Befunolol hydrochloride is a B-adrenergic receptor antagonist cornnory used topically in treatment of glaucoma because of a satisfactory intraocular pressure lowering apcity without relevant topical or systemic side effects. We repart herein a case of allergic contact dermatit.is due to befunc ol nydrochloride in 0.5% Bentos eyedrops, A 52-year-old Korean woman had suffered from erythemanedema with itching sensation on her left eye since Novembeir 18, 1992. She had used various ophtalrnic preparations including Bentos eyedrops containing befinolol hydrochloride 0,5% as its activ cinstituent since October, 1992 for treatment of glaucoma of her left eye. Patch test with the European standard series, rubber series, the patiants eyedrops and their individual constituents showed positive. reactions only to 0.5% Bentos eyedrops(as is) and to befunolol hydrochloride. We noted rapid improvement of skin lesions and syipsms after the withdrawal of Bentos eyedrops and applicatior of another B-blocker(carteolol hydrocilcide).
Dermatitis, Allergic Contact* ; Female ; Glaucoma ; Humans ; Intraocular Pressure ; Middle Aged ; Ophthalmic Solutions* ; Patch Tests ; Pruritus ; Rubber ; Sensation ; Skin

BACKGROUND: Persistent facial elangiectssia, erythema, and flushing are the major cosmetic problems in patients with rosacea, However various therapeutic modalities for roacea papules and pustules, including topical antibiotics, systemic antibiotics, isotretinoin, and systernic and topical metronidazole, are not effective in reducing telangiectasia and flushing reactions present inrosacea patients. The flashlamp-pumped pulsed dye laser has been deacribed as a succqssful treatment for port wine stains with telangiectasia as part of their abnomalities. A clinical study was therefore undertaken in a group of rosacea patients, who recieves this laser to areas of facial taieous lesions. OBJECTIVE: The purpose of the study was to evaluate the therapeutic effect of the flashlamp-pumped pulsed dye laser(SPTL-1) for osacea, especially telangiectasia and flusing reactions. METHODS: Forty-eight. patient with rosacea were studied to evaluatic the therapeutic effects of the SPTL-1 flashlamp-pumped pulsed dye laser (Candela corp.Wayland Mass.) at the Department of Dermatology in Dong-A University Hospital for 20 months from Januarg 1991 to August 1992. RESULTS: 1. Total therapeutic effects of this SPTL-1 laser showed excellent re:ults in 22.9%, good in 62.5%, fair in 8.3%, and poor in 6.3%. 2. Therapeutic effects of rosacea-associated lesions showed exeellerit or good results in 85.4% of patient,s with erythema and telangiectasia, 84% patients with papules, 100% patients with pustules, and 93.7% of patients with facial flushing. 3. Complications included trarsient hyperpigmentation (14.6%), section lary bacterial infection(6.3%), hypopigmentation(2.1%), and atropic scar(2.1%). 4. The recurrence rat.e was 2,9,%. CONCLUSION: The flashlamp-pumped pulsed dye laser (SPTL-1) is a dry effective mode of treatment for rosacea, including persistent telangiectasia and facial flushing ri.actions which were intractable to previous other therapeutic modalities.
Anti-Bacterial Agents ; Dermatology ; Erythema ; Flushing ; Humans ; Hyperpigmentation ; Isotretinoin ; Lasers, Dye* ; Metronidazole ; Port-Wine Stain ; Recurrence ; Rosacea* ; Telangiectasis

