1.Clinical Effect of Diltiazem Hydrochloride(Herben(R)) on Angina Pectoris.
Soon Kyu SUH ; Ki Suh PARK ; Kyung Ho KANG
Korean Circulation Journal 1982;12(1):161-167
The Diltiazem hydrochloride is a new calcium antagonist of which effect on angina pectoris has been reported. Authors studied the clinical effect of Diltiazem in 18 cases of angina pectoris including stable and unstable angina. The 14 cases were male and 4 cases were female with ages ranging 46 to 72 years. All cases had typical anginal attack on 1-6 times in everyday with transient improvement by sublingual nitroglycerin. After coutine physical and laboratory work-up, Diltiazem 30mg tablet was given 3 times a day for 3 consecutive weeks and checked the response of angical pain for first 3 times visit with 3 days interval and thereafter with one week interval. In 13 cases of 15 cases, the Diltiazem alone was medicated. There was considerable improvement of anginal attack in 13 cases of 15 cases with Diltiazem alone, namely complete subsidence of anginal attack throughout 3 weeks in 2 cases, only minimal substernal discomfort on effort once a week in 4 cases and in 7 cases the frequency and severity of anginal pain reduced to about 50% of control state. In 2 of 15 cases there were no effect on anginal pain until one week, subsequently a beta-blocker was added and the anginal attack improved considerably in both cases. In 3 cases of 18 cases, the anginal attacks were so severe and frequent that the Diltiazem with beta-blocker were given from the beginning. In one case the anginal pain disappeared completely and in two cases there were good effect. The effect of Diltiazem usually started to occurs in 3 days to one week after medication. The overall effectiveness of Diltiazem in angina pectoris was 87% with excellent effect in 40%, good effect in 27% and fair effect in 20%. In 5 cases of good response to Diltiazem, the stress exercise test by bicycle ergometer was carried out before and after one week medication with programs of 30 wt, 50 wt, 75 wt, and 100 wt loading for 4 minutes in each stage. The exercise tolerance improved about 25-50 wt, the ST depression by exercise became less by 1-2mm and the maximal heart rate increased by 4-9/min. These data showed marked improvement of exercise tolerance in angina pectoris by Dltiazem objectively. There were macular skin rash, diarrhea and mild dizziness in one case respectively which were improved without treatment. These data showed that Diltiazem was highly effective in angina pectoris except few very severe cases. In severe cases, the combined therapy of Diltiazem and beta-blocker was more effective.
Angina Pectoris*
;
Angina, Unstable
;
Calcium
;
Depression
;
Diarrhea
;
Diltiazem*
;
Dizziness
;
Exanthema
;
Exercise Test
;
Exercise Tolerance
;
Female
;
Heart Rate
;
Humans
;
Male
;
Nitroglycerin
2.Treatment of Severe Equinus Deformity Associated with Extensive Scarring of the Leg and Ankle with the Hinged Ilizarov and Free Tissue Transfer.
Soo Bong HAHN ; Hui Wan PARK ; Ki Won SUH
The Journal of the Korean Orthopaedic Association 1997;32(4):825-831
We evaluated the results following the use of hinged Ilizarov and free tissue transfer to correct the eqinus deformity of the foot associated with extensive scarring of the leg and ankle in nine patients. The deformity was secondary to ischemic and neuropathic changes after trauma to the leg, ankle and foot. The average age of the patients was seventeen years (range, thirteen to thirty-four years). The average duration of follow-up was twenty-one months (range, twelve to thirty-eight months). Free tissue transfer was done in all cases, parascapular flap was done in seyen cases, groin flap was done in two cases. Among the nine cases, free tissue transfer and hinged Ilizaov were done at the same time in four cases, The average interval of the other five patients between free tissue transfer and hinged Ilizaov was three months (range, two to four months). The duration of distraction was four to six weeks, and the apparatus was kept in place for an additional two months after the desired position of correction had been achieved. The results were evaluated using two criteria, dorsiflexion and range of motion of ankle joint. Criteria on dorsiflexion of ankle, the results were good in seven cases, fair in two cases. Criteria on range of motion of ankle, one case being performed ankle fusion was not evaluated. Total eight cases were evaluated for range of motion of ankle. The results were good in six cases, fair in two cases. On the basis of our results, we believe that severe eqinus deformities of the foot associated with extensive scarring of the leg and ankle can be corrected with heel cord lengthening, free tissue transfer and hinged Ilizarov.
Ankle Joint
;
Ankle*
;
Cicatrix*
;
Congenital Abnormalities
;
Equinus Deformity*
;
Follow-Up Studies
;
Foot
;
Groin
;
Heel
;
Humans
;
Leg*
;
Range of Motion, Articular
3.Antimicrobial drug susceptibility of enterobacter and citrobacter islated from clinical specimens.
