Leprosy has two polar types. The one tuberculoid leprosy (TL) is characterized by well preserved cellular immunity with a good prognosia and the other lepromatous leprosy(LL) shows no cellular immunity with a poor prognosis. The preaent study was designed to measure the activity of adenosine deaminase (ADA) in sera and erythrocytes of leprosy patients, as it's activities are known to be decreased in immune deficiency diseases. There were no significant differences in the erythrocyte ADA activities among normal subjects(9. 60+4. 43 units/1012 cells), TL patients (7. 12+2. 51 units/1012 cells) and LL patients(6. 96+0. 81 units/1012 cells), The ADA activities in sera of TL patients(20.15+2. 90 units/L) did not differ from those of normal subjects(20.44+ 2. 07 units/L), but the LL patients(17. 52+3. 30 units/L) showed a slightly lowered activity than those of normal subjects.
Adenosine Deaminase* ; Adenosine* ; Deficiency Diseases ; Erythrocytes* ; Humans ; Immunity, Cellular ; Leprosy* ; Leprosy, Tuberculoid ; Prognosis

From January 1971 to December 1980 the authors observed 165 cases of chronic ulcers of the extrernities in the Department of Dermatology, Chonnam University Hospital. The results obtained can be summarized as follows. 1) During this period, the mean average percent of ulcer patients seen was 0.41 of the yearly total patients. 2) The ages of onset was quite varied with the highest group in the 5th decade. The ratio of men to women was 2.93: 1. 3) The most common predilection site was right lower extremity. 4) Leprosy, especially T-type, was the most comrnon underlying disease.
Female ; Male ; Humans

Since Epsteins report in 1963, which identified topical corticosteroid therapy as a possible cause of striae formation, many adverse effects resulting from topical steroids therapy has heen observed in dermatological practice. In this study, 365 cases of side-effects with topical steroids in Department of Dermatology, Chonnarn University Hospital from 1972 to 1981 were analyzed, and the results obtained can be summerized as follows; 1. During this pericd, themean average percent of side effects with topical steroids was 0.85 of the yearly total patients and 12 different kinds of side-effects were found to be present in this study. 2. The annual rate of increase of side-effects with topical steroids (2.4%) was higher than that of yearly total patients (0.5%) and the annual frequency of the 12 side-effects was shown in Table 1. 3. The frequency of the 12 side-effects by age group was shown in Table 2. 4. The frequency of the 12 side-effects by season, sex and region was shown in Table 8. 5. The frequency of the 12 side-effects by lesion site was shown in Table 5. 6. T.he mean period of application with topical steroids was 4. 18 months and applied topical steroids were betamethasone-17-valerate(30.4%), fluocortolone (22.7%), hetamethasone dipropionate(12.9%), fluocmolone acetonide (9.0%) and prednisolone(8.8%) respectively. 7. The most frequent topical steroids and period of application causing each side-effects were as follows: betamethaaone-17-valerate for 1 month resulting in Steroid acne, betamethasone-17-valerate for 2 months resulting in Telangiectasia rubeosis et steroidica, triamcinolone acetonide for 1 month resulting in Perioral dermatitis and betarnethasone-17-valerate for 11 months resulting in Atropic striae.
Acne Vulgaris ; Dermatitis, Perioral ; Dermatology ; Fluocortolone ; Humans ; Seasons ; Steroids* ; Telangiectasis ; Triamcinolone Acetonide

The air-borne fungi are usually considered to be as non-pathogenic and saprophytic organisms. However, those can be causative factors of certain allergic disease, and produce mycotoxic diseases such as caused by aflatoxin B1,or opportunistic infections, since various kinds of antitumor agents and adrenocorticosteroids have been introduced to therapeutics, and those who are affected some malignant tumors or metabolic anomalous diseases. As the first step toward. understanding and controlling the diseases, the studies on the population of air-borne fungi seem to be necessary. Authors studied the fluctuations of population of air-borne fungi at monthly intervals from June 1974 through May 1975 and at various times of the day at different places in th hospital, and the results obtained were as follows: 1. The identified fungi species and the percentage of colony counts of each species were Hormodendrum sp. (37. 2% ), Penicillium sp. (18. 8% ), Aspergillus sp, (17. 6 % ), Alternaria sp. (6.3 %), Mycelia sterila (2.6 %), Paecilomyces sp. (1.2 %) RhodO torula sp. (1. 1 % ), Oospora, sp. (0, 7 % ), Rhizopus sp. (0. 6 %. ), Geotrichum sp. (0.4%), Monilia sp. (0.4%), Mucor sp. (0.4%), Trichoderma sp. (0.4%.), Trichosporon sp. (0. 1%), Stemphylium sp. (0. 1 % ), Helminthosporium sp. (0. 1%) Gliocladium sp. (0. 1,: ), Saccharomyces sp. (0. 1 % ), Trichothecium sp. (0. 03 % ), and other unknown species(11. 6%) in decreasing order of frequency. 2. The monthly fluctuations of number of cultured colonies of four major airborne fungi (Hormodendrum, Penicillium. Aspergillus, and Alternaria) were 649 in June, 105 in July, 372 in August, 431 in September, 188 in October, 241 in November and 89 in December 1974, and 92 in January, 115 in February, 77 in March, 178 in April and 116 in May 1975. 3. It was suggested that there might be a relationship among the humidity, the temperature and the population of the air-borne fungi because the abrupt drop in July seemed to be related to high level of tbe,humidity (86.8%) and the temyerature (24. 3'C). And since the total number of colonies decreased markedly in December 1974 and Junuary 1975, it seemed to be closely related to cold weather temperature. 4. The number of cultured colonies at various times of the day did not show much fluctuation, except that Aspergillus sp. showed sudden tremendous increase at. one occasion, at 3: 00 P.M. on 15th of June and that gradual increase of Hormodendrum sp. was noted on another occasion from 12: 00 A.M. on 15th of September. 5. With regard to the locations of sampling, such as the operating room, laboratory, ward and out-patient department in the hospital, the difference in the identified. fungi species, the number of colony counts and the relationship with the humidity A the temperature was not evident. Authors reviewed relevant literatures and made discussions also.
Aflatoxins ; Alternaria ; Antineoplastic Agents ; Aspergillus ; Candida ; Cryptococcus ; Fungi* ; Geotrichum ; Gliocladium ; Helminthosporium ; Humans ; Humidity ; Mucor ; Operating Rooms ; Opportunistic Infections ; Outpatients ; Paecilomyces ; Penicillium ; Rhizopus ; Saccharomyces ; Trichoderma ; Trichosporon ; Weather

