Introduction: the background and importance of present research work consists on demonstrating how the drug substance digestion changes depending from the media of fluid to be taken. Purpose: consists in comparative study of solution of the diclofenac sodium film coated tablets, produced in various countries, in different solvent media by the in vitro method. Materials and Methods: the solution research of each 50mg total 54 pieces of film coated diclofenac sodium, produced in three different factories such as A, B and C, was conducted in three different medias in juice (pH=3.8); distilled water (pH=6.7) and mineral water (pH=6). The solution was determined in centrifuge and measured 276 nm in spectrophotometer. Result: the solution of 50mg diclofenac sodium film coated tablet, produced in three different countries such as A,B and C: • The amount of drug substance released in the distilled water (pH=6.7) media has been counted in 15 minutes after begin of solution process the A factory-66%, the B factory-58% and the C factory-20%. At continuation of duration of solution had in 30 minutes the A factory-80%, the B factory-86%, the C factory-72%; in 45 minutes the A factory-82%; the B factory-88%; the C factory-66%; in 60 minutes the A factory-82%; the B factory-82%; the C factory-72% each respectively. • The amount of drug substance released in the juice (pH=3.8) media has been counted in 15 minutes after begin of solution process the A factory-50%, the B factory-42% and the C factory-60%. At continuation of duration of solution had in 30 minutes the A factory-82%, the B factory-40%, the C factory-72%; in 45 minutes the A factory-80%; the B factory-44%; the C factory-38%; in 60 minutes the A factory-56%; the B factory-66%; the C factory-58% each respectively. • The amount of drug substance released in the mineral water (pH=6) media has been counted in 15 minutes after begin of solution process the A factory-54%, the B factory-30% and the C factory-10%. At continuation of duration of solution had in 30 minutes the A factory-66%, the B factory-62%, the C factory-36%; in 45 minutes the A factory-82%; the B factory-82%; the C factory-38%; in 60 minutes the A factory-74%; the B factory-84%; the C factory-74% each respectively. Conclusion: from the above-mentioned experiment it is evident that the solution of the diclofenac sodium film coated tablet, produced in different countries, in different solvent media as distilled water, juice and mineral water is relatively different. It has showed how important is to take into account the auxiliary substance quality contained in current drug at choosing the fluid to be taken after the drug. Bibliography: - “Drug analysis” D. Dungerdorj, Z.Anuu 2012 - “Bioformation” A.I. Tikhonov, T.G. Yarnykh, I.A. Zupanets, O.S. Danikevich, E.E. Bogutskaya, N.V. Bezdetko, Yu.N. Azarenko 2003

Urogenital mycoplasmosis is infectious inflammatory disease of the urinary tract caused by Mycoplasma exclusively. Pathogens of mycoplasma and ureaplasma are related to their biological rare uniqueness. Mycoplasma and ureaplasma has very small size of genome and lack a rigid cell wall. They are able to enter host cell membrane and multiply in it. This protects them from cellular and humoral immune reaction. This unique feature is the reason why the infection is often mysterious and asymptomatic. The dangerous difficulty of the ureaplasma and mycoplasma infection of the urinary tract leads to infertility, chronic endometritis, pregnancy without growing, fetal anomalies, primary and secondary placental shortage. Therefore, it is necessary to determine diagnostic approach and to study the extent the influence eproduction and the prevalence of causative agent.We analyzed the objects which derived from women with the pathogen for the period beginning from January 2014 up until January 2015 collaborating with “Oncogenic” laboratory at the National Center for Research on Cancer based on the women clinic “UilsButemj”. Total of 43 women who diagnosed to have key cells by vaginal smear test were included in the PCR analysis. Total of 12 healthy women who does not have obstetric chronic anamnesis were selected to be included in the analysis by creating control group. The study was done by the prospective case study model. IBM SPSS 20.0 software was used to process the results of the study. 43 women who were involved in the analysis were chosen by the following criteria: 1.With genitourinary complaints, 2.With positive key cells of the vaginal smear test.The average life expectancy of the women surveyed was 31,4±5,6. (min 22, max 53). The majority or 92.7% obtained high education and 7.3% have secondary education. For marital status, 74.5% have their own families and 25.5% of the total women involved were single. There were 15 infertile women or 34.8%, 11 miscarriage women or 25.5% and 12 women with pregnancy without growing or 27.9%, 4 women diagnosed to be pregnant outside of the uterus or 9.3%. The infection combined with U parvum and M hominis which cause pathogen accounted for 40% among total infertile women. The more combined the infection the more virulent. The following originators were detected by the PCR analysis which was run among the total of 43 women with pathogen:U.parvum 32 women, or 74.4%, U.urealiticum 11, or 25.5%, M.hominis 24, or 55.8%, M. Genitalis 4, or 9.3%, Gardnerella 31, or 72.9%, were detected respectively in single or co-discovered way and the majority of them are U.parvum and Gardnerella originators. 10 women, or 83.3%, with U.parvum, 3 women, or 25% with U.urealiticum, 4 women, or 33.3% with M.hominis, 1 woman or 8.3% with M. Genitalis and 7 women, or 41.6% with Gardnerella were detected respectively by the PCR analysis which was done in healthy women without any obstetiic chronic memory. Therefore, types of ureaplasma and mycoplasma is infected to human body as situational pathogen creator and those situational pathogen creators lead to difficulty by creating pathogen in case they shifts to the pathogen creator form. The fact that there were 15 infertile women or 34.8%, 11 miscarried women or 25.5%, 12 pregnant women without growing or 27.9%, 4 pregnant women outside of vagina or 9.3% shows that these pathogen creators are the factor for further difficulty.

