1.Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model.
Khalid ASADI ; Lynnette R. FERGUSON ; Martin PHILPOTT ; Nishi KARUNASINGHE
Journal of Cancer Prevention 2017;22(3):135-146
BACKGROUND: Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root. METHODS: We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APC(MIN/+) (APC(MIN)) mouse, a genetic model of colorectal cancer. APC(MIN) and C57BL/6J wild-type mice (n=160) were divided into four feeding groups consuming diets containing 10% SL222 sweet potato flesh, 10% SL222 sweet potato skin, or 0.12% ARE (Anthocyanin rich-extract prepared from SL222 sweet potato at a concentration equivalent to the flesh-supplemented diet) or a control diet (AIN-76A) for 18 weeks. At 120 days of age, the mice were anaesthetised, and blood samples were collected before the mice were sacrificed. The intestines were used for adenoma enumeration. RESULTS: The SL222 sweet potato-supplemented diets reduced the adenoma number in the APC(MIN) mice. CONCLUSIONS: These data have significant implications for the use of this sweet potato variant in protection against colorectal cancer.
Adenoma
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Animals
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Anthocyanins
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Colorectal Neoplasms
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Diet
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Intestines
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Ipomoea batatas*
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Mice*
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Models, Genetic
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New Zealand
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Skin