The etiology and pathogenesis of lumbar disc herniation is not clearly proved although biochemical change, physical stress, genetic factor, autoimmune phenomenon and psychophysiologic phenomenon have been considered by many investigators. The most important one is a result of pathologic acceleration of normal aging of the tissue. The present study is aimed to investigate the changes of mucosubstances in normal aging and herniated disc which might have possible role on the disc herniation. The materials used in this study consisted of 123 cases of surgically removed herniated disc and 7 cases of normal control disc obtained from autopsy. Sections were cut and stained with periodic acid-schiff (P.A.S.)-alcian blue (pH 2.5) for the detection of neutral mucosubstances, alcian blue at pH 2.5 for nonsulfated acid mucosubstances, and alcian blue at pH 1.0 and Spicers diamine method (HID) for sulfated mucosubstances. The results were as follows. l. Of the 123 cases of lumbar disc herniation, there was a slight male preponderance over female with a ratio of 1.5:1.0. The most commonly affected level was L4-5 comprising 69 cases (56.1%), and up to three quarters of the patients the age was from 3rd to 5th decades in which it was rather evenly distributed. 2. The time interval between the appearance of symptoms and operation was less than 1 year in 77 cases (62.6%), in 32 cases (26.0%) being within 3 months. 3. Histochemical studies of the normal discs showed increase of neutral mucopolysaccharides with reduction of acid and sulfated mucopolysaccharides in the nucleus pulposus, and increase of all the mucosubstances in the annulus fibrosus by aging. 4. Histochemical studies of herniated disc showed an acceleration of the changes seen in normal changes. 5. Cartilaginous end plate formation was noted in 46,3% of herniated discs. The results obtained by the present investigation suggest that herniation of lumbar diosc is closely associated with accelerated or premature degeneration of the disc.
Acceleration ; Aging ; Alcian Blue ; Autopsy ; Female ; Glycosaminoglycans ; Humans ; Hydrogen-Ion Concentration ; Intervertebral Disc Displacement ; Male ; Methods ; Research Personnel

The purpose of this study was to evaluate the rewetting effect of water-based primer on the air-dried dentin. In this in vitro study, freshly extracted non-caries human molars and three-step adhesive system(SBMP) were used. Freshly extracted non-caries human molars and three-step adhesive system(SBMP) were used. Flat occlusal dentin surface were prepared using low-speed diamond saw. Prepared teeth were randomly divided into three groups. Group 1.(W); etched(35% phosphoric acid for 15s) and blot-dried, Group 2.(5D); 5s air-dried, Group 3.(30D); 30s air-dried. To obtain color contrast in CLSM observation, primer was mixed with rhodamine B and bonding resin was mixed with fluorescein. Microscopic sample of each group were obtained after longitudinal section. Morphological investigation of resin-dentin interface and thickness of hybrid layer measurement using CLSM were done. Microtensile bond strength for each specimen was measured. Specimen were observed under microscope to examine the failure patterns of interface between resin and dentin. The results of this study were as follows: 1. The results(mean) of Thickness of hybrid layer were W;19.67, 5D;20.9, 30D;10microm. Only 30D had statistically significant differences to W and 5D(P<0.05). 2. The results(mean) of Microtensile bond strength were W;16.02, 5D;14.69, 30D;11.14MPa. Only 30D had statistically significant differences to W and 5D(P<0.05). 3. There were positive correlation between Thickness of hybrid layer and microtensile bond strength(P<0.05).
Adhesives ; Dentin* ; Diamond ; Fluorescein ; Humans ; Molar ; Rhodamines ; Tooth

To investigate the liver diseases affecting infancy and Childhood and to make a clinicopathologic correlation, a total of 105 liver biopsies were examined and following results were obtained. 1. Of the 105 liver biopsies, 94 cases were available for the study, and the male to female ratio of liver biopsies in infancy and childhood was 1.8 : 1. 2. Of the 94 available cases, 36 were of diffuse hepatitis, 15 congenital biliary atresia, 4 liver cirrhosis and 3 were of malignant neoplasm. The liver biopsy showed only fatty metamorphosis in 12 cases(12.8%) and the remainings were of other rare liver diseases(19.1%) or of normal liver tissue(6.4%). 3. Diffuse hepatitis affected male 2.3 times more commonly than female, and comprised of 3 acute viral hepatitis, 3 chronic active hepatitis, 7 chronic persistent hepatitis, 1 cholangitis, 8 neonatal hepatitis and 14 nonspecific reactive hepatitis. 4. Congenital biliary atresia affected male and female in about equal frequency, and 13 of the 15 cases were extrahepatic. 5. Two of the 4 live cirrhosis were macronodular, and primary and 2ndary cirrhosis were encountered one in each. 6. Of the 12 cases of fatty metamorphosis, 8 were regarded clinically as Reye's syndrome. 7. Among 34 cases in which the serum HBsAg was tested, 11 were positive, namely all of 3 acut viral hepatitis, 2 chronic active hepatitis, 4 chronic persistent hepatitis and all of 2 macronodular cirrhosis. In neonatal hepatitis and congenital biliary atresia it was exclusively negative. 8. The clinical diagnosis was compatible with the biopsy diagnosis in 60.6% of 94 cases.
Biliary Atresia ; Biopsy* ; Cholangitis ; Diagnosis ; Female ; Fibrosis ; Hepatitis ; Hepatitis B Surface Antigens ; Hepatitis, Chronic ; Humans ; Liver Cirrhosis ; Liver Diseases ; Liver* ; Male ; Reye Syndrome

