1.Modified classification of anemia by RDW.
Hyeong Ki HWANG ; Myung Soo HYUN ; Bong Sup SHIM
Yeungnam University Journal of Medicine 1993;10(1):58-67
The author obtained index of red cell volume distribution width(RDW) and other red cell indices in 210 patients of various hematoncologic conditions and 200 healthy control group using, an automated blood analyzer, Coulter Counter Model S-plus II. This study performed to classify various etiologic anemia based on the MCV and RDW, to evaluate availability to the differential diagnosis in korean anemic distoders somewhat different from etiologies of anemias in foreginers. In the most of cases, the increase or decrease of MCV were always combined the pararell changes of MCH and MCHC: But the values of MCV and RDW were not correlated in control group and patient group. So the terms of heterogenous of homogenous anemia were meaningful morphologic classification than hypochromic or normochromic anemia. The heterogenous microcytic anemia contained iron deficiency anemia. In heterogenous normocytic anemia, myelophthisic anemia, acute leukemia were contained. In heterogenous macrocytic anemia, megaloblastic anemia, hemolytic anemia were contained. The homogenous microcytic anemia was observed in anemia of chronic disorders. In homogenous normocytic anemia, acute blood loss, chronic leukemia, multiple myeloma were contained. The aplastic anemia was belonged to homogenous macrocytic anemia. The diagnostic significance of RDW in hemoglobinopathies is most importhant. But this study was not contained hemoglobinopathies. Instead RDW was very helpful to differential diagnosis of most common anemias, iron deficiency anemia and anemia due to chronic disorders in Korea.
Anemia*
;
Anemia, Aplastic
;
Anemia, Hemolytic
;
Anemia, Iron-Deficiency
;
Anemia, Macrocytic
;
Anemia, Megaloblastic
;
Anemia, Myelophthisic
;
Cell Size
;
Classification*
;
Diagnosis, Differential
;
Erythrocyte Indices
;
Hemoglobinopathies
;
Humans
;
Korea
;
Leukemia
;
Multiple Myeloma
2.Changes of c-Fos Protein Expression in Rat Brain Neurons after Formalin Induced Pain.
Kyu Geun HWANG ; Myeong Dong SHIN ; Ki Soo YOO
Journal of the Korean Child Neurology Society 1999;7(1):29-41
PURPOSE: The effects of pain on brain is not well known. Also, differences between somatic and visceral pains have not been fully elucidated. This study was conducted to investigate changes in the expression of c-Fos protein after somatic and visceral pains were induced by formalin. METHODS: Male rats(n=65) were underwent one of three procedures : (i) Control group, rats were left undisturbed in their cages; (ii) Somatic pain group, rats were injected subcutaneously with 0.1 ml of 10% formalin in the plantar surface of right hindpaw; (iii) Visceral pain group, rats were administered with same amount of formalin, as described above, in the rectum. Rats were sacrificed at increasing times(30 minutes, 1 hour, 2 hours, 6 hours, 1 day, 3 days and 7 days) after noxious formalin stimuli to hindpaws and rectums. Rat brains were removed and sliced in rat brain matrix. Brain slices were coronal sectioned at interaural 5.70-6.70mm. Serial sections were immunohistochemically reacted with polyclonal c-Fos antibody. The numbers of c-Fos protein immunoreactive neurons in cingulate cortex, primary somatosensory area, and hippocampus were examined and analyzed statistically with Mann-Whitney U test. RESULTS: 1) The numbers of c-For protein immunoreactive neurons in cingulate cortex, primary somatosensory area and hippocampus peaked at 2 hours after somatic pain stimuli and reached almost normal conditions at 7 days. 2) The numbers of c-Fos protein immunoreactive neurons in cingulate cortex, primary somatosensory area and hippocampus peaked at 1 day after visceral pain stimuli and reached almost normal conditions at 7 days. 3) The numbers of c-Fos protein immunoreactive neurons of somatic pain groups were higher than that of visceral groups at all times and the difference of numbers peaked at 2 hours after pain stimuli. CONCLUSION: Reactions of somatic pain stimuli influenced more changable than visceral pain stimuli to brain. Conduction velocities of somatic pain were more faster than those of visceral pain. Higher numbers of c-Fos protein immunoreactive neurons were found in specific regions. These results provide some basic knowledge in understanding the mechanism and control of pain.
