The prognosis of unresectable advanced gastric cancer is extremely poor. We tried a neoadjuvant chemotherapy in locally advanced unresectable stomach cancer diagnosed by initial explo-laparotomy. After chemotherapy with the FADE regimen (5-fluorouracil + adriamycin + cisplatin + etoposide), the patient was diagnosed clinically as a complete response state on re-staging with radiological gastrointestinal study, fiber-gastroscopy and computerized tomography. During the second-look operation, the advanced cancer was completely resected and the pathological diagnosis was early gastric cancer (EGC) type IIc, stage II (T1N2Mo).
Adenocarcinoma/*drug therapy/radiography ; Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Case Report ; Cisplatin/*administration & dosage ; Combined Modality Therapy ; Doxorubicin/*administration & dosage ; Etoposide/*administration & dosage ; Fluorouracil/*administration & dosage ; Human ; Male ; Middle Age ; Stomach/pathology/radiography ; Stomach Neoplasms/drug therapy/radiography/*surgery ; Tomography, X-Ray Computed

Sixteen cases of male breast cancer seen over a 20-year period were reviewed. The causes of cancer of the male breast are no better understood, but major alterations in hormonal environment could be a significant factor. Some clinical characteristics correspond well with the results of other series. The median age at presentation was 61.7 years. The most frequent initial symptom was a painless mass, and the incidences of nipple discharge, central tumor location, and axillary node involvement were high. Males also had a higher incidence of local advancement which was associated with a longer delay in seeking treatment and small breast tissue. The pathologic type was infiltrating ductal type in all cases except one, and all cases showed favorable nuclear grade. Estrogen receptor analysis was performed from the tumor of 2 patients. Both of them showed a high receptor level. There was no locoregional relapse in 5 patients who received adjuvant radiotherapy in contrast to the 2 relapses in 3 patients who underwent surgery alone. And three of the five patients who received radiotherapy suffered from systemic metastasis which suggested the important role of adjuvant chemotherapy as well as radiotherapy. In light of the encouraging results about adjuvant chemotherapy in the treatment for female breast cancer with axillary lymph node involvement, it would be desirable to extend this policy to male breast cancer.
Adenocarcinoma/epidemiology ; Adult ; Aged ; Breast Neoplasms/*epidemiology/pathology/therapy ; Carcinoma, Intraductal, Noninfiltrating/*epidemiology/pathology/therapy ; Combined Modality Therapy ; Human ; Korea/epidemiology ; Lymphatic Metastasis ; Male ; Middle Age ; Neoplasms, Multiple Primary ; Retrospective Studies

BACKGROUND AND OBJECTIVES: For surgery of chronically inflamed submandibular gland, most head and neck surgeons carry out skin incision on the neck, but several clinical problems after surgery has been mentioned. An intraoral approach as an alternative to the standard transcervical approach has been reported. To evaluate a postoperative morbidity in the intraoral approach for excision of submandibular gland. SUBJECTS AND METHODS: A total of 62 surgery cases for chronic submandibular sialoadenitis with or without stone, including those resulting from benign tumor of submandibular gland, were carried out via intraoral approach during a 3-year period. RESULTS: Most patients (85.5%) had sialoadenitis with or without stone. Early postoperative complications developed in 87.1% of the temporary lingual sensory paresis, followed by temporary limitation of tongue movement in 67.7% and 2 cases of postoperative bleeding and 1 case of abscess formation. The tongue paresis resolved spontaneously in all patients in a mean period of 3-4 weeks, whereas late complications developed in 3 cases of residual salivary gland and abnormal sense of mouth floor and one case of gustatory sweating syndrome. No residual inflammation in Wharton's duct was noted. Neurological complications of hypoglossal and marginal mandibular nerves were not observed at all. CONCLUSION: The major advantages of this approach are no external scar, no injury to the marginal mandibular nerve or to the hypoglossal nerve, and no residual Whartons duct inflammation. The disadvantage is a more difficult dissection to transcervical approach before proper expert due to narrow surgical field, especially in the severe adhesion of salivary gland to surrounding tissue. However, with experience, the intraoral dissection of submandibular gland should be easier.
Abscess ; Cicatrix ; Head ; Hemorrhage ; Humans ; Hypoglossal Nerve ; Inflammation ; Mandibular Nerve ; Mouth Floor ; Neck ; Paresis ; Postoperative Complications ; Salivary Ducts ; Salivary Glands ; Sialadenitis ; Skin ; Submandibular Gland* ; Sweating, Gustatory ; Tongue