Additional two cases of Klinefelter's syndrome with a literatural review was presented Two cases were revealed characteristics of Klinefelter's syndrome such as small testes, hyalinization of seminiferous tubules, azoospermia, increased FSH, normal 17-ketogteroid and positive sex chromatin. One case was associated with left inguinal crytorchidism.
Azoospermia ; Hyalin ; Klinefelter Syndrome* ; Seminiferous Tubules ; Sex Chromatin ; Testis

No abstract available.
Child* ; Gastritis* ; Humans

PURPOSE: Ventricular late potentials have been shown to predict malignant ventricular arrhythmia and sudden cardiac death in patients with myocardial infarction and cardiomyopathy. Low amplitude and high frequency potentials at the end of the QRS complex can be detected on the body surface using signal-averaged electrocardiogram(SAECG). This study determines the age-related criteria of SAECG parameters and age-related differences. METHODS: SAECGs were obtained in 58 healthy children in five age groups(<1mo, 1-11mo, 1-5yr, 6-11yr, and 12-15yr). Three orthogonal leads(X, Y, Z) triggered with R-waves were amplified. In all recordings, a minimum of 250 beats were averaged after filtering with a 40Hz high- pass filter and 250Hz low-pass filter with noise level less than 0.7microvolt. RESULTS: The filtered QRS(f-QRS) duration was low, and the root mean square amplitude of terminal 40ms of f-QRS(RMS40) was high before 6years of age. The duration of low amplitude signal under 40microvolt(LAS) and late duration(LD) changed little during childhood. The criteria for significant ventricular late potential were as follows : f-QRS>98ms, RMS40<105microvolt, LAS>27ms, and LD>40ms for <1mo; f-QRS>109ms, RMS40<98microvolt, LAS>20ms, and LD>49ms for 1-11mo; f-QRS>114ms, RMS40<33microvolt, LAS>33ms, and LD>39ms for 1-5yr; f-QRS>112ms, RMS40<39 microvolt, LAS>30ms, and LD>45ms for 6-11yr; f-QRS>117ms, RMS40<18microvolt, LAS>37ms, and LD>30ms for 12-15yr. RMS40 and LAS correlated with f-QRS duration(r=-0.75, and 0.45 respectively, P<0.05), suggesting that these parameters are associated with ventricular muscle thickness and ventricular conduction time. CONCLUSION: Age-related differences in SAECG parameters may be due to ventricular muscle thickness and ventricular conduction time. This should be considered for the evaluation of ventricular late potential.
Arrhythmias, Cardiac ; Cardiomyopathies ; Child* ; Death, Sudden, Cardiac ; Electrocardiography* ; Humans ; Myocardial Infarction ; Noise

Tuberculosis cutis orificialis (TCO) is a rare manifestation of cutaneous tuberculosis that is caused by auto-inoculation of mycobacteria in patients with advanced internal tuberculosis. TCO occurs in oral, perianal, or genital mucosa and adjacent skin. The tongue is the most frequently affected site, but the perianal area can also be affected. A 39-year-old male presented with a 4-month history of painful ulcers on the perianal area. The histopathologic findings revealed granulomatous infiltrates composed of epithelioid cells and Langhans-type giant cells in the dermis, and a few acid-fast bacilli noted on Ziehl-Neelsen staining. The polymerase chain reaction (PCR) was positive for Mycobacterium tuberculosis and the chest X-ray showed findings consistent with active pulmonary tuberculosis in both upper lung zones. The skin lesion showed complete resolution 2 months after the start of treatment with antituberculosis agents. We report a case of TCO with perianal involvement in a patient with underlying active pulmonary tuberculosis.
Adult ; Dermis ; Epithelioid Cells ; Giant Cells, Langhans ; Humans ; Lung ; Male ; Mucous Membrane ; Mycobacterium tuberculosis ; Polymerase Chain Reaction ; Skin ; Thorax ; Tongue ; Tuberculosis ; Tuberculosis, Cutaneous ; Tuberculosis, Pulmonary ; Ulcer

Primary inoculation tuberculosis results from the direct inoculation of Mycobacterium tuberculosis into the skin of a person who has no natural or artificially acquired immunity to the organism. The pathogenesis requires a break in the skin from an abrasion or injury that allows entry of the tubercle bacilli. We report 3 cases of primary inoculation tuberculosis resulting from illegal acupuncture. Three patients over 70 years old presented with erythematous, ulcerative, indurated plaques on the back. Skin lesions had developed at the acupuncture sites 1 or 2 weeks after a session of acupuncture, which was intended to relieve back pain. An unlicensed, non-medically trained person conducted each session. The patients' past medical and family histories were unremarkable. Granulomatous inflammatory infiltration and acid-fast bacilli were observed histologically. M. tuberculosis was identified by mycobacterial culture and polymerase chain reaction. Nine months after the initiation of antituberculosis medication, skin lesions improved, and no evidence of recurrence or other organ involvement was observed at the 1-year follow-up visit.
Acupuncture ; Adaptive Immunity ; Back Pain ; Follow-Up Studies ; Humans ; Mycobacterium tuberculosis ; Polymerase Chain Reaction ; Recurrence ; Skin ; Tuberculosis ; Ulcer

