1.Full mouth rehabilitation with vertical dimension increase in patient with excessive worn dentition due to parafunctional mandibular movements: a case report
JiHoon PARK ; Seong-A KIM ; SunYoung YIM ; JooHyuk BANG ; HeeWon JANG ; YongSang LEE ; KeunWoo LEE
The Journal of Korean Academy of Prosthodontics 2024;62(2):113-122
beyond physiological levels can lead to vertical dimension loss, occlusal imbalance, temporomandibular joint disorders, and periodontal disease. In such cases, prosthodontic restoration becomes necessary emphasizing the importance of appropriate vertical dimension increase and stable occlusion in central relation (CR).In this case, a 74-year-old patient with clenching and grinding habit had severe teeth wear and after assessing interocclusal distance, wear degree, pronunciation, and facial profile, it was decided to perform full-mouth fixed prosthesis restoration with a 4 mm vertical dimension increase. And the significantly displaced Maximum Intercuspal Position (MICP) caused by parafunctional movements was re-established as a stable mutually protective occlusal relationship at centric relation and after a successful 4 months adaptation to provisional restorations, the final prosthesis was fabricated. During 4months of observation periods, stable occlusion in central relation and mutual protection occlusal relationships were maintained and the patient was satisfied with function and aesthetics, leading to this report.
2.Differentiation of Rat Neural Stem Cells Following Transplantation in the Brain of Huntington's Disease Rat Model.
Hwa Lee RYU ; So Yeon LEE ; Keunwoo PARK ; Changhoon KIM ; Byung Kwan JIN ; Churl K MIN
Experimental Neurobiology 2009;18(1):37-47
Stem cells provide an important means for regenerative medicine due to the capacity to generate multiple types of differentiated cells and at the same time to maintain self-renewal. To identify the therapeutic effect of the transplantation of neural stem cells, differentiation and migration capacity of the neural stem cells that were isolated from E14 rat embryo and maintained in culture were examined after transplantation to the striatum of the quinolinic acid (QA)-induced Huntington's disease rat model. in vitro co-culture of the neural stem cells with the mixture of primary neurons and astrocytes promoted the maturation and the synapse formation of neuronal progenies of neural stem cells. Following the implantation, the neural stem cells survived, differentiated, and migrated in the damaged striatum region, exhibiting immunoreactivities against nestin, Tuj-1, GFAP, GAD(67) and synapsin 1 to a varying degree. These data provide clear evidence supporting that the neural stem cells isolated from the rat embryo and maintained in the primary culture have a multiple capacity to differentiate into neurons or glial cells both in vitro and in vivo.
Animals
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Astrocytes
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Brain
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Coculture Techniques
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Embryonic Structures
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Huntington Disease
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Intermediate Filament Proteins
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Nerve Tissue Proteins
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Neural Stem Cells
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Neuroglia
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Neurons
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Quinolinic Acid
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Rats
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Regenerative Medicine
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Synapses
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Transplants