Autogenous bone-patellar tendon-bone is popular ligament substitute used in anterior cruciate liga- ment(ACL) reconstructions. Fracture of the patella is a rare but serious complication unique to this type of reconstruction. We report 4 cases of patellar fracture after autogenous bone-patellar tendon-bone ACL reconstruction.
Autografts* ; Ligaments ; Patella

No abstract available.
Amniotic Fluid* ; Female ; Humans*

PURPOSE: We intended to evaluate the results of arthroscopic anterior cruciate ligament(ACL) reconstruction using Bone-achilles tendon-bone composite allograft by analyzing the results clinically and radiologically. MATERIALS AND METHODS: From May 1996 to June 1999, we followed 23 patients who had arthroscopic ACL reconstruction using bone-achilles tendon-bone composite allograft for minimum 24 months, and measured laxity using KT-2000 arthrometer, Lysholm score and enlargement of tibial tunnel width on plain radiograph. RESULTS: In KT-2000 arthrometer test, there was only side-to-side differences of 1.67 +/-0.7 mm between the involved and contralateral limb. Lysholm score was 61.7 +/-10.2 preoperatively and 89.3 +/-5.1 at the last follow up. And there was no tibial tunnel enlargement more than 5 mm at the last follow up. CONCLUSION: Arthroscopic ACL reconstruction using bone-achilles tendon-bone composite allograft has advantage of preservation of anatomic structure and secure bone-to-bone fixation like the bone-patel-lar tendon-bone graft that bone-achilles tendon-bone composite allograft is a reasonable choice in ACL reconstruction.
Allografts* ; Anterior Cruciate Ligament Reconstruction* ; Anterior Cruciate Ligament* ; Extremities ; Follow-Up Studies ; Humans ; Transplants

The t(3;21) (q26;q22) is associated with chronic myelogenous leukemia in blast crisis, leukemia evolving from therapy-related myelodysplasia, and with leukemia following other hematopoietic proliferative diseases. The t(3;21) is rare secondary aberration in blast crisis of Philadelphia(Ph)-positive chronic myeloid leukemia, which may be restricted to patients entering myeloid blast crisis. We report here in one case of chronic myeloid leukemia in blast crisis which reveals both t(9;22) (q34;q11), and t(3;21) (q26 ;q22). A 62-year-old male was diagnosed as chronic myeloid leukemia 5 years ago, received hydroxyurea therapy, and admitted because of gingival bleeding and fever. On examination, splenomegaly and leukocytosis with proliferated blasts(91%) in peripheral blood were noted. Bone marrow aspirate showed hypercellularity with severe blast proliferation(92.5%) which revealed all negative in peroxidase and PAS stain. Cytogenetic study of bone marrow cells showed the karyotype 46, XY, t(3;21) (q26;q22), t(9;22) (q34;q11), which might be suspected as myeloid blast crisis. Above finding was confirmed by the result of immunophenotyping(CD13 43.6%, CD34 68.2%, HLA-DR 91.6%). He received intensive chemotherapy, but still sustained proliferation of blasts was noted . The follow up cytogenetic study was as follows: 46, XY, 4(3;21) (q26:22), t(9;22) (q34;q11)/46, XY, t(3;21)(q26;q22), del(8) (q22), t(9:22) (q34,q11)/46, XY (16/3/1). He died soon from severe pancytopenia and sepsis.
Blast Crisis* ; Bone Marrow ; Bone Marrow Cells ; Cytogenetics ; Drug Therapy ; Fever ; Follow-Up Studies ; Hemorrhage ; HLA-DR Antigens ; Humans ; Hydroxyurea ; Karyotype ; Leukemia ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive* ; Leukocytosis ; Male ; Middle Aged ; Pancytopenia ; Peroxidase ; Sepsis ; Splenomegaly

No abstract available.
Dermatomyositis* ; Stomach Neoplasms*

PURPOSE: To investigate the clinical outcome based on topographic supported customized corneal ablation (TOSCA). METHODS: The 20 patients (20eyes), who had already undertaken excimer laser surgery at least 6 months ago, resulting in decrease of best-corrected visual acuity, were included. Topography-guided corneal ablation was performed to correct de-centered ablation or irregular astigmatism using with the Mel-70-scan (ascleapion Meditec Inc. Germany) equipped with a Gaussian spot beam. RESULTS: The average uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA) in Log MAR scale was 0.52 +/- 0.35 and 0.33 +/- 0.14, preoperatively. The average of UCVA and BCVA was improved to 0.29 +/- 0.29 and 0.11 +/- 0.14, respectively after TOSCA was done. It was statistically significant difference (p<0.05). CONCLUSIONS: TOSCA may be considered as effective method to improve BCVA in patients who suffer from decrease of BCVA in duced by decentered ablation.
Astigmatism ; Humans ; Lasers, Excimer ; Visual Acuity