No abstract available.
Pyloric Stenosis, Hypertrophic*

No abstract available.
Adhesives*

BACKGROUND: Propioriacterium acnes plays an importantol in the development of inflammatory acne, and inflarnmatory lesions are improved by oralnc topical antibiotics. But as Pacnes frequently develop resistance to antibiotics in patients neing long term systemic antibiotic therapy, the theravuti effects diminish, and eventually thay fails. OBJECTIVE: The purpose of this study is to evaluate theerral susceptability of P. acnes to antibiotics and the difference in the MIC depending on the of oral and/or topical antibiotics, therapeutic effects and disease duration in patients with acie ulgaris. METHODS: We used twenty six strains of P. acnes which were obtained from patients with acne and performcd suseptibility testing for antibiotics usir the E test procedure. RESULTS: 1. The growth of P. acnes was completely inhibited by e ythromycin and chloramphenicol at concentrations of 0.023ug/ml and 0.064ug/ml, respectively cefoxitin at 0.094ug/ml, and by tetracycline and clindarnycin at 0.190 ug/ml. 2. P. acnes was mot susceptible to erythromycin, and olwed by chloramphenicol, cefoxitin, tetracycline, clindamycin in order of decreasing susceptibilit . 3. There were no significant differences in the MIC in reat in to previous antibiotic treatment. 4. For tetracycline, The MIC was significantly lower(p<0.01) in patients who improved after treatment. 5, For tetracycline and chloramphenicol, the MIC was grficantly lower(p<0.05) in patients with less than 2 years disease duration. CONCLUSION: The susptibility of antibiotics for P. acneias highest in erythromycin. There were no significant differences in the MIC in relation to prvious antibiotic treatment, and for some antibiotics the suseptibility was low in patients who dill not show clinical improvement or who had long disease duration.
Acne Vulgaris* ; Anti-Bacterial Agents* ; Asian Continental Ancestry Group ; Cefoxitin ; Chloramphenicol ; Clindamycin ; Erythromycin ; Humans ; Propionibacterium acnes* ; Propionibacterium* ; Tetracycline

BACKGROUND: Tandem duplication of chromosome 17p11.2-p12 including peripheral myelin protein 22 (PMP22) gene is the most frequent cause of Charcot-Marie-Tooth 1A (CMT1A). Patients carrying one extra copy of PMP22 develop CMT1A, whereas the deletion of the 17p11.2-p12 region causes hereditary neuropathy with the liability to pressure palsies (HNPP). In the present study, we established the genotyping methods of 6 microsatellite markers (D17S921, D17S9B, D17S9A, D17S4A, D17S918 and D17S122) within the 17p11.2-p12 regions by the hexaplex PCR for the genetic diagnosis of CMT1A duplication and HNPP deletion. METHODS: We established polymorphic behavior and genotyping methods of 6 microsatellite markers (D17S921, D17S9B, D17S9A, D17S4A, D17S918 and D17S122) within the duplication region. The 6 markers were amplified by hexaplex PCR reaction and analyzed by an automatic sequencing analyzer and genotyper program. RESULTS: The genotype distributions of all markers were not significantly deviated from the Hardy-Weinberg equilibrium (P>or=0.05). When comparing the control group and CMT1A, HNPP patients group by the distribution of allele, there is no significant difference in the 5 locus except in the 1 locus (D17S921) among HNPP patients. The specificity was more than 99.9%. The sensitivity of each CMT1 and HNPP was 56.3% (40/71 pedigrees) and 72.1% (31/43 HNPP pedigrees), respectively. CONCLUSIONS: The error rate for the system may be less than 0.001. According to this study, it is possible to have rapid and exact genetic diagnosis of both CMT1A and HNPP, which may be helpful for the development of personalized therapy according to genetic defects.
Alleles ; Charcot-Marie-Tooth Disease ; Diagnosis* ; Genotype ; Humans ; Microsatellite Repeats* ; Multiplex Polymerase Chain Reaction* ; Myelin Sheath ; Paralysis ; Polymerase Chain Reaction ; Sensitivity and Specificity

