1.Radiologic findings of mesoblastic nephroma.
Sei Jung OH ; Choon Sik YOON ; Ki Keun OH ; Myung Joon KIM
Journal of the Korean Radiological Society 1992;28(3):453-456
The mesoblastic nephroma is a rare benign renal tumor that frequently appears as a neonatal abdominal mass. This benign tumor is composed primarily of connective tissue that growth between intact nephrons and often replaces most of the renal parenchyme. Contrast media within the calyceal systems are seen within the tumor representing function by nephrons trapped within the mass. Prognosis after complete excision is excellent.
Connective Tissue
;
Contrast Media
;
Nephroma, Mesoblastic*
;
Nephrons
;
Prognosis
2.Topical fibronectin treatment in persistent corneal epithelial defects and corneal ulcers.
Ki San KIM ; Joon Sup OH ; In San KIM ; Joon Sung JO
Korean Journal of Ophthalmology 1990;4(1):5-11
Topical fibronectin, autologous and homologous, was used to treat nine patients (eleven eyes) with persistent corneal epithelial defects and corneal ulcers that failed to improve with standard therapy. The fibronectin was purified from autologous and homologous plasma by gelatin-Sepharose 4B affinity chromatography and administered topically, 500 micrograms/ml five times a day, for three weeks. Complete or nearly complete reepithelialization was achieved in all patients regardless of the source of fibronectin, autologous or homologous. But healing times varied. The average healing time was 41.7 +/- 14.7 days (35.7 +/- 12.4 days for autologous, 50.8 +/-14.4 days for homologous). Ocular symptoms were relieved significantly, and no side effects were observed. Over an average follow-up period of 5.2 months, no recurrences were noted. The results showed that homologous, as well as autologous, fibronectin was effective in patients with persistent corneal epithelial defects and corneal ulcers.
Administration, Topical
;
Adult
;
Aged
;
Blood Proteins/isolation & purification
;
Chromatography, Affinity
;
Corneal Diseases/*drug therapy
;
Corneal Ulcer/*drug therapy
;
Epithelium/drug effects
;
Female
;
Fibronectins/administration & dosage/isolation & purification/*therapeutic use
;
Humans
;
Male
;
Middle Aged
;
Visual Acuity
;
Wound Healing/drug effects
3.Comparison of tuberculin skin test results and adverse reactions following BCG vaccination in various infant groups of different ages.
In Seung PARK ; Dong Ki HAN ; Ho Joon LIM ; Sung Hee OH ; Hahng LEE
Journal of the Korean Pediatric Society 1993;36(9):1300-1307
Most authorities including WHO recommended immununizing infants with BCG as early as possible in areas prevalent with tuberculosis, however the optimal time for immunization has not well been characterized. Therefore the investigation was undertaken by vaccinating various infant groups of different ages with BCG and subsequently evaluating for adverse effects and tuberculin reactions, in order to contribute to undestanding the optimal time for immunization. Four hundred eighty three infants from the newborn nursery and the well baby clinic of Hanyang University Hospital who had no family history of tuberculosis were divided into three groups; group I of infants immunized within 7 days after birth, group II of infants immunized at about 1 month of age and group III of infants immunized at about 3 months of age. To each infant 0.1 ml of BCG(Institute Merieux, France) was administered intradermaly and approximately 3 months later tuberculin skin test using 5 TU PPD (NIH, Korea) was performed. Adverse reactions following BCG vaccination such as temperature elevation, induration alone or with suppuration at or near the injection site, and lymph node enlargement were also analyzed. The summary of the results is as follows. 1) Distribution of diameters of induration on tuberculin skin test illustrated incomplete bimodal configuration in all three different age groups. The means 2 standard deviations of diameters of indurations distributed on the main bells were 10.07 4.52 mm in group I, 10.65 3.82 mm in group II, and 10.83 5.08 mm in group III, and were not significantly different. 2) Criteria for positive tuberculin reaction was diameters of indurations equal to or greater than 6mm, 2 standard deviations below the mean values of diameters of indurations on the main bells. 3) The positive tuberculin reaction rates of 85.8% in group II and 88.6% in group III were significantly greater than 74.1% in group I. 4) Incidence of complications following BCG vaccination including temperature elevation, induration with suppuration, and localized lymphadenopathy was not different among three groups and the serious complications such as temperature elevation and lymphadenopathy were minimal. The data indicate that it is appropriate to immunize infants with BCG at about one month of age and the incidence of complications following BCG vaccination was not different among three infant groups of different ages.
Humans
;
Immunization
;
Incidence
;
Infant*
;
Infant, Newborn
;
Lymph Nodes
;
Lymphatic Diseases
;
Mycobacterium bovis*
;
Nurseries
;
Parturition
;
Skin Tests*
;
Skin*
;
Suppuration
;
Tuberculin Test
;
Tuberculin*
;
Tuberculosis
;
Vaccination*
4.CT Findings of Small Bowel Rupture after Abdominal Trauma.