Animals
;
Brain*
;
Formaldehyde*
;
Gyrus Cinguli
;
Hippocampus
;
Humans
;
Male
;
Neurons*
;
Nociceptive Pain
;
Rats*
;
Rectum
;
Visceral Pain
3.A clinical study on multiple myeloma.
Hyeong Ki HWANG ; Choong Ki LEE ; Myung Soo HYUN ; Bong Sup SHIM ; Hyun Woo LEE
Yeungnam University Journal of Medicine 1991;8(2):106-113
A clinical review of 31 cases of multiple myeloma which were diagnosed by criteria of the SWOG between May 1983 and February 1990 at Yeungnam University Hospital was done. The results were as followings: 1. The peak incidence was in 7th decade and male to female ratio was 1.8:1. 2. The most common presenting symptom at first diagnosis was bone pain (58%), but fever, dyspnea, dizziness and palpable mass were also noted. 3. The distribution of laboratory findings as following diagnostic criteria of Southwest oncology group (SWOG): Plasmacytoma on tissue biopsy was noted 6 cases, bone marrow plasmacytosis with more than 10% plasma cells was 22 cases, monoclonal globulin spike on serum electrophoresis was 24 cases, lytic bone lesions was observed 22 cases. 4. Initial clinical stages were classified as 2 cases in stage I, 3 cases in stage II, 26 cases in stage III (84%). 5. Immunoelectrophoresis revealed the distribution of IgG 64%, light chain 22%, IgA 10%, Kappa to Lambda ratio of 1.1:1. 6. Hematologic & biochemical findings revealed anemia with <8.5% of hemoglobin in 42%, hypercalcemia with <10.6 mg% of serum calcium in 22%, azotemia >2.0 mg% of serum creatinine in 19%. 7. The multiple punched out lesion of bone x-ray examination were noticed skull (65%), rib (42%), L-spine (35%), pelvis (23%), T-spine (19%). The initial skeletal roentgenographic findings showed osteoporosis, osteolytic lesion and fracture in 55%, only osteolytic lesion in 23%, only osteoporosis in 10%. 8. Complications of multiple myeloma, such as 10 cases of renal impairment, 8 cases of infection, 16 cases of compression fracture of spine were observed.
Anemia
;
Azotemia
;
Biopsy
;
Bone Marrow
;
Calcium
;
Clinical Study*
;
Creatinine
;
Diagnosis
;
Dizziness
;
Dyspnea
;
Electrophoresis
;
Female
;
Fever
;
Fractures, Compression
;
Humans
;
Hypercalcemia
;
Immunoelectrophoresis
;
Immunoglobulin A
;
Immunoglobulin G
;
Incidence
;
Male
;
Multiple Myeloma*
;
Osteoporosis
;
Pelvis
;
Plasma Cells
;
Plasmacytoma
;
Ribs
;
Skull
;
Spine
4.Actinomycosis on left submandibular area: a case report.
Jung Soo HONG ; Ki Yeul KIM ; See Ho CHOI ; Jung Hyun SEUL ; Hyeong Ki HWANG ; Chung Ki LEE
Yeungnam University Journal of Medicine 1991;8(1):231-237
Actinomycosis is a chronic suppurative and granulomatous bacterial infection characterized by contiguous spread, abscess formation and sinus tract formation. There are four clinical forms according to the lesional site, as 1) cervicofacial, 2) thoracic, 3) abdominal, and 4) disseminated form. Recently, we experienced a case of 54 year-old patient with left mandibular actinomycosis. The pathognomonic findings of actinomycosis is sulfur granule with multiple filaments in Gram-stain and the treatment of actinomycosis is surgical excision of mass or sinus tract with massive antibiotics (esp. Penicillin) therapy for 6 to 12 months.
