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4.AN IMMUNOHISTOCHEMICAL STUDY ON THE EXPRESS1ON OF TGF-beta IN THE AMELOBLASTOMA AND DEVELOPING TOOTH GERM OF HUMAN EMBRYO AND FETUSES.

Gil Hyun SUNG ; Soo Nam KIM ; Dong Keun LEE

Journal of the Korean Association of Oral and Maxillofacial Surgeons 1997;23(3):418-433

Dysregulation of TGF-beta that is a modulator of cell growth and differentiation can result in uncontrolled growth and tumor formation. Monitoring these pattern of genes and protein expression during tumor development will provide a basis for understanding normal growth and distortion of osteochondrogenesis. Our comparative studies on the experssion of TGF-beta protein indicate that TGF-beta may primarily be a regulator of epithelial differentiation during tooth development (between 4 weeks and 40 gestational weeks) and tumorigenesis of odontogenic neoplasm (ameloblastoma). In early human tooth germ (cap/early bell stage) TGF-beta protein was found in the epithelial dentallamina and enamel orgen. TGF-beta experessions were seen in inner and outer dental epithelium during bell stage. During enamel and cementum appositional stage, TGF-beta expression shifted from the ameloblast to the odontoblast. In eruption stage, TGF-beta expressions look like moderate positive pattern in odontoblast and rare pattern in enamel, dentin and cementum. TGF-beta expressions of follicular and plexiform amelobalstoma are moderate positive reaction in ectodermal tumor components and mild positive in vessels of stroma tissue. In acanthomatous type, TGF-beta expression was shown severely positive finding in stellate reticulum cell. TGF-beta expressions were noted moderate reaction in margin of tumor epithelium and stellate reticulum cell of granular ameloblastoma. In unicystic ameloblastoma, TGF-beta expression was rare feature in cystic luminal epithelium. With these result, I should be suggested that TGF-beta may play an important role in epithelial-mesenchymal interactions in human tooth morphogenesis and development of odontogenic epithelial tumors.
Ameloblastoma* ; Ameloblasts ; Carcinogenesis ; Dental Cementum ; Dental Enamel ; Dentin ; Ectoderm ; Embryonic Structures* ; Epithelium ; Fetus* ; Humans* ; Morphogenesis ; Odontoblasts ; Phenobarbital ; Reticulum ; Tooth Germ* ; Tooth* ; Transforming Growth Factor beta*

5.A case report of splenic pregnancy.

Sung Nam CHO ; Choon Keun LEE ; Jong Deok KIM

Korean Journal of Obstetrics and Gynecology 1992;35(7):1088-1091

6.An experimental study on the effect of condylar osteoplasty with preservation of articular covered soft tissue on the healing process in rabbit

Dong Ho JANG ; Dong Keun LEE ; Soo Nam KIM

Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 1991;13(3):241-251

7.Study on the Clinical Aspect of Failure to Thrive.

Hyung Keun NAM ; Myung Ik LEE ; Don Hee AHN ; Keun Chan SOHN

Journal of the Korean Pediatric Society 1989;32(3):303-310

8.Analysis of Viral Phenotype (SI / NSI) and V3 Domain Amino Acid Sequence in the Various HIV - 1 Subtype Isolates.

Jeong Gu NAM ; Chun KANG ; Sung Rae LEE ; Yong Keun PARK ; Joo Shil LEE

Journal of Bacteriology and Virology 2001;31(1):71-83

9.An experimental study on tissue response following implantation of the freeze-dried and radiation sterilized allogeneic bone in rectus abdominicus muscle

Chang Woo LEE ; Chang Joon YIM ; Dong Keun LEE ; Soo Nam KIM

Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 1991;13(3):265-277

10.The study of relationship between doppler velocity and placental vascular abnormalities of hypertensive pregnant women.

Chang Hwang HAN ; Keun Hwan SUNG ; Jung Bae KANG ; Jang Hyun NAM ; Keun Young LEE ; Sung Won KANG

Korean Journal of Obstetrics and Gynecology 1992;35(8):1109-1119

1.A clinical analysis of rectal cancer.

2.Clinical Observations of Meningitis.

3.Changing indication & clinical evaluation of 1238 vaginal hysterectomies.