Young Ju KIM ; Ki Joon SUNG ; Jin Hwan OH ; Joong Wha PARK ; Soo Yeun SHIM
Journal of the Korean Radiological Society 1995;32(5):757-761
PURPOSE: The accuracy of CT in the detection of injuries of the solid visceral organ is well established, but the value of CT in diagnosing small bowel rupture after abdominal trauma is controversal. This study was conducted to ascertain CT finding of small bowel rupture result from abdominal trauma. MATERIALS AND METHODS: A retrospective analysis of preoperative abdominal CT findings in 40 patients was performed. Small bowel rupture was confirmed by surgery. Precontrast and postcontrast enhanced CT images were obtained in all patients. RESULTS: Diagnostic findings of small bowel rupture including pneumoperitoneum or retroperitoneal air, discontinuity of the bowel wall and extravasation of oral contrast materials were observed in 33 cases(83%). Intraperitoneal or retroperitoneal free air was seen in 31 cases(78%) and intraperitoneal or retroperitoneal free fluid collection was seen in 38 patients(95%). Small bowel wall was thickened in 31 cases(78%), bowel wall was enhanced in 12 cases(30%) and bowel wall discontinuity and extravasation of oral contrast material was seen in 5 cases, respectively. CONCLUSION: The CT scan is sensitive and effective modality for evaluation of small bowel rupture after abdominal trauma, because of high detectability of diagnostic and suggestive CT findings.
Contrast Media
;
Humans
;
Pneumoperitoneum
;
Retrospective Studies
;
Rupture*
;
Tomography, X-Ray Computed
5.A survey of deaths in hospitalized patients for pulmonary tuberculosis.
Seung Joon OH ; Ki Heon YOON ; Jee Hong YOO ; Hong Mo KANG
Tuberculosis and Respiratory Diseases 1993;40(6):694-699
No abstract available.
Humans
;
Tuberculosis, Pulmonary*
6.Inhibitory of γ-aminobutyric acid on the contractility of isolated rat vas deferens.
Ki Young AHN ; Oh Cheol KWON ; Jeoung Hee HA ; Kwang Youn LEE ; Won Joon KIM
Yeungnam University Journal of Medicine 1992;9(2):382-395
GABA is an inhibitory neurotransmitter in central nervous system and produce sedative, antianxiety and muscle relaxing effects via GABA(A) receptor or GABA(B) receptor. Recently it is known that GABA is widely distributed throughout peripheral organs and may play a physiological role in certain organ. The vas deferens is innervated by species-difference. These study, therefore, was performed to investigate the mode and the mechanism of action of GABA on the norepinephrine-, ATP- and electric stimulation-induced contraction of vas deferens of rat. Sprague-Dawley rats were sacrificed by cervical dislocation. The smooth muscle strips were isolated from the prostatic portion and were mounted in the isolated muscle bath. PSS in the bath was aerated with 95/5%-O₂/CO₂ at 33℃. Muscle tensions were measured by isometric tension transducer and were recorded by biological recording system. 1. GABA, muscimol, a GABA(A) agonist, and baclofen, a GABA(B) agonist inhibited the electric field stimulation (EFS, 0.2Hz, 1mSec, 80V, monophasic square wave)-induced contraction with a rank order of potency of GABA greater than baclofen greater than muscimol. 2. The inhibitory effect of GABA was antagonized by delta aminovaleric acid (DAVA), a GABA(B) antagonist, but not by bicuculline, a GABA(A) intagonist. 3. The inhibitory effect of baclofen was antagonized by DAVA, but the effect of muscimol was not antagonized by bicuculline. 4. Exogenous norepinephrine (NE) and ATP contracted muscle strip concentration dependently, but the effect of acetylcholine was negligible and GABA did not affect the NE-and ATP-induced contractions. 5. GABA, baclofen and muscimol did not affect basal tone, and GABA did not affect the NE-and ATP-induced contractions. 6. EFS-induced contraction was inclucling 2 distinctable components. The first phasic component was inhibited by beta gamma-methylene ATP (mATP), a desensitizing agent of APT receptor and the second tonic component was reduced by pretreatment of reserpine (3 mg/Kg, IP). 7. GABA inhibited the EFS-induced contraction of reserpinized strips, but not the mATP-treated strips. These results suggest that in the prostatic portion of the rat vas deferens, adrenergic and purinergic neurotransmissions are exist, and GABA inhibits the release of ATP via presynaptic GABA(B) receptor on the excitatory neurons.