BACKGROUND: The prescriptions of multi-component have been the subject of chemical study fora long time. Therefore, when compounding the preparations of multi-component in traditionalmedicine, their taste is cautiously relied on, as the power of the medicine should not be subduedwith the power of another. Our research group has been carrying out tests on the raw materials,which are contained in multi-component prescriptions. However, research on multiple prescriptionsis relatively less being carried out.The traditional medicine naro-3 is used in traditionalmedical practicefor the treatment of inflammationand as a pain relieving remedy. Naro-3 is composed of 3 medicinal herbs including AconitumKuznezoffii Reichb, Terminalia chebula Retz, Piper longum L.GOAL: The aim of the study is to investigate some phytochemical compounds of traditional prescriptionNaro-3.OBJECTIVES:1. To reveal biological active substances of naro-3;2. The sum of the quantitative chemical study by spectrophotometry;3. To establish main criteria of standardMATERIALS AND METHODS: Traditional medicine narî-3 was produced from the Traditional Medicinefactoryof TMSTPC. In the phytochemical research, biological active substances were determinedby thin layer chromatography (TLC), on silica gel plats. The total contents of alkaloid and tannincompounds were determined by titrimetric method. TheMongolian pharmacopoeia was used fordetermination of quality parameters of traditional medicine Naro-3.RESULTS: TLC measurements of biological active substances of naro-3 showed that contains gallicacid and alkaloids respectively. The result of our research it was determined that the total tannin10.4 percent, total alkaloid 2.47 percent and organic acid 2.67 percent in drug Naro-3.CONCLUSION: The results of the study indicate that naro-3 contains a large amount of biologicalactive substances such as tannins, alkaloids and organic acids, which are connected with its painrelieving and anti-inflammatory effects.

Regardless the possession of any graduation and qualifications anywhere in order to train the doctors and medical professionals with the capabilities to work in any places there are the needs of the knowledgeable mentors to teach their knowledge, abilities and trends to the students in national, regional and international levels. This survey was started to determine the needs of the skills development of the mentors of the Mongolian National University of Medical Sciences under the mission to make it as one of the best 100 medical universities in the Asia-Pacific region and in order to create the favorable environment to accelerate the development of the university and creating a team consists from qualified mentors and researchers by improving the trainings, researches and clinical favorable environment including the quality improvement of the activities.The total of 333 mentors from the 5 structures and 3 branches of the Mongolian National University of Medical Sciences were surveyed to be developed by the University of Michigan including the use of the widely used questionnaires in the universities consisting from 7 groups and 81 questions to determine the needs of the mentors.The working range of the best medical mentors including their needs of the skills was studied. The 55.7% (50.4-61.0%) of the mentors included in the survey were told that the facilitation of the learning needed, 82.4% (78.3-86.5%) as the role models needed, 79.9% (75.6-84.2%) as the provision of the information is needed, 76.3% (71.7-80.9%) as 82.8% (78.8-86.9%) as the planning needed and 81.0% (76.8-85.2%) as the assessment of the training is needed.There is a need to develop the skills related to the 6 frameworks as the learning facilitation for the mentors, role model providers, information providers, resource developers, planners and assessors.

