To investigate if excimer laser ablation of the corneal stroma affect the Barrier function of the corneal endothelial cells and to establish the depth Of excimer laser ablation that will not impair endothelial barrier.
Corneal Stroma ; Endothelial Cells ; Lasers, Excimer* ; Permeability*

No abstract available.
Retrospective Studies* ; Ribs* ; Transplants*

The role of scintigraphic imaging has moved from the detection of lesions to the tissue-specific characterization of lesions over the past 2 decades. Major advances in nuclear medicine imaging include: 1) positron imaging, 2) improved instrumentation, such as the use of multidetector (dual or triple head) gamma cameras for single photon emission computed tomography, and 3) development of numerous new radiopharmaceuticals for positron or single photon imaging ( labeled glucose analogue, amino acids, fatty acids, hormones, drugs, receptor ligands, monoclonal antibodies, etc). These advanced have resulted in a significantly improved efficacy of radionuclide techniques for the evaluation of various of focal gepatic tumors is reviewed in this article with an emphasis on the clinical applications of various tracer studies and imaging findings.
Amino Acids ; Antibodies, Monoclonal ; Carcinoma, Hepatocellular ; Electrons ; Fatty Acids ; Gamma Cameras ; Glucose ; Hemangioma ; Ligands ; Nuclear Medicine* ; Radionuclide Imaging ; Radiopharmaceuticals ; Tomography, Emission-Computed, Single-Photon

168 patients with osteomyelitis who were admitted and operated in Department of Orthopedic Surgery, Seoul National University Hospital between January in 1972 and December in 1976 ware reviewed and analized. The following results were obtained. 1. 138 strains of bacteria were isolated from 167 pus culture in osteomyelitis, about 82.6% 2. Of these, 112 strains are staphillococcus aureus. (81.2%). 3. Degrees of Sensitivity to antibiotics were as follows: in sensitive order, cephalothin was 99.0%, gentamycin 98.0%, cloxacilnli 94.5%, lincocin 92.0%, kanamycin 86.3%, streptomycin 81.2%, and chloramphenicol 80.6% was resulted, 4. Resistant rate to antibiotics were as follows: in resistant order, penicillin 88.8%, oxytetracycline 79.6%, tetracycline 76.2%, and ampicillin 72.2% was resulted.
Ampicillin ; Anti-Bacterial Agents ; Bacteria ; Cephalothin ; Chloramphenicol ; Gentamicins ; Humans ; Kanamycin ; Lincomycin ; Orthopedics ; Osteomyelitis ; Oxytetracycline ; Penicillins ; Seoul ; Staphylococcus aureus ; Staphylococcus ; Streptomycin ; Suppuration ; Tetracycline

A total seven cases of tuberculous spondylitis of the lumbosacral junction were treated by transperitoneal anterior vertebral interbody fusion. The postoperative course was unevenful with minimal complications in all cases. There was no evidence of recurrence of infection, low back pain, or sciatica during follow-up periods of seven to sixty months. The clinical experience gained in this study leads us to conclude that the transperitoneal approach for tuberculous spondylitis of the lumbo-sacral junction is advantageous in that, the lesion is exposed under direct vision, so adequate curettage and the bone graft can be carried out accurately and easily.
Curettage ; Follow-Up Studies ; Low Back Pain ; Recurrence ; Sciatica ; Spondylitis ; Transplants

No abstract available.

We report a case of subcutaneous panniculitic T-cell lymphoma (SPTCL) which occurred in a 10-year-old Korean girl. Her disease presented as multiple erythematous subcutaneous nodules on the right cheek, left chest, abdomen, left flank, both calves, and left shin with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 2 months often with spiking fever. Histopathologic findings for the subcutaneous nodules revealed lobular panniculitis-like findings composed of atypical small, bland lymphocytes and histiocytes. Characteristically, atypical lymphocytes rimmed individual fat cells in a lace-like pattern and some histiocytes occasionally phagocytosed WBCs. Bone marrow findings revealed increased phagocytic histiocytes with engulfed hematopoietic cell. The immunophenotypic studies showed CD45RO (UCHLl)+, CD20-, CD4-, CD8+ and CD56+ (focal), lysozyme+, CD45 (LCA)+ and EBV-. She received three cycles of high-dose cyclophosphamide, adriamycin, vincristine, prednisolone (CHOP) and methotrexate, intrathecal methotrexate and one cycle of fludarabine, mitoxantrone and dexamethasone (FND) chemotherapy. She died of acute renal failure during multiple chemotherapy.
Abdomen ; Acute Kidney Injury ; Adipocytes ; Bone Marrow ; Cheek ; Child* ; Cyclophosphamide ; Dexamethasone ; Doxorubicin ; Drug Therapy ; Female ; Fever ; Glycogen Storage Disease Type VI ; Histiocytes ; Humans ; Lymphocytes ; Lymphoma, T-Cell* ; Lymphoma, T-Cell, Cutaneous ; Methotrexate ; Mitoxantrone ; Prednisolone ; T-Lymphocytes* ; Thorax ; Vincristine

