1.Gene Expressions of Mouse Submandibular Gland during the Developmental Stage and Their Antisense Inhibition in Organ Culture.
Yeon Sook KIM ; Suk Keun LEE ; Je G CHI
Korean Journal of Pathology 2000;34(6):395-412
This study is aimed to observe the expressions of different genes, including the extracellular matrix proteins, growth factors, and transcription factors during different developmental stages of mouse submandibular gland. Reverse transcription-polymerase chain reaction (RT-PCR) and the antisense inhibition in organ culture system were performed using mouse embryos and newborns. Total 140 mouse embryos (E14(80), E15(20), E16(20), E18(20)) and 30 newborn mice (D2(10), D3(10), D6(10)) obtained from 60 pregnant mice and 3 adult mice (3 weeks old) were used for the cDNA production and the salivary gland organ culture. Syndecan, perlecan, laminin alpha1 chain, TGF beta1, beta 3, and sonic hedgehog mRNAs were expressed in the early stage (E14~E16) of the submandibular gland development, whereas transglutaminase C (TGase C), E-cadherin, epimorphin, laminin beta2 and gamma1 chains, and HGF mRNAs were expressed in the middle and late stages (E16~E18, D2~D6). Antisense inhibition of different genes in the organ culture of E14 mouse embryos of submandibular gland showed specific growth retardation in the development of ductal and acinar cells. Especially, the antisense inhibition of perlecan, E-cadherin, laminin alpha1 chain, laminin beta2 chain, and syndecan mRNA arrested the growth of ductal and acinar cells. While the antisense inhibition of integrin beta5 greatly affected the acinar cell differentiation and also produced cystic dilatation of salivary ducts, the antisense inhibition of fibronectin showed aberrant growth of ectomesenchymal tissues of the mouse submandibular gland.
Acinar Cells
;
Adult
;
Animals
;
Cadherins
;
Dilatation
;
DNA, Complementary
;
Embryonic Structures
;
Extracellular Matrix Proteins
;
Fibronectins
;
Gene Expression*
;
Hedgehogs
;
Humans
;
Infant, Newborn
;
Intercellular Signaling Peptides and Proteins
;
Laminin
;
Mice*
;
Organ Culture Techniques*
;
RNA, Messenger
;
Salivary Ducts
;
Salivary Glands
;
Submandibular Gland*
;
Syndecans
;
Transcription Factors
2.Phenobarbital dosage and blood level for control of neonatal seizure.
Hye Soon KIM ; Keun LEE ; Young Sook KO
Journal of the Korean Pediatric Society 1993;36(12):1641-1646
Twenty-five neonates were observed for the relationship between phenobrbital loading dose, plasma concentrations and control of seizures. Nineteen neonates (76%) had seizures controlled by phenobarbital alone. Effective plasma concentration were 10.0~31.1microgram/ml. Although 14 neonates had seizures controlled by phenobarbital concentration below 20microgram/ml, neonate required level above 30microgram/ml. We found that continued benefit was obtained until phenobarbital plasma concentrations reached 40microgram/ml and there was no adverse effects on cardiorespiratory function. We recommend that plasma phenobarbital concentrations should equal or surpass 40microgram/ml before additional anticonvulsants are used for neonates with seizure.
Anticonvulsants
;
Humans
;
Infant, Newborn
;
Phenobarbital*
;
Plasma
;
Seizures*
3.The evaluation of radiological and clinical findings of bronchiectasis
Jung Keun YOO ; Sung Ihn KANG ; Kil Jung KIM ; Seung Sook KO ; Young Sook KIM ; Young Chul KIM
Journal of the Korean Radiological Society 1985;21(5):727-736
Bronchiectasis means a permanent abnormal dilatation of one or more large bronchi owing to destruction of theelastic and muscular components of the bronchial wall. Radiological study is the most importat and mandatory procedure. Especially bronchography is essential for the definitive diagnosis of bronchiectasis and for theprecise delineation of the type and extent of the disease. The radiological and clinical findings of 48 cases ofbronchiectasis diagnosed by bronchography and treated at Chosun University Hospital during the 5 years fromJanuary 1980 to Dec. 1984 were analyzed retrospectively. The results were as follows; 1. Among the 48 cases, 34cases(70.8%) were male and 14 cases(29.2%) were female. Peak incidence was in second decade. 2. Chronic cough,productive sputum and hemoptysis are main symptoms and others are chest pain, dyspnea and recurrent bouts ofpneumonia. The most common physical sign is persistent moist rales over the involved area in 23 cases(47.9%).Others are no sign in 17 cases(35.4%), wheezing in 11 cases(22.9%) and digit clubbing in 3 cases(6.3%). 3. Thepresumed causes were composed of not known in 30 cases(62.5%) and complications of measles in 7 cases(14.6%),pertusis in 5 cases(10.4%) and pneumonia in 4 cases(8.3%). Two cases were Kartagener's syndrom and unilateralhyperlucent lung. 4. Plain chest roentgenographic findings were abnormal in 42 cases(87.5%) but normal in 6cases(12.5%). The most common radiological findings was accentuation of lung markings in 36 cases(85.7%) theothers are include in order of frequency; pneumonic infiltration, linear radiolucencies, cystic radiolucencies,decreased affected lung volume air-fluid level and pleural thickening. 5. Bilateral bronchiectasis was demonstrated in 11 cases(22.9%) and the disease was much more often involved left lung than right. The mostcommonly involved lobe is left lower lobe, and the most common site of involvement was the posterior basal segmentof the lower lobe. The type of bronchiectasis is cylindrical in 22 cases(45.8%), varicose in 11 cases(22.9%),saccular in 9 cases(18.8%) and mixed type in 6 cases(12.5%)
Bronchi
;
Bronchiectasis
;
Bronchography
;
Chest Pain
;
Diagnosis
;
Dilatation
;
Dyspnea
;
Female
;
Hemoptysis
;
Humans
;
Incidence
;
Lung
;
Male
;
Measles
;
Pneumonia
;
Respiratory Sounds
;
Retrospective Studies
;
Sputum
;
Thorax
4.Bleeding from Dieulafoy's Vascular Malformation of the Proximal Ileum: A case report .
