1.Applications of porous inorganic materials in biomedicine and medicine
Haijun WANG ; Keyong ZHANG ; Yaqin LIU
Chinese Journal of Tissue Engineering Research 2008;12(41):8189-8192
Porous inorganic materials are solid-state compounds with regular porous structure.crystal or amorphous,which are closely related to the biochemical processes and wide applied in industry and daily life.Porous inorganic materials are a new kind Of functional materials due to their intriguing molecular topologies and wide distribution range of internal pore size.They have attracted tremendous attention due to comprehensive potential applications in ion exchange.selective adsorption.and catalysiS.This paper reviews researches and prospects of the applications of porous inorganic materials in the field of biology and medicine recently.Applications of porous inorganic materials in the field of biology and medicine mostly include the enzyme immobilizing,enzyme simulation. bioiogical sensors,controlled release drug carrier,antibacterial and auxiliary of anticancer drugs,etc.
2.Thermal Desorption Low Temperature Plasma Ionization Mass Spectrometry for Rapid and Sensitive Detection of Pesticides in Broomcorn
Shuang WANG ; Zhe WANG ; Keyong HOU ; Haiyang LI
Chinese Journal of Analytical Chemistry 2017;45(2):175-182
A thermal desorption low temperature plasma (TD-LTP) ionization was developed for rapid and sensitive detection of pesticides by direct mass spectrometry.The thermal desorption sampler was added in fount of the plasma generator.The sample was desorbed in the thermal desorption sampler firstly,and then the gas molecules were transported to the plasma generator by the carrier gas to be ionized.The utilization of thermal desorption sampler helps to shift the interaction of the gas phase plasma with the sample form gas-solid or gas-liquid to gas-gas,which increases the sensitivity and stability especially for non-volatile sample (e.g.pesticides) greatly compared with the traditional LTP ionization source.Under the optimal parameters of the thermal desorption LTP ionization source,the characteristic ions of 12 kinds of pesticides were investigated.Then the thermal desorption LTP ionization source was connected with the commercial ACQUITY TQD mass spectrometer to evaluate the pesticide residue level in broomcorn.
3.Effect of empathy on the insight in patients with first-episode schizophrenia
Ling CHEN ; Keyong WANG ; Xiaoming KONG ; Loufeng ZHANG
Chinese Journal of Behavioral Medicine and Brain Science 2015;24(6):525-527
Objective To investigate the effects of empathy on the insight of first-episode schizophrenia.Methods Empathy with tbe interpersonal reactivity index-C (IRI-C) was applied to 71 patients with first-episode schizophrenia and 69 healthy controls.In addition,schizophrenic patients were evaluated with scale of unawareness of mental disorder (SUMD) for the scores of clinical insight and positive and negative syndrome scale (PANSS) for clinical symptoms.Results Compared with the control group,the schizophrenic patients showed lower scores in the perspective taking ((13.85±1.86) vs (6.74±2.56),P<0.01),empathic concern ((14.28±2.16) vs (17.49± 2.73),P<0.01) of IRI-C,but higher subscale score ((10.28±2.78) vs (8.93±1.93),P<0.01) in personal distress.Pearson correlation analysis showed that,there were negatively significant correlations between insight score and perspective taking (r=-0.429,P<0.01),empathic concern (r=-0.709,P<0.01) subscores of IRI-C respectively.In addition,the insight total score was positively correlated with the positive symptoms subscores (r=0.545,P<0.01) of PANSS.Conclusion Patients with first-episode schizophrenia have significant empathy defects.And the empathic deficits are associated with the insight impairment among the schizophrenic patients,suggesting that patients' insight level can change by improving their empathy ability.
4.Relationship between prospective memory and social functioning in patients with schizophrenia
Qing WU ; Keyong WANG ; Geng CHENG ; Wenfei LI ; Ying WANG ; Limin WU
Chinese Journal of Behavioral Medicine and Brain Science 2012;21(2):146-148
ObjectiveTo investigate the event-based prospective memory (EBPM)and time-based prospective memory( TBPM )in stable patients with schizophrenia and to explore the relationships between prospective memory and social functioning.Methods40 schizophrenic patients and 40 normal controls matched in age,gender and education were assessed with a neuropsychological battery of tests including EBPM and TBPM tasks.The patients were also assessed with social disability screening schedule(SDSS).ResultsA statistically significant in EBPM was observed between patients with schizophrenia and normal controls (4.18 ± 1.04 vs 5.33 ±0.86,t=- 5.408,P < 0.01) and the same result in TBPM ( 3.45 ± 1.48 vs 5.20 ± 0.82,t =- 6.522,P < 0.01).In patients with schizophrenia TBPM was impaired more significantly than EBPM ( z=-3.238,P<0.01 ).After controlling the total score of PANSS,the negatively correlate was showed between the total scores of SDSS and EBPM ( r =- 0.346,P < 0.05 ),TBPM ( r =- 0.374,P < 0.05 ) in the patients.ConclusionThe results suggest schizophrenic patients impairs both EBPM and TBPM,and TBPM is impaired more significantly than EBPM.PM shows positively correlated with social functioning moderately in the patient.