We report a case of tuberculosis verrucosa cutis in a 33-year-old male patient who presented with mild itching verrucous plaque over the perineum. The Mantoux test revealed a positive reaction. The histophathologic picture consists of slight hyperkeratosis, irregular ac:anthosis overlying an inflammatory iafitrate in the dermis. Tuberculous granulomas with caseation necrosis were seen in the dermis. Tuber clebacillus was demonstrated. The patient was treated with Isoniazid, Rifampicin, and Pyrazine made for 6 months. To date, the skin lesions have markedly improved.
Adult ; Dermis ; Granuloma ; Humans ; Isoniazid ; Male ; Necrosis ; Perineum ; Pruritus ; Rifampin ; Skin ; Tuberculosis*

BACKGROUND: Uterine leiomyoma is the most common pelvic tumor, occurring in 20-25% of women in reproductive age. Gonadotropin releasing hormone agonist (GnRHa) has been reognized as a temporary medical management for this disorder. The etiology of these tumors is unknown but it has been shown that the insulin-like growth factors (IGF-I, IGF-II) are promoters of growth in nongynecologic tumors. Several recent studies have suggested the possible role of IGFs in human leiomyoma growth. The IGF binding proteins (IGFBPs) are believed to modulate actions of IGF and to have IGF-independent actions. The purpose of this study was to evaluate the type of IGF and IGFBP which may be involved in leiomyoma growth and to investigate a possible IGF related mechanism of action of GnRHa. METHOD: The IGFs and IGFBPs were measured by double antibody radioimmunoassay, western ligand blot and immunoprecipitation in the tissue cytosols of normal uterine myometria (n=15), nontumorous myometria adjacent to a leiomyoma and leiomyoma from patients nontreated (n=15) and treated (n=10) with GnRHa. RESULTS: The mean IGF-I and IGF-II level were significantly higher in leiomyoma from untreated patients than in the adjacent myometrium and normal myometrium but no significant differences in these IGF levels between normal myometrium and adjacent myometrium were noted. The IGFBP-2, IGFBP-3 and 26kDa IGFBP were detected variably but IGFBP-4 was consistently present in all tissues. There were no significant differences in the relative intensity for IGFBP-4 and the frequency of IGFBPs between leiomyoma, adjacent myometrium and normal myometrium from untreated patients. The IGF-I, IGF-II levels and the relative intensity of IGFBP-4 in leiomyoma from GnRHa-treated patients were significantly lower than those in untreated patients, but these levels in the adjacent myometrium were comparable. The frequency of each IGFBP in leiomyoma and the adjacent myornetrium from GnRHa-treated patients did not significantly differ from untreated patients. CONCLUSION: Both IGF-I and IGF-II are involved in the growth of leiomyoma and GnRHa may in part act to decrease size of leiomyoma by regulating the local levels of IGF-I, IGF-II and IGFBP-4.
Animals ; Cytosol ; Female ; Gonadotropin-Releasing Hormone ; Humans ; Immunoprecipitation ; Insulin-Like Growth Factor Binding Protein 2 ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor Binding Protein 4 ; Insulin-Like Growth Factor Binding Proteins ; Insulin-Like Growth Factor I ; Insulin-Like Growth Factor II ; Leiomyoma* ; Mice ; Myometrium ; Radioimmunoassay ; Somatomedins*

The spinal injuries were reported by relatively low incidence than other fracture and dislocation in the body. However, the rate of spine injury tend to increase year by year as the rate of traffic accident and industrial accident have been increased. Authors have experienced 403 cases of various type of injuries from Jan, 1966 to Aug. 1971. They were analysed as follows. 1. Out of 330 patient, males were 212 cases (64.2%) and female 118 (37.8%) Among them 74% of cases were between 20 to 40 years of age. About 51.9% of cases of the spinal injury were caused by traffic road accident. 2. The most most common fracture site in the spinal segments were between 12th thoracic spine and 2nd lumbar spine (69.0%) and most common types of spine injury was simple wedge fracture (70.7%) which is induced by flexion violence. 3. The stable injuries of the spine (69.4% 229 cases) were treated by functional methods such as bed rest, early ambulation. Injured spine were not immobilized in cast. They gave a more functional results than rigidly immobilized group. 4. 27 cases (8.2%) were complicated by paraplegia and mostly (59.3%) were caused by rotational fracture-dislocation. The common site of lesion were between D12-L2 (67.4%) 5. Among the 185 cases who were followed over 6 months, sponetaneous spinal fusion within 6 months after injury occured in 166 cases (89.7%) 76.8% of them were fused within 4 months. 6. Among the 27 paralysed cases, 3 were died within 2 weeks of admission, and 3 cases had complete recovery without residua.
Accidents, Occupational ; Accidents, Traffic ; Bed Rest ; Dislocations ; Early Ambulation ; Female ; Humans ; Incidence ; Male ; Paraplegia ; Spinal Fusion ; Spinal Injuries ; Spine ; Violence