1.Two-year Follow-up after Visual Laser Ablation of Prostate (V-LAP) for BPH.
Jong Bo CHOI ; Dong Sun KIM ; Duck Ki YOON
Korean Journal of Urology 2000;41(12):1546-1550
No abstract available.
Follow-Up Studies*
;
Laser Therapy*
;
Prostate*
2.Comparative study of serum soluble interleukin-2 receptor and hepatitis C virus RNA in patients with chronic hepatitis C virus infection.
Yoon Sun YANG ; Chang Seok KI ; Jong Won KIM
Korean Journal of Clinical Pathology 1997;17(5):781-790
BACKGROUND: T cell mediated immune destruction is an important mechanism of liver injury in patients with chronic hepatitis C. Serum levels of soluble interleukin-2 receptor(sIL-2R) seem to serve as a marker for the T cell activation and progressive liver injury, This study examined serum levels of sIft-2R and hepatitis C virus (HCV) RNA in patients with chronic HCV infection to determine the correlation with the severity of chronic hepatocellular damage. METHODS: Serum levels of sIft-2R in 73 patients with HCV infection (chronic hepatitis 52, liver cirrhosis 9, hepatocellular carcinoma 12) and 40 healthy controls were measured by sandwich enzyme immunoassay (CELLFREE, T Cell Sciences, USA). HCV RNA was quantified by QUANTIPLEX(TM) HCV RNA 2.0 assay (Chiron, USA) with duplication. This assay is a sandwich nucleic acid hybridization procedure using branched DNA amplification for the quantitation of HCV RNA. RESULTS: The sIL-2R levels of 52 patients with chronic hepatitis (591.4+/-238.7U/mL), 9 with liver cirrhosis(949.4+/-721.9 U/mL), and 12 with hepatocellular carcinoma (1,167.4+/- 554.4 U/mL) were significantly higher than those of healthy controls(370.8+/-71.8 U/mL) (p<0.001). A progressive and significant increase occurred in sIL-2R levels with chronic hepatitis C, liver cirrhosis and hepatocellular carcinoma (HCC) in order (p(0.001). The HCV RNA was detected in all patients and the means of HCV viral load were 3.3 MEq/mL in chronic hepatitis, 2.8 MEq/mL in cirrhosis, and 3.7 MEq/mL in HCC. There was no significant correlation between HCV RNA and the severity of liver injury in chronic HCV infection. There were no correlations among sIL-2R, HCV RNA and serum ALT. CONCLUSIONS: These results suggest that chronic hepatocellular injury by HCV progress mainly by T cell mediated immune response, not by direct cytopathic injury. Also, sIL-2R can be useful as a marker in monitoring the patients with HCV infection at high risk of getting HCC.
Carcinoma, Hepatocellular
;
DNA
;
Fibrosis
;
Hepacivirus*
;
Hepatitis C*
;
Hepatitis C, Chronic*
;
Hepatitis*
;
Hepatitis, Chronic*
;
Humans
;
Immunoenzyme Techniques
;
Interleukin-2*
;
Liver
;
Liver Cirrhosis
;
Nucleic Acid Hybridization
;
RNA
;
Viral Load
3.Comparative study of serum soluble interleukin-2 receptor and hepatitis C virus RNA in patients with chronic hepatitis C virus infection.
Yoon Sun YANG ; Chang Seok KI ; Jong Won KIM
Korean Journal of Clinical Pathology 1997;17(5):781-790
BACKGROUND: T cell mediated immune destruction is an important mechanism of liver injury in patients with chronic hepatitis C. Serum levels of soluble interleukin-2 receptor(sIL-2R) seem to serve as a marker for the T cell activation and progressive liver injury, This study examined serum levels of sIft-2R and hepatitis C virus (HCV) RNA in patients with chronic HCV infection to determine the correlation with the severity of chronic hepatocellular damage. METHODS: Serum levels of sIft-2R in 73 patients with HCV infection (chronic hepatitis 52, liver cirrhosis 9, hepatocellular carcinoma 12) and 40 healthy controls were measured by sandwich enzyme immunoassay (CELLFREE, T Cell Sciences, USA). HCV RNA was quantified by QUANTIPLEX(TM) HCV RNA 2.0 assay (Chiron, USA) with duplication. This assay is a sandwich nucleic acid hybridization procedure using branched DNA amplification for the quantitation of HCV RNA. RESULTS: The sIL-2R levels of 52 patients with chronic hepatitis (591.4+/-238.7U/mL), 9 with liver cirrhosis(949.4+/-721.9 U/mL), and 12 with hepatocellular carcinoma (1,167.4+/- 554.4 U/mL) were significantly higher than those of healthy controls(370.8+/-71.8 U/mL) (p<0.001). A progressive and significant increase occurred in sIL-2R levels with chronic hepatitis C, liver cirrhosis and hepatocellular carcinoma (HCC) in order (p(0.001). The HCV RNA was detected in all patients and the means of HCV viral load were 3.3 MEq/mL in chronic hepatitis, 2.8 MEq/mL in cirrhosis, and 3.7 MEq/mL in HCC. There was no significant correlation between HCV RNA and the severity of liver injury in chronic HCV infection. There were no correlations among sIL-2R, HCV RNA and serum ALT. CONCLUSIONS: These results suggest that chronic hepatocellular injury by HCV progress mainly by T cell mediated immune response, not by direct cytopathic injury. Also, sIL-2R can be useful as a marker in monitoring the patients with HCV infection at high risk of getting HCC.
