Aging ; Animals ; Collagen ; Cytoplasm ; Fibroblasts ; Golgi Apparatus ; Lysosomes ; Mandibular Condyle ; Mitochondria ; Organelles ; Rats ; Temporomandibular Joint

Dermoid cyst has evolved to represent any cyst filled with sebumlike and with evidence of specialized skin derivatives from defective embryonic development. Approximately 7% of all dermoid cyst arise in the head and neck region and 0.01% of all oral cysts. The anterior region of the floor of the mouth is the most common site of occurrence in the oral cavity. There is no sex predilection and the age at presentation is usually in the second or third decades. Clinically, the lesions present as a rubbery or doughy mass that vary in size from a few millimeters to 12 cm. An intraoral dermoid cyst usually presents as a slowly growing, painless swelling in the anterior floor of the mouth which may eventually cause elevation and displacement of the tongue resulting in dysphonia, dysphagia and dyapnea. Treatment involves surgical removal and recurrences have not been reported. We report three cases of dermoid cyst that were cared successfully in the department of dentistry, Kyung-pook National University. One case is a sublingual type, another case is a geniohyoid type, and the other is a lateral type.
Deglutition Disorders ; Dentistry ; Dermoid Cyst* ; Dysphonia ; Embryonic Development ; Female ; Head ; Mouth* ; Neck ; Pregnancy ; Recurrence ; Skin ; Tongue

The purpose of this study was to investigate the distribution pattern of CGRP immunoreactive nerve fibers in the healing mucosa of extracion wound. Maxillary 1st molars of rats were extracted. All extraction sites and adjacent tissues of 3 groups of rats(1-week, 2-week and 4-week groups) were removed en bloc and processed for immunostaining and were subjected to light microscopic examination. The results obtained were as follows; In 1-week group, there was no difference in the distribution pattern of CGRP immunoreactive nerve fiber between epithelial margin adjacent to extraction socket and normal gingival epithelium. In 2-week group, some CGRP-immunoreactive nerve fibers were seen in epithelial layer. In 4-week group, many intercellular CGRP immunoreactive nerve fibers were abundant in all layers of immature epithelium characterized by scab on the mucosa and thick keratinized cell layer with irregular surface. Intraepithelial CGRP immunoreactive nerve fibers were reduced to normal level in adjacent mature epithelium. These results suggest that density of CGRP immunoreactive nerve fibers are increased transiently in epithelium during reepithelialization process and CGRP released from these nerve fibers may play an important role in the reepithelialization in the wound healing.
Animals ; Epithelium ; Molar ; Mucous Membrane ; Nerve Fibers* ; Rats* ; Wound Healing ; Wounds and Injuries*

The present study has attempted to look into the mechanism of ras-induced carcinogenesis in a human epithelial cell system. Human epithelial cells immortalized with Ad12-SV40 hybrid virus were used to assess carcinogenic potential of the ras-oncogene. Cells transfected with pSV2-ras showed characteristics of cellular transformation. The transformation parameters such as cell density, soft-agar colony formation, and cell aggregation were significantly increased in the cells expressing ras oncoprotein. In addition, the duration required for the appearance of foci was shortened in the ras-transfected cells. Consistent with other reports, our results demonstrated an evidence that the ras-oncogene induced the cellular transformation of human epithelial cell system. When a high concentration of glucocorticoid was added into the media, transformation process was accelerated. It is speculated that glucocorticoid may provide an advantageous environment for the proliferation of the transformed cells. The induction of the intracellular free calcium concentrations following agonist treatment was significantly lower in the transformed cells than in the control cells. These effects were more manifested in the presence of extracellular cacium, indicating that the transformation process may alter the influx pathway of extracellular calcium. The induction of IP3 following agonist treatment was also lower in the transformed cells than in the control cells. Thus, it is suggested that phospholipase C-coupled pathway was down-regulated in the process of the ras-induced transformation. While the levels of TGF-beta1 and PAI-2 mRNAs were decreased, the level of fibronectin mRNA was increased. The results indicate that mechanism of the ras-induced transformation may be associated with the altered expressions of growth regulatory factors. The present study demonstrates an evidence that the ras-induced cellular transformation may be associated with alteration of signal transduction and growth regulatory factors. The study will contribute to improve the understanding of molecular mechanism of epithelium-derived cancers including oral cancer.
Calcium ; Carcinogenesis ; Cell Aggregation ; Cell Count ; Epithelial Cells* ; Fibronectins ; Humans* ; Mouth Neoplasms ; Phospholipases ; Plasminogen Activator Inhibitor 2 ; RNA, Messenger ; Signal Transduction* ; Transforming Growth Factor beta1

Academic Medical Centers ; Ameloblastoma ; Biopsy ; Daegu ; Fibroma ; Gyeongsangbuk-do ; Humans ; Molar ; Myxoma ; Odontogenic Cyst, Calcifying ; Odontogenic Tumors ; Odontoma ; Recurrence ; Sex Distribution ; Tooth

Calcium ; Carcinogenesis ; Cytosol ; Epithelial Cells ; Humans ; Hydrocortisone ; Membranes ; Methylnitronitrosoguanidine ; Mouth Neoplasms ; Protein Isoforms ; Protein Kinase C ; Protein Kinases ; Sensitivity and Specificity ; Signal Transduction

Cystic hygroma, a cystic subtype of lymphangioma, is relatively rare tumor of lymphatic origin. The lesion is a benign, painless, soft, compressible malformation of the lymphatic system. They can arise anywhere along the lymphatic system, however they are usually located in the head and neck regions and in most cases appear by the age of 2 years. The cases in the adult is rarely occurred and a few cases are described in the literature. Surgical excision remains the treatment of choice. But complete extirpation of these lesion is often impossible, because the tumor tends to spread along vital structures. Therefore recurrence rates are accordingly high. This is a case report about 19 year old male patient with cystic hygroma on right retromandibular area. We obtained the successful, functional and esthetic result by surgical excision of the mass. Therefore, we report the case with a review of literatures.
Adult ; Head ; Humans ; Lymphangioma ; Lymphangioma, Cystic ; Lymphatic System ; Male ; Neck ; Recurrence

Odontogenic Myxoma of the jaws is a rare benign tumor derived from embryonic mesenchymal elements of dental anlage. It appears to originate from the dental papilla, follicle or periodontal ligament. Odontogenic Myxoma of the maxilla is less frequent but behaves more aggressively than that of the mandible, because it spreads through the maxillary sinus. Radiographically, the tumors present as unilocular or multilocular radiolucent lesions with well-defined borders with fine, bony trabeculae. On gross examination, the tumor appears as a smooth, glistening, gelatinous, lobulated mass. On microscopic examination, these neoplasms exhibit loose arrangement of stellate-shaped cells. The intercellular substance is a mucinous and homogeneous matrix. We report a case of odontogenic myxoma of the maxilla observed in our clinic with good prognosis after partial maxillectomy.
Dental Papilla ; Gelatin ; Jaw ; Mandible ; Maxilla ; Maxillary Sinus ; Mucins ; Myxoma ; Periodontal Ligament ; Prognosis

Child ; Chin ; Congenital Abnormalities ; Diastema ; Female ; Gyeongsangbuk-do ; Heart ; Humans ; Hyoid Bone ; Incisor ; Jaw ; Lip ; Mandible ; Manubrium ; Mesoderm ; Neck ; Parturition ; Pregnancy ; Shock ; Surgery, Oral ; Tongue ; Transplants

Adenoma ; Adenoma, Pleomorphic ; Anesthesia, General ; Humans ; Mouth ; Palate ; Respiration ; Salivary Glands ; Salivary Glands, Minor