No abstract available.
Skin*

Dermatophytosis of the feet, i.e. tinea pedis, is one of the most frequent fungal infections and is caused by a dermatophyte. There are many predisposing factors to the disease such as living or environmental conditions; underlying endocrine or metabolic diseases, complicated individual immune mechanisms, long-term use of adrenocorticosteroids, antibiotics or other drugs and feet, per se, succeptable to infection of the organism by physio-anatomical condition. The authors performed clinical and mycological studies on 225 outpatients visiting the dermatological clinic of Chonnam University Hospital from April to September in 1977, who had clinical evidence of tinea pedis, dermatophytes infection of the feet. The incidence of tinea pedis was 8.9% of the whole 2531 out-patients who visited our clinic during that time. Of the 225 patients, the male patients were53%, the female patients 47%, and patients living in urban areas were affected about 2 times more frequently than those living in rural areas. The age distribution of the patients varied from 5 to 68 years old, but the most of them were in their third decade, at an actively working age. Concurreat infection with tinea pedis and other dermatophytosis was noted in 106 patients (47.1%). The patients with T. pedis and manus were most commonly observed, and the incidence of concurrent infection with T. pedis and T. manus was 31%;, T. cruris 19.8%, onychomycosis 17.0%, and with T. corporis 10.4% respectively. Id reaction or autoeczemation to the disease itself and inadequate or over treatment dermatitis developed in 19 patient*8.4%). It happened more in patients with tinea pedis alone than in thos with concurrent infection, but there was no difference between sexes. The positive rate of 10%. KOH mount was 59% in 173 preparations. The culture rate was about 7 times higher in the KOH positive group than in the negative group. Among the 39 strains of dermatophytes isolated by Sabouraud's dextrose agermedia from 111 patients and identified by 1% dextrose com meal agar media, bloo3 agar media and hair culture method, T. rubrum were 28 strains (71.l%) and T. mentagrophytes were 11 strains (28. 2%) The straivs of all noted hair perforation did not produce the pigmentation on 1% dextrose com meal agar media, and the strains which produced pigmentation on 1% dextrose com meal agar media did not perforate hair in hair culture. We cultured fungi from each lesion of 3 patients with concurrent infection of T.pedis, T.cruris, T.corporis, and dbtained T.rubrum only in all lesions of each patient. Upon making this observation, we presumed concurrent infection generally to be autoinoculation from one to another part.
Agar ; Age Distribution ; Aged ; Anti-Bacterial Agents ; Arthrodermataceae* ; Causality ; Dermatitis ; Female ; Foot* ; Fungi ; Glucose ; Hair ; Humans ; Incidence ; Jeollanam-do ; Male ; Meals ; Metabolic Diseases ; Onychomycosis ; Outpatients ; Pigmentation ; Tinea ; Tinea Pedis

As increasing numbers of antibiotics, adrenocorticosteroids, and antitumor agents have come into use, so increasing numbars of mycotic diseases have been identified. Qtomycosis, a mycotic infection of the extcrnal ear which is occasionally accompanied by dermatitis of the surrounding skin, is corsidered to be such a disease. While opinion vari.es as to whether otomycosis is caused by a saprophytic or a pathogenic organism, our clinical obs:rvations revealed pathological inflammation of the external auditory canal with profuse fungal elements. During August 1975, l3 specimens of ear wax were taken from patients whv visited the out-patient ENT clinic of this hospital. All patients had had their ears clea,ned at a barber shop prior to visiting the ENT clinic. Because ar cleaning instrumenta (scoops and brushes) are re-used m Korean Sarber shops, 204 of theae in- strum.ent;s were randomly selected from different barber shops and examined. KGH mounts and Lactophenol cot@ten blue stains were used to examine the specimens. Qf the lR ear wax specimens, I2 samples (92. 3%) reveaIed Aspergillus sp. and 1 sample (7. 7%) revealed Penicillium sp. Of the 204 ear cleaning instrumenta tested, l94 colonies grew in culture. Of these cultures, 146 (75. 3 %) were Aspergillus sp., 9 (4. 6%) were Mycelia sterila, 5 (2. 6%) were Fenicillium sp., 4 (2. 1 %) wr Al- terna,ria, 2 (l. 0%) were Stemphylium sp., 1 (0. 5%) was Geotrichum sp., and 27 (13. 9%) were of an unknown species. Of the 146 Aspergillius sp. cultures, 99 (67. 8%) were Asp. terreus, 17 (11.6%) were Asp. glaucus, 5 (3.4%) were Asp. niger, 17 (11. 6%) were Asp. flavus-oryzRC, R (2. 1 %) Were Asp. versicolor, and 5 (3. 4 %) were athers. Beca.use of the close correlation between the fungi cultivated from ear wax apc imens and those cultured from ea,r cleaning instruments, the authors believe that the ear cleaning instruments used in the barber shops could well have been the primary source of infection. In this study the authors also discuss the probable causative factbrs of otomycosis arrd a review of the literature is presented.
Anti-Bacterial Agents ; Antineoplastic Agents ; Aspergillus ; Cerumen ; Coloring Agents ; Dermatitis ; Ear ; Ear Canal ; Epidemiologic Studies* ; Fungi ; Geotrichum ; Humans ; Inflammation ; Niger ; Otomycosis* ; Outpatients ; Penicillium ; Skin ; Viperidae