OBJECTIVES: This study investigated the potential correlation between 4 plant-based diet indices and the predicted risk of coronary heart disease (CHD) in Korean men using the Framingham Risk Score. METHODS: The study included 12,356 men participants (aged ≥40 years) from the Health Examinees Study. Dietary intake was estimated using a validated food frequency questionnaire. Four plant-based diet indices were measured, including the overall plant-based diet index, the healthy plant-based diet index (hPDI), the unhealthy plant-based diet index (uPDI), and the pro-vegetarian diet index. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for the predicted 10-year risk of CHD. RESULTS: The study found that individuals in the highest hPDI quintile had a 19% lower risk score for CHD based on the Framingham Risk Score (model 3: HR, 0.80; 95% CI, 0.69 to 0.93; p for trend=0.010). In stratified analyses, the highest pro-vegetarian diet index was associated with a lower risk score for CHD in physically active individuals (HR, 0.74; 95% CI, 0.59 to 0.93; p for interaction=0.020). Conversely, the highest uPDI was associated with the highest risk score for CHD in those with a body mass index of ≥25 kg/m2 and a waist circumference ≥90 cm. CONCLUSIONS This prospective cohort study highlights the positive role of adhering to a high hPDI diet in the prevention of CHD in Korean men. Further prospective studies are needed to determine the association between various plant-based diet indices and the risk of CHD in Asian populations with different dietary habits.

Mongolia is a parliamentary republic country in the north of our country. Healthcare system is mainly composed of three parts: state-owned medical institutions, private clinics and mixed-ownership medical institutions, characteris by the wide coverage but uneven resources. Due to the folk customs and climate, diseases of the digestive system are more common, and the main diseases that cause deaths of Mongolian residents are ischemic heart disease, stroke, and liver cancer. Mongolia is located by and culturally related to China, so the development and dissemination of Traditional Chinese Medicine (TCM) is likely acceptable to the public. Mongolia’s traditional medicine and TCM have long-term exchanges and influences, promoting each other’s development, which also are protected by Mongolian laws. The concerns such as the inheritance, study and protection of Mongolian traditional medicine, the promotion of non-medicinal therapies restrict the development Mongolian and Chinese traditional medicine. It is recommended that Mongolian and TCM jointly promote the development and dissemination of traditional medicine in the world by cultivating high-level medical talents, increasing research and protection of herbal medicines, and expanding the application of non-drug therapies.

Mental health team includes a psychiatrist, a psychiatric nurse, psychologist and social workers. Mental health workers are more stressful than other sector’s workers. Mental workers are working with mental patients, who have chronic,severe and poor prognosis disorders for long time, and may have Work Burnout Syndrome (WBS). Worldwide, many researches are used Maslach Burnout Inventory (MBI) for assessing WBS. Our goal was to detect risk factors of WBS among mental health workers. We conducted the survey among workers mental (doctors, nurses and assistant nurses) and study design was a descriptive cross-sectional. We are used a questionnaire, is including MBI. Our subjects were 103 workers, who were 27 (26,2%) doctors, 32 (31,1%) nursesand 44 (42,75) nurse- assistant. They were 15 (14,6%) male and 88 (85,4%) female and average age was 38.21 (SD = 8.92). The worker’s average professional working year was 13.09 (SD = 9.76). Most of subjects (n=63 61.2%) were shift-workers and they (n=99 96.1%) have high workload. We determined 3 groups by level of MBS among mental workers, such as the group with EE’s high scale (n = 27; 27%), thegroup with DP’s high scale (n = 23; 22.8%) and the group with PA’s high scale (n = 50; 50.5%).MBS was high among NMHC’s workers. However their work time is low, but theyhave risk factors for MBI such as high workloads, shift work, number of patients. Workers of emergency department had termination burnout syndrome more than other acute departments. This was associated with working condition.

