Aim of this study is to determine levels of general health, occupational stress and burnout in nurses who are working in Shohadaye Kargar Hospital of Yazd. A cross- sectional study was conducted among nurses who are working in Shohadaye Kargar Hospital of Yazd in 2017-2018 years. The sample was randomly selected and total 200 nurses were enrolled to the study. The study instruments included Occupational stress questionnaire, Maslach Burnout Inventory and General Health Questionnaire. Collected Data were analyzed by using descriptive test and Pearson correlation coefficient and multivariate regression in SPSS. The findings of research indicated that total levels of occupational stress were high among 58.85 % of nurses. Regarding burnout, 35.93% of nurses had reported high levels of burnout. Less than one percent (0.37 %) of nurses have high mental health problems and 0.44 percent reported mid mental health problem. There was a statistically significant correlation between occupational stress with mental health (p<.001) and job burnout with mental health (p<.001). Occupational stress and job burnout may have undesired influences on nursing mental health and general function.