Carcinoma, Hepatocellular
;
DNA
;
Fibrosis
;
Hepacivirus*
;
Hepatitis C*
;
Hepatitis C, Chronic*
;
Hepatitis*
;
Hepatitis, Chronic*
;
Humans
;
Immunoenzyme Techniques
;
Interleukin-2*
;
Liver
;
Liver Cirrhosis
;
Nucleic Acid Hybridization
;
RNA
;
Viral Load
4.Quantitation of Hepatitis B Virus DNA in Sera of HBsAg-Positive Patients Using a Branched DNA Signal Amplification Assay.
Chang Seok KI ; Yoon Sun YANG ; Jong Won KIM
Korean Journal of Clinical Pathology 1997;17(5):870-877
BACKGROUND: Several studies have demonstrated that quantitation of hepatitis B virus (HBV) DNA in sera of HBsAg-positive patients is more useful test for the assessment of infectivity and for the evaluation of disease status than previously utilized numerous serological markers and qualitative polymerase chain reaction for the detection of HBV DNA. We tried to measure serum HBV DNA using a branched DNA (bDNA) signal amplification assay, which is recently introduced and known to be a simple and nonradioisotopic method. METHODS: Total forty patients with HBsAg were randomly selected and serum HBV DNA was measured with duplication using bDNA signal amplification assay (QUANTIPLEXTM HBV DNA ASSAY, Chiron, USA). Quantitation was determined from a standard curve and expressed as HBV DNA equivalents/mL (Eq/mL; 1 Eq = 1 molecule of the primary HBV DNA standard). Serum HBeAg, aspartate aminotransferase (AST), alanine aminotransferase (ALT) , and soluble interleukin-2 receptor (sIL-2R) were compared with HBV DNA. RESULTS: Serum HBV DNA was quantitated in 13 patients (32.5%) (range 6.4x106-7.4x109 Eq/mL, mean 1.8x109 Eq/mL, CV 8.1%). All eleven patients (100%) with both HBsAg and HBeAg an4 2 of 29 patients (6.9%) with HBsAg but not with HBeAg showed measurable HBV DNA (p < 0.001). In addition, serum levels of AST, ALT, and sIL-2R were significantly higher in HBV DNA measured patients compared with those of unmeasured patients. CONCLUSIONS: Above results show that more than half the HBsAg-positive patients do not have enough HBV DNA which is measurable with boNA signal amplification assay but all of HBeAg-positive patients and some of HBeAg-negative patients do. In addition, HBV DNA quantitation might be correlated with the disease activity in HBsAg-positive patients because serum levels of AST, ALT, and sIL-2R are higher in patients measured with HBV DNA than unmeasured.
Alanine Transaminase
;
Aspartate Aminotransferases
;
Branched DNA Signal Amplification Assay*
;
DNA
;
Hepatitis B e Antigens
;
Hepatitis B Surface Antigens
;
Hepatitis B virus*
;
Hepatitis B*
;
Hepatitis*
;
Humans
;
Interleukin-2
;
Polymerase Chain Reaction
5.Clinical Results of Open versus Endoscopic Carpal Tunnel Release.
Min Jong PARK ; Ki Sun SUNG ; Won Hwan OH ; Jong Sup SHIM
The Journal of the Korean Orthopaedic Association 1998;33(2):405-410
Open carpal tunnel release has been the standard method of sumical treatment of carpal tunnel syndrome. Recently endoscopic carpal tunnel release has been introduced and is heing used by many authors. The advantages of this new technique are less postoperative pain, rapid restoration of power and rapid return-to-work. However many considerate authors, in spite of these advantages. insist that the inevitahle risk of neurovascular injury during the endoscopic procedure should not he underestimated. The purpose of our study is to compare the clinical results of endoscopic carpal tunnel release with those of open release. 20 open carpal tunnel releases in 16 patients and 15 endoscopic carpal tunnel reieases (single-portal technique) in 11 patients were performed hy the first author. Preoperative conditions of both groups are not different. Authors compared the clinical results between the two groups with some parameters. The overall clinical results were not different significantly hetween two groups. Rapid return-to-work(36 days in endoscopic group versus 60 days in open group) and less postoperative scar and pillar pain in endoscopic group were demonstrated. However, the major complication of one median nerve injury in endoscopic group seemed to overweigh these some benefits. We suggest that the standard operative technique for carpal tunnel syndrome should be open carpal tunnel release and more considerations should be takcn in choosing endoscopic method because of its inherent risk.
