No abstract available.
Temporal Bone*

We report a case of type IV hyperlipoproteinemia associated with xanthoma tuberosum and diabets mellitus in a 48 year old female patient. She had several yellowish-brown papules on the knees and palms. The blood glucose level was elevated and serum lipid and lipoprotein analysis revealed patterns of type IV hyperlipoproteinemia. Histopathologic findings of yellowish-brown papules on the knee showed the aggregation of foam cells in the dermis. She has been treated with diet control and hypolipidemic drug(lovastatin and procetofen) and is under our continuing supervision.
Blood Glucose ; Dermis ; Diabetes Mellitus* ; Diet ; Female ; Foam Cells ; Humans ; Hyperlipoproteinemia Type IV* ; Knee ; Lipoproteins ; Middle Aged ; Organization and Administration ; Xanthomatosis*

We report a case of subungual solitary glomus tumor in a 28-year-old female, who has suffered from pain and tenderness of the left 4th finger tip for about 5 years. Simple surgical excision was performed for removal of the tumor mass and for the relief of the subjective symptoms. No recurrence has been observed for 5 months following excision of the tumor.
Adult ; Female ; Fingers ; Glomus Tumor* ; Humans ; Recurrence

BACKGROUND: Systemic PUVA therapy is a widely used method for treatment of vitiligo and psoriasis. However, there have been few studies concerning complications of systemic PUVA therapy. OBJECTIVE: We examined the dermatologic and ophthalmologic manifestations in patients receiving PUVA therapy. METHOD: We studied 42 patients who received systemic PUVA therapy for more than six months in our department. RESULTS: The results are summarized as follows. 1. Among the 42 patients, the number of male and female patients were 18(42.9%) and 24(57.1%) respectively. The mean age at the start of PUVA was 42 years and mean cumulative UVA dase was 996 J/cm2. 2. Among the 42 patients, hyperpigmentation found in 9(21.4%), PUVA lentigo in 8(19.0%), pruritus in 5(11.9%) and burn in 3(7.1%). 3. The ophthalmologic manifestations were conjunctivitis(13 cases, 31.0%), pteygium(7 cases, 16.7%), pingueculum(6 cases, 14.3%) and cataract(3 cases, 7.1%). CONCLUSION: Long term exposure to PUVA causes chronic clinical side effects of PUVA. Therefore careful follow-up of patients who receive long term PUVA therapy is necessary.
Burns ; Female ; Follow-Up Studies ; Humans ; Hyperpigmentation ; Lentigo ; Male ; Pruritus ; Psoriasis ; PUVA Therapy* ; Vitiligo

BACKGROUND: Tinea pedis is one of the most comrnon dermatoses in the general population. But its prevalence in the general populat,ion was not yet reported in Korea. OBJECTIVE: Prevalence of tinea pedis and associated tinea unguium were checked in the general population. METHODS: Six hundred fifty eight persons from 179 families of the college students were evaluated. Clinical examinatior. for tinea pedis and onychomycosis and collecting scales from the suspicious lesions of the family members were perforrned by educated college students. Then dermatologists exarnined those specimens mycologically by KOH ~tnount and fungal culture. RESULTS: The results were as follows 1. The prevalence of tinea pedis was 41.2% in the studied 658 persons. 2. Among all 271 patients with tinea pedis, 201 strains of dermatophytes were isolated. They were 143 strains of Trichophyton(T) rubrum, 49 strains of T. mentagrophytes and 9 mixed infections of T. rubrum and T. mentagrophytes. In the co existence of i,inea pedis and tinea unguiurn, isolated species were corresponding. 3. Among 179 families, 143 families (79.9%) had at least one patient with tinea pedis. The isolated species of derrnatophytes in a farnily were one organism, 71.4% and two or more organisms, 28.6% of 77 familiys with more than one patient. CONCLUSION: In our study, the prevalence rate of tinea pedis was 41.2%. That suggests that tinea pedis is a wide spr .ad disease in healthy adult in Korea.
Adult ; Arthrodermataceae ; Coinfection ; Daegu* ; Humans ; Korea ; Onychomycosis ; Prevalence* ; Skin Diseases ; Tinea Pedis* ; Tinea* ; Weights and Measures

We experienced a case of brainstem encephalitis that is possibly caused by herpes simplex virus infection in a 3 year-old girl. The diagnosis was made by clinical symptoms, neurologic exam, serologic test, brain CT, brain MRI and brainstem biopsy. Herpes simplex virus specific antibody was detected from cerebrospinal fluid and the titer was 11.78 by enzyme immunoassay. Stereotaxic brainstem biopsy was done for differenciate from brainstem glioma at 24th hospital day. Patient was treated with acyclovir and improved in association with neurologic sequallae at 3 months later. Brief review of literatures was made.
Acyclovir ; Biopsy ; Brain ; Brain Stem* ; Cerebrospinal Fluid ; Child, Preschool ; Diagnosis ; Encephalitis* ; Female ; Glioma ; Humans ; Immunoenzyme Techniques ; Magnetic Resonance Imaging ; Neurologic Manifestations ; Serologic Tests ; Simplexvirus

