1.A Histopathologic Study of Mammary Dysplasia.
Korean Journal of Pathology 1988;22(2):123-130
"Mammary dysplasia" and "fibroadenoma" represent almost all benign breast disease presenting with breast lumps. Mammary dysplasia comprises variable non-specific changes of stroma and epithelium, but fibroadenoma has been classified as a benign neoplasm, although both features not uncommonly coexist. Authors performed a blind microscopic review of 660 cases of benign breast lesions and the results are as followings. 1. Only 27.9% of all cases consisted of pure fibroadenoma in contrast to 57.5% in the original diagnosis. 2. Fibrocystic disease frequently contained foci of fibroadenoma showing varied stages (68.3%), and the younger age group presented more wide areas of fibroadenoma. 3. The most common feature of the fibrocystic disease was fibrosis, followed by cystic change, adenosis and epithelial hyperplasia in order of frequency. 4. Fibroadenoma may be a form of a spectrum produced by hormonal imbalance, and better classified as a nonneoplastic lesion.
2.The Cprrelation between LVH, LV Function and 24-hour Ambulatory Blood Pressure Monitoring in Patients with Newly Diagnosed Hypertension.
Keehyun LEE ; Gil Ja SHIN ; Hong Keun CHO
Korean Circulation Journal 1997;27(7):712-720
BACKGROUND: Left ventricular hypertrophy is one of the major cardiovascular risk factors. So it is generally thought to be a predictor of complication and prognosis of hypertension. The 24-hour noninvasive ambulatory blood pressure monitoring (ABP) has been shown to be superior to office BP inpredicting target organ involvement in patients with hypertension and assessing antihypertensivve therapy. To determine the correlation between blood pressure and left ventricular hypertrophy in patients with newly diaggnosed systemic hypertension, we evaluate blood pressure by 24-hour ABP, office BP and echocardiiographic parameters of left ventricular hypertrophy. METHODS: From january 1995 to September 1995, in 22 patients with untreated essential hypertension who were diagnosed recently (within 1 month). They were studied by 24-hour noninvasive ambulatory blood pressure monitoring and cross sectional, M-mode and pulsed Doppler echocardiography for examining the relation between ABP and echocardiographic parameters. In the present study, we divided the oatuebts by two groups; white-coat hypertensive group and sustained hypertensive group. RESULTS: 1) Among the 22 patients who were diagnosed by office blood pressure, the white-coat hypertension was in 7 cases (31.8%) and sustained hypertension was 15 cases (68.2%). 2) In sustained hypertensive group, LV mass, LV mass index and relative posterior septal wall thickness were significantly increased compared with white-cost hypertensive group. 3) 24-hour ABP and systolic BP and loading % were significantly correlated with relative posterior septal wall thickness (p<0.05). CONCLUSION: In patients with newly diagnosed hypertension (especially with sustained hypertension), there was left ventricular hypertrophy expressed by increasing of LV mass, LV mass index, and relative posterior septal wall thickness. And, there were close correlation between 24-hour ABP monitoring-especially systolic BP and loading % of systolic BP and LVH.
Blood Pressure
;
Blood Pressure Monitoring, Ambulatory*
;
Echocardiography
;
Echocardiography, Doppler, Pulsed
;
Humans
;
Hypertension*
;
Hypertrophy, Left Ventricular
;
Prognosis
;
Risk Factors
3.Histological and Biochemical Study on the Effect of Cadmium Chloride on the Rat Testis.
Won Sik KIM ; Pyung Keun MYUNG ; Eun Jin YANG ; Keun Ja CHO
Korean Journal of Anatomy 2000;33(1):29-40
Although cadmium is a well known heavy metal which has an influence testis and brings about male infertility, the mechanism of action in the testis is still fully unknown. In these experiment, cadmium chloride 4 mg/kg of body weight administered intraperitoneally to the rat (Sprague-Dawley) and sacrificed after 1 week, and morphological changes were observed by LM and TEM. In addition, electrophoresis, immunoprecipitation and Western blotting and N-terminal analysis performed to reveal the protein changes. 1. Major findings under light microscope were hemorrhagic necrosis and death of all the spermatogenic cells and supporting cells within the seminiferous tubules, and decreased volume of ECM, many apoptotic bodies, and death of interstitial cells and fibroblasts within interstitium. 2. The EM findings were disruption of nuclear membrane and disappearance of cell organelles of spermatogenic cells and supporting cells within seminiferous tubules, and decreased filopodia, increased inclusion bodies, vacuolation and apoptotic changes of the interstitial cells and fibroblastic cells, many short electron-dense collagen fibers in the extracellular matrix of interstitium. 3. Two proteins of molecular weight 42 kDa and 21 kDa which disappeared after cadmium treatment were rat collagen type I alpha 2. According to the above results, it is considered that cadmium degrades the collagen of the wall of small blood vessels within seminiferous tubules and interstitium and disrupts vascular walls, which results hemorrhagic necrosis, death of all the spermatogenic cells, and the death of interstitial cells and fibroblastic cells.
