This is the clinical statistics concerning the admissions in the Pediatric Department of the Chosun University Hospital during the past 5 years from Jan. 1975 to Dec. 1979. All the patients were classified by y Classification of Disease by W.H.O. The Obtained results are as follows: 1. Total number of admission during 5 year period were 3249 cases, of which 2121 cases (65.28%) were male, 1128 cases (34.72%) were female and male to female ratio was 1.88:1. 2. The number of patients were increased every year gradually. 3. On age group, Infancy age group was the most frequent group, 714 cases (22%), followed by School age group, 6679 cases (20.9%) and Preschool age group, 679 cases (20. 9% ) in the order of frequency. 4. On monthly distribution, there was the more admission in the September and the Autumn on season, 5. Infectious and Parasitic diseases were the most frequent, 840 cases(25. 9%), followed by Neonatal disease, 573 cases (17.6%) and Respiratory disease, 476 cases (14.7%) 6. Ten major leadil1g causes of hospitalization were Diarrheal disease, 323 cases (9. 9%) ,prematurity, pneumonia, common cold, epidemic encephalitis, hyperbilirubinemia, epilepsy, glomerulonephritis, hepatitis and typhoid fever in the order frequency.
Classification ; Common Cold ; Encephalitis, Arbovirus ; Epilepsy ; Female ; Glomerulonephritis ; Hepatitis ; Hospitalization ; Humans ; Hyperbilirubinemia ; Inpatients* ; Male ; Parasitic Diseases ; Pneumonia ; Seasons ; Typhoid Fever

With the availability of the method of analysis of serum protein using minute amounts of material, it was felt desirable to understand the protein metabolism and physiologic function in the body. The present study was undertaken to clarify the serum albumin, globulin and total protein at term to demonstrate the normal concentration and correlation between the 30 mother and newborn infant pairs. Serum albumin, globulin and total protein were determined by the Biuret method with pooled human serum. The A/G ration was calculated by formula of A/G. The following result were obstained. 1) In comparing the newborn infants of nonanemic mothers a albumin and total protein concentrations were higher and globlin concentrations decreased in the anemic mothers. 2) In comparing the nonanemic mothers and anemic mothers the mean albumin concentrations were nearly equal but globulin and total protein were slightly increased in the nonanemic mothers. 3) The mean serum albumin(of maternal and umbilical cord blood) was 3. 8+/-0. 35 gm/100 ml and 3. 8+/-0. 49 gm/100 ml respectively. 4) The mean serum globulin of mate. nal and umbilical cord blood was 2. 7+/-0. 41 gm/100 ml and 2. 32+/-0. 47 gm/100 ml respectively. The correlation of the globulin status between mot-hers and their newborn infants was not significant(r=0. 32). 5) The m-an serum total protein of maternal and umbilical cord blood was 6. 59+/-0. 59 gm/100 ml and 6. 02+/-0.57gm/100ml respectively.
Biuret ; Fetal Blood ; Humans ; Infant, Newborn* ; Metabolism ; Mothers* ; Serum Albumin* ; Umbilical Cord

PURPOSE: Carnitine plays a key role in the oxidation of fatty acids by facilitating their transport. As very low birth weight(VLBW) infants receiving total parenteral nutrition(TPN) with limited oral intake are likely to be carnitine-deficient state, they require exogenous supplementation of carnitine, however, effects of it remains controversial. To demonstrate effects of parenteral camitine supplementation on fat metabolism, weight gain and clinical outcome. We analyzed plasma levels of biochemical markers, changes of weight, and incidence of complications in 23 VLBW infants receiving TPN. METHOD: We randomly assigned 23 VLBW infants(<32 wks of gestational age) receiving TPN to carnitine-supplemented(100mg/kg per day) group(n=10) and control(n=13). Plasma total (TC), free(FC), and acyl carnitine(AC) levels and serum cholesterol, triglyceride and free fatty acid levels were measured before and 2 weeks after carnitine supplementation. RESULT: Decrements in TC for 2 weeks were significantly lower in carnitine group(41.6umol/l->32.3umol/l) than control group(46.3umol/l->25.2umol/l)(p<0.05). Changes of FC and AC were similar in both groups. Levels of cholesterol and triglyreride were similar in both groups. Days of regaining birth weight were faster in carnitine group than control group(15.3+/-3.4 vs 20. 8+/-11.1 days)(p<0.05). Rate of weight gain for two weeks were significantly faster than carnitine group than control group(p<0.05). No significant differences in clinical outcome were found. CONCLUSIONS: Carnitine supplementation in VLBW infants receiving TPN has an supportive nutritional regimen in that it reduces decrement in carnitine level and facilitate weight gain.
Biomarkers ; Birth Weight ; Carnitine* ; Cholesterol ; Fatty Acids ; Humans ; Incidence ; Infant* ; Infant, Very Low Birth Weight* ; Metabolism ; Parenteral Nutrition, Total ; Parturition ; Plasma ; Triglycerides ; Weight Gain