Carpal Tunnel Syndrome
;
Cicatrix
;
Humans
;
Median Nerve
;
Pain, Postoperative
;
Return to Work
6.A Case of Carbamazepine- Induced- Toxic Epidermal Necrolysis.
Kyung Shin PARK ; Chang Ki KIM ; Sun One KI ; Jong Houn BAE
Journal of Korean Neuropsychiatric Association 1997;36(5):948-951
The authors reported one case of toxic epidermal necrolysis that occurred in the carbamazepine treatment in a 47-year old male patient with aggressive organic mental disorder. This case developed toxic epidermal necrolysis while taking carbamazepine with a dose of 600mg/day. Toxic epidermal necrolysis did not improve after discontiuation of carbamazepine. We reviewed incidence and the natural history of toxic epidermal necrolysis.
Alcoholism
;
Carbamazepine
;
Cluster Analysis
;
Neurocognitive Disorders
;
Humans
;
Incidence
;
Male
;
Middle Aged
;
Natural History
;
Stevens-Johnson Syndrome*
7.Comparison of Compression Methods of Radiological Images for the Personal Archive.
Young Sun KIM ; Jong Hwa LEE ; Jong Oag PARK ; Tae Sung KI ; Jin Woo CHUNG ; Young Joon LEE
Journal of the Korean Radiological Society 1995;32(3):507-514
PURPOSE: This study was performed to evaluate the usefulness of compression of radiologic images by using personal computer(PC) and the clinically acceptable compression ratio for personal archiving. MATERIALS AND METHODS: The 300 images of total 60 cases including 10 cases each of plain radiograph, angiography, barium study, US, CT, and MRI were obtained from video camera recorder and were digitalized at image board of PC with 628 x430 matrix and archived to 8 bit gray scale for BMP, TIFF, PCX, GIF, 16 bit color for TGA, and 8 bit gray scale and 24 bit color for JPEG. We compared the image quality on each of the 6 image file formats and various compression ratios by using a ROC(receiver operating characteristic) analysis. RESULTS: The file size order was TGA, BMP, PCX, TIFF, GIF, and the smallest JPEG. The excution time for compression and decompression of images ranged from 10 to 20 seconds and from 4 to 7 seconds, respectively. The compression ratio for TGA and TIFF, PCX, and GIF was less than 1.5:1 whereas it was more than 3:1 for JPEG. The higher the compression ratio of JPEG, the more degradation of image quality occurred although compression ratio below 20:1 made no considerable difference. In the remainder, the image quality was same before and after the compression. The digital images of US, CT, and MR showed lower degradation of image quality than plain radiograph, angiography, and barium study. CONCLUSION: The clinically acceptable limiting compression ratio of JPEG was 20: 1 which would be adequate for managing the large volume of image database on a PC-based digital imaging system.
Angiography
;
Archives*
;
Barium
;
Decompression
;
Humans
;
Magnetic Resonance Imaging
8.Insecticide resistance in bedbugs(Cimex lectularius) in Korea.
Chul Hwan CHA ; Ki Sun HAM ; Jong June YOON ; Jong Hwan HWANG ; Kwan Woo LEE ; Sung Hoi KOO
The Korean Journal of Parasitology 1970;8(1):5-7
In the summer of 1969 from July through October, authors carried out a study of susceptibility in adult female bed bug(Cimex lectularius) in order to ascertain any development of resistance to insecticides in Korea. The test to DDT and Dieldrin was performed in laboratory by the continuous exposure of residues method, with standard impregnated paper used for adult mosqitoes. Some results so far obtained can be summarised as follows: LC(50) were 2.839% in DDT and 0.167% in Dieldrin. The resistance has been arisen 2.4-2.9 times in DDT and 1.6-2.4 times in Dieldrin as compared with London laboratory strain, but they were susceptible 1.4 times in DDT and 180 times in Dieldrin as compared to Israel resistance strain.
parasitology-arthropodology-bed bug-Cimex lectularius
;
prevention
;
chemotherapy
;
resistance
;
DDT
;
dieldrin
9.CT findings in ruptured hepatocellular carcinoma.
Sun Hee KIM ; Ki Whang KIM ; Jong Tae LEE ; Hyung Sik YOO
Journal of the Korean Radiological Society 1991;27(1):99-104
No abstract available.
Carcinoma, Hepatocellular*
10.A Clinical Study of Congenital Hypertrophic Pyloric Stenosis.
Kwang Sun PARK ; Young Ki PARK ; Jong Wan KIM ; Chang Kyu OH ; Mahn Kyoo YANG
Journal of the Korean Pediatric Society 1989;32(1):27-33
No abstract available.
Pyloric Stenosis, Hypertrophic*