Weber-Christian diaease is characterized by recurrent crops of subcutaneous nodules or plaques which occur during febrile periods and usually has spontaneous regression. Since the earlier case reports there have been instances of nodular panniculitis affecting visceral fat as well as the subcutaneous tissue. Death may rarely occur follow ing visceral involvement. We experienced a fatal case of Weber-Christian disease in a 32 year old female, who had prominent hepatomegaly and leukopenia accompanied by various general symptoms such as nausea, vomiting, abdominal pain, and cough. This case also had unusually large erythematous swelling of the face and aMomen in addition to multiple subcutaneous nodules in the extremities and trunk.
Abdominal Pain ; Adult ; Cough ; Extremities ; Female ; Hepatomegaly ; Humans ; Intra-Abdominal Fat ; Leukopenia ; Nausea ; Panniculitis ; Panniculitis, Nodular Nonsuppurative* ; Subcutaneous Tissue ; Vomiting

We report two cases of rare, and clinically atypical metastatic breast carcinoma; zosterifo pattern, and cicatrirical pattern. A 51-year-old female had zosteriform eruption in the right chest and arm, which was diagnosed as an inflammatory, and telangiectatic type breast carcinoma I. skin biopsy. Another patient, a 71-year-old female,. had a retraction of nipple and breast, al erythematous nodular plaques like a surgical scar with distant metastasis to the counterlateral inguinal lymph node. A skin biopsy disclosed nodular type lymphatic dissemination of brea.,: carcinoma. In both patients, cutaneous lesions were the first signs of breast cancer with a gra-r prognosis.
Aged ; Arm ; Biopsy ; Breast Neoplasms ; Breast* ; Cicatrix ; Female ; Humans ; Lymph Nodes ; Middle Aged ; Neoplasm Metastasis ; Nipples ; Prognosis ; Skin ; Thorax

An etiologic agent in seborrheic dermatitis is now considered to be due to Pityrosporum ovale. The connection between the yeast and the disease has been clearly dernonstrated in a number of patients treatd with antifungal agents. However, the fact, that Pityrosporum ovale (Pityrosporum orbiculare) belongs to the normal human cutaneou. flora makes it difficult, to explain the role of the organism in seborrheic dermatitis. In this clinical study, twenty eight subjects were divided into two group by treatment regimen of topical 2% ketoconazole shampoo(TKS)and 0.3% prednisolone valerate solution (PVS). Before and during the four weeks treatment periods, the number of Pityrosporum ovale on the scalp were evaluated by scrub Giemsa staining method, which estimat,ed by score scale, under direct. microscopic examination. Also clinical symptoms including erythema, scales and itching were recorded by scores every week and compared between two treatment group. Topical application of 2% ketoconazole shampoo(TKS) is a very effective treatment regimen to reduce the yeasr cell score(from 5.8+1.3 to 1.8+1.4) than PVS(from 6.4+1.3 to 3.5+1.5), significantly(p<0.05). So the results of this study acconsistent with the view that density of Pityrosgourum ovale plays a role in the cause and course of seborcheic derrnatitis on the scalp. And antifungal agent(TKS) shows favorable effects ori tnis disease clinically and mycologically.
Antifungal Agents ; Azure Stains ; Dermatitis, Seborrheic* ; Erythema ; Humans ; Ketoconazole* ; Malassezia ; Prednisolone ; Pruritus ; Scalp* ; Weights and Measures ; Yeasts