5.A study of prospective memory in the inpatients with abstinent male alcohol dependence
Qing WU ; Keyong WANG ; Zhihua ZHANG ; Liangjun PANG ; Yongmei WANG ; Bao HUANG ; Wangfa LIU
Chinese Journal of Behavioral Medicine and Brain Science 2013;(2):134-136
Objective To investigate thc cvent-based prospective memory (EBPM)and time-based prospective memory(TBPM)in the inpatients with abstinent alcohol dependence and the relationships between prospective memory and symptoms.Methods 32 male patients with alcohol dependence and 30 normal controls matched by age,education,HAMD and HAMA were assessed with a neuropsychological battery of tests including EBPM and TBPM tasks.Results A statistically significant in EBPM was observed between patients with alcohol dependence and normal controls (3.91 ± 0.69 vs.4.47 ± 0.63,t =-3.348,P < 0.0 1) and the same result in TBPM (3.28 ±0.77 vs.4.20 ±0.66,t=-5.032,P<0.01).The positively correlation was showed between the duration of abstinence and EBPM (r =0.444,P < 0.05),as well as TBPM (r =O.423,P < 0.05) in the patients.Conclusion The results suggest abstinent alcohol dependence patients impairs both EBPM and TBPM.PM shows correlated with duration of abstinence moderately in the patients.
6.The application of anchor nail combined with Krackow suture technique in the treatment of flesh achilles tendon rupture
Jian NA ; Yong XU ; Chao MA ; Hui WANG ; Sitong QIN ; Keyong MA
Chinese Journal of Postgraduates of Medicine 2011;34(35):29-31
Objective To explore and evaluate the advantages of anchor nail in the treatment of achilles tendon rupture.Methods The clinical data of 27 patients with fresh achilles tendon rupture who received the treatment of thread anchor nail from January 2007 to August 2010 was retrospectively analyzed.Among them,14 patients received Krackow method,7 patients received Lindholm method to repair achilles tendon,6 patients received anchor nail combined with Krackow suture technique repair of achilles tendon.Arner-Lindholm clinical evaluation criterion was used for objective evaluation.Results Twenty-seven patients got 1-36 ( 17.35 ± 5.70) months follow-up.According to the corresponding standard in the 14 cases using Krackow method,8 cases were excellent,2 cases were good,4 cases were bad,the excellent and good rate was 71.4%( 10/14);in the 7 cases using Lindholm method,5 cases were excellent,1 case was good,1 case was bad,the excellent and good rate was 85.7 (6/7) ; all of the 6 cases using anchor nail combined with Krackow suture technique repair of achilles tendon were excellent,the excellent and good rate was 100.0%(6/6).Postoperative incisions were primarily healing,joint range of motion were all right,without rigidity,gait were almost normal,without the secondary fracture of ligament.Conclusion Anchor nail combined with Krackow suture technique in the treatment of achilles tendon rupture has significant effect,it is worth to be popularized because of its preonunced effect.
7.A study of attention networks in the patients with obsessive-compulsive disorder and generalized anxiety disorder
Rui TAO ; Liling GAO ; Keyong WANG ; Wen XIE ; Chunyan ZHU ; Liangjun PANG
Chinese Journal of Behavioral Medicine and Brain Science 2014;23(9):786-788
Objective To investigate the attention network in patients with obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD).Methods 31 GAD patients,31 OCD patients and 30 healthy controls (HC) were tested with attention network test.Results There were significant differences in the main effects with respect to the alerting network(15.87±5.24,26.77±4.33,34.87±3.47) (F=4.619,P=0.012)) and the executive network(114.84±9.64,122.45±5.57,96.57±5.45) (F=3.388,P=0.038) among the OCD,GAD and HC groups.The three groups did significantly differ in RT of the attention network (F=19.808,P=0.000).For the HC group,there was significant main effects with respect to cue conditions(F=29.699,P=0.000).There was a significant correlation between the executive network and Hamilton anxiety scale (r=0.351) and also a significantly negative correlation between the alerting network and Hamilton depression scale (r=-0.267).Conclusion There are attention network damages in patients with OCD and GAD,which may be involved in the impairment of emotion.