Abscess
;
Actinomycosis*
;
Anti-Bacterial Agents
;
Bacterial Infections
;
Humans
;
Penicillins
;
Sulfur
5.A Case of Gastroenteritis Complicated with Empyema of Gall Bladder Caused by Salmonella Serogroup B.
Dong Soo KIM ; Ki Sup CHUNG ; Dong Shik CHIN ; Seung Hoon CHOI ; Eui Ho HWANG
Journal of the Korean Pediatric Society 1986;29(2):103-106
No abstract available.
Empyema*
;
Gastroenteritis*
;
Salmonella*
;
Urinary Bladder*
6.MR Findings of Brainstem Injury.
Sang Joon KIM ; Dae Chul SUH ; Choong Ki PARK ; Woo Cheol HWANG ; Man Soo PARK
Journal of the Korean Radiological Society 1995;32(2):237-241
PURPOSE: To analyze the characteristies of traumatic brainstem injury by CT and MR MATERIALS AND METHODS: CT and MR studies of 10 patients with traumatic brainstem lesion in MR were retrospectively reviewed, particularly attended to location, signal intensity and associated lesions. RESULTS: CT failed to depict 8 of 10 brainstem lesions. All lesions were detected in MR images with T2-weighted images showing higher detection rate (n=10) (100%) than Tl-weighted images (n=3) (30%) or CT (n=2) (20%). The brainstem lesions located in the dorsolateral aspects of the rostral brainstem(mid brain and upper pons)in 7 (70%) cases, in ventral aspects of rostral brain in 2 (20%) cases and in median portion of pons in 1 (10%) case. Corpus callosal (n=5), Iobar white matter(n=5) diffuse axonal injury, and 2 hemorrhagic lesions in basal ganglia were the associated findings. CONCLUSION: MR imaging is more helpful than CT in the detection of brainstem injury, especially T2 weighted images. Primary brainstem lesions were typically located in the dorsolateral aspect of rostral brainstem(midbrain and upper pons). Corpus callosum and white matter lesions were frequently associated.
Basal Ganglia
;
Brain
;
Brain Stem*
;
Corpus Callosum
;
Diffuse Axonal Injury
;
Humans
;
Magnetic Resonance Imaging
;
Pons
;
Retrospective Studies
7.Three Cases of Kaposi's Varicelliform Eruption.
Hyun Sug KIM ; Kae Yong HWANG ; Jong Soo CHOI ; Ki Hong KIM
Yeungnam University Journal of Medicine 1987;4(2):205-210
Kaposi's varicelliform eruption is a more or less generalized infection of the skin, and sometimes of internal organs, with herpes simplex, vaccinia or Coxsackie virus A 16; it appears in people who have atopic dermatitis or some other skin diseases. There is a predilection for infants and children, but no age-group is exempt. We reported 3 cases of Kaposi's varicelliform eruption with atopic dermatitis. They had characteristic multiple umbilicated vesicles on the sites that atopic dermatitis had been involved. A 14-year-old boy and a 2-month-old infant had fever. A 17-year-old boy had wide-spread vesicles. All three patients showed multinucleated giant cells on Tzanck test, that suggests herpes simplex virus origin. They were treated with acyclovir. Within 1 to 2 days after the initiation of the therapy, new lesions had ceased to develop. Most of the lesions were cleared in 7 days without complication.
Acyclovir
;
Adolescent
;
Child
;
Dermatitis, Atopic
;
Fever
;
Giant Cells
;
Herpes Simplex
;
Humans
;
Infant
;
Kaposi Varicelliform Eruption*
;
Male
;
Simplexvirus
;
Skin
;
Skin Diseases
;
Vaccinia
8.The effect of zonisamide in children with refractory epilepsies.
