1.Vertebrobasilar insufficiency by persistent trigeminal artery stenosis
Young Ho Park ; Keun-Hwa Jung ; Jae-Kyu Roh
Neurology Asia 2013;18(3):311-313
Persistent trigeminal artery is an embryonic remnant of the anastomotic channel linking the internal
carotid artery and the basilar artery. Cases of vertebrobasilar insufficiency caused by the persistent
trigeminal artery with internal carotid artery stenosis has been described previously, but vertebrobasilar
insufficiency entirely due to in situ stenosis of the persistent trigeminal artery has not been reported.
A 71-year-old man presented with frequent dizzy episodes. The brain MRI showed no parenchymal
lesions. MR angiography showed poor visualization of vertebrobasilar system. He was diagnosed as
having vertebrobasilar insufficiency. Cerebral angiography revealed that there was complete occlusion
at the vertebrobasilar junction, and the basilar artery was supplied by the persistent trigeminal artery
which had severe stenosis at its origin. There was no stenosis of the internal carotid artery of both
sides. We believe that this is the first report of vertebrobasilar insufficiency due to stenosed persistent
trigeminal artery, without internal carotid artery stenosis.
2.A Case of Fetal Cervical Immature Teratoma.
Si Hong PARK ; Kyong Hwa LEE ; In Yol CHOI ; Byong Chul YOON ; Jung Keun KIM
Korean Journal of Obstetrics and Gynecology 1999;42(11):2600-2603
Fetal teratomas rarely complicate pregnancy,having an incidance of only 20,000:1 to 40,000:1 of live births. Overthere, cervical teratomas are rare and accounts for only 5.5% of all neonatal teratomas. We have experienced a large cervical immature teratoma and present this case with a brief review of literatures.
Live Birth
;
Teratoma*
3.Challenges and Pitfalls of Stroke Therapeutics Research.
Korean Journal of Stroke 2011;13(1):11-15
Ischemia-reperfusion injury is complicated with multiple injury pathways. If a particular agent is used to restore blood flow and prevent cell death, many damaged neurons may come back to life. However, for stroke victims, there are no effective curative therapeutic approaches available other than thrombolytic treatment. The efficacy of neuroprotective agents are limited by low diffusion, narrow time window, strict dose titration, and lack of confidence at the preclinical level. NXY-059 reflects the fundamental limitation of neuroprotectant. There are recent attempts to overcome these limitations, with use of annexin A2, fingolimod, hydrogen, nitrite, and more. By covering two components, this report reviews what we have recently learned. In addition, it sheds light on some of the newer issues in clinical application.
Annexin A2
;
Benzenesulfonates
;
Cell Death
;
Diffusion
;
Hydrogen
;
Light
;
Multiple Trauma
;
Neurons
;
Neuroprotective Agents
;
Propylene Glycols
;
Reperfusion Injury
;
Sphingosine
;
Stroke
;
Fingolimod Hydrochloride
4.New Pathophysiological Considerations on Cerebral Aneurysms.
Neurointervention 2018;13(2):73-83
Cerebral aneurysm is a common cerebrovascular disease that is sometimes complicated by rupture or an enlarged mass. We are now aggressively evaluating and managing unruptured cerebral aneurysms based on a significant concern for the high morbidity and mortality related to its associated complications. However, the actual rupture rate is very low and the diagnostic and treatment modalities are expensive and invasive, which may lead to unnecessary costs and potential medical complications. This disproportionate situation is related to a poor understanding of the natural course and pathophysiology of cerebral aneurysms. In consideration of the concept that not all cerebral aneurysms must be removed, we need to examine their course and progression more accurately. Cerebral aneurysms may follow a variety of pathophysiological scenarios over their lifetime, from formation to growth and rupture. The disease course and the final outcome can differ depending on the timing and intensity of the pathological signals acting on the cerebral vessel wall. We should delineate a method of predicting the stability and risk of rupture of the lesion based on a comprehensive knowledge of the vessel wall integrity. This review deals with the basic knowledge and advanced concepts underlying the pathophysiology of cerebral aneurysms.
Cerebrovascular Disorders
;
Intracranial Aneurysm*
;
Methods
;
Mortality
;
Risk Factors
;
Rupture
5.Studies on familial of basophil histamine releasability.