Hee Jung KIM ; Jun Keun JUNG ; Young Min SUH ; Kyung Sook KIM ; Hoguen KIM
Korean Journal of Pathology 1999;33(12):1207-1210
Dieulafoy's vascular malformation is a rare cause of massive gastrointestinal bleeding. Most often it occurs in stomach within 6 cm from the gastroesophageal junction. Only a few cases have been reported to occur in the small intestine and colon. Occasionally, Dieulafoy's lesion of small intestine is difficult to recognize because of rarity, a paucity of symptoms and negative findings on barium studies. Therefore, this lesion needs to be considered in a patient with massive lower gastrointestinal bleeding. We report a case of Dieulafoy's vascular malformation in ileum 2 m proximal to ileocecal value in a 41-year-old woman who visited emergency clinic because of hematemesis, dizziness and vomiting. Small intestine revealed a wide-caliber artery within the submucosa showing intimal thickening, medial muscular hypertrophy and thrombosis.
Adult
;
Arteries
;
Barium
;
Colon
;
Dizziness
;
Emergencies
;
Esophagogastric Junction
;
Female
;
Hematemesis
;
Hemorrhage*
;
Humans
;
Hypertrophy
;
Ileum*
;
Intestine, Small
;
Stomach
;
Thrombosis
;
Vascular Malformations*
;
Vomiting
5.A Case of Bilateral Trochlear Nerve Palsy Following Cisternography.
Keun Hae KIM ; Sook Hyun YOON ; Sook Young KIM
Journal of the Korean Ophthalmological Society 2014;55(1):155-160
PURPOSE: To report a case of bilateral trochlear nerve palsy following cisternography. CASE SUMMARY: A 43-year-old male with intermittent watery rhinorrhea persisting for 3 months visited the neurosurgery department of our institute. His past medical history included removal of a pituitary adenoma 22 years prior to presentation. Cerebrospinal fluid leakage was suspected and cisternography was performed. The patient was referred to our ophthalmology department for diplopia 3 days after the cisternography. An alternate prism cover test showed 5 prism diopter (PD) right hypertrophia in the primary position, and underaction of bilateral superior oblique muscles and overaction of the left inferior oblique muscle. A positive Bielschowsky test with the head tilted to either side was observed and excyclotorsion was 9degrees on the double Maddox rod test. The patient was diagnosed with bilateral trochlear nerve palsy. After 2 years of follow-up, diplopia persisted and recession of the bilateral inferior oblique muscles was performed. After the surgery, diplopia disappeared, the fundus photography showed no excyclotorsion, and the double Maddox rod test indicated 3degrees of excyclotorsion. CONCLUSIONS: Cisternography should be carefully performed due to the possibility of bilateral trochlear nerve palsy, an extremely rare but possible occurrence following the procedure.
Adult
;
Cerebrospinal Fluid
;
Diplopia
;
Follow-Up Studies
;
Head
;
Humans
;
Male
;
Muscles
;
Neurosurgery
;
Ophthalmology
;
Photography
;
Pituitary Neoplasms
;
Spinal Puncture
;
Trochlear Nerve Diseases*
;
Trochlear Nerve*
6.A case of Merkel cell carcinoma with local recurrence.
Jong Sook KIM ; Young Ho WON ; Youn Keun KOOK ; Inn Ki CHUN ; Young Pio KIM
Korean Journal of Dermatology 1991;29(6):855-860
No abstract available.
Carcinoma, Merkel Cell*
;
Recurrence*
7.Cord Plasma Alpha-Fetoprotein Values and Neonatal Jaundice.
Mee Kyung NAMGOONG ; Sei Hee CHOI ; Ae Sook KIM ; Baek Keun LIM ; Jong Soo KIM
Journal of the Korean Pediatric Society 1986;29(8):24-27
No abstract available.
alpha-Fetoproteins*
;
Infant, Newborn
;
Jaundice, Neonatal*
;
Plasma*
8.The differnce of marriage-satisfaction score among family groups according to the family APGAR score and family adaptability cohesion evaluation scale.
In Sook KIM ; Sang Hee LEE ; Keun Mi LEE ; Soo Young KIM ; Seung Pil JUNG
Journal of the Korean Academy of Family Medicine 1993;14(12):797-803
No abstract available.
Apgar Score*
;
Humans
9.Congenital Esophageal Atresia Associated with Tracheal Bronchus and Imperforate Anus.
Si Houn HAHN ; Keun Haeng CHO ; Young Sook HONG ; Soon Kyum KIM
Journal of the Korean Pediatric Society 1989;32(4):550-555
No abstract available.
Anus, Imperforate*
;
Bronchi*
;
Esophageal Atresia*
10.Left cervical aortic arch and persistent left superior vena cava in the SAME patient: case report.
Jae Kyu KIM ; Jae Sook MA ; Heoung Keun KANG ; Hyon De CHUNG
Journal of the Korean Radiological Society 1991;27(1):82-86
No abstract available.
Aorta, Thoracic*
;
Humans
;
Vena Cava, Superior*