Ki Joong KIM ; Soo Ahn CHAE ; Tae Sung KO ; Dong Wook KIM ; Yong Seung HWANG
Journal of the Korean Pediatric Society 1993;36(8):1139-1145
Zonisamide was administered to 20 patients with refractory epileptic seizures. The mean duration of the administration was 6 months, and the mean dosage was 7.2 mg/kg/day. The efficacy of zonisamide was rated remarkable in 15% of the cases, improvement in 40%, and no change in 45%. The response rates of zonisamide were 62.5% for myoclonic seizures, 50% for tonic-clonic seizures, 80% for atonic seizures and 33.3% for atypical absence seizures. There was no correlation between the clinical response and dose or serum concentration of the drug. The adverse effects were observed in 35% of the cases which were drowsiness, dizziness, ataxia, nausea, and vomiting. In all cases, however, the administration of zonisamide could be continued.
Ataxia
;
Child*
;
Dizziness
;
Epilepsy*
;
Epilepsy, Absence
;
Humans
;
Nausea
;
Seizures
;
Sleep Stages
;
Vomiting
9.Comparison of anticancer drug efficacy using the short-term microplate culture and MTT dye reduction assay.
Nam Ki KIM ; Kwang Rae LEE ; Pyoung Han HWANG ; Jung Soo KIM
Journal of the Korean Pediatric Society 1993;36(10):1426-1433
Individual tumors, even those of the same histologic type, show varying sensitivity to specific cytotoxic agent. Therefore, sensitivity testing assume an increasingly important as an orientational aid in planning chemotherapy. In the past decade there have been many attempts to develop a chemosensitivity test that would predict the clinical effectiveness of various chemostherapeutic agents against human neoplasms. In the United States National Institue's anticancer drug screening program, a colorimetric assey based on the ability of live cells to reduce a tetrazolium-base compound(MTT) to a blue formazan product was used. There has been an increase in reports of a chemosensitivity assay that use tetrazolium dyes and current the assay is in use in our country. The efficacy of several anticancer drug (vincristine sulfate, Etoposide, doxorubicin CDDP) were evaluated using the in vitro chemosensitivity of MTT assay with two cancer cell lines (MOLT-4, KHOS/NP). The follows obtained. 1) CI50 on MOLT-4 are 0.55ng/ml and 0.81ng/ml for vincristine and oncovin, 142.30ng/ml and 78.75ng/ml for lastet and vepesid, and 19.75ng/ml, 20.43ng/ml and 8.66ng/ml for ADR, ADM and adriblastin, respectively. 2) CI50 on KHOS/NP are 691.35ng/ml, 873.73ng/ml, 1,205.22ng/ml, 768.81ng/ml and 672.19ng/ml for cisplan, cisplatin, cispatin, platinol and cisplatin G, and 9.22ng/ml, 11.46ng/ml and 4.28ng/ml for ADR, ADM and adriblastin, respectively. In conclusion the MTT dye reduction assay to anticancer drug sensitivity using short-term microplate culture might serve as a reliable tool for the selection of effective chemotherapeutic agents in patients with cancers.
Cell Line
;
Cisplatin
;
Coloring Agents
;
Doxorubicin
;
Drug Evaluation, Preclinical
;
Drug Therapy
;
Etoposide
;
Humans
;
United States
;
Vincristine
10.Two Cases of Allergic Contact Dermatitis to Betadine(R).
Kae Yong HWANG ; Byung Chun MUN ; Jong Soo CHOI ; Ki Hong KIM ; Jong Chul AHN
Yeungnam University Journal of Medicine 1986;3(1):387-393
Antiseptics are substances that kill or prevent the growth of microorganisms when applied to living tissue. They must be effective against microorganisms but must also retain their activity in presence of body fluids without being harmful locally or systemically. Among many antiseptics, Betadine(R) has been widely used because of its low toxicity and high germicidal efficacy. We reported 2 cases of allergic contact dermatitis to Betadine(R) in surgical patients. They had eczematous eruption along the Betadine(R) applying sites. Path tests Betadine(R) confirmed the diagnosis.
Anti-Infective Agents, Local
;
Body Fluids
;
Dermatitis, Allergic Contact*
;
Diagnosis
;
Humans