Yoon Keun KIM ; Jin Hwa JUNG ; Chang Keun KIM ; Young Yull KOH ; Sang Heon CHO ; Kyung Up MIN ; You Young KIM
Journal of Asthma, Allergy and Clinical Immunology 1998;18(4):628-639
BACKGROUND: Bronchial asthma is a complex genetic disorder. Although serum IgE level and bronchial hyperresponsiveness are well known to be under genetic control, the influence of genetic factors on basophil releasability has been seldom studied. OBJECTIVE: The present study was carried out to investigate whether genetic factors may influence the basophil histamine releasability. MATERIALS AND METHODS: We studied 50 children, 32 with atopic asthma (AA) and 18 normal control (NC), and their parents. Suspensions of leukocytes were isolated and stimulated with Ca ionophore and anti-IgE antibody. Then, histamine in the supernatant was as-sayed by an automated fluorometric analyzer. RESULTS: Among the probands, AA children had a significantly higher anti-IgE induced histamine release than NC children. In contrast, Ca ionophore-induced histamine release was similar between the two groups. Ca ionophore-induced or anti-IgE-induced histamine release was not significantly different between parents of AA children and those of NC children. However, the maximal histamine release by Ca ionophore in parents had a significant correlation with that of probands, whereas the values by anti-IgE were not correlated between probands and their parents. CONCLUSION: We confirmed that basophils from patients with atopic asthma are characterized by a specific increase in IgE-mediated histamine release. The significant correlation of Ca ionophore-induced maximal histamine release between children and their parents suggests that genetic factors may play an important role in the control of non-IgE-mediated relessability from basophils.
Asthma
;
Basophils*
;
Child
;
Genetics
;
Histamine Release
;
Histamine*
;
Humans
;
Immunoglobulin E
;
Leukocytes
;
Parents
;
Suspensions
6.The factors associated with Body Mass Index of adults.
Moo Kyung BAE ; Woo Keun LEE ; Chun Hwa SONG ; Keun Mi LEE ; Seung Pil JUNG
Journal of the Korean Academy of Family Medicine 1999;20(7):906-916
BACKGROUND: Overweight and obesity are associated with increased mortality and morbidity. Obesity is influenced by multiple factors, both genetic and environmental factors. We investigated the relationship between socioeconomic, behavioral, dietary, reproductive factors and body mass index(BMI). METHODS: The subject were 3000 adults who had visited the Health Screening and Diagnosis Center of Yeungnam University School of Medicine from February to June, 1997. We evaluated BMI and occupation, exercise, smoking, alcohol intake, total calory intake, fat and carbohydrate intake in both gender and reproductive factors in women. Then, we analyzed the association between BMI and such variables as above. RESULTS: 1629 men and 1371 women were analyzed. The mean BMI was 23.4+/- 2.8kg/M(2) in men, 22.9+/- 3.1kg/M(2) in women. In both gender, 9.7% of our population had BMl over 27. Mean BMI increased with age. Those who were active and light smokers( 20cigarette/day) had the lowest BMI in men. But no relationship was observed between BMI and exercise, smoking in women. Heavy alcohol drinkers(> 1cup/day) had higher BMI than other group in both gender. We found significant correlation between BMI and total calory intake, calory intake to recommended calory ratio in both gender. In women, the group whose number of parity was above 3 had significantly higher BMI than the other. And age at first birth was significantly correlated with BMI in a negative direction. CONCLUSIONS: Our results showed that BMI was associated with age, smoking, alcohol, total calory intake, calory intake to recommended calory ratio, parity, age at first birth. Socioeconomic class, exercise and diet composition appeared to have little influence.
Adult*
;
Birth Order
;
Body Mass Index*
;
Diagnosis
;
Diet
;
Female
;
Humans
;
Male
;
Mass Screening
;
Mortality
;
Obesity
;
Occupations
;
Overweight
;
Parity
;
Smoke
;
Smoking
;
Social Class
7.Comparative study on the activation status of eosinophils in exerise- and allergen-induced asthma.
