1.Clinical Studies on Sexual Precocity.
Journal of the Korean Pediatric Society 1986;29(3):23-32
No abstract available.
2.Two Cases Reports of Infantile Cortical Hyperostosis
Hyung Seok KIM ; Ki Sung HONG ; Ki Do HONG
The Journal of the Korean Orthopaedic Association 1981;16(4):951-954
The infantile cortical hyperostosis is relatively rare unknown cause disease. After the first report of a case of this was that of caffey in 1945, this disease is increasing in frequency. This disease characterized by subperiosteal new bone formation on various bone, leukocytosis, increased Erythrocyte Seidmentation Rate, fever. We experienced two cases of this and reported them in this paper with a brief review of tbe literature.
Erythrocytes
;
Fever
;
Hyperostosis, Cortical, Congenital
;
Leukocytosis
;
Osteogenesis
3.A Case of ALK-Negative Systemic Anaplastic Large Cell Lymphoma.
Hong Seok KIM ; Seung Joo SIM ; Dae Cheol KIM ; Jae Seok KIM ; Ki Hoon SONG ; Ki Ho KIM
Annals of Dermatology 2004;16(3):125-131
No abstract available.
Lymphoma, Large-Cell, Anaplastic*
4.Genitoplasty by horizontal osteotomy.
Young He JUNG ; Ki Young CHOI ; Seok Kwun KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1992;19(3):442-452
No abstract available.
Osteotomy*
5.Comparative study of serum soluble interleukin-2 receptor and hepatitis C virus RNA in patients with chronic hepatitis C virus infection.
Yoon Sun YANG ; Chang Seok KI ; Jong Won KIM
Korean Journal of Clinical Pathology 1997;17(5):781-790
BACKGROUND: T cell mediated immune destruction is an important mechanism of liver injury in patients with chronic hepatitis C. Serum levels of soluble interleukin-2 receptor(sIL-2R) seem to serve as a marker for the T cell activation and progressive liver injury, This study examined serum levels of sIft-2R and hepatitis C virus (HCV) RNA in patients with chronic HCV infection to determine the correlation with the severity of chronic hepatocellular damage. METHODS: Serum levels of sIft-2R in 73 patients with HCV infection (chronic hepatitis 52, liver cirrhosis 9, hepatocellular carcinoma 12) and 40 healthy controls were measured by sandwich enzyme immunoassay (CELLFREE, T Cell Sciences, USA). HCV RNA was quantified by QUANTIPLEX(TM) HCV RNA 2.0 assay (Chiron, USA) with duplication. This assay is a sandwich nucleic acid hybridization procedure using branched DNA amplification for the quantitation of HCV RNA. RESULTS: The sIL-2R levels of 52 patients with chronic hepatitis (591.4+/-238.7U/mL), 9 with liver cirrhosis(949.4+/-721.9 U/mL), and 12 with hepatocellular carcinoma (1,167.4+/- 554.4 U/mL) were significantly higher than those of healthy controls(370.8+/-71.8 U/mL) (p<0.001). A progressive and significant increase occurred in sIL-2R levels with chronic hepatitis C, liver cirrhosis and hepatocellular carcinoma (HCC) in order (p(0.001). The HCV RNA was detected in all patients and the means of HCV viral load were 3.3 MEq/mL in chronic hepatitis, 2.8 MEq/mL in cirrhosis, and 3.7 MEq/mL in HCC. There was no significant correlation between HCV RNA and the severity of liver injury in chronic HCV infection. There were no correlations among sIL-2R, HCV RNA and serum ALT. CONCLUSIONS: These results suggest that chronic hepatocellular injury by HCV progress mainly by T cell mediated immune response, not by direct cytopathic injury. Also, sIL-2R can be useful as a marker in monitoring the patients with HCV infection at high risk of getting HCC.
