No abstract available.

Two cases of multiple epiphyseal dysplasia in a 3 years old boy and a 10 years old girl are reported. Since Fairbanks description of the disease in 1935, it has been a well recognized entity which is a rare congenital developmental error characterized by mottling or irregularity in density and outline of several of the developing epiphyses, and dwarfism. Many reports indicate a definite hereditary and familiar distribution, particularly one series in which there were 10 cases in a single family, But in this report parent and siblings, all of whom were examined clinically, and roentgenographically showed no demonstrable stigmata of any growth disturbance. As the child develops, a subnormal growth rate becomes more obvious. The vertebrae are usually not affected so that dwarfing is confined to the extremity. The process rarely comes to attention of the physician until the child begin to walk, and then it is noted that one has a waddling gait and short stubby digits of the hands and feet. Intelligence is unaffected. Prognosis as to life expectancy and range of activity is good.
Child ; Christianity ; Dwarfism ; Epiphyses ; Extremities ; Female ; Foot ; Gait ; Hand ; Humans ; Intelligence ; Life Expectancy ; Male ; Osteochondrodysplasias ; Parents ; Prognosis ; Siblings ; Spine

One case of osteoid osteoma in the lamina of the fifth lumbar spine with hamstring muscle tightness was experienced and successfully treated by surgery at the department of orthopedic surgery in Seoul National University Hospital. Literature on the subject was reviewed in detail.
Muscle Tonus ; Orthopedics ; Osteoma, Osteoid ; Seoul ; Spine

The fracture of femoral head with concommittant hip dislocation is very rare and the choice of its treatment is still controversial. Various methods of treatment such as Judet prosthesis (Palin, 1954), mold arthroplasty (Lipscomb, 1958), Thompson endomedullary prosthesis (Burman, 1958), and bone peg fixation have been adopted without much success, but Sarmiento and Laird (1973) recently reported a case of femoral head fracture that was successfully treated with screw fixation of the fracture fragments. The authors present a case of femoral head fracture combined with dislocation of ipsilateral hip that was treated successfully by the Sarmientos screw fixation method. A two year follow-up indicated a normal hip function, restored without sequellae. The authors consider this method very valuable as a first step treatment.
Arthroplasty ; Dislocations ; Follow-Up Studies ; Fungi ; Head ; Hip Dislocation ; Hip ; Methods ; Prostheses and Implants

One case of cerebral embolism developed during cessation of supraventricular tachycardia in Wolff-Parkinson-White syndrome is reported with brief review. Twenty five years old, male was admitted to Seoul National University hospital with palpitation. He had numerous episodes of paroxysmal tachycardia for 3 years. He was diagnosed as Wolff-Parkinson-White syndrome at this hospital, ca 6 months prior to admission. Wolff-Parkinson-White syndrome was improved with atropine test at that time. The electrocardiogram on admission revealed Wolff-Parkinson-White synd rome associated with supraventricular tachycardia. He developed cerebral embolism after paroxysmal tachycardia of 22 days.
Atropine ; Electrocardiography ; Humans ; Intracranial Embolism* ; Male ; Seoul ; Tachycardia, Paroxysmal* ; Tachycardia, Supraventricular ; Wolff-Parkinson-White Syndrome*

We found a mistake in our recently published article.

No abstract available.
Adult* ; Esophageal Atresia* ; Fistula* ; Humans

No abstract available.
Fournier Gangrene ; Testis

Capsular fibrosis and contracture occurs in most breast reconstruction patients who undergo radiotherapy, and there is no definitive solution for its prevention. Simvastatin was effective at reducing fibrosis in various models. Peri-implant capsular formation is the result of tissue fibrosis development in irradiated breasts. The purpose of this study was to examine the effect of simvastatin on peri-implant fibrosis in rats. Eighteen male Sprague-Dawley rats were allocated to an experimental group (9 rats, 18 implants) or a control group (9 rats, 18 implants). Two hemispherical silicone implants, 10 mm in diameter, were inserted in subpanniculus pockets in each rat. The next day, 10-Gy of radiation from a clinical accelerator was targeted at the implants. Simvastatin (15 mg/kg/day) was administered by oral gavage in the experimental group, while animals in the control group received water. At 12 weeks post-implantation, peri-implant capsules were harvested and examined histologically and by real-time polymerase chain reaction. The average capsular thickness was 371.2 μm in the simvastatin group and 491.2 μm in the control group. The fibrosis ratio was significantly different, with 32.33% in the simvastatin group and 58.44% in the control group (P < 0.001). Connective tissue growth factor (CTGF) and transforming growth factor (TGF)-β1 gene expression decreased significantly in the simvastatin group compared to the control group (P < 0.001). This study shows that simvastatin reduces radiation-induced capsular fibrosis around silicone implants in rats. This finding offers an alternative therapeutic strategy for reducing capsular fibrosis and contracture after implant-based breast reconstruction.
Administration, Oral ; Animals ; Breast/*drug effects/metabolism/pathology/radiation effects ; *Breast Implants ; Connective Tissue Growth Factor/genetics/metabolism ; Fibrosis ; Gamma Rays ; Male ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Silicone Gels/*chemistry ; Simvastatin/*pharmacology ; Transforming Growth Factor beta1/metabolism

Capsular fibrosis and contracture occurs in most breast reconstruction patients who undergo radiotherapy, and there is no definitive solution for its prevention. Simvastatin was effective at reducing fibrosis in various models. Peri-implant capsular formation is the result of tissue fibrosis development in irradiated breasts. The purpose of this study was to examine the effect of simvastatin on peri-implant fibrosis in rats. Eighteen male Sprague-Dawley rats were allocated to an experimental group (9 rats, 18 implants) or a control group (9 rats, 18 implants). Two hemispherical silicone implants, 10 mm in diameter, were inserted in subpanniculus pockets in each rat. The next day, 10-Gy of radiation from a clinical accelerator was targeted at the implants. Simvastatin (15 mg/kg/day) was administered by oral gavage in the experimental group, while animals in the control group received water. At 12 weeks post-implantation, peri-implant capsules were harvested and examined histologically and by real-time polymerase chain reaction. The average capsular thickness was 371.2 μm in the simvastatin group and 491.2 μm in the control group. The fibrosis ratio was significantly different, with 32.33% in the simvastatin group and 58.44% in the control group (P < 0.001). Connective tissue growth factor (CTGF) and transforming growth factor (TGF)-β1 gene expression decreased significantly in the simvastatin group compared to the control group (P < 0.001). This study shows that simvastatin reduces radiation-induced capsular fibrosis around silicone implants in rats. This finding offers an alternative therapeutic strategy for reducing capsular fibrosis and contracture after implant-based breast reconstruction.
Administration, Oral ; Animals ; Breast/*drug effects/metabolism/pathology/radiation effects ; *Breast Implants ; Connective Tissue Growth Factor/genetics/metabolism ; Fibrosis ; Gamma Rays ; Male ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Silicone Gels/*chemistry ; Simvastatin/*pharmacology ; Transforming Growth Factor beta1/metabolism