Animals
;
Blood Vessels
;
Blotting, Western
;
Body Weight
;
Cadmium Chloride*
;
Cadmium*
;
Collagen
;
Collagen Type I
;
Electrophoresis
;
Extracellular Matrix
;
Fibroblasts
;
Immunoprecipitation
;
Inclusion Bodies
;
Infertility, Male
;
Male
;
Molecular Weight
;
Necrosis
;
Nuclear Envelope
;
Organelles
;
Pseudopodia
;
Rats*
;
Seminiferous Tubules
;
Testis*
4.Second to Fourth Digit Ratio as a Sex Determinant in Korean.
Korean Journal of Physical Anthropology 2012;25(4):137-144
The 2nd to 4th digit ratio (2D : 4D) as a predictor of the degree of expression of sexually dimorphic and other sex-hormone-mediated traits differs between the sexes, ethnics and race. The aim of this study is to identify characteristics and role of 2nd to 4th digit ratio as a sex determinant in Korean. This study was done on 664 individuals (332 males, 332 females). Data were collected by measuring index and ring finger length on both hands with digital callipers. The data were analyzed through the frequency, descriptive statistics, X2 test, independent t-test, paired t-test, Pearson correlation analysis using SPSS win 19.0. This study showed that the 2nd to 4th digit ratio (2D : 4D) in Korean men (0.96) was significantly lower than that of women (0.97). There was a significant difference in the types of 2nd and 4th finger length according to sex. There was a significant difference between right 2D : 4D and left 2D : 4D both of Korean men and women. Correlation between right and left hand digit ratio was .530 in men and .556 in women. The 2nd to 4th digit ratio accurately determinated sex in 89.1% males and 89.2% females for the left hand, and in 91.8% males and 91.9% females for the right hand. The results of this study suggest that 2nd to 4th digit ratio in Korean differs between males and females, moreover, it will be able to perform a role as a sex determinant.
Continental Population Groups
;
Female
;
Fingers
;
Hand
;
Humans
;
Male
5.A case of myelofibrosis.
Hae Jung CHO ; Keun Chull CHOI ; Chul LEE ; Myong Ho LEE ; Sook Ja PARK
Journal of the Korean Pediatric Society 1982;25(9):945-953
No abstract available.
Primary Myelofibrosis*
6.Seasonal Variation of Blood Pressure in Korean Hypertensives.
Korean Journal of Medicine 1997;53(6):769-777
OBJECTIVES: The mortality rate due to stroke and myocardial infarction by the complication of the hypertension were the major causes of death among the Korean followed by the cancer. There are many factors to affect the blood pressure variability such as physical activity, sleeping, activation of the autonomic nervous system, climate, cold exposure and seasonal variation. The blood pressure was increased by cold exposure. In general, blood pressure was increased in winter and the cardiovascualr mortality is also increased at winter. In Korea, we have distinct seasonal variation of the climate, we have no clinical data on the seasonal variation of the blood pressure. METHODS: To investigate the seasonal variation of blood pressure of Korean essential hypertensives and make effort to reduce the cardiovascualr mortality, we studied 63 hypertensive men and women hypertensives. RESULTS: 1) The mean age was 60+/-10 years with 19men and 44 women. The mean systolic blood pressure was 146+/-22mmHg, mean diastolic blood pressure was 91+/-11mmHg. 2) The mean systolic and diastolic blood pressure during the 12 months was 137+/-18mmHg, 86+/-10mmHg in men respectively. In women, the mean systolic blood pressure was 137+/-16mmHg and the mean diastolic blood pressure was 86+/-8mmHg. 3) The biochemical findings including hemoglobin, hematocrit and creatinine levels were significantly lower in women(P<0.05). 4) The systolic and diastolic blood pressure were significantly increased during the winter as January and February, 5) There was also significant increase of systolic blood pressure at the transitional zone to the sum- mer to autumn(P=0.0004). CONCLUSION: There was significant increase in systolic and diastolic blood pressure in winter in Korean hypertensives. This phenomenon was also observed the transitional zone to summer to autumn. So, during these period, more strict blood pressure control by frequent measurement and increase the room temperature may be recommended to reduce the cardiovascular mortality during winter.
Autonomic Nervous System
;
Blood Pressure*
;
Cause of Death
;
Climate
;
Cold Climate
;
Creatinine
;
Female
;
Hematocrit
;
Humans
;
Hypertension
;
Korea
;
Male
;
Mortality
;
Motor Activity
;
Myocardial Infarction
;
Seasons*
;
Stroke
7.Lateral Ventricular Indices in tuberculous Meningitis.
