No abstract available.
Breast Neoplasms* ; Breast*

No abstract available.
Antibodies, Monoclonal* ; Blood Cells*

BACKGROUND: Uterine leiomyoma is the most common pelvic tumor, occurring in 20-25% of women in reproductive age. Gonadotropin releasing hormone agonist (GnRHa) has been reognized as a temporary medical management for this disorder. The etiology of these tumors is unknown but it has been shown that the insulin-like growth factors (IGF-I, IGF-II) are promoters of growth in nongynecologic tumors. Several recent studies have suggested the possible role of IGFs in human leiomyoma growth. The IGF binding proteins (IGFBPs) are believed to modulate actions of IGF and to have IGF-independent actions. The purpose of this study was to evaluate the type of IGF and IGFBP which may be involved in leiomyoma growth and to investigate a possible IGF related mechanism of action of GnRHa. METHOD: The IGFs and IGFBPs were measured by double antibody radioimmunoassay, western ligand blot and immunoprecipitation in the tissue cytosols of normal uterine myometria (n=15), nontumorous myometria adjacent to a leiomyoma and leiomyoma from patients nontreated (n=15) and treated (n=10) with GnRHa. RESULTS: The mean IGF-I and IGF-II level were significantly higher in leiomyoma from untreated patients than in the adjacent myometrium and normal myometrium but no significant differences in these IGF levels between normal myometrium and adjacent myometrium were noted. The IGFBP-2, IGFBP-3 and 26kDa IGFBP were detected variably but IGFBP-4 was consistently present in all tissues. There were no significant differences in the relative intensity for IGFBP-4 and the frequency of IGFBPs between leiomyoma, adjacent myometrium and normal myometrium from untreated patients. The IGF-I, IGF-II levels and the relative intensity of IGFBP-4 in leiomyoma from GnRHa-treated patients were significantly lower than those in untreated patients, but these levels in the adjacent myometrium were comparable. The frequency of each IGFBP in leiomyoma and the adjacent myornetrium from GnRHa-treated patients did not significantly differ from untreated patients. CONCLUSION: Both IGF-I and IGF-II are involved in the growth of leiomyoma and GnRHa may in part act to decrease size of leiomyoma by regulating the local levels of IGF-I, IGF-II and IGFBP-4.
Animals ; Cytosol ; Female ; Gonadotropin-Releasing Hormone ; Humans ; Immunoprecipitation ; Insulin-Like Growth Factor Binding Protein 2 ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor Binding Protein 4 ; Insulin-Like Growth Factor Binding Proteins ; Insulin-Like Growth Factor I ; Insulin-Like Growth Factor II ; Leiomyoma* ; Mice ; Myometrium ; Radioimmunoassay ; Somatomedins*

No abstract available.
Edema* ; Gallbladder* ; Mucocutaneous Lymph Node Syndrome*

Rieger's syndrome is a rare autosomal dominant developmental anomaly characterized by ocular and systemic abnomalities. These disorders are typically bilateral and usually diagnosed at birth or in the childhood. The most common ocular defects are hypoplasia of the iris, a prominent Schwalbe's line with iris strands and corectopia. A large number of patients have glaucoma due to devel-opmental defects of the anterior chamber angle structure. The authors experienced a case of Rieger's syndrome which was found in 31-year-old female, who had characteristic ocular and other systemic abnormalities. Associated glaucoma was well controlled by filtering surgery.
Adult ; Anterior Chamber ; Atrophy ; Edema ; Female ; Filtering Surgery ; Frontal Lobe ; Glaucoma* ; Glioblastoma ; Humans ; Intracranial Pressure ; Iris ; Neurofibromatoses ; Optic Atrophy ; Optic Nerve ; Optic Nerve Diseases* ; Parturition ; Skin

No abstract available.
Anesthesia, Local* ; Arthroscopy* ; Knee*

The Morel-Lavallée lesion (MLL) is a closed soft-tissue degloving injury, resulting in characteristic hemo-lymphatic fluid collection between the fascia and subcutaneous layers. The MLL was managed routinely with drainage and compression bandages, but sclerotherapy can be used in patients with chronic lesions refractory to first-line therapy. This paper presents a case of extensive recurrent chronic MLL treated with sclerotherapy using Abnobaviscum, which has been used to treat adhesion in malignant pleural effusion.

No abstract available.
Diagnosis* ; Magnetic Resonance Imaging* ; Spinal Stenosis*

BACKGROUND: It is common practice for surgeons to place a T-tube after common bile duct exploration. T-tubes are regarded as safe and they allow postoperative cholangiography. But the unexpected cases of bile peritonitis after T-tube removal raised questions of common factors in etiology. The aim of this study is to investigate risk factors of biliary leakage after removal of T-tube from common bile duct. Materials and METHODS: Seven cases of biliary leakage after removal of T-tube have been experienced in Department of Surgery of Chonnam National University Hospital from January 1988 to March 2000. Seven cases were investigated with respect to the following parameters : presenting disease, underlying disease, laboratory findings, nutritional status, findings associate with T-tube, clinical findings and the results of treatments. RESULTS: The mean age of the patients was 62.9years(range, 45-77years). The presenting diseases were CBD stone with GB stone in three cases, CBD stone in two cases, IHBD stone in two cases. Previous medical history was unremarkable with the exceptions of one hypertensive patient and one patients with early gastric cancer concurrently undergoing treatment for hypertrophic cardiomyopathy. The mean body mass index(BMI) of the patients was 20.5. Arterial blood gas analyses and pulmonary function tests were normal. Preoperative laboratory findings were unremarkable except one patient of hypoalbuminemia. Liver function tests were normal, except in one patient with toxic hepatitis. In all cases, silastic T-tube was inserted following cholecystectomy and choledocholithotomy. The mean CBD diameter was 16.4mm (range, 12-21mm). CBD repair was done with absorbable sutures. Postoperative T-tube cholangiography revealed a remnant stone in the patients with the left intrahepatic stone and were unremarkable in all other cases. The T-tube was removed after a mean duration of 24.6days(range, 15-53). The abdomial pain and tenderness in all patients, most frequently in the right upper qudrant, was the significant sign and symptom associated with bile leakage. The symptoms resolved in four of five patients by drainage using a nelaton tube. The remaining patients(n=3) underwent reinsetion of T-tube. CONCLUSIONS: It is very difficult to predict the occurrence of bile leakage after T-tube removal. And early diagnosis and immediate percutaneous drainage make a good result in patient with localized peritonitis.
Bile* ; Blood Gas Analysis ; Cardiomyopathy, Hypertrophic ; Cholangiography ; Cholecystectomy ; Common Bile Duct* ; Drainage ; Drug-Induced Liver Injury ; Early Diagnosis ; Humans ; Hypoalbuminemia ; Jeollanam-do ; Liver Function Tests ; Nutritional Status ; Peritonitis* ; Respiratory Function Tests ; Risk Factors ; Stomach Neoplasms ; Sutures