Among the primary carcinoma of the extrahepatic bile duct, papillary carcinoma is the least common form and usually located in the distal common bile duct. The cholangiographic findings of the papillary carcinoma is similar to translucency produced by stone. We report a case of multiple papillary adenocarcinoma of the extrahepatic bile duct of which the cholangiographic findings mimicking stones.
Adenocarcinoma, Papillary* ; Bile Ducts, Extrahepatic* ; Calculi ; Carcinoma, Papillary ; Cholangiopancreatography, Endoscopic Retrograde* ; Common Bile Duct

No abstract available.
Myxoma* ; Perineum*

There is growing evidence that oxygen-derived free radicals(OFR's) play a role in the pathogenesis of pancreatic diseases, especially of acute pancreatitis. Many types of experimental ex vivo and in vitro pancreatitis can be inhibited by superoxide dismutase and catalse. (continue...)
Hyperamylasemia* ; Oxygen* ; Pancreatic Diseases ; Pancreatitis ; Superoxide Dismutase

No abstract available.
Female ; Lymphoma* ; Ovary*

No abstract available.
Female ; Neurilemmoma* ; Ovary*

Intramural duodenal hematoma is an uncommon condition, which usually develops after blunt abdominal trauma. It is also reported as a complication of anticoagulant therapy, blood dyscrasia, pancreatic disease, and diagnostic and therapeutic endoscopy. The typical clinical pictures of intramural duodenal hematoma consist of upper abdominal pain, vomiting, fever, and hematochezia, and it is rarely accompanied by intestinal obstruction, peritonitis, and pancreatitis as its complication. We report a case of intramural duodenal hematoma extended to peritoneal cavity, and accompanied by acute pancreatitis following therapeutic endoscopy for duodenal ulcer bleeding in a 32-year-old man who was on maintenance of anti-coagulation therapy after valvular heart surgery.
Acute Disease ; Adult ; Diagnosis, Differential ; Duodenal Diseases/*diagnosis/pathology/surgery ; Duodenal Ulcer/*complications ; Hematoma/*diagnosis/pathology/surgery ; *Hemostasis, Endoscopic ; Humans ; Male ; Pancreatitis/complications/*diagnosis ; Peptic Ulcer Hemorrhage/*therapy ; Postoperative Complications ; Tomography, X-Ray Computed

Compared with other types of cancers, pancreatic cancer is one of the most dreadful malignancies and is fifth leading cause of cancer-related death in Korea. It is difficult to expect early diagnosis or improvement in prognosis due to lack of specific early symptoms and effective diagnostic methods. Whereas cystic neoplasm of the pancreas is a rare type of pancreatic tumor, surgical resection provides good prognosis because of its low possibility of local invasion or distant metastasis. In case of pancreatic cystic tumor, radiologic differentiation between benign and malignant lesions is crucial for the selection of appropriate treatment and the prediction of prognosis. And ductal adenocarcinoma of pancreas presenting in cystic form is an uncommon type of cystic tumor, making it extremely rare among all pancreatic malignancies. We report two cases of atypical pancreatic ductal adenocarcinoma presenting as solid pseudopapillary tumor and intraductal papillary mucinous neoplasm, respectively.
Adenocarcinoma, Mucinous/*diagnosis/surgery ; Adenocarcinoma, Papillary/*diagnosis/surgery ; Adult ; Carcinoma, Pancreatic Ductal/*diagnosis/pathology/surgery ; Female ; Humans ; Male ; Middle Aged ; Pancreatectomy ; Pancreatic Neoplasms/*diagnosis/pathology/surgery ; Tomography, X-Ray Computed