PURPOSE: Sulphomucin is secreted by immature foveolar cells of the stomach and is expressed in gastric adenocarcinomas. Carcinoembryonic antigen (CEA) is well known to be expressed in gastric adenocarci nomas and is correlated with the cellular differentiation of gastric adenocarcinomas. However, at the moment, there are no conclusions about the relationships between the expression of sulphomucin and pathological classifications. METHODS: This study was designed to determine the significance of expression of sulphomucin and CEA in advanced gastric adenocarcinomas. Also, these two factors were compared with established clinicopathological prognostic factors. Thirty-two paraffin-embedded surgical specimens of gastric adenocarcinomas were obtained from January 1993 to December 1995 and were selected for study. The expressions of sulphomucin and CEA were studied by using the Spicer method and immunohistochemical staining with CEA 2-7 monoclonal antibody. RESULTS: The expressions of sulphomucin and CEA were positive in 9 (28%) cases and 25 (78%) cases, respectively. There was a significant correlation between sulphomucin expression and histologic differentiation (p<0.05). However, the expression of CEA was correlated with neither clinopathological factors nor sulphomucin expression. CONCLUSION: These results suggest that expressions of sulphomucin are well correlated with cellular differentiations of advanced gastric adenocarcinomas.
Adenocarcinoma* ; Carcinoembryonic Antigen ; Classification ; Noma ; Stomach

PURPOSE: Sulphomucin is secreted by immature foveolar cells of the stomach and is expressed in gastric adenocarcinomas. Carcinoembryonic antigen (CEA) is well known to be expressed in gastric adenocarci nomas and is correlated with the cellular differentiation of gastric adenocarcinomas. However, at the moment, there are no conclusions about the relationships between the expression of sulphomucin and pathological classifications. METHODS: This study was designed to determine the significance of expression of sulphomucin and CEA in advanced gastric adenocarcinomas. Also, these two factors were compared with established clinicopathological prognostic factors. Thirty-two paraffin-embedded surgical specimens of gastric adenocarcinomas were obtained from January 1993 to December 1995 and were selected for study. The expressions of sulphomucin and CEA were studied by using the Spicer method and immunohistochemical staining with CEA 2-7 monoclonal antibody. RESULTS: The expressions of sulphomucin and CEA were positive in 9 (28%) cases and 25 (78%) cases, respectively. There was a significant correlation between sulphomucin expression and histologic differentiation (p<0.05). However, the expression of CEA was correlated with neither clinopathological factors nor sulphomucin expression. CONCLUSION: These results suggest that expressions of sulphomucin are well correlated with cellular differentiations of advanced gastric adenocarcinomas.
Adenocarcinoma* ; Carcinoembryonic Antigen ; Classification ; Noma ; Stomach

OBJECTIVE: We conducted a study of the effect of an organic solvent on the failure of ovarian function after exposure to 2-bromopropane for 7 years. METHODS: We conducted a study on 25 female workers in a manufactory who were exposed to 2-bromopropane in 1994. Some of them experienced premature ovarian failure. We have investigated their recoveries from ovarian function and checked LH, FSH, E2, BMD for 7 years of period. RESULTS: 16 among 25 workers experienced amenorrhea, but the rest of them did not report amenorrhea. In 10 out of the 16 amenorrhea patients, recovery from amenorrhea were seen, but 6 did not recover from amenorrhea. Through ovarian biopsy, it was observed in the amenorrhea patients that mature follicles were lost and only primordial follicles were present. Through HRT, gradual decrease in FSH and increase in E2. in the amenorrhea patients were found. Also, their BMD were decreased, but gradually increased with female hormone replacement therapy. CONCLUSION: The study confirms that the exposure to 2-bromopropane leads to the serious ovarian toxicity and ovarian failure as well. In such case, the failure of ovarian function, which is reversible change, can be recovered after long-term periods. A significant factor which affect ovarian failure and recovery from ovarian function is patient's age. In industrial environment, physical and psychological damage due to the use of and exposure to chemical materials will likely increase. Hence, more studies of industrial materials used in working conditions are needed.
Amenorrhea ; Biopsy ; Female ; Follow-Up Studies* ; Hormone Replacement Therapy ; Humans ; Menopause, Premature ; Primary Ovarian Insufficiency

OBJECTIVE: Human MSCs (hMSCs) have the potential to differentiate along different lineages. Despite their potential clinical utilities for cellular and gene therapy, the fate of MSCs derived from human cord blood (UBMSCs) after systemic administration is mostly unknown. In this study we cultured UBMSCs and investigated distribution of them injected into the intravenous routes. METHODS: By flow cytometry, we investigated whether MSCs from human umbilical cord blood have similar characteristics of MSCs. In addition we induced those cells into the osteocyte and adipocyte to determine the characteristics of MSCs. UBMSCs were marked by transfection with LacZ-adeno virus and distribution of the injected cells were examined by x-gal staining in immuno-deficient mice. RESULTS: Umbilical cord blood-derived mononuclear cells, when set in culture, gave rise to adherent cells. Preterm, as compared with term pregnancy, cord blood is richer in MSCs. UBMSCs expressed several MSCs-related antigen (CD29 and CD44). Under appropriate culture conditions, UBMSCs were induced to differentiate to the osteocyte, and adipocyte lineages. UBMSCs were engrafted into various tissues after intravenous administration. When UBMSCs were transplanted into the distant site from cryogenic injury of mice brain, cells were preferentially migrated into the injured area. CONCLUSION: These results demonstrate that UBMSCs have the ability to proliferate extensively in culture, and they maintain their multi-lineage differentiation potential in vitro, and that they can integrate into various tissues after transplantation and migrate to injured area. Therefore, UBMSCs are promising candidates for developing cell-based therapeutic approaches for postnatal tissue repair.
Adipocytes ; Administration, Intravenous ; Animals ; Brain ; Fetal Blood* ; Flow Cytometry ; Genetic Therapy ; Humans* ; Mesenchymal Stromal Cells* ; Mice ; Osteocytes ; Pregnancy ; Transfection ; Umbilical Cord*