A case of Toxic Epidermal Necrolysis affecting 24 years old, male Korean, who has been suffering from Pulmonary Tuberculosis, is presented. The skin lesions of the case have been developed about two months after administration of Thioacetazone, 150 mg. per day. The cause of this case may be due to Thioacetazone, one of the antituberculous drugs. Diagnosis of Toxic Epidermal Necrolysis was estsblished by clinical characteristics, histopathological and laboratory studies, and review of literatures were made also.
Diagnosis ; Humans ; Male ; Skin ; Stevens-Johnson Syndrome* ; Thioacetazone ; Tuberculosis, Pulmonary ; Young Adult

Dyschromatosis Symmetrica Hereditaria (Toyama) is one of the pigment anormaly hereditary skin disease which is known to manifest the Japanese. Various authors such as Toyama, Matsumoto, Komaya-Dohi and Ichikawa-Hiraga have reported the disease under different diagnostic name. Clinical characteristics of the disease are shown to have multiple reticular dark brown spotty macular skin lesion mostly over the face, neck, back of hands, feet, fingers and toes, which are affecting symmetrically, without subjective symptom, and occasionally the pigmented and depigmented macular lesions are intermingled. Among these author's reports to the disease, one postulate those which Matsumoto and Komaya-Dohi's cases were essentially similar type in clinical manifestation and were described as showing spotty pigmented macules intermingling with the depigmented over the areas as those of Toyama's. In this article, a case of Dyschromatosis Symemtrica Hereditaria manifesting 21 years old Korean male, which is similar to Matsumoto's type, is presented. Search for the heredity back ground revealed that the grandfather and mother were affected by this disease, and authors assumed the types of heredity of the disease to be irregular non-sexlinked dominant inheritance. Authors presented also distinctions of the histopathological findings of the disease which are hyperkeratosis, increased melanin granules in stratum mucosum layer and imperfect or immatured granular cells, and discussions of differential diagnosis and review of literatures are made.
Asian Continental Ancestry Group ; Diagnosis, Differential ; Fingers ; Foot ; Hand ; Heredity ; Humans ; Male ; Melanins ; Mothers ; Neck ; Skin ; Skin Diseases ; Toes ; Wills ; Young Adult

The level of copayment increased in order to stabilize the financial condition of the health insurance on 1986. An important question regarding the policy was whether the increase in the level of copayments reduced the utilization of medical services in the poor selectively. In spite of the importance of the research question, no study has been reported. This study was designed to find out changes in nuniU rs of physician visits, to explain charac teristics influencing the difference of utilization before and after the program. Finally the interaction effect between the program and the level of income was examined for the abover question. A total of 10,421 persons from eight institutions was selected as the study sample. Research findings are as follows. 1. The number of physician visits decreased by ten percent as a result of increasing the level of copayment. 2. The decrease was remarkable in some groups such as children, rural area and large family. 3. The most important factor which explained the difference was the number of physician visits before the introduction of the new program.. The more numbers of physian visits during the last year were, the more numbers of physian visits decreased after the program. 4. The interaction term between the program and the level of income was statistically significant in the multiple regression model which explained physician visits and its coefficient was negative. It means that an increase in copayment did not reduced the number of physician visits in the poor, selectively. 5. It can be concluded that imposing adequate copayment reduces the use of medical services as well as medical costs without serious damage in access especially for the poor pule.
Child ; Humans ; Insurance, Health