No abstract available.
Hemorrhoids*

The epithelioid angiosarcoma is recently described ns a variant of ang-osarcoma based on its pathological feature, which is characterized by the epithelioid or histiocytoid morphology af the malignant tumor cells. The existence of vascular endothelial tumor with an epithelioid feature has been accepted for many years, most notablyn the forms of epithelioid hemangioma and epithelioid hemangioendo thelioma. In recent years, cutaneous angiosarcoma with epitheloid morphology have been reported as a cutaneos epithelioid angiosarcoma in the literatures. A 60-year-old man presente with a mild tender erythematous 2 x 2 x 2.5cm sized soft fluctuating single nodule with dark hemorrhagic crust on the left forehead for 3 months. He had had an abrasion wound on the lesion site of the forehead by an accidental trauma 5 month before the lesion appeared. Histopathological findings revealed that the tumor mass was chiefly composed of solid sheets of poorly differentiated malignant cells with an epithelioid feature. The characteristics of classical angiosarcoma such as primitive vascular spaces and clefts with malignat cells, and proliferating vessels were also found in some areas. The immunohistochemical stain wi.h the factor VIII related antigen ivas focally reactive in the tumor cells. Unfortunately he refused further treatment and expired 7 months after discharge at home without knowing the direct cause of his health. We report herein an interesting and rare case of the cutaneous epitheioid angiosarcoma which had typical clinical and histopathological findings and suggested as a case with a very aggressive course.
Forehead ; Hemangioma ; Hemangiosarcoma* ; Humans ; Middle Aged ; von Willebrand Factor ; Wounds and Injuries

Mycetoma is a clinical syndrome of localized, indolent, deforming, swollen lesions and sinuses, involving cutaneous and subcutaneous tissues, fascia, and bone. Its lesions. are composed of suppurat.ing abscesses, granulomata, and dra ning sinuses and the etiologic agents are wide variety of bacteria (actinomycotic mycetoma) and fungi(eumcotic mycetoma) from plant and soil. The patient was a 65-year-old female and a farnier. She was referred by the skin lesion loalized on the dorsum of her lefther left hand and wrist for three months. It showed multiple subcutaneclis nodules, abscesses, and discharging fitula based on the erythematous plaque. The skin biopsy frorn the lesion revealed the PAS positive hyphae in the granulocytic infiltration. Fungus cult,ure with a piece of tissue on sabouraud media shows hin, floccose, white colonies. Slide culture and biochemical idcrtification of pathogen led to the final diagnosis as Mycetoma caused by Pseudallescheria boydii(Monosporium apiospermum). The lesions disappeared gradualy following systemic oral administratior of Itraconazole 200mg daily for six weeks.
Abscess ; Aged ; Bacteria ; Biopsy ; Diagnosis ; Fascia ; Female ; Fungi ; Hand ; Humans ; Hyphae ; Itraconazole ; Mycetoma* ; Plants ; Pseudallescheria* ; Skin ; Soil ; Subcutaneous Tissue ; Wrist

BACKGROUND: Keloids may occur at any age, but tend tend velop between the ages of 10 and 30. The incidence and median age of onset are equal for both sexes. Keloids are common among the darker pigmented rices, but there have been a few clinia studies of keloids in Korea. OBJECTIVE: The purpcse of this study was to evaluate the variable clinical characteristics of keloids in Korea. METHODS: This clinical investigation was made with 223 of patients of keloid who had visited the Department of Derrnatology, Chonnam University Hosptal from January 1984 to December 1993. RESULTS: 1.The annual incidenie averaged over 10 years was 0.831 (361 cases of total 43,752 outpatients). 2.The ratio of male to female was 1: 0.94(Male. 115, Feila 108). 3.The mean age of the onset and at the first visit to our hospital were 24.5years and 29.2 years respectively. 4.In our series tte presternal area was the most commor saes, the shouder region next. Most keloids on the shoulder were related to BCG vaccination in ifoncy or chilhood. 5.The precipitating fa ctors associated with keloid were riaeeding dermatologic diseases(33.2 %), unknown(17.9%) rejection & vaccination(15.2%), operation(13.9%), burn(13.9%) and laceration(5.8%) in descending order. 6.Among preceeding as, iociated dermatologic diseases, acne w s the most common. 7. A positive family history is more likely in cases of mitile keloidal (p<0,001), and severe keloidal formation. 8.Most patients did not. complain of any symptorns(45.3%) nd a symptom of pain or tenderness(40.8%) was piesert rather than pruritus(13.9%). 9.The most prevaent tr eatment modality was intralesional injection with triamcinolone acetonide (84.3%). CONCLUSION: According, to this study, usually keloids occore in patients between 10 and 29 years of age, and most keloids were located on the antetio partion of the chest, shoulders, and face and scalp. A positive family history is more likely in as of multiple, severe keloidal for mation.
Acne Vulgaris ; Age of Onset ; Female ; Humans ; Incidence ; Injections, Intralesional ; Jeollanam-do ; Keloid* ; Korea ; Male ; Mycobacterium bovis ; Scalp ; Shoulder ; Thorax ; Triamcinolone Acetonide ; Vaccination