Young Yull KOH ; Jung Hwan CHOI ; Chan Hoo PARK ; Sun Young LEE ; Chang Keun KIM ; Jin Hwa JEONG
Korean Journal of Allergy 1997;17(3):286-298
Exercise is one of the most ubiquitous triggers of acute bouts of asthma. Late asthmatic responses(LARs) have been described following strenuous exercise, as in allergen-induced asthma. However, most studies have reported that airway responsiveness is not increased after exercise, even in subjects with LAR to exercise. This suggests that LAR after exercise may not be associated with inflammatory changes in the airways. We have frequently seen asthmatic children whose complaint is that symptoms are exacerbated at night after strenuous daytime exercise. Furthermore, airway responsiveness to allergen was reported to increase after LAR to exercise. Therefore, it is crucial to know whether exercise can induce airway inflammation, as in allergen-induced asthma. As an indirect measure to investigate it, we measured the activation status of eosinophil granulocyte in the peripheral blood during the early and late phase of exercise- or allergen-induced asthma. Eight subjects who showed early asthmatic response(EAR) and LAR(group 1), or EAR only (group 2) to allergen (Dermatophagoides pteronyssinus) challenge were selected. Similarly eight subjects who showed EAR and LAR(group 3), or EAR only (group 4) to exercise were selected. Blood samples were drawn at baseline, the early phase, the late phase, and 24 hours after each stimuli. Eosinofphil cationic protein (ECP) was measured in the serum. Eosinophil granulocytes were separated and the production of leukotriene C4 (LTC4) from purified eosinophfis was measured after stimulation with the calciumionophore. Serum levels of ECP were unchanged at EAR after allergen or exercise challenge. In the dual responder to allergen (group 1), serum ECP level was elevated at LAR and 24 hours after allergen challenge, as compared with the baseline level. On the other hand, in the dual responder to exercise (group 3), it remained unaltered up to 24 hours after exercise challenge. Eosinophils at EAR after allergen or exercise challenge in each group generated the similar amounts of LTC4 as baseline values. In group 1, the production of LTC4 was slightly increased though not significantly at LAR, and significantly increased 24 hours after allergen challenge. In group 3, it was increased significantly at LAR, but restored to the baseline values at 24 hours after exercise challenge. These results indicate that not only allergen but also exercise can activate eosinophils in accordance with LAR. The present findings suggest that LAR to exercise may also have the potential to induce airway eosinophilic inflammation although its duration may be shorter than that of LAR to allergen. Therefore exercise should be understood not only as a triggering factor of bronchoconstriction but also as one that incites or deteriorates airway inflammation.
Asthma*
;
Bronchoconstriction
;
Child
;
Ear
;
Eosinophils*
;
Granulocytes
;
Hand
;
Humans
;
Inflammation
;
Leukotriene C4
8.Risk Factors and Clinical Characteristics of Post-Renal Transplant Diabetes Mellitus.
Mi Hwa JANG ; Sun Dong JUNG ; Yong Hwan LEE ; Ji Hyun LEE ; Keun Tae KIM ; Jin Min KONG
Korean Journal of Nephrology 1998;17(6):957-963
To investigate the risk factors and clinical characteristics of postrenal transplant diabetes mellitus (PTDM), we reviewed the records of 177 renal allograft recipients in Maryknoll Hospiatal whose allografts had functioned longer than 6 months. Nineteen patients (10.7%) developed PTDM at 5.0+/-7.8 (1-52) months; 9 (47%) of these within 1 month. PTDM patients were older than nondiabetic renal transplants (42+/-2 vs 37+/-1 years, P<0.05). Body mass index tended to be higher in PTDM (23.5+/-1.0 vs 21.8+/-0.3kg/m2, P=0.09). Number of acute rejections (0.6+/-0.2 vs 0.5+/-0.1) and serum creatinine at 1 year after transplantation (1.2+/-0.8 vs 1.3+/-0.3mg/dL) were not different. Fasting (103.6+/-10.4 vs 84.4+/-1.6mg/dL, P<0.05) and postprandial (189.2+/-24.8 vs 118.6+/-2.3 mg/dL, P<0.01) blood sugars, measured before transplantation, were higher in PTDM. CsA blood level at 1 month posttransplantation was higher in PTDM (350+/-34 vs 279+/-8ng/mL, P<0.05). Fasting serum insulin was significantly higher (28.2+/-12.2 vs 7.3+/-2.0 microunit/dL, P<0.05) and serum C-peptide tended to be higher in PTDM patients compared with euglycemic renal recipients (6.3+/-1.6 vs 3.8+/-0.9ng/dL, P=0.08). All the PTDM patients were treated by either insulin or oral agent; 15 of 19 required no treatment after 4.7+/-6.9 months. In conclusion, prevalence of PTDM was 10.7%. PTDM patients were older. Body mass index was tended to be higher. Fasting and postprandial blood sugars, measured before transplantation, were higher in PTDM. Faslting serum insulin was higher and C-peptide tended to be higher in diabetics. These results suggested that increased insulin resistance plays a major role in the pathogenesis of PTDM.