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major cause of nosocomial infection and a molecular typing is necessary for proper epidemiologic investigations of sources and moles of spread in an outbreak. An nosocomial outbreak of MRSA in a neonatal intensive care unit at Ewha Womans University Mokdong Hospital was suspected. To investigate the clonality of isolates and control the spread of nosocomial outbreak, we performed plasmid restriction analysis of MRSA isolates from patients and medical staffs. METHODS: We studied 7 MRSA strains (umbilicus 4, blood 1, urine 1 and pus 1) from patients in a neonatal intensive care unit and the MRSA strains from nares and hands surveillance cultures of 26 medical staffs (4 medical doctors and 22 nurses). All MRSA strains were tested for antimicrobial susceptibility and plasmic analysis after EcoRI restriction. We analyzed the plasmid patterns of MRSA isolated from patients and compared with those from medical staffs. RESULTS: Ten MRSA strains (from 7 nares and 3 hands) were isolated from surveillance cultures of 26 medical staffs. Seven out of 10 MRSA strains from medical staffs revealed identical pattern of antibiogram which was the same pattern in all 7 MRSA strains from seven patients. Plasmid restriction patterns were classified 6 groups from A to F showing 2-10 bands. Six out of 7 MRSA strains from the patients showed group A(A1 5, A31) and 5 out of 10 MRSA strains from the medical staffs showed group A(A1 1, A21, A32, A41) and remainders showed different plasmid restriction analysis patterns. CONCLUSIONS: These results suggest that plasmid restriction analysis is a rapid, inexpensive, and good discriminating molecular typing of MRSA outbreak and is useful for the epidemiologic investigation of MRSA outbreaks in the clinical laboratory.
Cross Infection ; Disease Outbreaks ; Female ; Hand ; Humans ; Infant, Newborn ; Intensive Care, Neonatal ; Medical Staff ; Methicillin Resistance* ; Methicillin-Resistant Staphylococcus aureus* ; Microbial Sensitivity Tests ; Molecular Epidemiology* ; Molecular Typing ; Plasmids* ; Suppuration

No abstract available.
Colon, Descending* ; Leiomyosarcoma*

In a small island community with a population of less than 100 residents, nine persons died and five experienced severe illness during the period from November 1986 to May 1988. Their initial symptoms were sore throat and fever. Renal failure and hepatitis developed which one week after the onset. Oral mucosal ulcer developed in some cases. After one week, progressive respiratory failure and dyspnea developed evidently and severe respiratory distress and hypoxia preceded those fatal cases. Chest X-ray findings revealed bilateral diffuse multiple cystic lesion with occasional multiple large emphysematous bullae. Based on these features paraquat poisoning was diagnosed and route of poisoning was investigated. In three sources of drinking water, trace amount of paraquat was detected in November 1988, six months after the incidence of recent fatal case. In November 1988, soybean sauces and soybean pastes from 12 households were found contaminated with high concentration of paraquat, the cause of this mass poisoning has been suggested.
Anoxia ; Drinking Water ; Dyspnea ; Eating ; Family Characteristics ; Fever ; Hepatitis ; Humans ; Incidence ; Ointments ; Paraquat* ; Pharyngitis ; Poisoning* ; Renal Insufficiency ; Respiratory Insufficiency ; Soybeans ; Thorax ; Ulcer

PURPOSE: This study was conducted to examine how nurses' death anxiety and terminal care stress affect their terminal care performance in the clinical setting. METHODS: The study enrolled 180 registered nurses with experience of attending dying patients at a university hospital located in Seoul, Korea. Collected data were analyzed with descriptive statistics, one-way ANOVA and Pearson's correlation using SPSS 18.0 for Windows. RESULTS: Nurses showed significant differences in the level of death anxiety and terminal care stress as well as terminal care performance by working division, marital status, educational background and hospice training. A significant relationship was found between terminal care stress and terminal care performance. CONCLUSION: The study results showed that efforts to ease nurses' death anxiety and terminal care stress could improve their terminal care performance. Further study should be conducted to investigate other factors that affect nurses' terminal care performance from various perspectives and develop a terminal care manual which can be used as guidance for nurses in charge of terminal patient care.
Anxiety ; Fees and Charges ; Hospices ; Humans ; Korea ; Marital Status ; Nursing Services ; Patient Care ; Terminal Care

We have reported a case of acute spontaneous spinal epidural hematoma in a male patient aged 79-year-old who had suddenly felt a strong pain in the right buttock and lower abdomen. Shortly after he noticed weakness in his legs and two hours later he was completely paraplegic. Operation was undertaken 13 hours after the onset of the illness. A laminectomy was mode from T11 to L1 and a massive epidural hematoma removed mainly from the right posterolateral aspect of the cord.
Abdomen ; Aged ; Buttocks ; Hematoma ; Hematoma, Epidural, Spinal* ; Humans ; Laminectomy ; Leg ; Male

A 35-year-old male patient with hydrocephalus due to spontaneous subarachnoid hemorrhage secondary to brain tumor were treated with ventriculo-peritoneal shunt. Subsequently an unusual liver abscess developed at right lobe of liver which was drained successfully through the percutaneous puncture method. The liver abscess and ventriculitis was controlled with systemic, intrathecal and intraventricular antibiotics administrations. The authors have never seen a report of liver abscess after the ventriculoperitoneal shunt. The computed tomographic findings, managements of infection and a review of the literature is presented.
Adult ; Anti-Bacterial Agents ; Brain Neoplasms ; Humans ; Hydrocephalus ; Klebsiella oxytoca ; Liver Abscess* ; Liver* ; Male ; Punctures ; Subarachnoid Hemorrhage ; Ventriculoperitoneal Shunt