The incidence of diabetes mellitus is in increasing tendency because of expension of medical care, economic development and increasing of the population of the aged person recently. The diabetic foot is one of serious complication of diabetes. With the advancement of the method of treatment of diabetes the other acute metabolic complications are decreased, but the development of diabetic gangrene encounteres at any age of adult life with increasing of incidence according to the duration of diabetes. The most of them requires operation, and its treatment is difficult frequently because of high incidence of wound problem in healing. So it is important to educate and prevent for lowering its incidence. From January 1978 to December 1984, 38 patients with diabetic foot were treated and analysed at Department of Orthopaedic Surgery of Presbyterian Medical Center. The results obtained are as follow. 1. The average of annual incidence of diabetic gangrene was 2.85%. There was increasing tendency of incidence to 1981, thereafter decreasing tendency. 2. 71% of patients with gangrene were in over-50 year age group. 3.72% of patients were in duration of diabetes more than 5 years. 4.79% of patiens were in inadequate treatment before admisson. 5. There was no relationship between fasting blood sugar level and development of gangrence. 6. The most common site of the lesion was big toe. 7. The most common predisposing fector was local pressure (39%), then minor trauma, and burn injury. 8. The primary wound healing rate was 53% after operation. 9. There was no relationship between the lowest palpable artery and primary wound healing. 10. The most common combined complication of diabetes was retinopathy (47%), then neuropathy and hypertension. 11. The rate of bacterial infection was 66%, and the most common organism was staphylococcus aureus (36%).
Adult ; Arteries ; Bacterial Infections ; Blood Glucose ; Burns ; Clinical Study ; Diabetes Mellitus ; Diabetic Foot ; Economic Development ; Fasting ; Gangrene ; Hallux ; Humans ; Hypertension ; Incidence ; Methods ; Protestantism ; Staphylococcus aureus ; Wound Healing ; Wounds and Injuries

The so-called "Hereditary Multiple Exostoses" disease is characterized by hard, irregular prominences appearing in the metaphyseal region of the bones. Though transmitted as an autosomal dominant trait, skipped generation are reported and presumably represent spontaneous mutations. We experienced one case of hereditary multiple exostoses of 15 years old male patient, whose father and one brother were also affected. A brief review of related literature is also presented.
Adolescent ; Exostoses ; Exostoses, Multiple Hereditary* ; Fathers ; Humans ; Male ; Siblings

Chylous ascites in neonates is an unusual and etiologically poor understood entity. We report a male newborn who suffered from abdominal distension and respiratory distress after birth. Paracentesis was performed and ascitic fluid was obstained. Analysis of the fluid revealed cell count (RBC 10,000/mm3, WBC 800/mm3: segmented form-72%, lymphocyte form- 28%), protein 4,100 mg/dl, glucose 57 mg/dl, cholesterol 53 mg/dl, triglyceride 28 mg/dl. Culture of ascitic fluid grew no bacteria. A plain film of abdomen and abdominal sonogram showed massive ascites. On the 4th hospital day, gastrografin enema showed microcolon and ileal atresia. On the 6th hospital day, ileocolostomy has been performed and operative findings sho- wed blind pouch in terminal ileum, massive inflammation and extensive adhesion on peritoneum. After operation, he gained weight by continuous gavage feeding. He discharged on the 36th hospital day.
Abdomen ; Ascites ; Ascitic Fluid ; Bacteria ; Cell Count ; Cholesterol ; Chylous Ascites* ; Diatrizoate Meglumine ; Enema ; Glucose ; Humans ; Ileum ; Infant, Newborn ; Inflammation ; Lymphocytes ; Male ; Paracentesis ; Parturition ; Peritoneum ; Triglycerides

Mycobacterium tuberculosis infrequently infects muscle. We experienced a case of tuberculosis myositis compli-cated with usual interstitial pneumonia(UIP). A 56 year-old male patient was admitted due to erythematous painful swelling on left proximal upper ex-tremity and right inner thigh for 10 months. The level of serum creatine kinase, lactic acid dehydrogenase, serum glutamic oxaloacetic transaminase, serum glutamic pyru-vate transaminase and aldolase were elevated. Electromyo-graphy showed low amplitude, short duration, polyphasic motor unit potentials at left biceps brachii, flexor carpi radialis longus, extensor carpi radialis longus, right adductor longus and early recruitment pattern at right biceps brachii. Mcscle biopy showed the findings compatible with tuberculosis. Interstitial lung disease was suspected on chest x-ray and high-resornance computerized tomography, usual in-terstitial pneumonia(UIP) was confirmed by open lung biopsy. We started anti-tuberculosis medication and pred-nisolone for the treatment of tuberculous myositis and UIP, respectively. After 4 weeks of treatment, patient' s symptoms of myositis were improved. The patient is being followed up for monitoring treatment response to prednisolne for UIP.
Aspartate Aminotransferases ; Biopsy ; Creatine Kinase ; Fructose-Bisphosphate Aldolase ; Humans ; Idiopathic Pulmonary Fibrosis* ; Lactic Acid ; Lung ; Lung Diseases, Interstitial ; Male ; Middle Aged ; Mycobacterium tuberculosis ; Myositis* ; Oxidoreductases ; Thigh ; Thorax ; Tuberculosis