Sung Duck PAIK ; Won Ki BAEK ; Seong Il SUH ; Jong Wook PARK ; Min Ho SUH
Journal of the Korean Society for Microbiology 1993;28(6):443-451
No abstract available.
Citrobacter*
;
Enterobacter*
4.Characterization of R plasmid and antimicrobial drug resistance of kelbsiella pneumoniae isolated from clinical specimens.
Kyung Ran LEE ; Won Ki BAEK ; Seong Il SUH ; Jong Wook PARK ; Min Ho SUH
Journal of the Korean Society for Microbiology 1991;26(1):25-35
No abstract available.
Drug Resistance, Microbial*
;
Plasmids*
;
Pneumonia*
5.Antimicrobial resistance of escherichia coli isolated from clinical specimens.
Sung Duck PAIK ; Won Ki BAEK ; Seong Il SUH ; Jong Wook PARK ; Min Ho SUH
Journal of the Korean Society for Microbiology 1993;28(4):261-267
No abstract available.
Escherichia coli*
;
Escherichia*
6.Effect of Atenolol(Tenormin(R)) on Blood Pressure and Plasma Renin Activity in Essential Hypertension.
Soon Kyu SUH ; Sae Wha YOO ; Soon Chang PARK ; Joon Sock KIM ; Kyung Ho KANG ; Ki Suh PARK
Korean Circulation Journal 1982;12(1):145-151
The effect of Atenolol on the blood pressure were studied in 31 cases of essential hypertension and on the effect of plasma renin activity in 8 cases. There were 8 cases of male with age 49.5(42-70) and 23 cases of female with age 49(35-71) years. 27 cases of 31 cases were untreated hypertensive patients and 4 cases were refractory to hypotensive drugs of diuretics and vasodilators. The Atenolol 50mg once-daily was given to all patients orally for 3 weeks. The blood pressure, heart rate, ECG and symptoms were checked in one week interval. In 8 cases, the plasma renin activity was measured by Dainabot Kit before and after one week medication. The results were as follows: 1. In 27 cases of untreated hypertension, the control blood pressure was 182.9/11.4mmHg in average. The blood pressure decreased in average by 18.3/11mmHg in one week, 23.7/15.9mmHg in two week and 21.5/10.5mmHg in three week. The heart rate also decreased by 7.4/min. in one week, 14.9/min. in two week and 7.8/min. in three week. These data showed considerable reduction of blood pressure and heart rate with 50mg Atenolol once-daily. 2. The basal plasma renin activity after one week medication was reduced by 46% in 8 cases and this data showed considerable reduction regardless control level of basal plasma renin activity. 3. There were considerable blood pressure reduction by adding Atenolol 50mg once-daily to diuretics and vasodilator to which patient's blood pressures were refractory. 4. There was no orthostatic hypotension or serious side effect by Atenolol medication.
Atenolol
;
Blood Pressure*
;
Diuretics
;
Electrocardiography
;
Female
;
Heart Rate
;
Humans
;
Hypertension*
;
Hypotension, Orthostatic
;
Male
;
Plasma*
;
Renin*
;
Vasodilator Agents
7.MR Findings of Brainstem Injury.
Sang Joon KIM ; Dae Chul SUH ; Choong Ki PARK ; Woo Cheol HWANG ; Man Soo PARK
Journal of the Korean Radiological Society 1995;32(2):237-241
PURPOSE: To analyze the characteristies of traumatic brainstem injury by CT and MR MATERIALS AND METHODS: CT and MR studies of 10 patients with traumatic brainstem lesion in MR were retrospectively reviewed, particularly attended to location, signal intensity and associated lesions. RESULTS: CT failed to depict 8 of 10 brainstem lesions. All lesions were detected in MR images with T2-weighted images showing higher detection rate (n=10) (100%) than Tl-weighted images (n=3) (30%) or CT (n=2) (20%). The brainstem lesions located in the dorsolateral aspects of the rostral brainstem(mid brain and upper pons)in 7 (70%) cases, in ventral aspects of rostral brain in 2 (20%) cases and in median portion of pons in 1 (10%) case. Corpus callosal (n=5), Iobar white matter(n=5) diffuse axonal injury, and 2 hemorrhagic lesions in basal ganglia were the associated findings. CONCLUSION: MR imaging is more helpful than CT in the detection of brainstem injury, especially T2 weighted images. Primary brainstem lesions were typically located in the dorsolateral aspect of rostral brainstem(midbrain and upper pons). Corpus callosum and white matter lesions were frequently associated.