BACKGROUND: Persistent facial elangiectssia, erythema, and flushing are the major cosmetic problems in patients with rosacea, However various therapeutic modalities for roacea papules and pustules, including topical antibiotics, systemic antibiotics, isotretinoin, and systernic and topical metronidazole, are not effective in reducing telangiectasia and flushing reactions present inrosacea patients. The flashlamp-pumped pulsed dye laser has been deacribed as a succqssful treatment for port wine stains with telangiectasia as part of their abnomalities. A clinical study was therefore undertaken in a group of rosacea patients, who recieves this laser to areas of facial taieous lesions. OBJECTIVE: The purpose of the study was to evaluate the therapeutic effect of the flashlamp-pumped pulsed dye laser(SPTL-1) for osacea, especially telangiectasia and flusing reactions. METHODS: Forty-eight. patient with rosacea were studied to evaluatic the therapeutic effects of the SPTL-1 flashlamp-pumped pulsed dye laser (Candela corp.Wayland Mass.) at the Department of Dermatology in Dong-A University Hospital for 20 months from Januarg 1991 to August 1992. RESULTS: 1. Total therapeutic effects of this SPTL-1 laser showed excellent re:ults in 22.9%, good in 62.5%, fair in 8.3%, and poor in 6.3%. 2. Therapeutic effects of rosacea-associated lesions showed exeellerit or good results in 85.4% of patient,s with erythema and telangiectasia, 84% patients with papules, 100% patients with pustules, and 93.7% of patients with facial flushing. 3. Complications included trarsient hyperpigmentation (14.6%), section lary bacterial infection(6.3%), hypopigmentation(2.1%), and atropic scar(2.1%). 4. The recurrence rat.e was 2,9,%. CONCLUSION: The flashlamp-pumped pulsed dye laser (SPTL-1) is a dry effective mode of treatment for rosacea, including persistent telangiectasia and facial flushing ri.actions which were intractable to previous other therapeutic modalities.
Anti-Bacterial Agents ; Dermatology ; Erythema ; Flushing ; Humans ; Hyperpigmentation ; Isotretinoin ; Lasers, Dye* ; Metronidazole ; Port-Wine Stain ; Recurrence ; Rosacea* ; Telangiectasis

Chronic actinic dermatitis was recently proposed to be a syndrome of chronic photosen-sitivity that incudes photosensitive eczema, persitent light reection, photosensitivity dermatitis and actinic reticuloid. We report herein a case of chronic actinic dermatitis which occured in a 60-year-old man. He suffered from a chronic eczematous dermatitis affecting e posed skin and some covered area with a feature of erythroderma. Phototesting showed abnormal photosensitivity to both UVB and UVA as will as to visible light. Skin biopsy specimes revealed histologic findings of spongiotic dermatitis in which dermal infiltrates were mainy consisted of T lymphocytes with suppressor T cells dominance on immunohistochemistry.
Actins ; Biopsy ; Dermatitis ; Dermatitis, Exfoliative ; Eczema ; Humans ; Immunohistochemistry ; Light ; Middle Aged ; Photosensitivity Disorders* ; Skin ; T-Lymphocytes

PURPOSE: To describe soft-tissue radiographic and high-resolution CT findings of radiation-induced lung injury of rabbit over time and to correlate them with pathologic findings. MATERIALS AND METHODS: 15 rabbits were irradiated in the right lung with one fraction of 2000 cGy. After 4, 6, 12, 20, 24 weeks, 3 rabbits in each group were sacrificed and soft-tissue radiographs and high-resolution CT of their lung tissue were obtained. Radiological findings were correlated with pathologic findings. RESULTS: On soft- tissue radiogram, radiation pneumonitis shown as consolidation with air-bronchogram occurred in 3 cases after 6 weeks, and in 1 case after 12 weeks of irradiation. In addition, pneumonic consolidation with adjacent pleural contraction was seen in 2 cases after 12 weeks of irradiation. Fibrotic changes indicated by decreased volume occurred after 20 weeks and combined bronchiectatic change and bronchial wall thickening appeared after 20 weeks(N=1), and 24 weeks(N=3). HRCT findings of radiation pneumonitis were homogeneous, increased attenuation after 4 weeks(N=3), 6 and 12 weeks (each N=I), patchy consolidation after 6 and 12 weeks(each N=2), discrete consolidation after 12, 20 and 24 weeks(each N=I) and solid consolidation after 20 and 24 weeks(each N=2). Pathologically radiation pneumonitis and pulmonary congestion were seen after 4 and 6 weeks. After 6 weeks, collagen and reticulin fibers were detected along alveolar wall. Mixed radiation pneumonitis and fibrosis were detected after 12 weeks. 20 weeks after irradiation, fibrosis was well defined in interstitium and in 24 weeks, decreased number of alveoli and thickening of bronchial wall were defined. CONCLUSION: Radiation pneumonitis was provoked 4 weeks after irradiation on rabbit lung and progressed into radiation fibrosis 20 weeks after irradiation on soft-tissue radiographs and high-resolution CT. High-resolution CT is more precise in detecting early radiation pneumonitis and detailed pathologic findings.
Collagen ; Estrogens, Conjugated (USP) ; Fibrosis ; Lung Injury ; Lung* ; Rabbits ; Radiation Pneumonitis ; Reticulin

