The microform cleft lip is the mildest expression of cleft lip and nose deformity, but it has no specific definition, classification, and few methods have been reported for its correction. It is characterized by deformity of the nostril, skin striae of the upper lip, notching of peaked Cupid's bow, deformity of the vermilion, and anomaly of the upper lateral incisior and alveolar ridge on the affected region. Sixty-three microform cleft lip patients were operated on between Dec. 1993 and Sep. 1998 in our department(29 males and 34 females). The age of the patients ranged from 5 months to 30 years(Mean 9 years). We classified and treated the microform cleft lip as follows: Class I: Cleft lip nose with very slight lip deformity Class II: Minimal lip deformity without vermilion notching Class III: Mild lip deformity with slight vermilion notching. The goals in the correction of a microform cleft lip are to obtain an esthetically pleasing upper lip and nose, and to reestablish muscle continuity for improved function. To attain these goals, we used the above classification and satisfactory results were obtained by treating the microform cleft according to the classification.
Alveolar Process ; Classification* ; Cleft Lip* ; Congenital Abnormalities ; Humans ; Lip ; Male ; Microfilming* ; Nose ; Skin

The chromosome constitution of 11 superficial and 2 invasive transitional cell carcinomas of the bladder has been examined by culture technique. Of the 11 superficial tumors, 6 (54.5%) had the modal number ranging in the diploid area (40-49 chromosomes) and 5 of them (83.5%) had no recurrence for more than 1 year. Six (54.5%) out of 11 superficial tumors had 1 to 3 marker chromosomes and only 2 (33.3%) of them recurred but 1 (20%) out of remaining 5 (no marker chromosome) superficial bladder tumors has recurred. On the other hand. all invasive transitional cell carcinomas of the bladder had hyperdiploid modes and marker chromosomes. Although the numbers of subject for this study are small we speculate that a large number of chromosomes and presence of marker chromosome might be correlated with aggressiveness of a particular tumor diathesis but the meaning of marker chromosome should be reevaluated. So in order to get the prognostic information chromosomal analysis should be thought combined with other prognostic factors.
Carcinoma, Transitional Cell* ; Constitution and Bylaws ; Culture Techniques ; Cytogenetic Analysis ; Diploidy ; Disease Susceptibility ; Hand ; Recurrence ; Urinary Bladder Neoplasms ; Urinary Bladder*

No abstract available.
Mycobacterium bovis* ; Recurrence* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

PURPOSE: Since the 1940s, the incidence of prostatic abscess appears to have declined and the type of infecting organism has changed. So we evaluated the change on clinical characteristics of prostatic abscess in recent years. MATERIALS AND METHODS: From 1991 to 1997, we treated 12 patients with prostatic abscess. Mean patient age was 52.2years(range 22 to 69). An analysis was made of history, presenting symptoms, digital rectal examination(DRE) and usefulness of transrectal sonography(TRUS). Diagnostic work-up included analysis of midstream urine for leucocytes and common pathogens. Treatment included antibiotic therapy with or without percutaneous cystostomy, or together with surgical drainage. RESULTS: Medical history revealed predisposing diseases in 7 cases : diabetes mellitus(2 patients), previously treated gonococcal urethritis(2 patients), percutaneous cystostomy due to urethral rupture(1 patient), BPH(1 patient) and chronic hepatic disorder(1 patient). The characteristics of the initial DRE revealed increased prostatic size in 11 patients, tenderness and heating sense in 9 patients, fluctuation in 6 patients. In 12 patients, diagnosis was based on TRUS. In 2 patients with mimicking prostate cancer, pelvic MRI was done and prostatic abscess was confirmed. All patients demonstrated leucocytes in their midstream urine. Causative pathogens in midstream urine were found in 8 patients: Staphylococcus aureus(4 patients), Escherichia coli(3 patients), Proteus vulgaris(1 patient) and Candida albicans(1 patient). In one patient, mixed infection was found. All patients received antibiotic treatment. In one patient, transrectal aspiration was performed by sono-guided puncture, one patient underwent transurethral incision of the prostate(TUIP) and two patients underwent TURP. In eight patients, antibiotic treatment alone was administered and led to cure. CONCLUSIONS: An analysis of 12 patients with prostatic abscess was presented. Diabetes was not so common in predisposing factor of prostatic abscess as compared with previous literatures. S. aureus and E. coli were the main causative organisms. Besides C. albicans, nosocomial organism, was observed in 1 patient. We have found TRUS to be helpful in the diagnosis and follow-up of this disease. In addition, pelvic MRI is considered as a noninvasive technique helpful in differentiation with prostatic cancer. Definitive treatment is complete surgical drainage, but there is no difference in results of treatment between patients with antibiotics only and those with mixed surgical drainage and antibiotic coverage.
Abscess* ; Anti-Bacterial Agents ; Candida ; Causality ; Coinfection ; Cystostomy ; Diagnosis ; Drainage ; Escherichia ; Follow-Up Studies ; Heating ; Hot Temperature ; Humans ; Incidence ; Magnetic Resonance Imaging ; Prostatic Neoplasms ; Proteus ; Punctures ; Staphylococcus ; Transurethral Resection of Prostate