Dermatofibromas are common benign fibrohistiocytic tumors that occur primarily as a solitary lesion, while multiple eruptive dermatofibromas (MEDFs) are a rare presentation of dermatofibromas and MEDFs are frequently associated with altered immunity, such as autoimmune diseases and immunosuppression. It is still unclear why MEDFs occur in association with these conditions, but this relationship may suggest that MEDFs are the result of an abortive immunoreactive process. We herein report on a case of MEDF that developed in a patient who was diagnosed with systemic lupus erythematosus.
Autoimmune Diseases ; Histiocytoma, Benign Fibrous ; Humans ; Immunosuppression ; Lupus Erythematosus, Systemic

Turner's syndrome (TS) is a genetic disorder caused by numeric and/or structural abnormalities of the X chromosome. It is characterized by a short stature, gonadal dysgenesis, and frequently by webbed neck, cubitus valgus, lymphedema, broad chest with wide spaced nipples, micrognathia, and brachimetacarpalia. Several cutaneous manifestations are associated with TS, including melanocytic nevi, hypertrophic scarring, and vitiligo. Rarely reported findings include hemangiomas, angiokeratomas, and halo nevi. We present a case of halo nevi and vitiligo in a 13-year-old girl with TS. To the best of our knowledge, halo nevi and vitiligo in TS has not been reported in the Korean literature.
Adolescent ; Angiokeratoma ; Cicatrix, Hypertrophic ; Gonadal Dysgenesis ; Hemangioma ; Humans ; Lymphedema ; Neck ; Nevus, Halo ; Nevus, Pigmented ; Nipples ; Thorax ; Turner Syndrome ; Vitiligo ; X Chromosome

BACKGROUND: Herpes simplex virus (HSV) and varicella zoster virus (VZV) are two of the most common causes of mucocutaneous vesicular eruptions. Their diagnoses are usually made clinically, but the clinical distinction between HSV and VZV is sometimes difficult. OBJECTIVE: We investigated the usefulness of polymerase chain reaction (PCR) and Tzanck test in patients with HSV and VZV infections. METHODS: From June 2008 through June 2010, a total of 396 patients (53 patients with HSV and 343 patients with VZV) were included in this study. Wright-stained smears of scrapings from the base of skin lesions and viral DNA amplification by PCR were examined in all patients. We compared the positivity rates of Tzanck test and PCR according to virus type and duration of skin lesions. RESULTS: The overall positivity rates of Tzanck test and PCR were 56.6% and 86.9%, respectively, and the difference between the positivity rates of the two tests was statistically significant (p<0.0001). The Tzanck test was positive in 41.5% and 58.9% of the HSV and VZV cases, respectively, and the difference was statistically significant (p=0.0259). For PCR, there were no significant differences between the HSV and VZV cases. The positivity rate of the Tzanck test decreased in the old skin lesions over 7 days; however, PCR method showed no significant differences in positivity rates according to duration of the skin lesions. CONCLUSION: PCR is a more sensitive method for the diagnoses of HSV and VZV infections, and it can be utilized for diagnosis even of old skin lesions.
Chickenpox ; DNA, Viral ; Herpes Simplex ; Herpesvirus 3, Human ; Humans ; Methylmethacrylates ; Polymerase Chain Reaction ; Polystyrenes ; Simplexvirus ; Skin ; Viruses

Congenital syphilis occurs when Treponema pallidum crosses the placenta during pregnancy or from contact with an infectious genital lesion during delivery. Cutaneous manifestations of congenital syphilis are relatively common, occurring in approximately 30% to 70% of patients. Maculopapular lesions, vesiculobullous lesions, condylomata lata lesions, annular lesions, and erythema multiforme-like targetoid lesions have been reported. We report on a premature newborn with congenital syphilis who presented with generalized bullous and pustular eruption and desquamation at birth.
Blister ; Erythema ; Humans ; Infant, Newborn ; Parturition ; Placenta ; Pregnancy ; Syphilis ; Syphilis, Congenital ; Treponema pallidum

No abstract available.
Biopsy, Fine-Needle*