Carcinoma, Hepatocellular
;
DNA
;
Fibrosis
;
Hepacivirus*
;
Hepatitis C*
;
Hepatitis C, Chronic*
;
Hepatitis*
;
Hepatitis, Chronic*
;
Humans
;
Immunoenzyme Techniques
;
Interleukin-2*
;
Liver
;
Liver Cirrhosis
;
Nucleic Acid Hybridization
;
RNA
;
Viral Load
6.Comparative study of serum soluble interleukin-2 receptor and hepatitis C virus RNA in patients with chronic hepatitis C virus infection.
Yoon Sun YANG ; Chang Seok KI ; Jong Won KIM
Korean Journal of Clinical Pathology 1997;17(5):781-790
BACKGROUND: T cell mediated immune destruction is an important mechanism of liver injury in patients with chronic hepatitis C. Serum levels of soluble interleukin-2 receptor(sIL-2R) seem to serve as a marker for the T cell activation and progressive liver injury, This study examined serum levels of sIft-2R and hepatitis C virus (HCV) RNA in patients with chronic HCV infection to determine the correlation with the severity of chronic hepatocellular damage. METHODS: Serum levels of sIft-2R in 73 patients with HCV infection (chronic hepatitis 52, liver cirrhosis 9, hepatocellular carcinoma 12) and 40 healthy controls were measured by sandwich enzyme immunoassay (CELLFREE, T Cell Sciences, USA). HCV RNA was quantified by QUANTIPLEX(TM) HCV RNA 2.0 assay (Chiron, USA) with duplication. This assay is a sandwich nucleic acid hybridization procedure using branched DNA amplification for the quantitation of HCV RNA. RESULTS: The sIL-2R levels of 52 patients with chronic hepatitis (591.4+/-238.7U/mL), 9 with liver cirrhosis(949.4+/-721.9 U/mL), and 12 with hepatocellular carcinoma (1,167.4+/- 554.4 U/mL) were significantly higher than those of healthy controls(370.8+/-71.8 U/mL) (p<0.001). A progressive and significant increase occurred in sIL-2R levels with chronic hepatitis C, liver cirrhosis and hepatocellular carcinoma (HCC) in order (p(0.001). The HCV RNA was detected in all patients and the means of HCV viral load were 3.3 MEq/mL in chronic hepatitis, 2.8 MEq/mL in cirrhosis, and 3.7 MEq/mL in HCC. There was no significant correlation between HCV RNA and the severity of liver injury in chronic HCV infection. There were no correlations among sIL-2R, HCV RNA and serum ALT. CONCLUSIONS: These results suggest that chronic hepatocellular injury by HCV progress mainly by T cell mediated immune response, not by direct cytopathic injury. Also, sIL-2R can be useful as a marker in monitoring the patients with HCV infection at high risk of getting HCC.
Carcinoma, Hepatocellular
;
DNA
;
Fibrosis
;
Hepacivirus*
;
Hepatitis C*
;
Hepatitis C, Chronic*
;
Hepatitis*
;
Hepatitis, Chronic*
;
Humans
;
Immunoenzyme Techniques
;
Interleukin-2*
;
Liver
;
Liver Cirrhosis
;
Nucleic Acid Hybridization
;
RNA
;
Viral Load
7.Quantitation of Hepatitis B Virus DNA in Sera of HBsAg-Positive Patients Using a Branched DNA Signal Amplification Assay.
