disease. So authors performed a prospective clinical study to evaluate the efficacy of IVGG 1g/kg plus ASA 50mg/kg/day. METHODS: We treated 29 patients who were admitted to Inha University Hospital from June 1993 through May 1994 with IVGG 1g/kg plus ASA 50mg/kg/d. We compared the outcomes of above patients with those of two other groups of patients, group A and B in authors' previous study. Group A(20 patients) had been treated with IVGG 2g/kg plus ASA 50mg/kg/d and group B(19 patients) with IVGG 2g/kg plus ASA 100mg/kg/d. The outcomes had been similar in group A and B, which was published on this journal in 1995 (vol. 38:378-385). RESULTS: 1) Twenty five patients(86.2%; group C) were given only one dose of IVGG 1g/kg, and remaining 4 patients(13.8%; group D) were given two doses of IVGG 1g/kg because of persistent high fever. 2) The age and sex distributions, durations of fever before treatment, and durations of ASA therapy in group C were not significantly different from those in group A and B (p>0.05). 3) Laboratory findings on admission in group C were not significantly different from those in group A and B, except that the mean ESR was lower in group C than in group A and B (35.1+/-19.8 vs 55.5+/-5.95 & 50.2+/-11.4mm/hr; p<0.01, respectively). 4) The durations of fever after treatment in group C were not significantly different from those in group A and B (1.32+/-1.07 vs 2.65+/-3.28 & 1.74+/-1.52 days; p>0.05, respectively). 5) In group C, the mean hemoglobin concentration at the 3rd week of illness was higher than in group A (11.1+/-0.98 vs 10.1+/-1.24g/dl; p<0.05), the mean platelet count at the 2nd week of illness was lower than in group A (59.4+/-18.0x10(4) vs 73.6+/-19.0x10(4)/ l; p<0.05), and the mean ESRs at the 2nd and 3rd week of illness were lower than in group A (43.3+/-14.7 vs 54.0+/-9.16, 31.9+/-19.0 vs 47.7+/-13.0mm/hr; p<0.05, respectively). Other follow-up laboratory findings in group C were not significantly different from those in group A and B. 6) Echocardiography was done 2 and 4 weeks after onset of illness. Coronary arterial dilation was observed in four(4/25; 16%) and two(2/23; 8.7%) patients respectively in group C, and the proportions were not significantly different from those in group A(40% & 25%) and B(31.6% & 10.5%) (p>0.05, respectively). In follow-up examinations, coronary aneurysm was observed in only one(1/23; 4.3%) in group C, which was similar to group A(1/18; 5.5%) and B(1/19; 5.2%) (p>0.05, respectively). Giant aneurysm was not observed in any patients. 7) Four patients(group D) were given one more dose of IVGG 1g/kg because high fever persisted 48 hours after injection of the first dose of IVGG. Afterthen fever subsided within 1 to 7 days. Echocardiography revealed mild coronary arterial dilation in two patients initially, but follow-up examinations revealed no coronary aneurysm. CONCLUSIONS: The medium-dose combined regimen with IVGG 1g/kg plus ASA 50mg/kg/d seems to be more cost-effective than the high-dose regimen with IVGG 2g/kg plus ASA 50-100mg/kg/d. If high fever persists 48 hours or more after the first dose of IVGG 1g/kg, it is desirable to give one more dose of IVGG 1g/kg.
Aneurysm
;
Aspirin*
;
Coronary Aneurysm
;
Echocardiography
;
Fever
;
Follow-Up Studies
;
Humans
;
Mucocutaneous Lymph Node Syndrome*
;
Platelet Count
;
Prospective Studies
;
Sex Distribution
7.Prophylactic Effect of Mitomycin C and Bacillus Calmette-Guerin in Stage T1 of the Superficial Bladder Cancer.
Ki Woon SON ; Hyeon Su KIM ; Tae Hee OH
Korean Journal of Urology 1997;38(9):957-962
We compared the efficacy and toxicity of mitomycin C and Bacillus Calmette-Guerin (BCG) intravesical instillation in 86 patients with stage T1 of the superficial bladder tumor. Of them, 34 patients were received mitomycin C (40 mg/40 ml sodium chloride, once a week for 8 weeks) and 26 patients were received BCG (120 mg/50 ml sodium chlorids, once a week for 6 weeks) after transurethrat resection of bladder tumor and 24 patients (control) underwent transurethral resection alone. The mean follow up period was 24.8 months in control group, 26.8 months in mitomycin C group and 25.7 months in BCG group. The mean time to recur was 11.3 months in control group, 11.5 months in mitomcyin C group and 15.9 in BCG group but there was no significant difference among each groups (p>0.05). The overall recurrence rate was 34.6% in BCG group compared with 70.5% in mitomycin C group and 75.0% in control group, showing significant difference (p<0.05). Side effects were more common after BCG instillation than mitomycin C instillation. The most common side effect after BCG instillation was hematuria in 14 patients (53.8%). That of mitomycin C was cystitis in 10 patients (29.4%). Our study suggests that the prophylactic efficacy of BCG was significantly superior to that of mitomycin C, but there was no significant superiority regarding prophylactic effect of reduced mean time to recur in stage T1 bladder cancer patients. Additionally, further follow up studies were needed in mitomycln C.