Ja Wook KOO ; Hang Bo CHO ; In Joon SEOL ; soo Jee MOON ; Hahng LEE ; Keun Soo LEE
Journal of the Korean Pediatric Society 1988;31(8):984-991
No abstract available.
Tuberculosis, Meningeal*
8.Change of Second to Fourth Digit Ratio according to Age in Korean Children.
Korean Journal of Physical Anthropology 2015;28(4):197-203
The 2nd to 4th digit ratio (2D : 4D) reflects exposure level of sex hormones in fetal period. The aim of this study is to identify a change of digit ratio according to age and a critical age showing gender difference in Korean children. This study was done on 1,182 children (588 males, 594 females). Data were collected by measuring index and ring finger length on both hands by photocopy. The data were analyzed using SPSS win 21.0. This study showed that the 2nd and 4th finger length and digit ratio of both hands increased with age both male and female. There was no differences in 2nd to 4th digit ratio between males and females until they were 3 years old. However, there were significant differences in 2nd to 4th digit ratio between males and females from the age of four. The results suggest that digit ratio in Korean children increases with age and a critical age showing gender difference is from the age of four.
Child*
;
Female
;
Fingers
;
Gonadal Steroid Hormones
;
Hand
;
Humans
;
Male
9.A Case of AIDS-related Kaposi's Sarcoma.
Dong Keun LEE ; Kyeong Jin CHON ; Sook Ja SON ; Dong Jun KIM ; Dong Il CHO
Annals of Dermatology 2000;12(3):211-214
We herein report a case of AIDS-related Kaposi's sarcoma (KS) in a 36-year-old male patient, who had a solitary nodular skin lesion on the left supraclavicular area. The histopathologic findings showed typical features of KS as spindle cell proliferation and vascular spaces lined with endothelial cells. The patient's serum was positive for antibodies to the human immunodeficiency virus (HIV) and he had opportunistic infection of Pneumocystis carinii pneumonia and pulmonary tuberculosis. The WBC count was 1,200/mm3 and CD4 count was 50/mm3 with decreased CD4/CD8 ratio to 0.06. He died due to an aggravated respiratory infection.
Adult
;
Antibodies
;
CD4 Lymphocyte Count
;
Cell Proliferation
;
Endothelial Cells
;
HIV
;
Humans
;
Male
;
Opportunistic Infections
;
Pneumonia, Pneumocystis
;
Sarcoma, Kaposi*
;
Skin
;
Tuberculosis, Pulmonary
10.A Case of Dermatomyositis Manifestated by the Paroxysmal Supraventricular Tachycardia.
Young Sun KIM ; Sun Hee MAENG ; Hong Keun CHO ; Si Hoon PARK ; Gil Ja SHIN
Korean Circulation Journal 1997;27(11):1211-1217
Dermatomyositis is a disease of unknown etiology characterized by inflammation and degeneration of skeletal muscles and cutaneous abnormalities. Cardiac involvement in dermatomyositis-polymyositis is thought to be rare. In recent year, however, there has been an increasing number of reports on cardiac abnormalities in adult dermatomyositis and polymyositis due to development of noninvasive diagnostic techniques. Categorically, these abnormalities have included electrocardiographic changes, cardiac arrhythmias, congestive heart failure, coronary artery disease, and pericarditis. A 56-year-old woman was admittied to the Ewha womans University Hospital with dyspnea and palpitation. She was diagnosed as having dermatomyositis and followed up our department of Dermatology. Electrocardiogram showed a paroxysmal supraventricular tachycardia at as rate of 195/min. The patient was treated with 240mg/day verapamil p.o, 60mg/day prednisone p.o, there was marked improvement of symptoms. Systematic study of cardiac function utilizing echocardiography, Holter monitoring, thallium-201-scan, and gated blood pool studies were conducted in five newly diagnosed patients with dematomyositis-polymyositis. A significant elevation of serum CPK-MB is indicative of cardiac involvement. Cardiac involvement is a serious prognostic sign. We report a case with the review of the literature.
Adult
;
Arrhythmias, Cardiac
;
Coronary Artery Disease
;
Dermatology
;
Dermatomyositis*
;
Dyspnea
;
Echocardiography
;
Electrocardiography
;
Electrocardiography, Ambulatory
;
Female
;
Heart Failure
;
Humans
;
Inflammation
;
Middle Aged
;
Muscle, Skeletal
;
Pericarditis
;
Polymyositis
;
Prednisone
;
Prognosis
;
Tachycardia, Supraventricular*
;
Verapamil