Chang Seok KI ; Yoon Sun YANG ; Jong Won KIM
Korean Journal of Clinical Pathology 1997;17(5):870-877
BACKGROUND: Several studies have demonstrated that quantitation of hepatitis B virus (HBV) DNA in sera of HBsAg-positive patients is more useful test for the assessment of infectivity and for the evaluation of disease status than previously utilized numerous serological markers and qualitative polymerase chain reaction for the detection of HBV DNA. We tried to measure serum HBV DNA using a branched DNA (bDNA) signal amplification assay, which is recently introduced and known to be a simple and nonradioisotopic method. METHODS: Total forty patients with HBsAg were randomly selected and serum HBV DNA was measured with duplication using bDNA signal amplification assay (QUANTIPLEXTM HBV DNA ASSAY, Chiron, USA). Quantitation was determined from a standard curve and expressed as HBV DNA equivalents/mL (Eq/mL; 1 Eq = 1 molecule of the primary HBV DNA standard). Serum HBeAg, aspartate aminotransferase (AST), alanine aminotransferase (ALT) , and soluble interleukin-2 receptor (sIL-2R) were compared with HBV DNA. RESULTS: Serum HBV DNA was quantitated in 13 patients (32.5%) (range 6.4x106-7.4x109 Eq/mL, mean 1.8x109 Eq/mL, CV 8.1%). All eleven patients (100%) with both HBsAg and HBeAg an4 2 of 29 patients (6.9%) with HBsAg but not with HBeAg showed measurable HBV DNA (p < 0.001). In addition, serum levels of AST, ALT, and sIL-2R were significantly higher in HBV DNA measured patients compared with those of unmeasured patients. CONCLUSIONS: Above results show that more than half the HBsAg-positive patients do not have enough HBV DNA which is measurable with boNA signal amplification assay but all of HBeAg-positive patients and some of HBeAg-negative patients do. In addition, HBV DNA quantitation might be correlated with the disease activity in HBsAg-positive patients because serum levels of AST, ALT, and sIL-2R are higher in patients measured with HBV DNA than unmeasured.
Alanine Transaminase
;
Aspartate Aminotransferases
;
Branched DNA Signal Amplification Assay*
;
DNA
;
Hepatitis B e Antigens
;
Hepatitis B Surface Antigens
;
Hepatitis B virus*
;
Hepatitis B*
;
Hepatitis*
;
Humans
;
Interleukin-2
;
Polymerase Chain Reaction
8.The Analysis of Factors Affecting the Corneal Endothelial Cells during Vitrectomy.
Ki Seok KIM ; Jin Seong YOO ; Noh Hoon KYAK
Journal of the Korean Ophthalmological Society 2000;41(12):2598-2602
No Abstract Available.
Endothelial Cells*
;
Vitrectomy*
9.The Result of the Dacryocystorhinostomy on the Chronic Dacryocystitis.
Byung Joo KIM ; Yong Seok YOO ; Han Ki CHANG
Journal of the Korean Ophthalmological Society 1991;32(9):715-719
We performed 75 cases of daryocystorhinostomy from Jan. 1988 to Dec. 1990. A routine dacryocystography was performed prior to operation in all cases. A modified T oti's method was applied as a surgical technique "H" shaped incision was done. Both anterior and posterior flaps were sutured adequately and vaseline guaze was used as a plugging agent for 7 to 10 days Success was achieved in 72(96.0%) of 75 cases. The causes of 3-failures were organized granulation tissue and trauma.
10.The Statistical Study of The Lateral Tibio
Hyeung Seok KIM ; Ki Do HONG ; Soon Hak HONG
The Journal of the Korean Orthopaedic Association 1988;23(5):1255-1258
The study was conducted to determine the lateral tibio-articular angle of ankle joint in 100 korean adults(160 cases) ranging from second to eight decades of age. The authors have defined as the lateral tibio-articular angle of ankle joint, that is the sharp angle between the lateral tibial axis which is the lateral longitudinal line through each midpoints of the upper and lower one third of the tibia, and the line to connect the anterior and posterior tips of the tibial articular surface of ankle joint. 1. It was 79.3°±3.4°in all cases. 2. It was 79.2°±3.6°in male and 79.6°±2.7°in female. It was reduced in male approximately 0.4°compared with female. 3. It was 79.1°±3.1°in the left side and 79.5°±3.6°in the right side. It was reduced approximately 0.4°in the left side compared with the right side. 4. It was reduced approximately 0.9°in the left side compared with both sides of the same person.
Adult
;
Ankle Joint
;
Ankle
;
Female
;
Humans
;
Male
;
Statistics as Topic
;
Tibia