Administration, Intravesical
;
Bacillus*
;
Cystitis
;
Follow-Up Studies
;
Hematuria
;
Humans
;
Mitomycin*
;
Mycobacterium bovis
;
Recurrence
;
Sodium
;
Sodium Chloride
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
8.A Case of Burkitt's Lymphoma with Bilateral Renal Enlargement.
Jun Hee PARK ; In Kyu LEE ; Jong Woon CHOI ; Soon Ki KIM ; Byong Kwan SON ; Jin Ju KIM
Journal of the Korean Pediatric Society 1995;38(1):122-128
Burkitt's lymphoma is a distinct pathologic entity characterized as a diffuse undifferentiated malignant lymphoma of B-lymphocyte origin. We experienced a case of Burkitt's lymphoma with bilateral renal enlargement in which a 3year-old male patient was admitted with complaints of abdominal distention and facial edema. Laboratory examination revealed positivity for CD 19, CD 10, CD 20 and c-myc on flow cytometry, bilateral renal enlargement(10x12cm in longitudinal length) on abdominal ultrasonogram and CT, malignant lymphoma of Buritt's type with prominent nucleoli and cytospin of cerebrospinal fluid. Initially he showed tumor lysis syndrome and clinical stage D by Zigler(stage IV by Murphy) with CNS involvement. After initial management with hydration, urine alkalinization and allopurinol, combination chemotherapy had been applied with the craniospinal radiotherapy according to the CCG 503 II regimane, with achievement of complete remission. Thus we report a case of Burkitt's lymphoma with bilateral renal enlargement with a biref review of literatures.
Allopurinol
;
B-Lymphocytes
;
Burkitt Lymphoma*
;
Cerebrospinal Fluid
;
Drug Therapy, Combination
;
Edema
;
Flow Cytometry
;
Humans
;
Lymphoma
;
Male
;
Radiotherapy
;
Tumor Lysis Syndrome
;
Ultrasonography
9.Cold lesions in Tc-MDP bone scans of patients with skeleted metastases.
Chang Woon CHOI ; Hyung In YANG ; Sang Kyoon BAE ; Dong Soo LEE ; In SON ; Joon Ki JEONG ; Myung Chul LEE ; Chang Soon KOH
Korean Journal of Nuclear Medicine 1993;27(1):98-103
No abstract available.
Humans
;
Neoplasm Metastasis*
10.Epidemiologic Study of Measles Outbreak in School-Aged Children in East KyongGi-Do Area.
In Kyu YI ; Jong Woon CHOI ; Soon Ki KIM ; Byong Kwan SON ; Jeung Gyu KIM ; Seong Ki YU ; Myung Cheol JO ; Il Suk JANG
Journal of the Korean Pediatric Society 1996;39(1):63-71
PURPOSE: There was marked decline of measles outbreak in the world since the first measles vaccine had been introduced. Recently, however, measles outbreak in the vaccinated children have been reported worldwide, which was ascribed to the possibilities of primary or secondary vaccine failure. We investigated the incidence in the school-aged children in the Kyong-gi Do area, the larger district which covers the urban and rural area, by the questionnaire. METHODS: The questionnaires which were asked to the students' parents of 14 elementary schools in and nearest Sungnam city, Kyong-Gi Do for their present age, experience of measles attack and vaccination, and the age of measles attack. The answers of this questionnaire were analysed by SAS computer program. RESULTS: 1) Measles vaccination rate at 9 months was 70.5% and MMR vaccination rate at 15 months was 91.3%. 2) Measles attack rate among unvaccinated group was 53.8%, and 16.1% in vaccinated group. There was significant low risk of measles attack among vaccinated group than unvaccinated group(relative risk=3.35, p<0.001). 3) Vaccine efficacy of measles in this age group was 69%. 4) Age distribution of measles outbreak reveals bimodal pattern, the graph shows two peak incidence of 1 year-old and 6 years-old. 5) There were no significant differences of measles incidence in the different medical care service center that measles vaccination had been done. CONCLUSIONS: Despite high rate of measles vaccine coverage in Sungnam, the attack rate of measles in the vaccinated population was relatively high. There may be due to primary, secondary vaccine failure or the other factors. The policy of measles vaccination in Korea should be reestablished as soon as possible.
Age Distribution
;
Child*
;
Epidemiologic Studies*
;
Gyeonggi-do*
;
Humans
;
Incidence
;
Korea
;
Measles Vaccine
;
Measles*
;
Measles-Mumps-Rubella Vaccine
;
Parents
;
Surveys and Questionnaires
;
Vaccination