We present two cases of lymphangioma circumscriptum according to the clinical pattern and histopathological findings, one with lesions on the tongue and the other with lesions of the oral mucous membrane. The first case was a 5 year-old boy with a plaque of grouped transluscent vesicles resembling frog's spawn on ventral surface of the tongue of three years duration. The second case, also a 5 year-old boy, had a lymphangioma circumscriptum lesion in the right buccal mucous membrane which developed several months after birth and eventually produeed swelling of the right cheek. The histopathological findings of both cases showed variable-sized dilated lymphatic channels lined by one layer of normal endothelial cells, extending to the deep dermis, subcutaneous tissue and muscle layer and resembling the spongy type variant of classical lymphangoima circumscriptum using the classification of lymphangioma of Peacheyet al.
Cheek ; Child, Preschool ; Classification ; Dermis ; Endothelial Cells ; Humans ; Lymphangioma ; Male ; Mouth* ; Mucous Membrane ; Parturition ; Subcutaneous Tissue ; Tongue

There are several ELISA(enzyme linked immunosobent assay) kits to be highly sensitive and specific in the screening test for antibodies to HIV. However, these have several problems such as high false-positive rate, low reproducibility and complex test procedures. A new serological test, the gelatin particle agglutination test(PAT), was developed and reported as good test having the same sensitivity with ELISA, and simple and easy procedure. The purpose of this study is com parison of two screening tests, ELISA and PAT, for detection of antibodies to HIV In one hundred two prostitutes, who used to contact with foreigners such as U.S. army personels, 10 syphilitic patients in Chonnam University hospital and 3 HIV infected patients, the serological results were equal in both tests, so there. was 100% concordance rate of seroreactivity between ELISA and PAT. Among 13 serum samples with false positive in ELISA test, only one sample revealed also reactive in PAT, which suggest indirectly us for PAT to be more specific than ELISA. The quantitative test with PAT of 4 consecutive serums during 4 months in the AIDS patient with Kaposi's sarcoma. However, in overall serum titer, the AIDS patient was higher than asymptomatic infected person. Thus the PAT test should be also useful for the mass screcning and quantitative test of anti-HIV antibody, and is highly recommedable for detection of HIV infection because the test can be performed with simple procedure and techique in addition ecoomically low cost and shortened time for the test.
Agglutination ; Antibodies ; Emigrants and Immigrants ; Enzyme-Linked Immunosorbent Assay* ; Gelatin ; HIV ; HIV Infections ; Humans ; Jeollanam-do ; Mass Screening* ; Sarcoma, Kaposi ; Serologic Tests ; Sex Workers

Proliferating trichilemmal tumor is a relatively uncommon tumor which develops preferentially as a solitary tumor on the scalp of elderly women. Histologically, the tumor i epresents a proliferation of the outer root sheath epithelium in a characteristic pattern, but the presense of cellular atypia, dyskera.totic cells and mitotic figures may lead to a false impression of squamous cell carcinoma. We report a case of proliferating trichliemmal tumor in a 70-yeiir-old male who presented with a slowly growing tumor on his right inguinal area for 2 years. This case is unusual in that the tumor occurred on the inguinal are anoher than the scalp in a male.
Aged ; Carcinoma, Squamous Cell ; Epithelium ; Female ; Humans ; Male ; Scalp