INTRODUCTION:According to the report from 2010, Mongolian water consumption was 550 million cubic meter andapproximately 9.1% of the total Mongolian population obtain their water from inadequate hygiene waterresources - springs and rivers. Due to non-hygiene water usage has caused water-born communicableand non communicable diseases among the population. In the last years there has been issue of pollutionof one of the Mongolia’s more representative river Selenge and its following rivers -Kharaa, Orkhon andit is necessary to evaluate water pollution of these rivers.GOAL:To determine water chemical and biological pollution of Kharaa and Orkhon river and to evaluate waterqualityMaterials and MethodsWe collected water, sediments and macro invertebrates sample from three points of river -upstream,midstream, downstream and for Kharaa river the samples were collected from Tunkhel, Mandal andBayangol soum, fo Orkhon river the sequence was Orkhontuul, Orkhon, Khushaat soum. Samples werecollected June, August, October of 2011, 2013.In water sample, we determined physic-chemical 15 parameters including temperature, pH, total dissolvedsolids, conductivity, smell, color, hardness, sulfate, chloride, nitrate, nitrite, ammonia, dissolved oxygen,biological oxygen demand and mercury using their standard methods. Macro invertebrate samples werecollected to evaluate water quality and we determined mercury in sediments and macroinvertebratesamples to evaluate mercury contamination.RESULT:Physic-chemical results of the water showed that water of Kharaa, Orkhon rivers were classified lowmineralized, soft water and nutrient pollution indicators for ‘slightly polluted’category. For dissolved andbiochemical oxygen, they were belong to the category of ‘pure water’.There were no correlation between 2012 and 2013 results and mercury in water, sediments and macroinvertebrates were qualified standard value.CONCLUSION:According to research results water quality of Kharaa, Orkhon river was good and have less pollution andit is possible to use in household consumption after proper cleaning and disinfection.

Background. The abuse experiences can change the normal development of the child with the consequences being visible after many years even throughout the whole life. The relation between childhood abuse and the psychiatric disorder in adulthood is reported in a great number of epidemiological studies and researches based on the clinical population surveillance. Numerous studies have significantly expressed the relation between childhood abuse and anxiety, the development of anxiety disorders. Limited research has shown a possible association between exposures to child abuse the risk of developing physical parameter changes as an adult.Goal. To study anxiety and some physical parameters among abused adolescentsMaterials and Method. There were selected46 abused children and 48 non abused children aged between 11-16 years old. The Spence Children’s Anxiety Scale (SCAS; Spence, 1997) is a38-item selfreport questionnaire that assesses multiple symptoms of childhood anxiety disorders based on current diagnosticcriteria. The height, weight, heart rate, breath rate and blood pressure of all participants in the study were measured according to standardized methodology.Results. Average age of all subjects in the study was13.51±1.61 and 60% of them were female and 41% male. All anxiety symptoms of case group was statistically significance higher (p<0.01) than the control group. Significantly more abused children (147.09±10.16) showed stunting compared to 4 sm of non-abused (151.53±10.26).Conclusion. In the present study, abused children were 2.8 times as likely as children with no maltreatment. Also significant stunting was found among abused children identified does differ from the growth of children who are not abused.

BACKGROUND. Traditional medicine is the oldest form of health care in the world and is used in the prevention and treatment of physical and mental illnesses3. Traditional medicine is also variously known as complementary and alternative, or ethnic medicine, and it still plays a key role in many countries today11. Plant produces a wide variety of secondary metabolites which are used either directly as precursors or as lead compounds in the pharmaceutical industry. It is expected that plant extracts showing target sites other than those used by antibiotics will be active against drug resistant microbial pathogens7. Antibacterial activities of various extracts, including methanol, ethanol, butanol and ethyl acetate crude extracts from traditional Tiishal medicine and its medicinal plants ingredients were carried out. Staphylococcus aureus, Pseudomonas aeruginosa, Micrococcus luteus, Salmonella enterica. For this purpose extract of drug Tiishal were prepared and tested by “Disc Diffusion Method”. As a result of this study it was found that the extract of Tiishal generally revealed antimicrobial activity against both gram positive bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Micrococcus luteus) and gram-negative bacteria (Salmonella enterica). The to study found that antibacterial activity of the ethanol extracts of each 6 samples showed little inhibition on Sal. enterica. METHODS. Traditional medicine Tiishal was produced from the Manba Datsan clinic and training center for traditional Mongolian medicine. Tiishal medicine was prepared by the standard MNS 5585:2006, № 0333151207 Tiishal medicine instructional method. The main medicinal herbs of Tiishal include Juniperus pseudosabinaFisch., Gentiana barbata Froel., Cynomorium songaricum Rupr., Sophora alopecuroides L., and Tricholoma mongolicum Imai (1:1:1:1:1) ratio. The antimicrobial activity of the ethanol, methanol, butanol and ethyl acetate extracts was carried by disc diffusion method. RESULTS. A total 4 strains were used for the antibacterial activity test. The extracts of methanol, and ethanol of J. pseudosabina revealed the highest antibacterial activity against Bac. subtilis, Ps. aeruginosa, S. aureus, and S. enteric with the diameters of inhibition zones between 6.0 - 10.0 mm. СONCLUSION. “Tiishal”, ethanol and methanol extracts of 5 different plants showed relatively low inhibition of bacterial growth.