Allografts
;
Blood Glucose
;
Body Mass Index
;
C-Peptide
;
Creatinine
;
Cyclosporine
;
Diabetes Mellitus*
;
Fasting
;
Humans
;
Insulin
;
Insulin Resistance
;
Prevalence
;
Risk Factors*
9.Postoperative Change in Mood and Cognition of the Elderly Patients.
Hwa Yeon KANG ; Jin Se KIM ; Seong Keun LEE ; In Kwa JUNG
Journal of Korean Geriatric Psychiatry 1998;2(2):198-206
OBJECTIVES: Surgery is being offered to an increasing proportion of the over 60s and postpoerative cognitive dysfunction may occur in the elderly. We investigated that age could be a risk factor. The confounding effects, such as learning effect due to repeated testing and the effect of distress on the test performance, were controlled for by control group. METHOD: Twenty patients aged at least 60 years completed neuropsychological test 1 day before and 1 week after surgery. We measured Mini-Mental Status Examination (MMSE), digit span, 'A' test, similarity test, Digit Symbol Substitution Test (DSST), Beck Depression Inventory (BDI), Montgomery-Asberg Depression Rating Scale (MADRS) and State Anxiety Inventory (SAI). The authors compared postoperative cognitive dysfunction by neuropsychological test in the elderly patients with those in the control group. RESULTS: One week after operation, there was no cognitive impairment compared with before operation. Advanced age might not contribute to cognitive impairment except DSST. And there was an improvement in the scores for BDI and SAI in the control group only. We did not find a significant relation between early postoperative cognitive dysfunction and mood state before operation. Because the elderly patients had lower educational level and more depressive than control group before operation, we thought that the deterioration of DSST did not happened with operation, but by insufficiency of learning effect in the elderly patients. CONCLUSION: Cognition in the elderly patients was not impaired significantly after operation when attention was paid to the known perioperative influences on mental function.
Aged*
;
Anxiety
;
Cognition*
;
Depression
;
Humans
;
Learning
;
Neuropsychological Tests
;
Risk Factors
10.Decreased Vasomotor Reactivity in Alzheimer's Disease.
Soon Tae LEE ; Keun Hwa JUNG ; Yong Seok LEE
Journal of Clinical Neurology 2007;3(1):18-23
BACKGROUND: Reduced cerebral blood flow and microvascular abnormalities have been suggested as the vascular pathogenesis of Alzheimer's disease (AD). Transcranial Doppler sonography (TCD) can be used as a noninvasive method for measuring cerebral vasomotor reactivity (VMR) which represent the capability of arterioles to dilate and constrict in order to maintain cerebral blood flow. OBJECTIVE: The objective of this study was to determine whether VMR is decreased in AD patients. Methods: Seventeen consecutive patients who met NINDS-ADRDA criteria for AD, and 17 age- and sex-matched controls were included in this study. MRI and MRA were performed for the grading of white-matter lesions. Patients with cerebral infarct or stenosis of the middle cerebral artery (MCA) were excluded. The fixed TCD probe was used to monitor the mean flow velocity (MFV) in the MCA. A 6-L rebreathing bag was applied to patients for at least 5 minutes to elevate the CO2 concentration, which was continuously monitored with a capnometer. VMR was calculated as the percentage change in the MFV. RESULTS: Baseline characteristics - including cerebrovascular risk factors, grades of white-matter lesions, baseline MFV, and pulsatility index - did not differ between the two groups. Mini-Mental State Examination score was significantly low in AD group (20.5 vs. 27.5, p<0.05). VMR was significantly reduced in AD group both in the right-side (24.5% vs. 36.6%, p<0.05) and left-side (20.7% vs. 34.1%, p<0.05) MCAs. CONCLUSIONS: Our finding that VMR is reduced in AD may be suggestive of underlying microangiopathic mechanism in AD patients. Future studies should check the validity of these experimental and hypothesis-generating pilot results.
Alzheimer Disease*
;
Arterioles
;
Constriction, Pathologic
;
Humans
;
Magnetic Resonance Imaging
;
Middle Cerebral Artery
;
Risk Factors
;
Ultrasonography, Doppler, Transcranial