1.Pregnancy rate and live birth rate from in vitro fertilization treatment
Khadbaatar R ; Khukhii S ; Bayartsogt Z ; Amarzaya L
Mongolian Medical Sciences 2016;176(2):15-18
BackgroundConducting IVF treatment in laboratory environment by using ARTechnologies in idiopathic infertility,which cannot be treated by both drug treatment and surgical treatment in Mongolia, and preparinglegal environment are the crucial issues in treating infertility. The study is theoretically and practicallysignificant to properly determine pregnancy rate and live birth rate after embryo transfer treatmentin Mongolia.GoalAim of the study is to determine pregnancy rate and live birth rate after IVF treatment in coupleshaving infertility problem.Objectives1. To determine pregnancy rate in conjunction with age factor after conducting In vitro fertilizationin laboratory environment in couples with infertility problem.2. To determine live birth rate after pregnancy in conjunction with age factor.Materials and MethodsThe information of 180 couples aged 22-46 y.o., who received IVF treatment in “Unimed International”hospital’s IVF Center between March 2014 and June 2015, has been used in this study. Pregnancyrate as well as live birth rate after in vitro fertilization treatment has been determined. Statistic datawere calculated by SPSS-20 and Microsoft office excel 2013.ResultsThe average age of 180 women treated by In vitro fertilization treatment was 35.21±5.1 y.o. Sortedby age group: aged ≤30 y.o. was 34 (18.8%), aged between 31-34 y.o. was 41 (22.7%), agedbetween 35-39 y.o. was 80 (44.4%) and aged ≥40 y.o. was 25 (13.8%). 71 (39.44%) of womentreated by In vitro fertilization became pregnant. Sorted by their age: aged ≤30 y.o. was 18 (52.9%),aged between 31-34 y.o. was 20 (48.7%), aged between 35-39 y.o. was 28 (35.0%) and aged ≥40y.o. was 5 (20.0%). Resulted live birth from pregnancy is 56 (78.8%). Sorted by their age: aged≤30 y.o. was 16 (88.8%), aged between 31-34 y.o. was 18 (90.0 %), aged between 35-39 y.o. was22 (78.5%) and aged ≥40 y.o. was 2 (40.0%). Multiple births from total live birth is 16 (28.57%),amongst them 14 (25.0%) were twin births and 2 (3.51%) of them had triplet birth.Conclusions:1. IVF treatment in laboratory environment by using ARTechnologies in idiopathic infertility, whichcannot be treated by both drug treatment and surgical treatment, have good results (averagepregnancy rate was 39.44%).2. Live birth rate from total pregnancy was 56 (78.8%).3. Multiple birth from total live birth is 16 (28.57%). 14 (25.0%) were twins and 2 (3.51%) weretriplets.4. The IVF success rate depends on variable factors such as maternal age, cause of infertility,embryo status, reproductive history and lifestyle factors.
2.A study on risk factors influencing the outcomes of In vitro fertilization (IVF)
Amarzaya L ; Khadbaatar R ; Erkhembaatar T ; Gunjinlkham S ; Khulan Ch ; Jargalsaikhan B
Mongolian Journal of Health Sciences 2025;87(3):21-28
Background:
Infertility is defined as the inability of couples to conceive
despite engaging in regular, unprotected sexual intercourse for over a year.
Assisted reproductive technology (ART), particularly in vitro fertilization (IVF),
has emerged as the most widely utilized solution for infertility. The cause
of infertility, a woman's ovarian reserve, response, egg and sperm quality,
the number and quality of embryos, and various other factors influence the
outcome of IVF. Despite significant advancements in ART, predicting IVF
outcomes remains challenging, especially when tailoring treatment strategies
to individual patient factors.
Aim:
To investigate the clinical indicators, ovarian reserve markers, and
stimulation outcomes influencing the success of IVF treatment in Mongolian
women.
Materials and Methods:
A prospective study was conducted at the Unimed
International Hospital IVF Center between October 2023 and August 2024.
Clinical and demographic factors, ovarian reserve markers (FSH, AMH, AFC),
and ovarian stimulation outcomes were analyzed in 242 women aged 25-44
years undergoing IVF. Logistic regression analysis was performed to identify
risk factors and predictors of clinical pregnancy, with a statistical significance
threshold set at p<0.05.
Results:
Among 208 women who underwent embryo transfer, the clinical
pregnancy rate was 36.5%, and biochemical pregnancy was observed in
38.4%. Age was a significant predictor, with older age groups (35-39 years:
OR=7.11, p=0.004; 40-44 years: OR=12.65, p=0.004) associated with reduced
IVF success. Ovarian reserve markers, including AMH (OR=2.49, p<0.001)
and AFC (OR=1.56, p<0.001), were significantly correlated with pregnancy
outcomes, whereas FSH was not significant (p=0.518). Higher numbers of
pre-ovulatory follicles (POF) (OR=1.03, p=0.040) and high-grade embryos
(OR=1.26, p=0.045) increased the likelihood of clinical pregnancy. No
significant associations were observed between total gonadotrophin dosage,
ovarian sensitivity index, and fertilization rate with pregnancy outcomes.
Conclusion
Age and ovarian reserve markers (AMH, AFC) are critical
predictors of IVF success, while pre-ovulatory follicle counts and number
of high-grade embryos significantly enhance pregnancy likelihood. These
findings emphasize the importance of personalized ART protocols tailored to
ovarian reserve and age-related factors to optimize IVF outcomes.
3.A rare case of complete androgen insensitivity syndrome (cais) with serous cystadenoma
Amarzaya L ; Kherlen O ; Khadbaatar R ; Khulan Ch ; Lkhagva-Ochir M
Mongolian Journal of Health Sciences 2025;87(3):40-42
Complete androgen insensitivity syndrome (CAIS), also known as Morris
syndrome, is a rare X-linked recessive disorder characterized by a
46XY karyotype and a female external phenotype. We present the case
of a 32-year-old patient who presented to Unimed International Hospital
in 2024 with primary amenorrhea, infertility, and chronic pelvic pain.
Clinical examination, imaging, and laboratory investigations led to the
diagnosis of CAIS. Laparoscopic surgery was performed to remove bilateral
gonadal structures and a cystic mass on the left side. Histopathological
analysis revealed testicular tissue and a serous cystadenoma
originating from the left mesonephric remnant. Following gonadectomy,
hormone replacement therapy was initiated, resulting in stabilization of
hormone levels. This rare case highlights the possibility of mesonephric
remnant-derived cystadenoma in CAIS and underscores the diagnostic
value of cytogenetic and histological evaluations, especially in distinguishing
between ovarian and testicular tissue when imaging findings
are inconclusive.