Abstract Integrating digital health technologies, including mobile applications and digital biomarkers, with traditional medicinal plants and phytochemicals may enhance the effectiveness of standard antidepressants. Mechanisms through which phytochemicals and digital health tools may alleviate depression are described based on currently known mechanisms. Traditional medicinal plants and phytochemicals may enhance the efficacy of standard antidepressants. This article provides an in-depth discussion of the known mechanisms through which phytochemicals and medicinal herbs may alleviate depression, and examines the diagnostic, preventive, and treatment practices for major depressive disorder (MDD), focusing on integrating digital innovations and phytotherapy.