The pathogeoesis of papulonecrotic tuberculid had been thought to be the result of hernatogenous dissemination from primary tuberculous focus of other organs. But, today, the existence of papulonecrotic tuberculid as a rare cutaneous reaction to the Mycobacterium bacillus is questioned. Papulonecrotic tuberculid is, however, a real entity in underdeveloped countries where tuberculosis is more common. We report a case having papulonecrotie tuberculid associated with cervical lymph node tuberculosis confirmed by typical histopathology and by clinical response to antituberculous chemotherapy. This case supports Iden et al's view (1) that skepticism regarding the existence of papulonecrotic tuberculid is probably the result of the current decreased prevalence of untreated tuberculosis and consequently increased rarity of this entity.
Bacillus ; Drug Therapy ; Mycobacterium ; Prevalence ; Tuberculosis ; Tuberculosis, Cutaneous* ; Tuberculosis, Lymph Node

Generalized sterile pustular eruptions occur in various dermatoses including pustular psoriasis, erythema multiforme, Sneddon-Wilkinsan disease and others. Recentlr, acute eruptions of disseminated sterile pustules have been reported. The etiology is not related to a gepetic predisposition to psoriasis but to drug ingestion or viral infections, thus termed toxic pustuloderm; (T. P.). In this report, we present a typical case of T. P. observed iu our department. Our patient, an 18-year-old male, with no personal or family history of psoriasis, was given drug medication including amoxicillin for fever and chilling sensation. Pustilar eruptions first, appeared on his face about two days aft.er the medication and gradually spread to the trunk and limbs. The skin examination revealed numerous small pustules on an erythematous base. Laboratory examination revealed neutrophilic leukocytosis and an elevated sedimentation rate skin biopsy showed subeorneal and spongiform neutrophilic pustules Upon interruption of the amoxicillin, the pustules cleared rapidly in 3 days and there has been ri.o recui rence of any rash over a 7-month follow-up period.
Adolescent ; Amoxicillin ; Biopsy ; Eating ; Erythema Multiforme ; Exanthema ; Extremities ; Fever ; Follow-Up Studies ; Giant Cell Tumors ; Humans ; Leukocytosis ; Male ; Neutrophils ; Psoriasis ; Sensation ; Skin ; Skin Diseases

Rhabdomyosarcoma are reportedly the most common soft tissue sarcoma occuring in childhood, but the biliary tree is a rare site of origin for this tumor. Recently we experienced a case of embryonal rhabdomyosarcoma of the biliary tree in a 30-month-old child. UItrasonography showed hypoechoic mass filling the dilated left. intrahepatic & extrahepatic bile ducts, and CT showed hypodense mass with heterogeneous enhancement after contrast infusion. Intraoperative cholangiography showed filling defects within the dilated left. intrahepatic & extrahepatic bile ducts. Postoperative MRI showed residual mass within the left. intrahepatic duct which was hypointense on T1WI and hyperintense on T2WI.
Bile Ducts, Extrahepatic ; Biliary Tract* ; Child ; Child, Preschool ; Cholangiography ; Humans ; Magnetic Resonance Imaging ; Rhabdomyosarcoma ; Rhabdomyosarcoma, Embryonal* ; Sarcoma

Rhabdomyosarcoma are reportedly the most common soft tissue sarcoma occuring in childhood, but the biliary tree is a rare site of origin for this tumor. Recently we experienced a case of embryonal rhabdomyosarcoma of the biliary tree in a 30-month-old child. UItrasonography showed hypoechoic mass filling the dilated left. intrahepatic & extrahepatic bile ducts, and CT showed hypodense mass with heterogeneous enhancement after contrast infusion. Intraoperative cholangiography showed filling defects within the dilated left. intrahepatic & extrahepatic bile ducts. Postoperative MRI showed residual mass within the left. intrahepatic duct which was hypointense on T1WI and hyperintense on T2WI.
Bile Ducts, Extrahepatic ; Biliary Tract* ; Child ; Child, Preschool ; Cholangiography ; Humans ; Magnetic Resonance Imaging ; Rhabdomyosarcoma ; Rhabdomyosarcoma, Embryonal* ; Sarcoma

Authors report the radiologic findings of two cases of multiple bile-duct hamartoma in the liver. Ultrasonography and computed tomography of the liver were performed in two female patients. In one patient, ERCP was performed. Ultrasonography and computed tomography showed scattered multiple hypoechoic and low attenuated lesions, measuring up to 2cm in both lobe and ERCP showed communication of these lesions with the biliary system. Multiple bile-duct hamartoma should be included in the differential diagnosis of multiple small cystic lesions in the liver.
Biliary Tract ; Cholangiopancreatography, Endoscopic Retrograde ; Diagnosis, Differential ; Female ; Hamartoma* ; Humans ; Liver ; Ultrasonography