Acetylcholine
;
Adenosine Triphosphate
;
Animals
;
Baclofen
;
Baths
;
Bicuculline
;
Central Nervous System
;
Dislocations
;
gamma-Aminobutyric Acid
;
Muscimol
;
Muscle, Smooth
;
Neurons
;
Neurotransmitter Agents
;
Norepinephrine
;
Rats*
;
Rats, Sprague-Dawley
;
Receptors, GABA-A
;
Reserpine
;
Transducers
;
Vas Deferens*
7.Occult Mediastinal Ganglioneuroblastoma Presenting with Myoclonic Encephalopathy as Paraneoplastic Syndrome.
Hahng LEE ; Dong Ki HAN ; Jae Won OH ; In Joon SEOL ; Eun Kyung HONG ; Seok Chol JEON
Journal of the Korean Pediatric Society 1994;37(5):695-700
Ganglioneruroblastoma and neuroblastoma are among commonest types of childhood malignancy and a number of unique paraneoplastic syndromes have associated with both localized and disseminated neuroblastoma. The coincidence of neuroblastoma and myoclonic encephalopathy or other paraneoplastic syndromes occurs relatively rare, and therefore, failure to recognize this association could result in delays in both diagnosis and treatment, and the result could prove to be unfortunately fatal. The mechanism which underlies the remote damaging effect of neural crest tumor, especially neuroblastoma, on the nervous system resulting in myoclonic encephalopathy is by no means clear. In addition the nature and the extent of the pathologic lesion are inconsistent. We experienced a case of myoclonic encephalopathy associated with an occult mediastinal ganglioneuroblastoma in a 22-month-old girl who was hospitalized for inability to walk without support and tilting of the head to the left side. She became increasingly ataxic, and during the hospitalization myoclonic jerks of upper extremities and head along with chaotic, rapidly flickering, multidirectional spontaneous eye movements, were noted. Laboratory data included normal complete blood count, urinalysis, BUN and creatinine, electrolytes and bone marrow. Chest X-ray and chest CT revealed a relatively well marginated right posterior mediastinal mass. In a 24 hours urine excretion test, VMA and catecholamines were increased. Over the next 2 weeks, a surgical exploration revealed a right posterior mediastinal mass. Microscopically the mass proved to be a ganglioneuroblastoma, extending to right innominate artery and right axillary lymph nodes. Within 2 weeks after the surgery, radiotherapy (2,400 rads) and chemotherapy (CTX, DTIC, VCR) were started, but corticosteroid was not used. She has been free of tumor and abnormal neurological systemic symptoms and signs for 1 1/2 year since the completion of chemotherapy. In the 3 1/2 years follow-up period, her neurologic symptoms has completely resolved by the completion of 2 years chemotherapy. We report a case of mycoclonic encephalopathy associated with hidden ganglioneuroblastoma in 22-month-old girl.
Blood Cell Count
;
Bone Marrow
;
Brachiocephalic Trunk
;
Catecholamines
;
Creatinine
;
Dacarbazine
;
Diagnosis
;
Drug Therapy
;
Electrolytes
;
Epilepsies, Myoclonic*
;
Eye Movements
;
Female
;
Follow-Up Studies
;
Ganglioneuroblastoma*
;
Head
;
Hospitalization
;
Humans
;
Infant
;
Lymph Nodes
;
Myoclonus
;
Nervous System
;
Neural Crest
;
Neuroblastoma
;
Neurologic Manifestations
;
Paraneoplastic Syndromes*
;
Radiotherapy
;
Thorax
;
Tomography, X-Ray Computed
;
Upper Extremity
;
Urinalysis
8.Anti-HCV EIA by three diagnostic reagent.
Young Chul OH ; Bum Ryoul CHOI ; Hyung Joon BAE ; Ki Hong KIM ; Sang In KIM
Korean Journal of Blood Transfusion 1992;3(1):47-53
No abstract available.
9.Multiple hamartomas(mesenchymomas) of the unilateral chest wall in infancy: CT findings.
Myung Joon KIM ; Choon Sik YOON ; Ki Keun OH ; Jong Tae LEE ; Woo Hee JUNG
Journal of the Korean Radiological Society 1992;28(5):794-797
A case of multiple hamartomas of the unilateral chest wall in a four month old infant is presented. There have been a few reports on the CT findings of the chest wall hamartoma in infancy. We describe bone changes of the ribs and mineralization of this rare tumor on the CT scan, and the locations of two separate masses.
Hamartoma
;
Humans
;
Infant
;
Miners
;
Ribs
;
Thoracic Wall*
;
Thorax*
;
Tomography, X-Ray Computed
10.The clinical experience of 1000 cases in open heart surgery.
Chung Ki CHUNG ; Bong Suck OH ; Sang Hyung KIM ; Dong Joon LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(3):271-279
No abstract available.
Heart*
;
Thoracic Surgery*