The role of scintigraphic imaging has moved from the detection of lesions to the tissue-specific characterization of lesions over the past 2 decades. Major advances in nuclear medicine imaging include: 1) positron imaging, 2) improved instrumentation, such as the use of multidetector (dual or triple head) gamma cameras for single photon emission computed tomography, and 3) development of numerous new radiopharmaceuticals for positron or single photon imaging ( labeled glucose analogue, amino acids, fatty acids, hormones, drugs, receptor ligands, monoclonal antibodies, etc). These advanced have resulted in a significantly improved efficacy of radionuclide techniques for the evaluation of various of focal gepatic tumors is reviewed in this article with an emphasis on the clinical applications of various tracer studies and imaging findings.
Amino Acids ; Antibodies, Monoclonal ; Carcinoma, Hepatocellular ; Electrons ; Fatty Acids ; Gamma Cameras ; Glucose ; Hemangioma ; Ligands ; Nuclear Medicine* ; Radionuclide Imaging ; Radiopharmaceuticals ; Tomography, Emission-Computed, Single-Photon

The purpose of this report is to study further the presence and nature of the serum inhibitory factor against C. albicans and to investigate whether the pregnant mother sera and corresponding the sera of newborn cord blood would have any differend in inhibitory effect compared with normal adult sera. The sei um samples were obtained from 100 normal healthy adults, 50 pregnant mothers, and 5() samples of sera of newborn cord blood respectively. The degree of candidal growth was determined by the change of percent transmission on pectrophotometry of the organism inoculated in nutrient broth during 24-hour incubation. The results obtained were as follows: The sei a from normal healthy adults were found to retain the inhibitory effects on in vit o candidal growth compared with control, The inhibitory effect of pregnant mother or infant cord sera was also demonstrated, but v, as weaker than that of norrnal adult sera. The inhibitory effect of each group sera was reversed nearly to the control level after con..plete saturation with iron. The inhibitory action of normal adults sera in the standard strain of C. albicans was weaker than in the strain from the patient, The nature of the human serum inhibitory factor against in vitro growth of C. albicans seems to be closely related with the unbound iron-binding capacity of transferrin
Adult ; Candida albicans* ; Candida* ; Fetal Blood ; Humans* ; Infant ; Infant, Newborn ; Iron ; Mothers ; Transferrin

Gangrenous skin disease is characterized by rapidly progressive necrosis of the subcutaneoua tissue. It is mainly caused by Group A b-hemolytic Streptococcus. We are now reporting three cases of gangrenous skin diseases including gangrene due to Vibrio vulnificus, streptococcal gangrene, and ecthyma gangrenosum. Their treatment was as follows: early surgical debridment, the correction of fluidelectrolyte depletion, and antibiotics. When fresh granulation tissues were seen on the wound base, we performed so called Island skin graft. 3 to 5 weeks later, there were good cosmetic and functional results. These results reveals that among several curative measures of gangrenous skin diseases early surgical debridment is the most important one. We belive many dermatologists should be concerned about skin surgery progressively.
Anti-Bacterial Agents ; Dermatologic Surgical Procedures ; Ecthyma ; Gangrene ; Granulation Tissue ; Necrosis ; Skin Diseases* ; Skin* ; Streptococcus ; Transplants* ; Vibrio vulnificus ; Wounds and Injuries

Trichophyton(T.) verrucosum had not been reported until now in Korea. We report herein a case of kerion celsi caused by T. verrucosum considered the first case in Korea and its epidemiologic enviroment. She was a 10 years old girl living in cattle country. Three weeks ago, three small erythematous nodules were developed and rapidly progressed to be large boggy mass like tumefactions. Histopathologically, fungal hyphae and spores were found in hair follicles in H & E and PAS stain. In fungal study, characteristic features of T. verrucosum were found as chains of chlamidospores et als. With above results, we could diagnose these lesions as kerion celsi caused by T. verrucosum which were transmitted from a cattle. After 4 weeks-administration of ketoconazole, lesions were healed completely.
Animals ; Cattle ; Child ; Epidemiologic Studies* ; Female ; Hair Follicle ; Humans ; Hyphae ; Ketoconazole ; Korea ; Spores ; Tinea Capitis* ; Trichophyton*