No abstract available.
Citrobacter* ; Enterobacter*

Embryonal rhabdomyosarcoma of the prostate is a rare and highly malignant disease. We experienced three cases of embryonal rhabdomyosarcomas in recent years, and they were clinically studied.
Prostate* ; Rhabdomyosarcoma, Embryonal*

We report a case of multiple leatiginea syndrome in an 8 year old boy. He had numeroua lentigines acattered over his face, trunk, buttock and thlghe, and eome larger black macular leeians on the trunk and thighs. Gn phyaiaal examinatlon, he wae well developed but he had ocular hyperteloriem. Chest roentgenogram showed hypertrophy of both ventricles. Electrocardiogram and audiogram revealed conduction defects and severe sensorineural deafness, reepectively. Blopsy af dark brown lesion from the back showed the histopathologlc pattern of lentigo.
Buttocks ; Child ; Deafness ; Electrocardiography ; Humans ; Hypertrophy ; Lentigo ; LEOPARD Syndrome* ; Male ; Thigh ; Thorax

No abstract available.
Escherichia coli* ; Escherichia*

No abstract available.
Antibodies, Anticardiolipin* ; Female ; Pregnancy ; Pregnancy Outcome* ; Pregnancy*

BACKGROUND: Transforming growth factor (TGF)- has a large variety of biological functions, including the modulation of inflammation and the immune system, and is presumed to play important roles in repairing wounds and reducing scarring. The objective of this study is to examine the effects of TGF-1 on healing wounds and reducing scarring. We have also analysed the ability of the hemagglutinating virus of Japan (HVJ) liposome mediated antisense oligodeoxynucleotides (ODNs) to specifically inhibit wound-induced expressions of TGF-1 proteins and mRNA in the rat skin. METHODS: Skin wounds were created on the backs of 80 anesthetized rats. The first group of wounds, as the controls, was unmanipulated. The second group of wounds, as positive controls or an excessive scarring model, was injected with TGF-1 subcutaneously. The third group of wounds was injected with anti-TGF-1 antibody subcutaneously. The fourth group of wounds was injected with HVJ liposome mediated antisense ODNs for TGF-1 subcutaneously. The wounds of all groups were bisected and analysed histologically 5, 10, 15, 30, and 50 days after the wounds were made. RESULTS: All control wounds (TGF-1 or no injection) healed with scarring, whereas the wounds treated with the antibody or antisense ODNs healed with less scar formation compared to the control group. The wounds treated with the antibody or antisense ODNs had fewer macrophages, less collagen and fibronectin contents than the other wounds. Northern blotting and in situ hybridization analysis showed that wound sites treated with HVJ liposome mediated antisense ODNs for TGF-1 exhibited decreased levels of TGF-1 mRNA after injury. CONCLUSIONS: These findings suggest an important new approach to controlling scarring in normal wound healing, complementing the practice of adding exogenous growth factors to chronic wounds in the attempt to inhibit collagen deposition.
Animals ; Blotting, Northern ; Cicatrix* ; Collagen ; Complement System Proteins ; Fibronectins ; Genetic Therapy* ; Immune System ; In Situ Hybridization ; Inflammation ; Intercellular Signaling Peptides and Proteins ; Liposomes ; Macrophages ; Oligodeoxyribonucleotides ; Oligoribonucleotides ; Rats ; RNA, Messenger ; Sendai virus ; Skin ; Transforming Growth Factor beta ; Transforming Growth Factors ; Wound Healing ; Wounds and Injuries