In 2008 high blood pressure in adults aged 25 and over in the world was 40%.Cambodia is currently challenged by the escalating burden of high blood pressure, together with other associated non-communicable diseases. The prevalence of high blood pressure in adults aged 25 to 64 was 11.2% in 2010. This means that one in every ten people has high blood pressure. By gender, the prevalence of high blood pressure in men and women is 12.8% and 9.6% respectively. In urban areas the prevalence of high blood pressure was16.9% while in the rural areas the prevalence of high blood pressure was 10%.However, there is an opportunity to prevent increasing burden of high blood pressure in Cambodia. To reduce the burden of high blood pressure and premature deaths due to heart disease and stroke in Cambodia, tobacco control and salt reduction programs need to be strengthened. In addition, those with hypertension including lifestyle modification and medications need to be better managed, and prevention of complications enhanced. It is important to look for co-morbidities in those with high blood pressure, to provide enhanced care in the community that facilitates compliance to drug treatment, and to encourage lifestyle modifications.