8.Bronchial artery embolization in hemoptysis
Hongxiu DAI ; Dingcai YANG ; Weihong LIU ; Heqing TANG ; Keyong LIU ; Xiaohua ZHAO ; Yiqing TAN ; Jun WANG
Chinese Journal of Interventional Imaging and Therapy 2005;2(4):303-307
Massive hemoptysis is one of the most dreaded of all respiratory emergencies and can have a variety of underlying causes. It is mostly caused by bleeding from bronchial circulation. Bronchial artery embolization is now considered to be the treatment of choice for acute massive hemoptysis. Bronchial artery embolization (BAE) is a safe and effective nonsurgical treatment for patients with massive hemoptysis. However, nonbronchial systemic arteries can be a significant source of massive hemoptysis and a cause of recurrence after successful BAE. So knowledge of the bronchial artery anatomy, together with an understanding of the pathophysiologic features of massive hemoptysis, are essential for planning and performing BAE in affected patients. In addition, interventional radiologists should be familiar with the techniques, results, efficacy, safety and possible complications of BAE and with the characteristics of the various embolic agents. Bronchial arterial catheterisation in human via a percutaneous approach has been practiced for 32 years (1973) in the world and 20 years (1986) in China, initially for direct chemotherapy treatment for bronchial malignancies and then for the embolization of patients with massive haemoptysis. A review of clinical experience to evaluate technique,embolic materials,outcome and complications of BAE is presented.
9.Association of oxygen saturation of arterial hemoglobin with late-onsethypertension in Chinese Han population resided in the Daxinganling area
Xueyan LI ; Hao ZHANG ; Ningning WANG ; Li ZHOU ; Jingping LI ; Keyong ZHANG ; Changchun QIU
Basic & Clinical Medicine 2017;37(8):1077-1081
Objective To identify the association of oxygen saturation of arterial hemoglobin (SaO2) with late-onset hypertension in the Chinese Han population located in the Daxinganling area.Methods A total participants were selected by convenience sampling methods from the Daxinganling area.All data were collected from each person by the questionnaire record of physical examinations as well as biochemical index measuring.SaO2 was noninvasively measured with finger pulse oxymetry,the reported SaO2 was the average of three readings taken 10 seconds apart.Results There were significant differences for SaO2 within the population of individuals,the mean SaO2 values was 97.71%±6.14%,with range from 88% to 100%.There was association of SaO2 with sex,BMI and age.SaO2 level declined with BMI and age increasing.Particularly,it was found that the risk increasing to hypertension was marked association with SaO2 rapid drop.During the period from 40-50 years of age,SaO2 declined from 97.85% to 97.64%,The risk to hypertension increased more than 10 times(P<0.001).That implicated hypoxia mightinvolve in the etiology of hypertension.Conclusions The preliminary results demonstrated the rapid decline of SaO2 with lapse of age may be one of the major risk factors to hypertension,it may be helpful to explain late-onset hypertension to some extent at least.
10.A study of prospective memory in patients with late-onset depression
Ying WANG ; Keyong WANG ; Xulai ZHANG ; Qing WU ; Wangfa LIU ; Li WANG ; Longcai FEI ; Ying HUANG ; Limin WU ; Jun XIE
Chinese Journal of Behavioral Medicine and Brain Science 2012;21(8):725-727
ObjectiveTo investigate the event-based prospective memory (EBPM)and time-based prospective memory( TBPM )in late-onset depressive patients and to explore the relationships between prospective memory and depressive symptoms.Methods 32 late-onset depressive patients and 30 normal controls matched in age,gender and education were assessed with a neuropsychological battery of tests including EBPM and TBPM tasks.The patients were also assessed with Hamilton Depression Scale (HAMD).ResultsA statistically significant in EBPM was observed between patients with late-onset depression and normal controls (2.31 ± 1.06 vs 3.07± 0.87,t =- 3.052,P < 0.01) and the same result in TBPM (2.03 ± 0.93 vs 2.67 ± 0.92,t =- 2.695,P <0.01 ).The negatively correlate was showed between the total scores of HAMD and EBPM ( r =- 0.436,P =0.013 ),TBPM ( r =- 0.467,P =0.007 ) in the patients.ConclusionThe results suggest late-onset depressive patients impair both EBPM and TBPM.Prospective memory shows correlation with depressive symptoms in the patients.