Basal Ganglia
;
Brain
;
Brain Stem*
;
Corpus Callosum
;
Diffuse Axonal Injury
;
Humans
;
Magnetic Resonance Imaging
;
Pons
;
Retrospective Studies
8.Soft tissue sparganosis.
Ki Soon PARK ; Yul LEE ; Soo Young CHUNG ; Choong Ki PARK ; Kwan Sup LEE ; In Hwan CHO ; Hyoung Sim SUH
Journal of the Korean Radiological Society 1993;29(6):1288-1294
Sparganosis is a rare tissue-parasitic infestation caused by a plerocercoid tapeworm larva(sparganum), genus Spirometra. The most common clinical presentation of sparganosis is a palpable subcutaneous mass or masses. Fifteen simple radiographs and 10 ultrasonograms of 17 patients with operatively verified subcutaneous sparganosis were retrospectively analyzed to find its radiologic characteristics for preoperative diagnosis of sparganosis. The locations of the subcutaneous sparganosis were lower extremity, abdominal wall, breast, inguinal region and scrotum in order of frequency. The simple radiographs showed linear or elongated calcification with or without nodular elongated shaped soft tissue mass shadows in 8 patients, soft tissue mass shadow only in 2 patients and lateral abdominal wall thickening in 1 patient. But no specific findings was noted in 4 patients with small abdominal and inguinal masses. We could classify the subcutaneous sparganosis by ultrasound into 2 types: one is long band-like hypoechoic structures, corresponding to the subcutaneous tunnel-like tracks formed by migration of sparganum larva and the other is elongated or ovoid hypoechoic nodules, representing granulomas. Long band-like hypoechoic structures within or associated with mixed echoic granulomatous masses were noted in 6 patients and elongated or ovoid hypoechoic mass or masses were noted in 4 patients. In conclusion, sparganosis should be considered when these radiologic findings-irregular linear calcifications on simple radiograph and long ban-like hypoechoic structures on ultrasonography, corresponding to the subcutaneous tunnel-like tracks formed by migration of sparganum larva-are noted in the patients who have subcutaneous palpable mass or masses. And radiologic examination especially ultrasonography is very helpful to diagnose sparganosis.
Abdominal Wall
;
Breast
;
Cestoda
;
Diagnosis
;
Granuloma
;
Humans
;
Larva
;
Lower Extremity
;
Retrospective Studies
;
Scrotum
;
Sparganosis*
;
Sparganum
;
Spirometra
;
Ultrasonography
9.Flow Cytometric DNA Analysis of Prostate Adenocarcinoma :Correlation with histologic grade and DNA ploidy.
Hong Ki LEE ; Kwang Sun SUH ; Dae Young KANG ; Jong Woo PARK
Korean Journal of Pathology 1993;27(1):40-49
Nuclear DNA content of 32 cases of prostate adenocarcinoma diagnosed 1986-1991 was determined by flow cytometry, with the use of paraffin-embedded archival tissue. The present study was done to define the relationship between clinical stage, histopathological grade, and DNA ploidy. Aneuploidy was found in 10(31.3%) cases including 7 cases of near-tetraploidy. Among diploid tumors, 36.4% were localized disease(stage A and B), 13.6% were characterized by invasion outside the prostate(stage C), and 50.0% showed distant metastasis(stage D). Among aneuploid tumors, 10.0% were stage B, 50.0% stage C, and 40.0% stage D. The degree of glandular differentiation was characterized by the Gleason score and the percentage of sampled tissue involved by carcinoma was graded by Dhom's method. Apparent correlation was found between Gleason grade and Dhom grade(P<0.05). All 13 tumors with a Gleason grade I(score of 2 to 5) were diploid. Four of 9 tumors with a Gleason grade II(score of 6 to 7) were aneuploid(near-tetraploidy 33.3%, aneuploidy 11.1%) and 60.0%, of tumors with a Gleason grade III(score of 8 to 10) were aneuploid(near-tetraploidy 40.0%, aneuploidy 20%). The percentage of aneuploid cases increased with advanced clinical stage, but the relationship between aneuploidy versus clinical stage was not significant. However, it can be concluded that DNA ploidy correlates well with Gleason grade(p<0.05), which may have predictive prognostic value for prostate adeno-carcinomas.
Adenocarcinoma
10.Characterization of Unstable Bladder in the Rat with Infravesical Outlet Obstruction.
Hee Chang JUNG ; Tong Choon PARK ; Ki Hak MOON ; Jun Kyu SUH ; Jung Hyun KIM
Journal of the Korean Continence Society 1999;3(1):15-20
No abstract available.
Animals
;
Calcium
;
Rats*
;
Urinary Bladder*