Splenic abscess is an uncommon but frequently fatal condition. Signs and symptoms are variable and do not always include left upper quadrant pain or tenderness. Unexplained thrombocytosis in a septic patient with persistent left pleural effusion is suggestive of splenic abscess. We report a case of splenic abscess with complicated multiple fistulas by Klebsiella pneumoniae which was successfully managed by antibiotic therapy, and percutaneous catheter drainage.
Abscess* ; Catheters ; Drainage ; Fistula* ; Humans ; Klebsiella pneumoniae* ; Klebsiella* ; Pleural Effusion ; Thrombocytosis

OBJECTIVE: Lung cancer arises after a series of morphological changes, which take several years to progress from normal epithelium to invasive cancer. Multiple molecular changes and growth factors factor production have been documented in lung cancers, both small cell and non-small cell types. Insulin-like growth factors(IGFs) are important mitogenic and anabolic peptides, both in vivo and in vitro, and are thought to be significant autocrine-paracrine factors involved in normal and malignant cell proliferation. In this study, we have investigated (delete) the degree of expression of IGF-1 on the immunohistochemical staining in human non-small cell lung cancer(NSCLC) cells and small cell lung cancer (SCLC) cells were investigated. METHODS: Immunohistochemical staining for IGF-1 was performed in 15 cases of small cell carcinoma, 15 cases of squamous cell carcinoma, 15 cases of adenocarcinoma, and 12 cases of bronchoalveolar carcinoma. RESULTS: The NSCLC cells showed significantly increased expression The expression of IGF-1 on the immunohistochemical staining significantly increased in NSCLC cells than in SCLC cells. CONCLUSION: These results suggest that IGF-1 are expressed the expression of IGF-1 in human lung cancer cells(.), and the (The) immunohistochemical staining of IGF-1 in lung cancer cell lines may help in differentiation of may assist in the differentiation of NSCLC and SCLC.
Adenocarcinoma ; Carcinoma, Small Cell ; Carcinoma, Squamous Cell ; Cell Line ; Cell Proliferation ; Epithelium ; Humans* ; Insulin-Like Growth Factor I ; Intercellular Signaling Peptides and Proteins ; Lung Neoplasms* ; Lung* ; Peptides ; Small Cell Lung Carcinoma

OBJECTIVE: To investigate the differential expression of junctional proteins in the normal and preeclamptic human placenta and the effect of ginsenoside Rk1 in junctional proteins. METHODS: Placental tissues from 10 women with severe preeclampsia and 5 normal women were collected at the time of their cesarean section. Five of 10 preeclamptic women were complicated with intrauterine growth restriction (IUGR). Immunohistochemistry and Western blotting was employed to localize junctional proteins (zo-1, occludin and plakoglobin) positive cells. The placental explant culture was performed to investigate if Rk1 can attenuate the expression of junctional proteins (zo-1, occluding and plakoglobin) induced by deferoxamine-induced hypoxia. Rk1 was treated at the day 3 and Western blot analysis was performed for protein quantification. RESULTS: There was no different expression of zo-1 and plakoglobin among all the study groups. Occludin showed negative at the endothelial cells of the terminal villi in both normal and preeclampsia groups. At the endothelial cells of the stem villi, occludin was detected in both normal and severe preeclamptic placenta with normal fetal growth. However, severe preeclampsia with IUGR were decreased expression of occludin at the endothelial cells of the stem villi. When we administered Rk1 to the placenta treated with DFO, expression of occludin was not different. CONCLUSION: The placental expression of zo-1 and plakoglobin were not different among the study groups, while that of occludin was significantly decreased at the endothelium of stem villi in severe preeclampsia with IUGR. Rk-1 showed no effect on the placental junctional proteins. These results suggest that occludin may play a role in pathophysiology of fetal growth restriction in utero.
Anoxia ; Blotting, Western ; Cesarean Section ; Endothelial Cells ; Endothelium ; Female ; Fetal Development ; Fetal Growth Retardation ; gamma Catenin ; Ginsenosides ; Humans ; Immunohistochemistry ; Occludin ; Placenta ; Pre-Eclampsia ; Pregnancy ; Proteins